Use of Self Monitoring of Blood Glucose in Glycaemic Control of Non-Insulin Treated Type 2 Diabetes Mellitus Patients

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Publisher : Open Dissertation Press
ISBN 13 : 9781374680999
Total Pages : pages
Book Rating : 4.6/5 (89 download)

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Book Synopsis Use of Self Monitoring of Blood Glucose in Glycaemic Control of Non-Insulin Treated Type 2 Diabetes Mellitus Patients by : 梁心銘

Download or read book Use of Self Monitoring of Blood Glucose in Glycaemic Control of Non-Insulin Treated Type 2 Diabetes Mellitus Patients written by 梁心銘 and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Use of Self Monitoring of Blood Glucose in Glycaemic Control of Non-insulin Treated Type 2 Diabetes Mellitus Patients" by 梁心銘, Sum-ming, Leung, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4072112 Subjects: Blood sugar monitoring Non-insulin-dependent diabetes Diabetes Mellitus

Systematic Review on Self-Monitoring of Blood Glucose for Non-Insulin-Using Type 2 Diabetes Patients

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Publisher :
ISBN 13 : 9781361300565
Total Pages : pages
Book Rating : 4.3/5 (5 download)

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Book Synopsis Systematic Review on Self-Monitoring of Blood Glucose for Non-Insulin-Using Type 2 Diabetes Patients by : Shan Xiao

Download or read book Systematic Review on Self-Monitoring of Blood Glucose for Non-Insulin-Using Type 2 Diabetes Patients written by Shan Xiao and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Systematic Review on Self-monitoring of Blood Glucose for Non-insulin-using Type 2 Diabetes Patients" by Shan, Xiao, 肖珊, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: The increasing prevalence causes great burden to global health. Although there is not yet an agreement on the effect of SMBG for non-insulin-treating type 2 DM patients in comprehensive management, some guidelines recommended all diabetes patients should conduct SMBG. This literature review of 5 meta-analyses and 13 randomized controlled clinical trials assessed the effectiveness of SMBG in glucose control (HbA1c), detection of hypoglycemia, non-glycemic outcomes and potential influence factors(duration of diabetes, baseline HaB1c level, SMBG frequency, SMBG duration, co-interventions) of SMBG efficacy on type 2 diabetes patients not using insulin. The method of this literature review is through a comprehensive electronic literature search of Ovid MEDLINE, EMBASE, the Cochrane Library and China Journals Full-text Database. Both English and Chinese language literatures were reviewed. All meta-analysis and randomized controlled trials of type 2 diabetes non-insulin-using patients taking SMBG to improve the glycemic control and other outcomes were included. In these studies, absolute HbA1c reduction, recognized episodes of hypoglycemia, wellbeing, QALY, DALY, complication morbidity, mortality were used as outcome measures if available. A score list based on the PRISMA Statement was used to evaluate the quality of meta-analyses. 5 meta-analysis all reported a statistical significant but clinical modest-moderate difference in HbA1c reduction between SMBG and non-SMBG group, a new published randomized controlled trial with small cohort enrolled in none of the meta- analyses did not support this conclusion. Evidence showed frequency of SMBG did not influence the efficacy of SMBG, co-interventions as education/consultation, regimen change played a positive roll on SMBG efficacy. Whether baseline HbA1c, duration of diabetes or SMBG itself have an effect on SMBG efficacy was still unknown. There is inadequate evidence of SMBG efficacy of detection of hypoglycemia of patient-oriented outcomes. No eligible Chinese article was defined to enroll in this review. This review did not support to suggest all type 2 diabetes patients not using insulin to conduct SMBG at the frequency the guidelines recommended. Carefully designed and longer-term trials are needed to obtain evidence that is more robust. Further investigation would provide more evidence of the characteristics of potential influence factors, which may help to define the specific population or optimal mode that guarantee the greatest efficacy of SMBG. DOI: 10.5353/th_b4842673 Subjects: Blood sugar monitoring Non-insulin-dependent diabetes

Hypoglycemia in Diabetes

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Publisher : American Diabetes Association
ISBN 13 : 1580406491
Total Pages : 194 pages
Book Rating : 4.5/5 (84 download)

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Book Synopsis Hypoglycemia in Diabetes by : Philip Cryer

Download or read book Hypoglycemia in Diabetes written by Philip Cryer and published by American Diabetes Association. This book was released on 2016-07-12 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for diabetes researchers and medical professionals who work closely with patients with diabetes, this newly updated and expanded edition provides new perspectives and direct insight into the causes and consequences of this serious medical condition from one of the foremost experts in the field. Using the latest scientific and medical developments and trends, readers will learn how to identify, prevent, and treat this challenging phenomenon within the parameters of the diabetes care regimen.

