Heritable Human Genome Editing

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Author :
Publisher : National Academies Press
ISBN 13 : 0309671132
Total Pages : 239 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Heritable Human Genome Editing by : The Royal Society

Download or read book Heritable Human Genome Editing written by The Royal Society and published by National Academies Press. This book was released on 2021-01-16 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing

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Author :
Publisher : World Health Organization
ISBN 13 : 9240034609
Total Pages : 9 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing by :

Download or read book WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing written by and published by World Health Organization. This book was released on 2021-08-31 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: The report of the sixth meeting of the WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing summarizes the meeting that was held virtually on 25–26 March 2021. It provides a summary of the past activities of the Committee, the discussions, outcomes and future work of the Committee.

Human Genome Editing

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Author :
Publisher : National Academies Press
ISBN 13 : 0309452880
Total Pages : 329 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Human Genome Editing by : National Academies of Sciences, Engineering, and Medicine

Download or read book Human Genome Editing written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-08-13 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing. Human Genome Editing

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Author :
Publisher : World Health Organization
ISBN 13 : 9240030409
Total Pages : 15 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing. Human Genome Editing by :

Download or read book WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing. Human Genome Editing written by and published by World Health Organization. This book was released on 2021-07-12 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Altered Inheritance

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Author :
Publisher : Harvard University Press
ISBN 13 : 0674976711
Total Pages : 305 pages
Book Rating : 4.6/5 (749 download)

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Book Synopsis Altered Inheritance by : Françoise Baylis

Download or read book Altered Inheritance written by Françoise Baylis and published by Harvard University Press. This book was released on 2019-09-17 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: A leading bioethicist offers critical insights into the scientific, ethical, and political implications of human genome editing. Designer babies, once found only in science fiction, have become a reality. We are entering a new era of human evolution with the advent of a technology called CRISPR, which allows scientists to modify our genes. Although CRISPR shows great promise for therapeutic use, it raises thorny ethical, legal, political, and societal concerns because it can be used to make permanent changes to future generations. What if changes intended for the good turn out to have unforeseen negative effects? What if the divide between the haves and have-nots widens as a result? Who decides whether we genetically modify human beings and, if so, how? Françoise Baylis insists that we must all have a role in determining our future as a species. The scientists who develop and use genome-editing tools should not be the only ones making decisions about future uses of the technology. Such decisions must be the fruit of a broad societal consensus. Baylis argues that it is in our collective interest to assess and steer the development and implementation of biomedical technologies. Members of the public with different interests and diverse perspectives must be among the decision makers; only in this way can we ensure that societal concerns are taken into account and that responsible decisions are made. We must be engaged and informed, think critically, and raise our voices as we create our future together. Sharp, rousing, timely, and thought-provoking, Altered Inheritance is essential reading. The future of humanity is in our hands.

WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing. Human Genome Editing

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Author :
Publisher : World Health Organization
ISBN 13 : 9240030069
Total Pages : 103 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing. Human Genome Editing by :

Download or read book WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing. Human Genome Editing written by and published by World Health Organization. This book was released on 2021-07-12 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt:

WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing. Human Genome Editing

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Author :
Publisher : World Health Organization
ISBN 13 : 9240030387
Total Pages : 64 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing. Human Genome Editing by :

Download or read book WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing. Human Genome Editing written by and published by World Health Organization. This book was released on 2021-07-12 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hacking Darwin

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Author :
Publisher : Sourcebooks, Inc.
ISBN 13 : 1492670103
Total Pages : 253 pages
Book Rating : 4.4/5 (926 download)

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Book Synopsis Hacking Darwin by : Jamie Metzl

Download or read book Hacking Darwin written by Jamie Metzl and published by Sourcebooks, Inc.. This book was released on 2019-04-23 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A gifted and thoughtful writer, Metzl brings us to the frontiers of biology and technology, and reveals a world full of promise and peril." — Siddhartha Mukherjee MD, New York Times bestselling author of The Emperor of All Maladies and The Gene A groundbreaking exploration of genetic engineering and its impact on the future of our species from leading geopolitical expert and technology futurist, Jamie Metzl. At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race. Enter the laboratories where scientists are turning science fiction into reality. In this captivating and thought-provoking nonfiction science book, Jamie Metzl delves into the ethical, scientific, political, and technological dimensions of genetic engineering, and shares how it will shape the course of human evolution. Cutting-edge insights into the field of genetic engineering and its implications for humanity's future Explores the transformative power of genetic technologies and their potential to reshape human life Examines the ethical considerations surrounding genetic engineering and the choices we face as a species Engaging narrative that delves into the scientific breakthroughs and real-world applications of genetic technologies Provides a balanced perspective on the promises and risks associated with genetic engineering Raises thought-provoking questions about the future of reproduction, human health, and our relationship with nature Drawing on his extensive background in genetics, national security, and foreign policy, Metzl paints a vivid picture of a world where advancements in technology empower us to take control of our own evolution, but also cautions against the pitfalls and ethical dilemmas that could arise if not properly managed. Hacking Darwin is a must-read for anyone interested in the intersection of science, technology, and humanity's future.

