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Using Machine Learning And Optical Coherence Tomography To Generate A Non Contact Biopsy Images
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Book Synopsis Using Machine Learning and Optical Coherence Tomography to Generate a Non Contact Biopsy Images by : Yonatan Winetraub
Download or read book Using Machine Learning and Optical Coherence Tomography to Generate a Non Contact Biopsy Images written by Yonatan Winetraub and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In vivo Biomedical imaging is an important part of diagnostic, therapeutic medical treatment and research. The field is constantly searching for viable clinical tools at the micro-scale (single cell resolution). Optical Coherence Tomography (OCT) enables real-time imaging of living tissues in 3D up to 1mm. In this work we develop tools and models to better quantify the OCT signal, we then apply those tools on two exciting applications in living mice brain imaging and early detection of skin cancer. We have developed a model to accurately quantify the signals produced by endogenous scattering in OCT imaging. This model predicts distinct concentration-dependent signal trends that arise from the underlying physics of OCT detection. The relation between OCT signal and particle concentration is approximately linear at low concentrations. However, at higher concentrations, interference effects cause signal to increase with a square root dependence on the number of particles within a voxel. Predictions were validated by measuring OCT signals from phantom models as well as living animals. More generally, the model described herein may inform the interpretation of detected signals in modalities that rely on coherence-based detection or are susceptible to interference effects. We then build a theoretical model for speckle noise, one of OCT's most prominent issues preventing us from experiencing the full potential of this technology. Our theoretical analysis using Monte Carlo simulations indicates that pure angular compounding (a common technology for reducing speckle) can improve the signal-to-noise ratio by no more than a factor of 1.3. We conclude that speckle reduction using angular compounding is equivalent to spatial averaging. We then shift gears and present how the above tools could be used to detect microscopic movement in living brain. We introduce a novel OCT-based neuroimaging setting and accompanied feature segmentation algorithm enabling rapid, accurate, and high-resolution imaging of 700 mu depth across the mouse cortex, in-vivo. We demonstrate 3D reconstruction of microarchitectural elements in a whole cortical column. Features as Central Nervous System cell bodies density, volume, and average distance to the nearest cell can be quantified to better study the brain by this highly transformative and versatile platform. We developed a laser-based barcoding technology that allows us to achieve precise registration of OCT images with H&E pathology images. This approach enabled us to assemble a library of > 1000 OCT - H&E images pairs from human skin samples. We then train a generative adversarial neural network on the image library and demonstrate the ability to virtually generate realistic H&E images directly from OCT images. The combination of the above technologies opens the door to a virtual biopsy allowing clinicians to examine H&E sections of a suspected area but bypassing the intensive and expensive biopsy.
Book Synopsis Optical Coherence Tomography by : Wolfgang Drexler
Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Book Synopsis Image Processing and Machine Learning Algorithms for Optical Coherence Tomography and Fundoscopic Imaging Applications by :
Download or read book Image Processing and Machine Learning Algorithms for Optical Coherence Tomography and Fundoscopic Imaging Applications written by and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis High Resolution Imaging in Microscopy and Ophthalmology by : Josef F. Bille
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Book Synopsis Estimation of Volumetric Optical Coherence Tomography Measurements from 2D Color Fundus Photographs Using Machine Learning by : Samuel Steven Johnson
Download or read book Estimation of Volumetric Optical Coherence Tomography Measurements from 2D Color Fundus Photographs Using Machine Learning written by Samuel Steven Johnson and published by . This book was released on 2019 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because of the recent success of deep-learning methods in imaging domains, a convolutional neural network was also trained using the same data as was used with the random forest classifier. Because training data is used to help fine tune model parameters for deep learning, a subset of twelve randomly selected patients was strictly withheld from the training process to be used for testing. Comparing the prediction results on the withheld data with the OCT ground truth, we achieved a root-mean-square (RMS) error of 2.07 mm3 for the entire ONH region. Regional volumes for the nasal, temporal, inferior, superior, and peripapillary regions had RMS errors of 0.75 mm3, 0.82 mm3, 0.85 mm3, 0.91 mm3, and 1.62 mm3, respectively. Although the errors are slightly higher than those from the random forest model, the test dataset was smaller as we could not use a leave-patient-out validation approach and this may not be representative of the whole dataset since results were not averaged as before. It is also known that deep learning models require larger training datasets to achieve similar results to traditional machine-learning methods. For these reasons, and the fact that the errors were close to those of traditional methods, we believe deep learning approaches for estimating local retinal thickness in cases of optic disc swelling still holds promise with larger datasets. Both of the proposed approaches allow for clinicians to assess optic nerve edema in both a qualitative and quantitative manner using strictly fundus photography. The predictions allow for overall optic nerve head volume to be calculated as well as regional and local volumes which was not possible before.