Practical CGM

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Publisher : American Diabetes Association
ISBN 13 : 1580406262
Total Pages : 130 pages
Book Rating : 4.5/5 (84 download)

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Book Synopsis Practical CGM by : Gary Scheiner

Download or read book Practical CGM written by Gary Scheiner and published by American Diabetes Association. This book was released on 2015-05-06 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Use of real-time continuous glucose monitors among people with type 1 and type 2 diabetes is growing rapidly and should continue to grow until an artificial pancreas is brought to market. Likewise, use of professional systems in healthcare practices is expanding. But, other than manufacturer instructional manuals and some book chapters on CGMs, there are no standalone publications available with concise, non-commercial instructions on CGM prescription and use. Additionally, continuous glucose monitors are too often not used to their full and proper potential. This leaves users with suboptimal glucose control and can result in system abandonment. To address this, diabetes educator and author Gary Scheiner has created Practical CGM: Improving Patient Outcomes through Continuous Glucose Monitoring to give healthcare providers the skill to make more effective use of the data generated by continuous glucose monitors, in both real-time and on a retrospective analytic basis. Using a plain-language approach and distilling content to concise, practical tips and techniques, Scheiner has created a guide that will help practitioners optimize patient use of CGM systems and, ultimately, improve glucose control and patient health outcomes.

Managing Diabetes and Hyperglycemia in the Hospital Setting

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Publisher : American Diabetes Association
ISBN 13 : 1580406572
Total Pages : 338 pages
Book Rating : 4.5/5 (84 download)

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Book Synopsis Managing Diabetes and Hyperglycemia in the Hospital Setting by : Boris Draznin

Download or read book Managing Diabetes and Hyperglycemia in the Hospital Setting written by Boris Draznin and published by American Diabetes Association. This book was released on 2016-05-20 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the number of patients with diabetes increases annually, it is not surprising that the number of patients with diabetes who are admitted to the hospital also increases. Once in the hospital, patients with diabetes or hyperglycemia may be admitted to the Intensive Care Unit, require urgent or elective surgery, enteral or parenteral nutrition, intravenous insulin infusion, or therapies that significantly impact glycemic control (e.g., steroids). Because many clinical outcomes are influenced by the degree of glycemic control, knowledge of the best practices in inpatient diabetes management is extremely important. The field of inpatient management of diabetes and hyperglycemia has grown substantially in the last several years. This body of knowledge is summarized in this book, so it can reach the audience of hospitalists, endocrinologists, nurses and other team members who take care of hospitalized patients with diabetes and hyperglycemia.

Self-monitoring of Blood Glucose in Noninsulin-treated Diabetes

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Publisher :
ISBN 13 :
Total Pages : 18 pages
Book Rating : 4.:/5 (111 download)

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Book Synopsis Self-monitoring of Blood Glucose in Noninsulin-treated Diabetes by :

Download or read book Self-monitoring of Blood Glucose in Noninsulin-treated Diabetes written by and published by . This book was released on 2009 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: People with diabetes use test strips as a means to check their blood glucose levels. Systematic self-monitoring of blood glucose is necessary for successful insultin therapy aimed at controlling glucose. However, in patients with noninsulin-treated type 2 diabetes, the benefit of systematic self-monitoring has been called into question. This report reviews the scientific evidence for systematic self-monitoring of blood glucose with test sticks in patients with type 2 diabetes, but who are not receiving insulin therapy. The Swedish National Board of Health and Welfare commissioned the report to use as a basis for their national guidelines on diabetes care. SBU is producing three additional reports within the framework of the National Board of Health and Welfare's guidelines on diabetes -- patient education in managing diabetes, intensive glucose lowering therapy in diabetes, and dietary treatment of diabetes. Conclusions The scientific evidence does not show any benefits from systematic self-monitoring of blood glucose (SMBG) with test sticks in people with noninsulin-treated type 2 diabetes. Examples of specific situations where people with noninsulin-treated type 2 diabetes may have reason to use test sticks include symptoms of hypoglycemia, particularly in patients being treated with sulfonylurea agents and meglitinides. Self-monitoring may also be needed for other purposes, e.g., educational purposes in conjunction with changes in therapy or acute disease. A more restrictive use of test sticks in this patient group would reduce costs and would not increase medical risks.

Compliance with Therapeutic Regimens

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Publisher : Baltimore : Johns Hopkins University Press
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Compliance with Therapeutic Regimens by : R. Brian Haynes

Download or read book Compliance with Therapeutic Regimens written by R. Brian Haynes and published by Baltimore : Johns Hopkins University Press. This book was released on 1976 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Does Daily Self-monitoring of Blood Sugar Levels Improve Blood Sugar Control and Quality of Life for Patients with Type 2 Diabetes who Do Not Use Insulin?

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Does Daily Self-monitoring of Blood Sugar Levels Improve Blood Sugar Control and Quality of Life for Patients with Type 2 Diabetes who Do Not Use Insulin? by : Laura A. Young

Download or read book Does Daily Self-monitoring of Blood Sugar Levels Improve Blood Sugar Control and Quality of Life for Patients with Type 2 Diabetes who Do Not Use Insulin? written by Laura A. Young and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the nearly 75% of patients living with type 2 diabetes mellitus (T2DM) who do not use insulin, decisions regarding self-monitoring of blood glucose (SMBG) can be especially problematic. While in theory SMBG holds great promise for sparking favorable behavior change, it is a resource-intensive activity without firmly established patient benefits.OBJECTIVES: The overarching goal was to assess the impact of 3 different SMBG testing approaches on patient-centered outcomes in patients with non-insulin-treated T2DM within the real-world clinic setting.OBJECTIVE 1: Assess SMBG effectiveness on 2 primary patient-centered outcomes, glycemic control (A1c) and health-related quality of life (HRQOL), over 1 year in 450 participants with non-insulin-treated diabetes mellitus (DM) in the following 3 groups: (1) no SMBG testing, (2) once-daily SMBG testing with standard patient feedback consisting of glucose values immediately reported to the patient through the glucometer, and (3) once-daily SMBG testing with enhanced patient feedback consisting of glucose values immediately reported to the patient plus automated, tailored messaging also delivered via the glucometer. OBJECTIVE 2: Evaluate the impact of SMBG on secondary patient-centered outcomes including (1) DM-related quality of life, (2) DM self-care, (3) DM treatment satisfaction, (4) DM self-efficacy, (5) patient-provider communication, (6) hypoglycemia frequency, and (7) health care utilization. OBJECTIVE 3: Conduct qualitative assessments of the patient participant and provider experience for all 3 intervention groups. This objective supports efficient translation of study findings to real-world clinic settings by exploring such issues as patient-provider communications, use of the glucometer and accompanying reports, utility of the treatment algorithm given to providers, and practice burden. METHODS: Using a stakeholder engagement approach, we developed and implemented a pragmatic trial. We randomly assigned 450 patients with non-insulin-treated T2DM in 15 North Carolina primary care practices to 3 arms without masking of treatment assignment: (1) no SMBG, (2) once-daily testing with standard feedback consisting of glucose values being immediately reported to the patient through the glucometer, and (3) once-daily SMBG with enhanced patient feedback consisting of glucose values being immediately reported to the patient plus automated, tailored feedback messaging delivered to the patient through the glucometer following each testing. Coprimary outcomes included glycemic control (A1c) and HRQOL at 52 weeks. RESULTS: A total of 450 patients were randomized and 92.9% completed the final visit. There were no significant differences in glycemic control across all 3 groups (P = 0.74; estimated adjusted mean A1c difference: SMBG with messaging vs no SMBG −0.09% [95% CI, −0.31% to 0.14%]; SMBG vs No SMBG −0.05% [95% CI, −0.27% to 0.17%]). There were also no significant differences found in HRQOL. There were no notable differences in key adverse events, including hypoglycemia frequency, health care utilization, or insulin initiation. CONCLUSIONS: In patients with non-insulin-treated type 2 diabetes, at 1 year we observed no clinically or statistically significant differences in glycemic control or HRQOL between patients who performed SMBG compared with those who did not perform SMBG. The addition of tailored feedback provided through messaging via a meter did not provide any advantage in glycemic control.

Diabetes

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Publisher : Johns Hopkins Health
ISBN 13 : 1933087455
Total Pages : 95 pages
Book Rating : 4.9/5 (33 download)

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Book Synopsis Diabetes by : Christopher D. Saudek

Download or read book Diabetes written by Christopher D. Saudek and published by Johns Hopkins Health. This book was released on 2007 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Self-Monitoring of Blood Glucose in Patients with Type 2 Diabetes Mellitus: Meta Analysis of Effectiveness

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Author :
Publisher : Createspace Independent Pub
ISBN 13 : 9781490477008
Total Pages : 52 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis Self-Monitoring of Blood Glucose in Patients with Type 2 Diabetes Mellitus: Meta Analysis of Effectiveness by : U. S. Department of Veterans Affairs

Download or read book Self-Monitoring of Blood Glucose in Patients with Type 2 Diabetes Mellitus: Meta Analysis of Effectiveness written by U. S. Department of Veterans Affairs and published by Createspace Independent Pub. This book was released on 2013-06-18 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the World Health Organization, at least 180 million people worldwide suffer from diabetes. Though prevalent throughout the world, diabetes is more common (especially type 2) in more developed countries like the United States. The National Diabetes Information Clearinghouse estimates that diabetes costs $132 billion in the United States alone every year. Given these estimates along with the projection that the worldwide incidence of diabetes will double in the next 20 years, 1 intensified research into better management of this chronic disease is paramount. Tighter control of blood glucose is advocated as a means to reduce microvascular and macrovascular complications. VA has performance measures assessing the proportion of patients meeting certain A1c goals, currently 7% and 9%. Theoretically, self-monitoring of blood glucose (SMBG) can improve compliance with recommendations on diet and exercise and medication regimens. The American Diabetes Association has recommended that the optimal frequency of SMBG for patients with type 2 diabetes should be adequate to facilitate reaching glucose goals. This hypothesis is based on the expectation that life style changes are facilitated by SMBG. Under these conditions, we should expect an improvement of glycemic control SMBG may decrease patient management costs, and because of the high prevalence of type 2 diabetes, efforts to establish the efficacy of SMBG in type 2 diabetes mellitus are of greater relevance. Methods to achieve improved glycemic control, and therefore a higher proportion of patients meeting target A1c levels, include diet, exercise, and medication. However, evidence supporting the use of SMBG for diabetics not requiring insulin is not as clear. The purpose of this review is to analyze the literature to answer four key questions given to us by VA: 1) Is regular self-monitoring of blood glucose effective in achieving target A1c levels for patients with type 2 diabetes?; 2) Is regular self-monitoring of blood glucose effective in maintaining target A1c levels for patients with type 2 diabetes?; 3) Does regular self-monitoring of blood glucose reduce the frequency of hypoglycemia in patients with type 2 diabetes?; 4) Is there evidence that different frequencies of testing result in differences in improvements in A1c?

Type 2 Diabetes

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Publisher :
ISBN 13 : 9781860163333
Total Pages : 279 pages
Book Rating : 4.1/5 (633 download)

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Book Synopsis Type 2 Diabetes by : National Collaborating Centre for Chronic Conditions (Great Britain)

Download or read book Type 2 Diabetes written by National Collaborating Centre for Chronic Conditions (Great Britain) and published by . This book was released on 2008 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guideline covers topics such as the control of cholesterol and lipid levels, the management of hypertension and the control of blood glucose levels.

Self-monitoring of Blood Glucose in Non-insulin Treated Patients with Type 2 Diabetes

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Publisher :
ISBN 13 :
Total Pages : 11 pages
Book Rating : 4.:/5 (742 download)

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Book Synopsis Self-monitoring of Blood Glucose in Non-insulin Treated Patients with Type 2 Diabetes by : Carine Joëlle Houriet

Download or read book Self-monitoring of Blood Glucose in Non-insulin Treated Patients with Type 2 Diabetes written by Carine Joëlle Houriet and published by . This book was released on 2010 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Insulin therapy in type 2 diabetes

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Publisher : SICS Editore
ISBN 13 : 8869304914
Total Pages : 31 pages
Book Rating : 4.8/5 (693 download)

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Book Synopsis Insulin therapy in type 2 diabetes by : Sics Editore

Download or read book Insulin therapy in type 2 diabetes written by Sics Editore and published by SICS Editore. This book was released on 2014-10-01 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glucose control in type 2 diabetes can be improved with additional insulin, self-monitoring of blood glucose and self-adjusting of the insulin dose. Insuling therapy can be safely started in primary care. Evening insulin is the therapy of choice in most patients. A realistic target in type 2 diabetics is to reduce the HbA1c level to 7.0 % (53 mmol/mol).

A Self-management Guide for Type 2 Diabetes Mellitus Patients from Middle Eastern Countries

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Publisher : Cambridge Scholars Publishing
ISBN 13 : 152755418X
Total Pages : 176 pages
Book Rating : 4.5/5 (275 download)

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Book Synopsis A Self-management Guide for Type 2 Diabetes Mellitus Patients from Middle Eastern Countries by : Ehab Mudher Mikhael

Download or read book A Self-management Guide for Type 2 Diabetes Mellitus Patients from Middle Eastern Countries written by Ehab Mudher Mikhael and published by Cambridge Scholars Publishing. This book was released on 2020-06-04 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains, in a simple and practical way, how and when the diabetic patient should conduct self-management activities. These include healthy eating, physical activity, the consumption of medication, the monitoring of blood glucose level, the cessation of smoking, and foot care, among others. Such activities can help the patient to establish a level of control over their condition, and thus reduce the risk of developing serious complications. As such, this book will be of particular interest to diabetic patients and their family members, as it will provide them with further information in their fight against diabetes. Additionally, it will also appeal to physicians, pharmacists and nurses as a guide for their work in educating diabetic patients.

Self-monitoring Blood Glucose in Type 2 Diabetes: a Continuous Improvement Initiative

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)

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Book Synopsis Self-monitoring Blood Glucose in Type 2 Diabetes: a Continuous Improvement Initiative by : Rossi Maria Chiara

Download or read book Self-monitoring Blood Glucose in Type 2 Diabetes: a Continuous Improvement Initiative written by Rossi Maria Chiara and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Self-monitoring blood glucose (SMBG) is a key tool for therapeutic decision and structured patient education. Despite there is evidence that SMBG improves metabolic control both in insulin-treated and in non insulin treated patients with type 2 diabetes (T2DM), the prescription and execution of SMBG is suboptimal and heterogeneous. AIM: AMD Annals initiative aims to improve quality of diabetes care in Italy. This analysis assessed the use of SMBG in patients with T2DM to evaluate frequency of SMBG, metabolic control, and hypoglycemia in the different therapeutic schemes including or not insulin. METHOD: A specific software has been used for the standardized extraction of the information contained in the electronic medical records. Extracted data included clinical data, therapies and all SMBG values downloaded on EMR by different glucose meters routinely used by the patients. Sample was constituted by T2DM patients with at least one HbA1c value during the years 2014 and 2015 and with at least 1 available SMBG value measured in the 90 days before the HbA1c test. RESULTS: Overall 21 centers and 27,768 observations were included in the analysis. Frequency of SMBG, levels of fasting and post-prandial blood glucose (FBG and PPG), and values below 60 mg/dl were evaluated in the following treatment schemes: metformin only (N=3188); secretagogues only (N=685); metformin + secretagogues (N=2929); metformin + DPP-IV inhibitor (N=612); metformin + secretagogues + DPP-IV (N=3132); metformin + secretagogues + acarbose (N=337); GLP1RA + metformin + secretagogue (N=375); GLP1RA + metformin (N=516); basal insulin + metformin + secretagogues (N=3486); basal + short acting insulin + metformin (N=1666); basal + short acting insulin (N=6842). SMBG was frequently recommended also to patients not treated with insulin: 45.7% of observations referred to patients not treated with insulin. Frequency of SMBG was suboptimal in all treatment schemes; even patients treated with schemes including insulin monitored their glucose less than two times per day. Furthermore, 39.5% of SMBG tests could not be univocally classified as FBG or post-prandial glucose (PPG). In all treatment schemes, of those values which could be univocally classified, over 95% of SMBG tests were FBG values and less than 5% were PPG values. Pre-breakfast FBG values represented about 50% of all available FBG values in all treatment schemes. The frequency of SMBG does not substantially differed among the most common schemes with oral agents, irrespective of the use of secretagogues. The average FBG during three months was over 130 mg/dl in 38% to 84% of the cases in the different schemes, while average PPG was over 140 mg/dl in 36% to 73% of the cases. Even when looking at the most common therapeutic approaches, it emerged that substantial proportions of cases have elevated FBG and PPG, even though average HbA1c levels were often acceptable. The use of therapeutic schemes including secretagogues was associated with a two to three-fold increased risk of glycemic values

The Effect of Blood Glucose Self-monitoring in Patients with Non-insulin Treated Type 2 Diabetes

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (357 download)

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Book Synopsis The Effect of Blood Glucose Self-monitoring in Patients with Non-insulin Treated Type 2 Diabetes by : Alisha N. Wade

Download or read book The Effect of Blood Glucose Self-monitoring in Patients with Non-insulin Treated Type 2 Diabetes written by Alisha N. Wade and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Insulin Action

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792381136
Total Pages : 206 pages
Book Rating : 4.3/5 (811 download)

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Book Synopsis Insulin Action by : Ashok K. Srivastava

Download or read book Insulin Action written by Ashok K. Srivastava and published by Springer Science & Business Media. This book was released on 1998-05-31 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.