Governing, Protecting, and Regulating the Future of Genome Editing

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Author :
Publisher : BRILL
ISBN 13 : 9004526137
Total Pages : 319 pages
Book Rating : 4.0/5 (45 download)

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Book Synopsis Governing, Protecting, and Regulating the Future of Genome Editing by : Santa Slokenberga

Download or read book Governing, Protecting, and Regulating the Future of Genome Editing written by Santa Slokenberga and published by BRILL. This book was released on 2023-03-06 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited collection examines the ethical, legal, social and policy implications of genome editing technologies. Moreover, it offers a broad spectrum of timely legal analysis related to bringing genome editing to the market and making it available to patients, including addressing genome editing technology regulation through procedures for regulatory approval, patent law and competition law. In twelve chapters, this volume offers persuasive arguments for justifying transformative regulatory interventions regarding human genome editing, as well as the various legal venues for introducing necessary or desirable changes needed to create an environment for realizing the potential of genome editing technology for the benefit of patients and society.

WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing

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Author :
Publisher : World Health Organization
ISBN 13 : 9240034773
Total Pages : 10 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing by :

Download or read book WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing written by and published by World Health Organization. This book was released on 2021-09-21 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Promise and Peril of CRISPR

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Author :
Publisher : JHU Press
ISBN 13 : 1421449315
Total Pages : 196 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis The Promise and Peril of CRISPR by : Neal Baer

Download or read book The Promise and Peril of CRISPR written by Neal Baer and published by JHU Press. This book was released on 2024-07-02 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely collection of essays on the pressing possibilities and risks of gene-editing technology. Scientists and genetic engineers are becoming increasingly adept at editing the human genome. How far can—and should—they go in editing future generations? In The Promise and Peril of CRISPR, editor Neal Baer brings together a timely collection of essays by influential bioethicists, philosophers, and geneticists to explore the moral, ethical, and policy challenges posed by CRISPR technology. We are at a technological and ethical crossroads in grappling with the impacts of genetic editing. Gene-editing technology holds the promise of curing more than 7,000 known genetic diseases. Yet with that promise comes the peril of using CRISPR to edit the human genome, which could not only lead to manipulating human evolution, but also to creating and releasing pathogens capable of wreaking havoc on human, animal, and plant life. Although CRISPR has already cured several genetic diseases, it could also be used to design biological weapons or to edit the embryos of people who can afford to purchase genetic "enhancements" for their children. What role can and should the public play in discussing the far-reaching implications of gene editing? What oversights should be put in place to prevent a rogue scientist from engineering another baby – as was recently done with twins in China? Essay contributors offer informed predictions and guidelines for how the uses of CRISPR today will affect life in the future. Decisions we make now may have unpredictable consequences for future generations. For anyone concerned about the uses and potential abuses of gene editing, these essays provide a critical and comprehensive discussion of the central issues surrounding CRISPR technology. Contributors: Florence Ashley, R. Alta Charo, Marcy Darnovsky, Kevin Doxzen, Rosemarie Garland-Thomson, Gigi Kwik Gronvall, Jodi Halpern, Katie Hasson, Andrew C. Heinrich, Jacqueline Humphries, J. Benjamin Hurlbut, Ellen D. Jorgensen, Peter F. R. Mills, Carol Padden, Marcus Schultz-Bergin, Robert Sparrow, Sandra Sufian, Krystal Tsosie, Ethan Weiss, Rachel M. West

Regulation and Governance of Gene Editing Technologies (CRISPR, etc.)

