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Workshop The Biophysics Of The Cochlea Molecules To Models
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Book Synopsis Biophysics Of The Cochlea: From Molecules To Models - Proceedings Of The International Symposium by : Anthony W Gummer
Download or read book Biophysics Of The Cochlea: From Molecules To Models - Proceedings Of The International Symposium written by Anthony W Gummer and published by World Scientific. This book was released on 2003-02-28 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the proceedings of an international hearing-research conference held in Germany 2002. The conference brought together experts in genetics, molecular and cellular biology, physiology, engineering, physics, mathematics, audiology and medicine to synthesize and extend our understanding of how the cochlea works. Topics are discussed experimentally and theoretically at the molecular, cellular and whole-organ levels. Some of the topics are: mechanosensitivity of motor proteins; mechanochemical transduction by motor proteins; mechanoelectrical transduction in the stereocilia of hair cells; electromechanical transduction in the stereocilia, soma and synapses of hair cells; multidimensional vibration of the organ of Corti; and otoacoustic emissions. This book will be invaluable to researchers and students in auditory science.The proceedings have been selected for coverage in:• Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings)
Book Synopsis Concepts and Challenges in the Biophysics of Hearing by : Nigel Paul Cooper
Download or read book Concepts and Challenges in the Biophysics of Hearing written by Nigel Paul Cooper and published by World Scientific. This book was released on 2009 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of cutting-edge research on the mechanical operation of the peripheral auditory system. Bringing together over 50 theoretical and experimental studies by leading researchers, it covers the molecular, cellular and systems levels using a powerful combination of biological, mathematical and engineering techniques. In addition to the scientific papers, the book includes the comments and discussions raised by the individual manuscripts at the time of their presentation, and a final chapter with the edited transcripts of a discussion session covering "outstanding topics" between some of the most prominent researchers in the field. The first-hand information provided by these transcripts will make the book particularly interesting.Renowned contributors to the book include Profs. JF Ashmore (FRS, UK), E de Boer (The Netherlands), W Brownell (USA), P Dallos (USA), R Fettiplace (FRS, USA), AW Gummer (Germany), AJ Hudspeth (USA), DC Mountain (USA), AL Nuttall (USA), IJ Russell (FRS, UK), CA Shera (USA), and H Wada (Japan).
Download or read book Biophysics written by William Bialek and published by Princeton University Press. This book was released on 2012-12-17 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: A physicist's guide to the phenomena of life Interactions between the fields of physics and biology reach back over a century, and some of the most significant developments in biology—from the discovery of DNA's structure to imaging of the human brain—have involved collaboration across this disciplinary boundary. For a new generation of physicists, the phenomena of life pose exciting challenges to physics itself, and biophysics has emerged as an important subfield of this discipline. Here, William Bialek provides the first graduate-level introduction to biophysics aimed at physics students. Bialek begins by exploring how photon counting in vision offers important lessons about the opportunities for quantitative, physics-style experiments on diverse biological phenomena. He draws from these lessons three general physical principles—the importance of noise, the need to understand the extraordinary performance of living systems without appealing to finely tuned parameters, and the critical role of the representation and flow of information in the business of life. Bialek then applies these principles to a broad range of phenomena, including the control of gene expression, perception and memory, protein folding, the mechanics of the inner ear, the dynamics of biochemical reactions, and pattern formation in developing embryos. Featuring numerous problems and exercises throughout, Biophysics emphasizes the unifying power of abstract physical principles to motivate new and novel experiments on biological systems. Covers a range of biological phenomena from the physicist's perspective Features 200 problems Draws on statistical mechanics, quantum mechanics, and related mathematical concepts Includes an annotated bibliography and detailed appendixes
Book Synopsis Mathematical modelling and electrophysiological monitoring of the regulation of cochlear amplification by : Greg A. O'Beirne
Download or read book Mathematical modelling and electrophysiological monitoring of the regulation of cochlear amplification written by Greg A. O'Beirne and published by The University of Western Australia. This book was released on 2005-08-30 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cochlea presumably possesses a number of regulatory mechanisms to maintain cochlear sensitivity in the face of disturbances to its function. Evidence for such mechanisms can be found in the time-course of the recovery of CAP thresholds during experimental manipulations, and in observations of slow oscillations in cochlear micromechanics following exposure to low-frequency tones (the “bounce phenomenon”) and other perturbations. To increase our understanding of the these oscillatory processes within the cochlea, and OHCs in particular, investigations into cochlear regulation were carried out using a combination of mathematical modelling of the ionic and mechanical interactions likely to exist within the OHCs, and electrophysiological experiments conducted in guinea pigs. The electrophysiological experiments consisted of electrocochleographic recordings and, in some cases, measurement of otoacoustic emissions, during a variety of experimental perturbations, including the application of force to the cochlear wall, exposure to very-low-frequency tones, injection of direct current into scala tympani, and intracochlear perfusions of artificial perilymph containing altered concentrations of potassium, sodium, and sucrose. To obtain a panoramic view of cochlear regulation under these conditions, software was written to enable the interleaved and near-simultaneous measurement of multiple indicators of cochlear function, including the compound action potential (CAP) threshold, amplitude and waveshape at multiple frequencies, the OHC transfer curves derived from low-frequency cochlear microphonic (CM) waveforms, distortion-product otoacoustic emissions (DPOAEs), the spectrum of the round-window neural noise (SNN), and the endocochlear potential (EP). The mathematical model takes into account the known electrical properties of OHC, and includes the effect of fast and slow-motility of the cell body on transducer operating point and apical conductance. Central to the operation of the model is a putative intracellular 2nd-messenger system based on cytosolic calcium, which is involved in regulation of i) the operating point of OHC MET channels via slow motility and axial stiffness; ii) the permeability of the basolateral wall to potassium (via calcium-sensitive potassium channels); and iii) the cytosolic concentration of calcium itself, via modulation of its own sequestration into (and release from) intracellular storage organelles, and extrusion from the cell. The model was constructed in a manner which allowed simulation of different cochlear perturbations, and the comparison of results from these simulations to experimental data. The mathematical model we have developed provided a physiologically-plausible and internally-consistent explanation for the time-courses of the cochlear changes observed during a number of different perturbations. We show that much of the oscillatory behaviour within the cochlea is consistent with underlying oscillations in cytosolic calcium concentration. We conclude that a number of the discrepancies between the simulation results and the experimental data can be resolved if the cytosolic calcium functions as two distinct pools: one which controls basolateral permeability and one which controls slow motility. This two-calcium-pool model is discussed.
Book Synopsis Auditory Mechanisms: Processes And Models - Proceedings Of The Ninth International Symposium (With Cd-rom) by : Alfred L Nuttall
Download or read book Auditory Mechanisms: Processes And Models - Proceedings Of The Ninth International Symposium (With Cd-rom) written by Alfred L Nuttall and published by World Scientific. This book was released on 2006-08-10 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: The workshop brought together experts in genetics, molecular and cellular biology, physiology, engineering, physics, mathematics, audiology and medicine to present current work and to review the critical issues of inner ear function. A special emphasis of the workshop was on analytical model based studies. Experimentalists and theoreticians thus shared their points of view. The topics ranged from consideration of the hearing organ as a system to the study and modeling of individual auditory cells including molecular aspects of function. Some of the topics in the book are: motor proteins in hair cells; mechanical and electrical aspects of transduction by motor proteins; function of proteins in stereocilia of hair cells; production of acoustic force by stereocilia, mechanical properties of hair cells and the organ of Corti; mechanical vibration of the organ of Corti; wave propagation in tissue and fluids of the inner ear; sound amplification in the cochlea; critical oscillations; cochlear nonlinearity, and mechanisms for the production of otoacoustic emissions. This book will be invaluable to researchers and students in auditory science.
Book Synopsis Automated Nanohandling by Microrobots by : Sergej Fatikow
Download or read book Automated Nanohandling by Microrobots written by Sergej Fatikow and published by Springer Science & Business Media. This book was released on 2008 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to robot-based nanohandling. It presents work on the development of a versatile microrobot-based nanohandling robot station inside a scanning electron microscope (SEM). Those unfamiliar with the subject will find the text, which is complemented throughout by the extensive use of illustrations, clear and simple to understand. The author has published two books and numerous papers in the field, and holds more than 50 patents.
Book Synopsis The Biophysics of Cell Membranes by : Richard M. Epand
Download or read book The Biophysics of Cell Membranes written by Richard M. Epand and published by Springer. This book was released on 2017-09-25 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the modulation of biological membranes by specific biophysical properties. The readers are introduced to emerging biophysical approaches that mimick specific states (like membrane lipid asymmetry, membrane curvature, lipid flip-flop, lipid phase separation) that are relevant to the functioning of biological membranes. The first chapter describes innovative methods to mimic the prevailing asymmetry in biological membranes by forming asymmetrical membranes made of monolayers with different compositions. One of the chapters illustrates how physical parameters, like curvature and elasticity, can affect and modulate the interactions between lipids and proteins. This volume also describes the sensitivity of certain ion channels to mechanical forces and it presents an analysis of how cell shape is determined by both the cytoskeleton and the lipid domains in the membrane. The last chapter provides evidence that liposomes can be used as a minimal cellular model to reconstitute processes related to the origin of life. Each topic covered in this volume is presented by leading experts in the field who are able to present clear, authoritative and up-to-date reviews. The novelty of the methods proposed and their potential for a deeper molecular description of membrane functioning are particularly relevant experts in the areas of biochemistry, biophysics and cell biology, while also presenting clear and thorough introductions, making the material suitable for students in these fields as well.