Book Synopsis Artificial Intelligence in Medical Imaging by : Erik R. Ranschaert
Download or read book Artificial Intelligence in Medical Imaging written by Erik R. Ranschaert and published by Springer. This book was released on 2019-01-29 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a thorough overview of the ongoing evolution in the application of artificial intelligence (AI) within healthcare and radiology, enabling readers to gain a deeper insight into the technological background of AI and the impacts of new and emerging technologies on medical imaging. After an introduction on game changers in radiology, such as deep learning technology, the technological evolution of AI in computing science and medical image computing is described, with explanation of basic principles and the types and subtypes of AI. Subsequent sections address the use of imaging biomarkers, the development and validation of AI applications, and various aspects and issues relating to the growing role of big data in radiology. Diverse real-life clinical applications of AI are then outlined for different body parts, demonstrating their ability to add value to daily radiology practices. The concluding section focuses on the impact of AI on radiology and the implications for radiologists, for example with respect to training. Written by radiologists and IT professionals, the book will be of high value for radiologists, medical/clinical physicists, IT specialists, and imaging informatics professionals.
Book Synopsis Optical Coherence Tomography and Its Non-medical Applications by : Michael Wang
Download or read book Optical Coherence Tomography and Its Non-medical Applications written by Michael Wang and published by BoD – Books on Demand. This book was released on 2020-05-27 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a promising non-invasive non-contact 3D imaging technique that can be used to evaluate and inspect material surfaces, multilayer polymer films, fiber coils, and coatings. OCT can be used for the examination of cultural heritage objects and 3D imaging of microstructures. With subsurface 3D fingerprint imaging capability, OCT could be a valuable tool for enhancing security in biometric applications. OCT can also be used for the evaluation of fastener flushness for improving aerodynamic performance of high-speed aircraft. More and more OCT non-medical applications are emerging. In this book, we present some recent advancements in OCT technology and non-medical applications.
Book Synopsis Optical Coherence Tomography by : Mark E. Brezinski
Download or read book Optical Coherence Tomography written by Mark E. Brezinski and published by Elsevier. This book was released on 2006-08-25 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography gives a broad treatment of the subject which will include 1)the optics, science, and physics needed to understand the technology 2) a description of applications with a critical look at how the technology will successfully address actual clinical need, and 3) a discussion of delivery of OCT to the patient, FDA approval and comparisons with available competing technologies. The required mathematical rigor will be present where needed but be presented in such a way that it will not prevent non-scientists and non-engineers from gaining a basic understanding of OCT and the applications as well as the issues of bringing the technology to the market. Optical Coherence Tomography is a new medical high-resolution imaging technology which offers distinct advantages over current medical imaging technologies and is attracting a large number of researchers. Provides non-scientists and non-engineers basic understanding of Optical Coherence Tomography applications and issues.
Book Synopsis Clinical Applications of Optical Coherence Tomography Angiography by : Francesco Bandello
Download or read book Clinical Applications of Optical Coherence Tomography Angiography written by Francesco Bandello and published by S. Karger AG (Switzerland). This book was released on 2020 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The recent introduction of optical coherence tomography angiography (OCTA) has remarkably expanded our knowledge of different retinal, chorioretinal, and optic disc disorders. OCTA is nowadays often introduced as a routine exam in clinical practice, granting the opportunity to non-invasively investigate retinal and choroidal circulation. In this book, many major experts in posterior eye imaging share their experiences and their latest images and ideas about OCTA"--
Book Synopsis Histopathological Image Analysis by : Gurcan
Download or read book Histopathological Image Analysis written by Gurcan and published by Wiley-Blackwell. This book was released on with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Second Harmonic Generation Imaging by : Francesco S. Pavone
Download or read book Second Harmonic Generation Imaging written by Francesco S. Pavone and published by Taylor & Francis. This book was released on 2016-04-19 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical a
Book Synopsis Medical Imaging Systems by : Andreas Maier
Download or read book Medical Imaging Systems written by Andreas Maier and published by Springer. This book was released on 2018-08-02 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.
Book Synopsis Bio-Imaging by : Rajagopal Vadivambal
Download or read book Bio-Imaging written by Rajagopal Vadivambal and published by CRC Press. This book was released on 2015-08-27 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlights the Emergence of Image Processing in Food and AgricultureIn addition to uses specifically related to health and other industries, biological imaging is now being used for a variety of applications in food and agriculture. Bio-Imaging: Principles, Techniques, and Applications fully details and outlines the processes of bio-imaging applica
Book Synopsis Optical Coherence Tomography in Neurologic Diseases by : Peter A. Calabresi
Download or read book Optical Coherence Tomography in Neurologic Diseases written by Peter A. Calabresi and published by Cambridge University Press. This book was released on 2015-05-14 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive review of the use of optical coherence tomography in neurological diseases for neurologists, neuro-ophthalmologists, and neuroradiologists.
Book Synopsis Optical Coherence Tomography of Ocular Diseases by : Joel S. Schuman
Download or read book Optical Coherence Tomography of Ocular Diseases written by Joel S. Schuman and published by . This book was released on 2022 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Optical Coherence Tomography of Ocular Diseases, Fourth Edition covers a range of subjects, from principles and operation techniques to clinical interpretation and the latest innovations in OCT. This book is an essential text for imaging technology. OCT now occupies a dominant role as a diagnostic tool for retinal conditions and glaucoma. At the same time, the technology continues to show potential for emerging clinical and research applications across all the ophthalmological subspecialties. To reflect these rapid advances, this new edition of Optical Coherence Tomography of Ocular Diseases features a complete and thorough revision of the existing text as well as the addition of cutting-edge content to bring this classic resource completely up to date"--
Book Synopsis Lab-on-Fiber Technology by : Andrea Cusano
Download or read book Lab-on-Fiber Technology written by Andrea Cusano and published by Springer. This book was released on 2014-07-29 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on a research field that is rapidly emerging as one of the most promising ones for the global optics and photonics community: the “lab-on-fiber” technology. Inspired by the well-established "lab on-a-chip" concept, this new technology essentially envisages novel and highly functionalized devices completely integrated into a single optical fiber for both communication and sensing applications. Based on the R&D experience of some of the world's leading authorities in the fields of optics, photonics, nanotechnology, and material science, this book provides a broad and accurate description of the main developments and achievements in the lab-on-fiber technology roadmap, also highlighting the new perspectives and challenges to be faced. This book is essential for scientists interested in the cutting-edge fiber optic technology, but also for graduate students.
Book Synopsis Artificial Intelligence in Ophthalmology by : Andrzej Grzybowski
Download or read book Artificial Intelligence in Ophthalmology written by Andrzej Grzybowski and published by Springer Nature. This book was released on 2021-10-13 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a wide-ranging overview of artificial intelligence (AI), machine learning (ML) and deep learning (DL) algorithms in ophthalmology. Expertly written chapters examine AI in age-related macular degeneration, glaucoma, retinopathy of prematurity and diabetic retinopathy screening. AI perspectives, systems and limitations are all carefully assessed throughout the book as well as the technical aspects of DL systems for retinal diseases including the application of Google DeepMind, the Singapore algorithm, and the Johns Hopkins algorithm. Artificial Intelligence in Ophthalmology meets the need for a resource that reviews the benefits and pitfalls of AI, ML and DL in ophthalmology. Ophthalmologists, optometrists, eye-care workers, neurologists, cardiologists, internal medicine specialists, AI engineers and IT specialists with an interest in how AI can help with early diagnosis and monitoring treatment in ophthalmic patients will find this book to be an indispensable guide to an evolving area of healthcare technology.