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832503918
Total Pages : 113 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Regulation and Governance of Gene Editing Technologies (CRISPR, etc.) by : Alberto Asquer

Download or read book Regulation and Governance of Gene Editing Technologies (CRISPR, etc.) written by Alberto Asquer and published by Frontiers Media SA. This book was released on 2022-11-04 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:

WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing

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Author :
Publisher : World Health Organization
ISBN 13 : 9240034757
Total Pages : 10 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing by :

Download or read book WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing written by and published by World Health Organization. This book was released on 2021-09-21 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Second WHO consultative meeting on a global guidance framework to harness the responsible use of life sciences

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Author :
Publisher : World Health Organization
ISBN 13 : 9240039546
Total Pages : 17 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis Second WHO consultative meeting on a global guidance framework to harness the responsible use of life sciences by :

Download or read book Second WHO consultative meeting on a global guidance framework to harness the responsible use of life sciences written by and published by World Health Organization. This book was released on 2021-12-10 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Regulation of Genome Editing in Human iPS Cells

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Author :
Publisher : Springer Nature
ISBN 13 : 3030930238
Total Pages : 340 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Regulation of Genome Editing in Human iPS Cells by : Hans-Georg Dederer

Download or read book Regulation of Genome Editing in Human iPS Cells written by Hans-Georg Dederer and published by Springer Nature. This book was released on 2022-05-23 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a concise overview of currently applicable regulatory frameworks of states which are among the world leaders in research and development (R&D) of cell and gene therapies. Developments in genome editing are expected to lead to new possibilities for the treatment of hereditary diseases in humans. The treatment of such often severe but hitherto uncurable diseases can be based on genome-edited induced pluripotent stem cells (iPS cells). Such treatments constitute combined cell/gene therapies. These therapies need to be governed by a regulatory framework which ensures quality, safety, and efficacy of the relevant therapeutic products. On the other hand, such regulations may retard product approval and impede R&D. Accordingly, national regulations for therapies based on genome-edited iPS cells are an important and, as the case may be, decisive factor for both researchers and industry regarding their decision where to locate their R&D activities. Therefore, regulatory frameworks impact significantly on the competitiveness of states and their economies. This is why a comparative analysis of laws and regulations of different countries matters. Such a comparative legal analysis provides an important insight into regulatory concepts which, in turn, may inspire adjustments of, or amendments to, domestic legal regimes. For this purpose, experts present country reports on France, Germany, Japan, South Korea, Switzerland, and the USA. The reports on France and Germany also refer to the parameters and implications arising from pertinent EU law. This contributed volume is aimed at researchers, but also at, e.g., legal scholars, lawmakers, regulators, and political decision makers.

Comparative Legal Frameworks for Pre-Implantation Embryonic Genetic Interventions

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Author :
Publisher : Springer
ISBN 13 : 3030223086
Total Pages : 339 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Comparative Legal Frameworks for Pre-Implantation Embryonic Genetic Interventions by : Pin Lean Lau

Download or read book Comparative Legal Frameworks for Pre-Implantation Embryonic Genetic Interventions written by Pin Lean Lau and published by Springer. This book was released on 2019-08-01 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the possibilities for the use of ​international human rights law ​(and specifically, international biomedical laws related to the protection of human rights and the human genome) to provide a guiding framework for the future regulation of genetic modifications applied to human embryos and other precursor materials, when these are made with the aim of implanting a genetically altered embryo in a woman. The significance and timeliness of the work derives from the recent availability of CRISPR/​Cas9 and other gene editing tools, and from lacunae in international law regarding the legality of embryo modification with these tools and appropriate governance structures for the oversight of resulting practices. The emergence of ​improved genome editing tools like CRISPR/Cas9, holds the promise of eradicating genetic diseases in the near future. But its possible future applications with Pre-Implantation Genetic Diagnosis (PGD) raises a plethora of legal and ethical concerns about "remaking" future human beings. The work aims to address an urgent call, to embed these rising concerns about biomedical advancements into the fundamental tailoring of legal systems. Suitable regulatory approaches, coupled with careful reflection of global biomedical laws and individual constitutional systems must be explored. The Book analyzes the impact of reproductive biomedical technologies on the legal and ethical dimensions of regulatory frameworks in selected constitutional systems like the US, the UK, Australia, Malaysia and Thailand. Employing a comparative law methodology, the work reveals a dynamic intersection between legal cultures, socio-philosophical reasoning and the development of a human rights-based framework in bio-political studies. Navigating towards a truly internationalized biomedical approach to emerging technologies, it presents an understanding why a renegotiation and reinvigoration of a contemporary and "new" universal shared values system in the ​international human rights discourse is now necessary.

Embryonic Stem Cells and the Law

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Author :
Publisher : Springer Nature
ISBN 13 : 3031597508
Total Pages : 286 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Embryonic Stem Cells and the Law by : Joshua Weiser

Download or read book Embryonic Stem Cells and the Law written by Joshua Weiser and published by Springer Nature. This book was released on with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: