Virotherapy

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Oncolytic Virotherapy

Author : Ahmed Majeed Al-Shammari
Publisher : Frontiers Media SA
ISBN 13 : 2832539424
Total Pages : 213 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Oncolytic Virotherapy by : Ahmed Majeed Al-Shammari

Download or read book Oncolytic Virotherapy written by Ahmed Majeed Al-Shammari and published by Frontiers Media SA. This book was released on 2023-11-20 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using viruses to treat cancer is an established concept, and many viruses have shown promising anti-tumor efficacies. Oncolytic viruses are safe and well-characterized pathogens with a stable genome. The outstanding clinical results for oncolytic virotherapy deserve serious attention and consideration to make it a treatment option alongside classical cancer therapeutics. Virotherapy uses replication-competent oncolytic viruses to replicate and destroy cancer cells selectively. The transformed nature of cancer cells offers a permissive environment for some viruses’ replication and to complement viral mutations. The in situ amplification and spread within the tumor mass is the key benefit of such replication-competent viruses. Oncolytic virotherapy is divided into two main groups, according to tumor specificity: naturally oncolytic viruses to replicate in human cancer cells; and gene-modified viruses engineered to accomplish selective oncolysis.

Oncolytic Viruses

Author : Christine E. Engeland
Publisher : Humana
ISBN 13 : 9781493997961
Total Pages : 329 pages
Book Rating : 4.9/5 (979 download)

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Book Synopsis Oncolytic Viruses by : Christine E. Engeland

Download or read book Oncolytic Viruses written by Christine E. Engeland and published by Humana. This book was released on 2020-09-19 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide a guide for virologists, translational researchers, and clinicians in the field of cancer research by providing reference protocols and methodologies from vector development through clinical translation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Oncolytic Viruses: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Progress in Cancer Immunotherapy

Author : Shuren Zhang
Publisher : Springer
ISBN 13 : 9401775559
Total Pages : 283 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Progress in Cancer Immunotherapy by : Shuren Zhang

Download or read book Progress in Cancer Immunotherapy written by Shuren Zhang and published by Springer. This book was released on 2016-05-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. Thanks to rapid advances in molecular biology and immunology, it has become increasingly evident that cancer growth is influenced by host immune responses. With the success of a number of clinical trials, immunotherapy has become a promising treatment modality of cancer. This book covers five major topics, including monoclonal antibodies, biological response modifiers, cancer vaccines, adoptive cellular therapy and oncolytic viruses. It also examines the combination of different immune strategies as well as the combination of immunotherapy with other treatments to increase anti-tumor effects. Through the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors.

Recent Advances in Cancer Research and Therapy

Author : Xin-Yuan Liu
Publisher : Elsevier
ISBN 13 : 012397836X
Total Pages : 700 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Recent Advances in Cancer Research and Therapy by : Xin-Yuan Liu

Download or read book Recent Advances in Cancer Research and Therapy written by Xin-Yuan Liu and published by Elsevier. This book was released on 2012-05-18 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy. There is also a discussion of current cancer research in China including traditional Chinese medicine. Written by leading scientists in the field, this book provides an essential insight into the current state of cancer therapy and treatment. Includes a wide range of research areas including a focus on biotherapy and the development of novel cancer therapeutic strategies. Formatted for a broad audience including all working in researching cancer treatments and therapies. Discusses special traits and results of Chinese cancer research.

Virotherapy

Author : Fouad Sabry
Publisher : One Billion Knowledgeable
ISBN 13 :
Total Pages : 363 pages
Book Rating : 4.:/5 (661 download)

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Book Synopsis Virotherapy by : Fouad Sabry

Download or read book Virotherapy written by Fouad Sabry and published by One Billion Knowledgeable. This book was released on 2022-10-05 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: What Is Virotherapy Reprogramming viruses in order to cure illness is an example of virotherapy, which is a kind of treatment that makes use of biotechnology to turn viruses into therapeutic agents. Anti-cancer oncolytic viruses, viral vectors for gene therapy, and viral immunotherapy are the three primary subspecialties that fall under the umbrella term "virotherapy." Gene overexpression, gene knockout, and suicide gene delivery are the three distinct approaches that are used by these branches throughout the therapeutic process. Gene overexpression results in the addition of genetic sequences that make up for insufficient or nonexistent amounts of essential gene expression. Gene silencing or expression reduction may be achieved by gene deletion by using RNA-based techniques. The delivery of suicide genes involves the introduction of genetic sequences that trigger an apoptotic response in cells; this is often done in order to eliminate malignant growths. In a somewhat different setting, the term "virotherapy" may also refer to the use of viruses to cure certain medical problems by eliminating infections. This is one definition of the term. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Virotherapy Chapter 2: Gene therapy Chapter 3: Immunotherapy Chapter 4: Cancer vaccine Chapter 5: Chimeric antigen receptor T cell Chapter 6: Cancer immunotherapy Chapter 7: Oncolytic virus Chapter 8: Viral vector Chapter 9: Murine respirovirus Chapter 10: Oncolytics Biotech Chapter 11: Pelareorep Chapter 12: Molecular oncology Chapter 13: Pexastimogene devacirepvec Chapter 14: Talimogene laherparepvec Chapter 15: Oncolytic herpes virus Chapter 16: Oncolytic adenovirus Chapter 17: Measles virus encoding the human thyroidal sodium iodide symporter Chapter 18: Timeline of cancer treatment development Chapter 19: Julianna Lisziewicz Chapter 20: Oncolytic AAV Chapter 21: Viral vector vaccine (II) Answering the public top questions about virotherapy. (III) Real world examples for the usage of virotherapy in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of virotherapy' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of virotherapy.

Human Herpesviruses

Author : Yasushi Kawaguchi
Publisher : Springer
ISBN 13 : 9811072302
Total Pages : 501 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Human Herpesviruses by : Yasushi Kawaguchi

Download or read book Human Herpesviruses written by Yasushi Kawaguchi and published by Springer. This book was released on 2018-06-12 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces and reviews several topics for each human herpesvirus. One of the most important features of the book is that it covers aspects of both basic research and clinical medicine. Herpesviridae, a family of double-strand DNA viruses, has unique biological features by which these viruses establish latency after primary infection and reactivate in later life. Nine human herpesviruses are known so far, and each of them causes a variety of diseases in both primary infection and reactivation. Since the discovery of each human herpesvirus, an abundance of findings related to them has accumulated in basic research and clinical medicine. However, the vast majority of biological features is still masked in mystery. Furthermore, a strategy of treatment and prevention has not yet been established for most human herpesviruses. A wide range of readers will be interested in this volume with its treatment of problematic points and latest findings in the field.

New Trends in the Applications of Differential Equations in Sciences

Author : Angela Slavova
Publisher : Springer Nature
ISBN 13 : 3031214846
Total Pages : 457 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis New Trends in the Applications of Differential Equations in Sciences by : Angela Slavova

Download or read book New Trends in the Applications of Differential Equations in Sciences written by Angela Slavova and published by Springer Nature. This book was released on 2023-03-17 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book convenes peer-reviewed, selected papers presented at the Ninth International Conference New Trends in the Applications of Differential Equations in Sciences (NTADES) held in Sozopol, Bulgaria, June 17–20, 2022. The works are devoted to many applications of differential equations in different fields of science. A number of phenomena in nature (physics, chemistry, biology) and in society (economics) result in problems leading to the study of linear and nonlinear differential equations, stochastic equations, statistics, analysis, numerical analysis, optimization, and more. The main topics are presented in the five parts of the book - applications in mathematical physics, mathematical biology, financial mathematics, neuroscience, and fractional analysis. In this volume, the reader will find a wide range of problems concerning recent achievements in both theoretical and applied mathematics. The main goal is to promote the exchange of new ideas and research between scientists, who develop and study differential equations, and researchers, who apply them for solving real-life problems. The book promotes basic research in mathematics leading to new methods and techniques useful for applications of differential equations. The NTADES 2022 conference was organized in cooperation with the Society of Industrial and Applied Mathematics (SIAM), the major international organization for Industrial and Applied Mathematics and for the promotion of interdisciplinary collaboration between applied mathematics and science, engineering, finance, and neuroscience.

XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010

Author : Nicolas Pallikarakis
Publisher : Springer Science & Business Media
ISBN 13 : 3642130399
Total Pages : 1000 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 by : Nicolas Pallikarakis

Download or read book XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 written by Nicolas Pallikarakis and published by Springer Science & Business Media. This book was released on 2010-05-28 with total page 1000 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past three decades, the exploding number of new technologies and applications introduced in medical practice, often powered by advances in biosignal processing and biomedical imaging, created an amazing account of new possibilities for diagnosis and therapy, but also raised major questions of appropriateness and safety. The accelerated development in this field, alongside with the promotion of electronic health care solutions, is often on the basis of an uncontrolled diffusion and use of medical technology. The emergence and use of medical devices is multiplied rapidly and today there exist more than one million different products available on the world market. Despite the fact that the rising cost of health care, partly resulting from the new emerging technological applications, forms the most serious and urgent problem for many governments today, another important concern is that of patient safety and user protection, issues that should never be compromised and expelled from the Biomedical Engineering research practice agenda.

Malignant Pleural Mesothelioma

Author : Takashi Nakano
Publisher : Springer Nature
ISBN 13 : 981159158X
Total Pages : 352 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Malignant Pleural Mesothelioma by : Takashi Nakano

Download or read book Malignant Pleural Mesothelioma written by Takashi Nakano and published by Springer Nature. This book was released on 2021-02-05 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides essential information on recent advances in molecular genetics, epidemiology, translational research, and the latest results of clinical trials on mesothelioma. Significant progress has been made in understanding mesothelioma biology, and in developing new therapies for this refractory tumor, malignant pleural mesothelioma (MPM). Not only does this volume summarize the latest research-based data on the disease; it also shares insights into future research directions. The book consists of 5 themed sections on: epidemiology, pathogenesis, screening and early detection, molecular genetics, and clinical aspects and management. Several chapters focus on new trends in the field, e.g. immune therapy and identification of biomarkers, molecular oncogenesis including genetic susceptibility, and molecular diagnostic pathology. The book also highlights new cancer treatment approaches, such as immunotherapy based on immune checkpoint inhibitors, which has meant a paradigm shift in other types of cancer, and given some hope to MPM patients. In turn, it discusses recent molecular pathological studies on mesothelioma, which claim to offer more accurate classifications than traditional morphology and immunohistochemistry-based approaches. All of these cutting-edge analyses provide the basis for a closing discussion on future developments and research directions. Malignant Pleural Mesothelioma - Advances in Pathogenesis, Diagnosis, and Treatments has been edited and authored by respected researchers and will be of interest to medical, surgical and radiation oncologists; pulmonologists; pathologists and basic researchers alike. Since the disease represents a significant diagnostic and therapeutic challenge, scientists and clinicians from learners to experts, as well as fellows in training in these subspecialties, will value this book.

Adenoviral Vectors for Gene Therapy

Author : David T. Curiel
Publisher : Academic Press
ISBN 13 : 0128005106
Total Pages : 868 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Adenoviral Vectors for Gene Therapy by : David T. Curiel

Download or read book Adenoviral Vectors for Gene Therapy written by David T. Curiel and published by Academic Press. This book was released on 2016-03-10 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

Mathematical Models of Cancer and Different Therapies

Author : Regina Padmanabhan
Publisher : Springer Nature
ISBN 13 : 9811586403
Total Pages : 256 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Mathematical Models of Cancer and Different Therapies by : Regina Padmanabhan

Download or read book Mathematical Models of Cancer and Different Therapies written by Regina Padmanabhan and published by Springer Nature. This book was released on 2020-10-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unified framework for various currently available mathematical models that are used to analyze progression and regression in cancer development, and to predict its dynamics with respect to therapeutic interventions. Accurate and reliable model representations of cancer dynamics are milestones in the field of cancer research. Mathematical modeling approaches are becoming increasingly common in cancer research, as these quantitative approaches can help to validate hypotheses concerning cancer dynamics and thus elucidate the complexly interlaced mechanisms involved. Even though the related conceptual and technical information is growing at an exponential rate, the application of said information and realization of useful healthcare devices are lagging behind. In order to remedy this discrepancy, more interdisciplinary research works and course curricula need to be introduced in academic, industrial, and clinical organizations alike. To that end, this book reformulates most of the existing mathematical models as special cases of a general model, allowing readers to easily get an overall idea of cancer dynamics and its modeling. Moreover, the book will help bridge the gap between biologists and engineers, as it brings together cancer dynamics, the main steps involved in mathematical modeling, and control strategies developed for cancer management. This also allows readers in both medical and engineering fields to compare and contrast all the therapy-based models developed to date using a single source, and to identify unexplored research directions.

Cancer Regional Therapy

Author : Yuman Fong
Publisher : Springer Nature
ISBN 13 : 3030288919
Total Pages : 490 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Cancer Regional Therapy by : Yuman Fong

Download or read book Cancer Regional Therapy written by Yuman Fong and published by Springer Nature. This book was released on 2019-12-10 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a state-of-the-art overview of cancer regional therapy (CRT) for the surgeons and interventional radiologists active in CRT development and research. The goals of this book are 1) to review the theory and practice of cancer regional therapies including pharmacology, devices, techniques, and workflow, 2) illustrate the most common procedures performed in the interventional and operating rooms, and 3) discuss data supporting use of CRT. This is meant to be a definitive text on the theory and practice of CRT. It begins with a summary of the history, technical principles that underlie regional therapy. The following parts discuss current data and practice in peritoneal, liver, limb, pleural and other sites. Included in the practice are considerations of workflow and financial issues revolving around CRT. Novel techniques and therapies under investigation are presented to inform the direction of the field. Cancer Regional Therapy summarizes the history, current technology, common procedures, and future prospects in this field and includes procedures from many surgical and interventional radiologic disciplines.

Mesenchymal Stromal Cells as Tumor Stromal Modulators

Author : Marcela Bolontrade
Publisher : Academic Press
ISBN 13 : 0128031034
Total Pages : 642 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mesenchymal Stromal Cells as Tumor Stromal Modulators by : Marcela Bolontrade

Download or read book Mesenchymal Stromal Cells as Tumor Stromal Modulators written by Marcela Bolontrade and published by Academic Press. This book was released on 2016-10-24 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

Harnessing Oncolytic Virus-mediated Antitumor Immunity

Author : Philippe Fournier
Publisher : Frontiers Media SA
ISBN 13 : 2889194507
Total Pages : 111 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Harnessing Oncolytic Virus-mediated Antitumor Immunity by : Philippe Fournier

Download or read book Harnessing Oncolytic Virus-mediated Antitumor Immunity written by Philippe Fournier and published by Frontiers Media SA. This book was released on 2015-03-02 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.

Human Gene Therapy: Current Opportunities and Future Trends

Author : G. M. Rubanyi
Publisher : Springer Science & Business Media
ISBN 13 : 3662053527
Total Pages : 256 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Human Gene Therapy: Current Opportunities and Future Trends by : G. M. Rubanyi

Download or read book Human Gene Therapy: Current Opportunities and Future Trends written by G. M. Rubanyi and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genetics, molecular biology and gene delivery technologies in recent years have led to new gene therapy strategies for treatment of a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases. Stem cell-based therapies and gene expression regulatory systems as novel platform technologies for various gene therapy applications are also discussed. Leading experts give excellent overviews of basic molecular aspects and clinical applications in this new emerging biomedical field.

AACR 2022 Proceedings: Part B April 11-13

Author : American Association for Cancer Research
Publisher : CTI Meeting Technology
ISBN 13 : 1005543747
Total Pages : 3696 pages
Book Rating : 4.0/5 (55 download)

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Book Synopsis AACR 2022 Proceedings: Part B April 11-13 by : American Association for Cancer Research

Download or read book AACR 2022 Proceedings: Part B April 11-13 written by American Association for Cancer Research and published by CTI Meeting Technology. This book was released on 2022-05-09 with total page 3696 pages. Available in PDF, EPUB and Kindle. Book excerpt: The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.

Advances in Precision Medicine Oncology

Author : Hilal Arnouk
Publisher : BoD – Books on Demand
ISBN 13 : 183968867X
Total Pages : 262 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Advances in Precision Medicine Oncology by : Hilal Arnouk

Download or read book Advances in Precision Medicine Oncology written by Hilal Arnouk and published by BoD – Books on Demand. This book was released on 2021-07-21 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in precision medicine and immuno-oncology have led to highly specific and efficacious cancer therapies such as monoclonal antibodies and immune checkpoint inhibitors (ICIs). This book provides an up-to-date overview of advances in the field of immuno-oncology. Chapters cover such topics as ICIs and how they mount a robust immune response against cancer cells as well as the response of ICIs to treatment predictive biomarkers and their potential immune-related adverse events (irAEs). Additionally, the book includes a comprehensive review of the powerful FDA-approved therapeutic agent doxorubicin, highlighting the molecular mechanisms behind doxorubicin’s drug resistance and critical side effects.