Xenobiotic Metabolism

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Handbook of Metabolic Pathways of Xenobiotics

Author : Philip Lee
Publisher : Wiley
ISBN 13 : 9780470749104
Total Pages : 2560 pages
Book Rating : 4.7/5 (491 download)

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Book Synopsis Handbook of Metabolic Pathways of Xenobiotics by : Philip Lee

Download or read book Handbook of Metabolic Pathways of Xenobiotics written by Philip Lee and published by Wiley. This book was released on 2014-03-17 with total page 2560 pages. Available in PDF, EPUB and Kindle. Book excerpt: If you’re working on or studying the effects of drug metabolisms, then this reference is for you! Handbook of Metabolic Pathways of Xenobiotics is an essential new reference which presents the metabolic fate of xenobiotics in animals and plants, and shows the metabolic pathways in the environment. Presenting a comprehensive guide to understanding the metabolisms of xenobiotics, the Handbook of Metabolic Pathways of Xenobiotics spans five volumes: Volumes 1-2 are Review Articles and Volumes 3-5 are Compound Articles. Review Articles present detailed reviews on the techniques and methods used to establish in vitro and in vivo metabolic pathways. Compound Articles are carefully selected lists of key chemicals representing agrochemicals, pharmaceuticals, animal health products and industrial chemicals. An essential addition to every library, this introduction, guide and catalogue presents: Current topics in the metabolism of xenobiotics Topics of both scientific and regulatory importance are covered, including in vitro high throughput metabolism screens, computer-aided metabolism predictions, and advances in bioanalytical techniques. Techniques and methods used in metabolic pathways 29 chapters provide an introduction to the understanding of drug metabolism and detail how to establish in vitro and in vivo metabolic pathways. Biotransformation pathways Presented as a catalogue of short articles covering major pharmaceuticals, agrochemicals, animal health products and industrial chemicals. Each article summarizes the chemical properties and uses, and presents a detailed review of the chemical and metabolic pathways in soil, plants and animals. Over 450 examples of xenobiotics and their fate in animals and plants Each compound includes systematic information about the metabolic pathway of drugs for human and veterinary medicine, agrochemicals and major industrial chemicals. Chemical and biological fate data The Handbook summarises data from scientific literature, patent literature, industrial resources and regulatory agencies, such as the EPA, FDA, EU, WHO and FAO, in a single reference for the first time. An essential reference for everyone working and studying pharmacokinetics and drug metabolism Coverage of the chemical and biological reactivity of molecules and primary sub-structures makes this an ideal reference for students and research scientists. The broad and diverse coverage of chemical and biological fate under different exposure and biological compartments make this a useful resource for regulatory and developmental scientists. Experience the scope of content offered in the Handbook of Metabolic Pathways of Xenobiotics for yourself, download these articles today: Review Article: Fundamentals of organic chemistry as applicable to the biotransformation of foreign compounds Review Article: Metabolic stability screen in drug discovery Review Article: Unusual metabolic reactions and pathways Compound Article: Ganoderic acid D Compound Article: Milnacipran Compound Article: Tenofovir Online Edition Coming Soon! Featuring the same great content as the five volume print set, the Handbook of Metabolic Pathways for Xenobiotics will be available on Wiley Online Library in summer 2014. The online reference will benefit from the enhanced functionality powered by The Smart Article – learn more about The Smart Article at wileyonlinelibrary.com/thesmartarticle. Free trials will be available when the Online Edition goes live, bookmark this page or sign-up for regular product alerts at www.wiley.com/email to stay informed.

Metabolism of Drugs and Other Xenobiotics

Author : Pavel Anzenbacher
Publisher : John Wiley & Sons
ISBN 13 : 352732903X
Total Pages : 755 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Metabolism of Drugs and Other Xenobiotics by : Pavel Anzenbacher

Download or read book Metabolism of Drugs and Other Xenobiotics written by Pavel Anzenbacher and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.

Xenobiotic Metabolism and Disposition

Author : Harry P.A. Illing
Publisher : CRC Press
ISBN 13 : 100071456X
Total Pages : 229 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Xenobiotic Metabolism and Disposition by : Harry P.A. Illing

Download or read book Xenobiotic Metabolism and Disposition written by Harry P.A. Illing and published by CRC Press. This book was released on 2019-11-11 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such studies.

Microbial Metabolism of Xenobiotic Compounds

Author : Pankaj Kumar Arora
Publisher : Springer
ISBN 13 : 9811374627
Total Pages : 357 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Microbial Metabolism of Xenobiotic Compounds by : Pankaj Kumar Arora

Download or read book Microbial Metabolism of Xenobiotic Compounds written by Pankaj Kumar Arora and published by Springer. This book was released on 2019-06-27 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Xenobiotic compounds including pesticides, nitrophenols, pyridine, polycyclic aromatic compounds and polychlorinated biphenyls are widely spread in environment due to anthropogenic activities. Most of them are highly toxic to living beings due to their mutagenic and carcinogenic properties. Therefore, the removal of these compounds from environment is an essential step for environmental sustainability. Microbial remediation has emerged as an effective technology for degradation of these xenobiotic compounds as microorganisms have unique ability to utilize these compounds as their sole source of carbon and energy. The primary goal of this book is to provide detailed information of microbial degradation of many xenobiotic compounds in various microorganisms.

Enzyme Systems that Metabolise Drugs and Other Xenobiotics

Author : Costas Ioannides
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 600 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Enzyme Systems that Metabolise Drugs and Other Xenobiotics by : Costas Ioannides

Download or read book Enzyme Systems that Metabolise Drugs and Other Xenobiotics written by Costas Ioannides and published by John Wiley & Sons. This book was released on 2002 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include: * enzyme function in the metabolism and bioactivation of xenobiotics * substrate specificity * tissue distribution * species distribution (to include laboratory animals and humans) * hormonal regulation * sex differences * modulation by prior exposure to other chemicals * age-dependent expression * pharmacogenetics and modulation by disease. Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.

Hydrolysis in Drug and Prodrug Metabolism

Author : Bernard Testa
Publisher : John Wiley & Sons
ISBN 13 : 9783906390253
Total Pages : 808 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Hydrolysis in Drug and Prodrug Metabolism by : Bernard Testa

Download or read book Hydrolysis in Drug and Prodrug Metabolism written by Bernard Testa and published by John Wiley & Sons. This book was released on 2003-08 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.

Metabolism of Xenobiotics

Author : International Society for the Study of Xenobiotics
Publisher : Taylor & Francis Group
ISBN 13 :
Total Pages : 400 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Metabolism of Xenobiotics by : International Society for the Study of Xenobiotics

Download or read book Metabolism of Xenobiotics written by International Society for the Study of Xenobiotics and published by Taylor & Francis Group. This book was released on 1988 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Food Factors for Cancer Prevention

Author : Hajime Ohigashi
Publisher : Springer Science & Business Media
ISBN 13 : 4431670173
Total Pages : 661 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Food Factors for Cancer Prevention by : Hajime Ohigashi

Download or read book Food Factors for Cancer Prevention written by Hajime Ohigashi and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemoprevention is currently regarded as one of the most promising avenues for the control of cancer, with human epidemiological and animal studies indicating that the risk of cancer may be modified by changes in diet. Over 100 papers are collected in this volume, the proceedings of the International Conference on Food Factors: Chemistry and Cancer Prevention, held in Hamamatsu, Japan, in December 1995. Special emphasis is placed on chemical, biological, and molecular properties of phytochemicals in teas, fruit, vegetables, herbs, and spices, and on their potential for cancer prevention. Also discussed are the cancer-preventive effects of vitamins, lipids, carotenoids, flavonoids, and other components of diet. The findings presented here will be invaluable to all who are interested in diet and cancer prevention, and especially to biochemists, pharmacologists, food scientists, and nutritionists.

Drug Metabolism

Author : Mino R. Caira
Publisher : Springer Science & Business Media
ISBN 13 : 140204142X
Total Pages : 431 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Drug Metabolism by : Mino R. Caira

Download or read book Drug Metabolism written by Mino R. Caira and published by Springer Science & Business Media. This book was released on 2006-07-10 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Biological Reactive Intermediates III

Author : James J. Kocsis
Publisher : Springer Science & Business Media
ISBN 13 : 1468451340
Total Pages : 1028 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Biological Reactive Intermediates III by : James J. Kocsis

Download or read book Biological Reactive Intermediates III written by James J. Kocsis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1028 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.

A Textbook of Modern Toxicology

Author : Ernest Hodgson
Publisher : McGraw-Hill Medical Publishing
ISBN 13 :
Total Pages : 518 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis A Textbook of Modern Toxicology by : Ernest Hodgson

Download or read book A Textbook of Modern Toxicology written by Ernest Hodgson and published by McGraw-Hill Medical Publishing. This book was released on 1997 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised edition reflects changes in the core curriculum subjects covered in the basic toxicology course for graduate students. Designed as an introductory textbook, it emphasizes the fundamental basis of toxic action at the cellular and molecular levels and lays the foundation for specialized courses in toxicology. Additional topics include metabolic activation and cellular protection, clinical toxicology diagnosis and treatment, ecosystems, environmental toxicology, ecotoxicology, case histories, and future consideration for environmental and human health.

Encyclopedia of Cancer

Author : Manfred Schwab
Publisher : Springer Science & Business Media
ISBN 13 : 3540368477
Total Pages : 3307 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Encyclopedia of Cancer by : Manfred Schwab

Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Biochemistry of Redox Reactions

Author : Bernard Testa
Publisher : Academic Press
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Biochemistry of Redox Reactions by : Bernard Testa

Download or read book Biochemistry of Redox Reactions written by Bernard Testa and published by Academic Press. This book was released on 1995 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surpassing the 1976 book by Testa and Jenner, Drug Metabolism: Chemical and Biochemical Aspects (Dekker), this informative, up-to-date text includes the following features, unavailable elsewhere: First in a set of books to provide a comprehensive coverage of drug metabolism; Opening chapter provides a general introduction to the complete set of books; Other chapters cover reaction mechanisms, catalytic cycles, regio- and stereoselectivities, types of substrates, reactivity of intermediates, and drug-enzyme interactions; Extensive detailed diagrams of reaction pathways and chemical structures * First in a set of books providing a comprehensive coverage of drug metabolism * Opening chapter provides a general introduction to the complete set of books * Other chapters cover reaction mechanisms, catalytic cycles, regio and stereoselectivities, types of substrates, reactivity of intermediates and drug-enzyme interactions * Extensive detailed diagrams of reaction pathways and chemical structures

Xenobiotics in Chemical Carcinogenesis

Author : Akhileshwar Kumar Srivastava
Publisher : Academic Press
ISBN 13 : 0323906818
Total Pages : 328 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Xenobiotics in Chemical Carcinogenesis by : Akhileshwar Kumar Srivastava

Download or read book Xenobiotics in Chemical Carcinogenesis written by Akhileshwar Kumar Srivastava and published by Academic Press. This book was released on 2022-02-17 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development. Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants. Covers the exposure and transmission of various toxic xenobiotics substances, including nanomaterials, to humans and their interaction with specific tissues in precipitating the development of cancers Unravels the toxicokinetic and toxicodynamic processes of toxic xenobiotics in bioaccumulation Examines the genetic aberrations in cancer genomes by genetic-environmental interactions in carcinogenesis Explains the biotransformation mechanisms of toxic xenobiotics by gut microbes in humans

Human Drug Metabolism

Author : Michael D. Coleman
Publisher : John Wiley & Sons
ISBN 13 : 9780470689349
Total Pages : 360 pages
Book Rating : 4.6/5 (893 download)

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Book Synopsis Human Drug Metabolism by : Michael D. Coleman

Download or read book Human Drug Metabolism written by Michael D. Coleman and published by John Wiley & Sons. This book was released on 2010-03-30 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.

Xenobiotic Metabolism and Disposition

Author : Ryūichi Katō
Publisher : Taylor & Francis
ISBN 13 : 9780850667370
Total Pages : 612 pages
Book Rating : 4.6/5 (673 download)

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Book Synopsis Xenobiotic Metabolism and Disposition by : Ryūichi Katō

Download or read book Xenobiotic Metabolism and Disposition written by Ryūichi Katō and published by Taylor & Francis. This book was released on 1989 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Papers of the May, 1988 meeting. They provide an overview of recent research and current theory in the field. Topics include the molecular biology and multiplicity of cytochrome P-450; non-P-450 enzymes; drug design and delivery; stereochemical aspects; characteristics of drug metabolism in humans;

Xenobiotic Metabolism

Author : John W. Finley
Publisher :
ISBN 13 : 9780608039084
Total Pages : 392 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Xenobiotic Metabolism by : John W. Finley

Download or read book Xenobiotic Metabolism written by John W. Finley and published by . This book was released on 1985-01-01 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: