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A Handbook Of Transcription Factors
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Book Synopsis A Handbook of Transcription Factors by : Timothy R. Hughes
Download or read book A Handbook of Transcription Factors written by Timothy R. Hughes and published by Springer Science & Business Media. This book was released on 2011-05-10 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.
Book Synopsis A Handbook of Transcription Factors by : Timothy R. Hughes
Download or read book A Handbook of Transcription Factors written by Timothy R. Hughes and published by Springer. This book was released on 2011-05-26 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.
Book Synopsis Eukaryotic Transcription Factors by : David S. Latchman
Download or read book Eukaryotic Transcription Factors written by David S. Latchman and published by Academic Press. This book was released on 2003-11-21 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. Major families of eukaryotic transcription factors described Mechanisms of gene activation and repression analysed Structure-function relationships indicated Interaction between transcription factors and chromatin structure described Roles in inducible and cell type-specific gene expression Roles in development, differentiation and human diseases including cancer Methods of study in vitro and in vivo
Book Synopsis Transcription Factors by : Joseph Locker
Download or read book Transcription Factors written by Joseph Locker and published by Garland Science. This book was released on 2003-12-16 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription factors are important in regulating gene expression, and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes and factors that control transcription in eukaryotic cells. It examines the regulatory systems that modulate gene expression in all cells,a s well as the more specialized systems that regulate localized gene expression throughout the mammalian organism. Transcription Factors updates classical knowledge with recent advances to provide a full and comprehensive coverage of the field for postgraduates and researchers in molecular biology involved in the study of gene regulation.
Book Synopsis Transcription Factors and Human Disease by : Gregg L. Semenza
Download or read book Transcription Factors and Human Disease written by Gregg L. Semenza and published by Oxford Monographs on Medical G. This book was released on 1998 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses. Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.
Book Synopsis Handbook of Transcription Factor NF-kappaB by : Sankar Ghosh
Download or read book Handbook of Transcription Factor NF-kappaB written by Sankar Ghosh and published by CRC Press. This book was released on 2006-10-20 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB is proving to be the most protean of all transcription factors. It has been shown to function in most cell types as a key regulator of a number of inducible genes. Research on the responsibilities and resulting pathologies of NF-kB has been prolific, but until now there has been no consolidated, multidisciplinary reference. Providing contributions from leading authorities involved with seminal discoveries on the subject, Handbook of Transcription Factor NF-kappaB is an entry point to understanding the broad role of this widely studied factor. Beginning with a summary, the authors introduce the uninitiated reader to the complexities of the NF-kB system. They explain how a multitude of extracellular and intercellular signals integrated at the level of this transcription factor have led to fundamental insights about many aspects of gene regulation and signal transduction. The chapters delve into specific research aspects concerning the function and regulation of NF-kB in a number of biological systems. They discuss inflammation, innate and adaptive immunity, liver integrity, and nervous system development, as well as the formation of hair, skin, teeth, and many other aspects of the developing vertebrate body. The pathological effects of excess NF-kB activity are addressed in chapters on diseases related to chronic inflammation, such as heart disease, muscular dystrophy, cancer, and tumor proliferation, as well as diseases caused by inherent deficiencies in NF-kB. The text culminates in a discussion of current efforts to develop therapies aimed at inhibiting the aberrant activity of NF-kB in different diseases.
Book Synopsis Transcription Factors by : David Latchman
Download or read book Transcription Factors written by David Latchman and published by OUP Oxford. This book was released on 1999-04-08 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition five years ago, a wide range of new methodologies have been developed to facilitate studies on both isolated parts of the genome and the genome as a whole. This new edition has been updated and expanded so that it provides a comprehensive guide to the methods currently available to characterize the function and activity of an individual transcription factor. All the original chapters have been fully updated or rewritten and additional chapters cover the use of in vitro transcription assays, analysis of chromatin structure, use of the genomic binding site assay and analysis of transcription factor modifications. As with the previous edition, the book starts with a series of chapters concerned with characterizing the proteins binding to a specific DNA sequence and then a chapter on more detailed characterization of the protein itself. The next two chapters describe the isolation of cDNA clones encoding a transcription factor using oligonucleotides predicted from protein sequence and screening of a cDNA expression library. Chapter 6 deals with identification of transcription factors based on sequence homology analysis by both experimental screening and database searches. Chapter 7 is a new chapter that describes methods of identifying the target genes of a previously uncharacterized factor. The next chapters deal with analysis of transcription factor function. Chapter 8 deals with general techniques, and then the following chapters cover the specialized techniques of in vitro transcription assays using transcriptionally active nuclear extracts derived from rat brain, and analysis of the effect of transcription factors on chromatin structure. The final chapter describes methods for detecting the phosphorylation and glycosylation state of transcription factors.
Book Synopsis Transcriptional Regulation in Eukaryotes by : Michael F. Carey
Download or read book Transcriptional Regulation in Eukaryotes written by Michael F. Carey and published by CSHL Press. This book was released on 2000 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the genome era, the analysis of gene expression has become a critical requirement in many laboratories. But there has been no comprehensive source of strategic, conceptual, and technical information to guide this often complex task. Transcriptional Regulation in Eukaryotes answers that need. Written by two experienced investigators, Michael Carey and Stephen Smale at the UCLA School of Medicine, and based in part on the Gene Expression course taught at Cold Spring Harbor Laboratory, this book directly addresses all the concerns of a laboratory studying the regulation of a newly isolated gene and the biochemistry of a new transcription factor. This important and unique book is essential reading for anyone pursuing the analysis of gene expression in model systems or disease states.
Book Synopsis Plant Transcription Factors by : Daniel H Gonzalez
Download or read book Plant Transcription Factors written by Daniel H Gonzalez and published by Academic Press. This book was released on 2015-07-07 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Transcription Factors: Evolutionary, Structural and Functional Aspects is the only publication that provides a comprehensive compilation of plant transcription factor families and their complex roles in plant biology. While the majority of information about transcription factors is based on mammalian systems, this publication discusses plant transcription factors, including the important aspects and unifying themes to understanding transcription factors and the important roles of particular families in specific processes. Provides an entry point for transcription factor literature Offers compilation of information into one single resource for rapid consultation on different plant transcription factor features Integrates the knowledge about different transcription factors, along with cross-referencing Provides information on the unique aspects surrounding plant transcription factors
Book Synopsis Transcription Factors in Eukaryotes by : Athanasios Papavassiliou
Download or read book Transcription Factors in Eukaryotes written by Athanasios Papavassiliou and published by International Thomson Publishing Services. This book was released on 1997 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transcription Factor Protocols by : Martin J. Tymms
Download or read book Transcription Factor Protocols written by Martin J. Tymms and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effort to sequence the human genome is now moving toward a c- clusion. As all of the protein coding sequences are described, an increasing emphasis will be placed on understanding gene function and regulation. One important aspect of this analysis is the study of how transcription factors re- late transcriptional initiation by RNA polymerase II, which is responsible for transcribing nuclear genes encoding messenger RNAs. The initiation of Class II transcription is dependent upon transcription factors binding to DNA e- ments that include the core or basal promoter elements, proximal promoter elements, and distal enhancer elements. General initiation factors are involved in positioning RNA polymerase II on the core promoter, but the complex - teraction of these proteins and transcriptional activators binding to DNA e- ments outside the core promoter regulate the rate of transcriptional initiation. This initiation process appears to be a crucial step in the modulation of mRNA levels in response to developmental and environmental signals. Transcription Factor Protocols provides step-by-step procedures for key techniques that have been developed to study DNA sequences and the protein factors that regulate the transcription of protein encoding genes. This volume is aimed at providing researchers in the field with the well-detailed protocols that have been the hallmark of previous volumes of the Methods in Molecular TM Biology series.
Book Synopsis The Secret Lives of Transcription Factors by : Willis X. Li
Download or read book The Secret Lives of Transcription Factors written by Willis X. Li and published by Springer Nature. This book was released on 2023-04-25 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
Book Synopsis Transcription by : Ronald C. Conaway
Download or read book Transcription written by Ronald C. Conaway and published by Raven Press (ID). This book was released on 1994 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a coherent account of many productive lines of investigation, organized as a series of mini-reviews that focus on major research areas including studies on the structure and mechanisms of action of bacterial, viral, and eukaryotic RNA polymerases, and the transcription factors that control their activities. Each review provides a brief but up-to-date account of the progress of research in a particular area, a discussion of the major issues and questions driving that research, and a brief description of the evolving approaches and technologies used to address those questions. Annotation copyright by Book News, Inc., Portland, OR
Book Synopsis Transcription Factors: Advances in Research and Application: 2011 Edition by :
Download or read book Transcription Factors: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription Factors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Transcription Factors in a concise format. The editors have built Transcription Factors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Transcription Factors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Transcription Factors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Transcription Factors by : Paul J. Higgins
Download or read book Transcription Factors written by Paul J. Higgins and published by Humana Press. This book was released on 2010-08-20 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last few years, significant breakthroughs in transcription research expanded our appreciation for the complexity of molecular controls on gene expression in mammalian cells. In Transcription Factors: Methods and Protocols, experts in the field describe state-of-the-art approaches that investigators can use to probe critical mechanisms underlying transcription factor nuclear-cytoplasmic trafficking as well as to assess the functional impact of post-translational modifications on transcription factor function. The chapters are written by prominent scientists, many of whom developed these methods, and highlight protocols that focus on specific transcription factor family members with particular relevance to human disease. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and current, Transcription Factors: Methods and Protocols compiles the latest techniques for elucidating controls on transcription factor intracellular localization and activity, and consequently is unlike any other methods-based text on transcriptional regulation today.
Book Synopsis Transcription Factor Regulatory Networks by : Qi Song
Download or read book Transcription Factor Regulatory Networks written by Qi Song and published by Humana. This book was released on 2022-10-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers various state-of-the-art techniques regarding the associations between transcription factors (TFs) and genes, with a focus on providing methodological and practical references for researchers. The contents cover diverse protocols and summaries of TFs including screening of TF-DNA interactions, detection of open chromatin regions, identification of epigenetic regulations, engineering TFs with genome editing tools, detection of transcriptional activities, computational analysis of TF networks, functions and druggabilities of TFs in biomedical research, and much more. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice from the experts to ensure successful research results. Authoritative and cutting-edge, Transcription Factor Regulatory Networks aims to benefit readers who are interested in using state-of-the-art techniques to study TFs and their myriad effects in cellular life.
Book Synopsis Mechanisms of Gene Regulation by : Carsten Carlberg
Download or read book Mechanisms of Gene Regulation written by Carsten Carlberg and published by Springer. This book was released on 2016-06-06 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.