Book Synopsis The Journal of the Acoustical Society of America by : Acoustical Society of America
Download or read book The Journal of the Acoustical Society of America written by Acoustical Society of America and published by . This book was released on 2005 with total page 1288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Computational Protein Design by : Ilan Samish
Download or read book Computational Protein Design written by Ilan Samish and published by Humana. This book was released on 2016-12-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim this volume is to present the methods, challenges, software, and applications of this widespread and yet still evolving and maturing field. Computational Protein Design, the first book with this title, guides readers through computational protein design approaches, software and tailored solutions to specific case-study targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Protein Design aims to ensure successful results in the further study of this vital field.
Book Synopsis Converging Technologies for Improving Human Performance by : Mihail C. Roco
Download or read book Converging Technologies for Improving Human Performance written by Mihail C. Roco and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: M. C. Roco and W.S. Bainbridge In the early decades of the 21st century, concentrated efforts can unify science based on the unity of nature, thereby advancing the combination of nanotechnology, biotechnology, information technology, and new technologies based in cognitive science. With proper attention to ethical issues and societal needs, converging in human abilities, societal technologies could achieve a tremendous improvement outcomes, the nation's productivity, and the quality of life. This is a broad, cross cutting, emerging and timely opportunity of interest to individuals, society and humanity in the long term. The phrase "convergent technologies" refers to the synergistic combination of four major "NBIC" (nano-bio-info-cogno) provinces of science and technology, each of which is currently progressing at a rapid rate: (a) nanoscience and nanotechnology; (b) biotechnology and biomedicine, including genetic engineering; (c) information technology, including advanced computing and communications; (d) cognitive science, including cognitive neuroscience. Timely and Broad Opportunity. Convergence of diverse technologies is based on material unity at the nanoscale and on technology integration from that scale.
Author :National Institutes of Health (U.S.). Division of Research Grants Publisher : ISBN 13 : Total Pages :1124 pages Book Rating :4.3/5 (91 download)
Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants
Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1972 with total page 1124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Integrative Biophysics by : Fritz-Albert Popp
Download or read book Integrative Biophysics written by Fritz-Albert Popp and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the specialists working in this interdisciplinary field of physics, biology, biophysics and medicine are associated with "The International Institute of Biophysics" (IIB), in Neuss, Germany, where basic research and possibilities for applications are coordinated. The growth in this field is indicated by the increase in financial support, interest from the scientific community and frequency of publications. Audience: The scientists of IIB have presented the most essential background and applications of biophotonics in these lecture notes in biophysics, based on the summer school lectures by this group. This book is devoted to questions of elementary biophysics, as well as current developments and applications. It will be of interest to graduate and postgraduate students, life scientists, and the responsible officials of industries and governments looking for non-invasive methods of investigating biological tissues.
Book Synopsis An Invitation to Mathematical Physics and Its History by : Jont Allen
Download or read book An Invitation to Mathematical Physics and Its History written by Jont Allen and published by Springer Nature. This book was released on 2020-09-22 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state of the art book takes an applications based approach to teaching mathematics to engineering and applied sciences students. The book lays emphasis on associating mathematical concepts with their physical counterparts, training students of engineering in mathematics to help them learn how things work. The book covers the concepts of number systems, algebra equations and calculus through discussions on mathematics and physics, discussing their intertwined history in a chronological order. The book includes examples, homework problems, and exercises. This book can be used to teach a first course in engineering mathematics or as a refresher on basic mathematical physics. Besides serving as core textbook, this book will also appeal to undergraduate students with cross-disciplinary interests as a supplementary text or reader.
Download or read book Research Awards Index written by and published by . This book was released on 1981 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Physiological Acoustics by : Juergen Tonndorf
Download or read book Physiological Acoustics written by Juergen Tonndorf and published by . This book was released on 1981 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Principles of Clinical Pharmacology by : Arthur J. Atkinson Jr.
Download or read book Principles of Clinical Pharmacology written by Arthur J. Atkinson Jr. and published by Elsevier. This book was released on 2011-04-28 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists. - Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy - Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course - Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study - Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry - Expanded coverage of pharmacogenetics - Expanded coverage of drug transporters and their role in interactions - Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions - A new chapter on drug discovery that focuses on oncologic agents - Inclusion of therapeutic antibodies in chapter on biotechnology products
Download or read book Biophysics written by Roland Glaser and published by Springer Science & Business Media. This book was released on 2012-04-23 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysics is the science of physical principles underlying all processes of life, including the dynamics and kinetics of biological systems. This fully revised 2nd English edition is an introductory text that spans all steps of biological organization, from the molecular, to the organism level, as well as influences of environmental factors. In response to the enormous progress recently made, especially in theoretical and molecular biophysics, the author has updated the text, integrating new results and developments concerning protein folding and dynamics, molecular aspects of membrane assembly and transport, noise-enhanced processes, and photo-biophysics. The advances made in theoretical biology in the last decade call for a fully new conception of the corresponding sections. Thus, the book provides the background needed for fundamental training in biophysics and, in addition, offers a great deal of advanced biophysical knowledge.
