Use Of Cannabis In The Treatment Of Post Traumatic Stress Disorder

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The Health Effects of Cannabis and Cannabinoids

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309453070
Total Pages : 487 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis The Health Effects of Cannabis and Cannabinoids by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Health Effects of Cannabis and Cannabinoids written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-03-31 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.

Therapeutic Uses of Cannabis

Author : British Medical Association
Publisher : CRC Press
ISBN 13 : 9789057023170
Total Pages : 160 pages
Book Rating : 4.0/5 (231 download)

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Book Synopsis Therapeutic Uses of Cannabis by : British Medical Association

Download or read book Therapeutic Uses of Cannabis written by British Medical Association and published by CRC Press. This book was released on 1997-11-18 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the last Annual Representative Meeting of the British Medical Association a motion was passed that `certain additional cannabinoids should be legalized for wider medicinal use.'' This report supports this landmark statement by reviewing the scientific evidence for the therapeutic use of cannabinoids and sets the agenda for change. It will be welcomed by those who believe that cannabinoids can be used in medical treatment. The report discusses in a clear and readable form the use and adverse effects of the drug for nausea, multiple sclerosis, pain, epilepsy, glaucoma, and asthma.

Cannabis Dependence

Author : Roger Roffman
Publisher : Cambridge University Press
ISBN 13 : 9780521814478
Total Pages : 416 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Cannabis Dependence by : Roger Roffman

Download or read book Cannabis Dependence written by Roger Roffman and published by Cambridge University Press. This book was released on 2006-02-23 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-science review looks at all aspects of cannabis dependence, from whether it occurs to how to prevent it.

Medicinal Cannabis and CBD in Mental Healthcare

Author : Kylie O'Brien
Publisher : Springer Nature
ISBN 13 : 3030785599
Total Pages : 591 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Medicinal Cannabis and CBD in Mental Healthcare by : Kylie O'Brien

Download or read book Medicinal Cannabis and CBD in Mental Healthcare written by Kylie O'Brien and published by Springer Nature. This book was released on 2021-10-27 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book functions as a clinician’s guide to the use of cannabidiol (CBD) in the treatment of mental health conditions. It conveys the scientific evidence of efficacy of CBD as well as THC and addresses the social stigma attached to its medical use. The book describes the endocannabinoid system, how stress and the endocannabinoid system interact and key constituents, pharmacokinetics and safety aspects of medicinal cannabis, focusing on CBD and THC. Chapters on specific mental health conditions describe the underpinning pathomechanisms including how the endocannabinoid system is involved, and summarises the scientific evidence including animal and human research for the use of CBD and THC in treatment of such conditions. Topics covered include anxiety, depression, post-traumatic stress disorder, insomnia, Alzheimer's Disease and autism spectrum disorder. Chapters also discuss treatment guidelines and case studies. Unique and focused, Medicinal Cannabis and CBD in Mental Healthcare is an invaluable reference for medical practitioners seeking to adopt CBD-use in their treatment plans.

Cannabinoids as Therapeutics

Author : Raphael Mechoulam
Publisher : Springer Science & Business Media
ISBN 13 : 376437358X
Total Pages : 278 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis Cannabinoids as Therapeutics by : Raphael Mechoulam

Download or read book Cannabinoids as Therapeutics written by Raphael Mechoulam and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Only a few years ago the endocannabinoid system was unknown. Today we are aware that endocannabinoids are involved in many of the functions of the mammalian body - in neuroprotection, appetite and suckling, pain, reproduction, anxiety, memory, bone formation etc. This volume presents an up-to-date picture of some of the major fields of endocannabinoid research. It summarizes the actions of the endocannabinoids on various physiological systems and opens new therapeutic windows to a large number of diseases. The first chapter, on the use of Cannabis in India, can be viewed as an expression of thanks to the herbal practitioners, who for centuries passed on the medical traditions associated with the drug. The chapter on chemistry is a short summary of active plant, synthetic and endogenous cannabinoids being investigated today, many of which are mentioned later in the book. Cannabidiol is an unusual cannabinoid - it does not bind to the known receptors and yet exerts a variety of effects. Hence a chapter is devoted to it. Further chapters deal with the endocannabinoid system and the endocannabinoids in a variety of conditions and physiological systems. The concluding chapter describes the research done on Sativex®, a standardized plant extract, shortly to be introduced in Canada as a drug for multiple sclerosis. The intended audience is drug researchers (medicinal chemists, pharmacologists, clinicians), neuroscientists, physiologists, and clinicians interested in the effect of the endocannabinoid system in various physiological systems.

Behavioral Neurobiology of PTSD

Author : Eric Vermetten
Publisher : Springer
ISBN 13 : 3319948245
Total Pages : 274 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Behavioral Neurobiology of PTSD by : Eric Vermetten

Download or read book Behavioral Neurobiology of PTSD written by Eric Vermetten and published by Springer. This book was released on 2018-08-25 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the behavioral neuroscience that supports our understanding of the neurobiology of trauma risk and response. The collection of articles focuses on both preclinical and clinical reviews of (1) state-of-the-art knowledge of mechanisms of posttraumatic stress disorder (PTSD) and co-occurring disorders, (2) the biological and psychological constructs that support risk and resiliency for trauma disorders, and (3), novel treatment strategies and therapeutics on the horizon.

Endocannabinoid Signaling

Author : Mauro Maccarrone
Publisher : Humana
ISBN 13 : 9781493935376
Total Pages : 0 pages
Book Rating : 4.9/5 (353 download)

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Book Synopsis Endocannabinoid Signaling by : Mauro Maccarrone

Download or read book Endocannabinoid Signaling written by Mauro Maccarrone and published by Humana. This book was released on 2016-06-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume encompasses all major methodologies to interrogate endocannabinoid systems (ECS) and endocannabinoids (eCBs) signaling. With increasing interest towards the manifold activities of eCBs, this book discusses the chemical, biochemical, and molecular biological assays, and activity of distinct elements of the ECS. These include membrane, nuclear receptors, biosynthetic and hydrolytic enzymes, and membrane transporters and oxidative enzymes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Timely and cutting edge, Endocannabinoid Signaling: Methods and Protocols is a valuable resource and will help chemists, drug designers, biochemists, molecular biologists, cell biologists, pharmacologists, and (electro) physiologists navigate the mare magnum of endocannabinoid research.

Marijuana and Madness

Author : David Castle
Publisher : Cambridge University Press
ISBN 13 : 9781139451659
Total Pages : 238 pages
Book Rating : 4.4/5 (516 download)

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Book Synopsis Marijuana and Madness by : David Castle

Download or read book Marijuana and Madness written by David Castle and published by Cambridge University Press. This book was released on 2004-05-27 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the psychiatry and neuroscience of Cannabis sativa (marijuana), with particular emphasis on psychotic disorders. It outlines developments in our understanding of the human cannabinoid system, and links this knowledge to clinical and epidemiological facts about the impact of cannabis on mental health. Clinically focused chapters review not only the direct psychomimetic properties of cannabis, but also the impact consumption has on the courses of evolving or established mental illness such as schizophrenia. A number of controversial issues are critically explored, including whether a discrete 'cannabis psychosis' exists, and whether cannabis can actually cause schizophrenia. Effects of cannabis on mood, notably depression, are reviewed, as are its effects on cognition. This book will be of interest to all members of the mental health team, as well as to neuroscientists and those involved in drug and alcohol research.

Marijuana and Mental Health

Author : Michael T. Compton, M.D., M.P.H.
Publisher : American Psychiatric Pub
ISBN 13 : 1615370080
Total Pages : 258 pages
Book Rating : 4.6/5 (153 download)

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Book Synopsis Marijuana and Mental Health by : Michael T. Compton, M.D., M.P.H.

Download or read book Marijuana and Mental Health written by Michael T. Compton, M.D., M.P.H. and published by American Psychiatric Pub. This book was released on 2016-03-18 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: With relatable clinical vignettes that illustrate the applicability of each chapter’s content, as well as key chapter points that summarize major themes, Marijuana and Mental Health is the definitive, single source of comprehensive information on marijuana and mental health in modern American society. Balanced, focused, and highly readable, chapters address topics such as the effects of marijuana on the brain and mind, marijuana-related policy and legislation, the complex link between marijuana use and psychotic disorders, synthetic cannabinoids, and the treatment and prevention of marijuana misuse. Beyond offering clinical and research psychiatrists, psychiatric residents and fellows, clinical psychologists, and psychiatric nurses a comprehensive but concise compilation of research in this area, this reference informs clinical mental health practice as well as policy decisions by articulating the connection between marijuana and mental health, particularly in the United States.

Posttraumatic Stress Disorder

Author : Chris R. Brewin
Publisher : Yale University Press
ISBN 13 : 9780300123746
Total Pages : 292 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Posttraumatic Stress Disorder by : Chris R. Brewin

Download or read book Posttraumatic Stress Disorder written by Chris R. Brewin and published by Yale University Press. This book was released on 2007-01-01 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building on this analysis, Brewin provides valuable information on who will be vulnerable to traumatic stress, how to tell whether someone is likely to be suffering from PTSD, why some interventions work and others are ineffective and what could and should be done to help survivors."--Jacket.

Medicinal Cannabis

Author : Deborah Malka
Publisher : CRC Press
ISBN 13 : 1000486273
Total Pages : 433 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Medicinal Cannabis by : Deborah Malka

Download or read book Medicinal Cannabis written by Deborah Malka and published by CRC Press. This book was released on 2021-12-05 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides instruction for health professionals wanting to gain knowledge about the clinical aspects of cannabis medicine. How to use cannabis with real patients, not just theoretically, its pitfalls and challenges, as well as rewards, is a vastly under-covered topic. Now that some form of medical cannabis is approved in almost all US states, health care providers and patients Need to Know how to achieve maximum benefits by best use of this versatile herbal medicine. Medicinal Cannabis: Pearls for Clinical Practice introduces the scientific background of how cannabis acts medicinally, its components and how cannabis affects a specific condition. Key Features: Provides instruction for health professionals wanting to understand the clinical practice of cannabis medicine Reviews the chemistry, physiology and mechanisms of action of cannabinoids, endocannabinoids and cannabis with a focus on clinical relevance Presents information on practice management of specific patient populations, including pediatric, youth, adult, elderly and pets Features over 150 case reports with learning "Pearls" from the author’s clinical practice for 35 medical conditions Discusses specifics of dosing and delivery of cannabis in detail, with strategies to promote the benefit/risk ratio About the Author Deborah Malka, MD, PhD, is a holistic physician with certification in Integrative Holistic Medicine. Prior to clinical practice, Dr. Malka completed her PhD in Human Genetics from Columbia University, and studied both natural and traditional medicine, with degrees from the University of New Mexico School of Medicine and the Santa Fe College of Natural Medicine. She has specialized in cannabis medicine for the past 15 years, treating over 30,000 patients.

Healing with Cannabis

Author : Cheryl Pellerin
Publisher : Simon and Schuster
ISBN 13 : 1510751904
Total Pages : 586 pages
Book Rating : 4.5/5 (17 download)

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Book Synopsis Healing with Cannabis by : Cheryl Pellerin

Download or read book Healing with Cannabis written by Cheryl Pellerin and published by Simon and Schuster. This book was released on 2020-08-04 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Named a 2023 TOP BOOK ON CANNABIS by CBD Oracle 2020 GOLD MEDAL WINNER of the Nonfiction Book Awards (Nonfiction Authors Association) An Informative Read for an Audience Interested in Why and How Medical Cannabis Helps Treat a Range of Illnesses—Maybe All of Them With cannabis approved in fourteen states (including the District and two US territories), medical cannabis approved in at least 35 states, and hemp (very-low-THC cannabis) off the controlled substances list, millions now treat their ills with medical cannabis or non-intoxicating cannabinoids like CBD. But lots of them don’t know why or how cannabis works in the body. Healing with Cannabis informs readers about an ancient biological system newly discovered in every vertebrate on the planet—the endocannabinoid system. This system is the only reason cannabis works in the body, and it’s why cannabis is effective in a broad range of disorders. The book offers an informal tone, a little humor, interviews with some of the most knowledgeable cannabinoid scientists, color images, and a selection of research and clinical trials to recount the story of the endocannabinoid system, its origins in the earliest forms of life on Earth, the evolution of its elements, and the discoveries, millions of years later, of more of its elements over time. Healing with Cannabis explains the surprising reasons evolution conserved the endocannabinoid system over a billion years and tells specifically how cannabis has positive effects on some of society’s most devastating illnesses, including neurodegenerative diseases, post-traumatic stress disorder, pain, movement disorders, cancer and chemotherapy, and addiction. The book also shows how medical cannabis, widely available, will change the face of public health, and how nearly everyone can benefit from this versatile medicine that has a 5,000-year history of safe and effective use.

Behavioral Neurobiology of the Endocannabinoid System

Author : Dave Kendall
Publisher : Springer Science & Business Media
ISBN 13 : 3540889558
Total Pages : 418 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Behavioral Neurobiology of the Endocannabinoid System by : Dave Kendall

Download or read book Behavioral Neurobiology of the Endocannabinoid System written by Dave Kendall and published by Springer Science & Business Media. This book was released on 2009-08-14 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endocannabinoid signaling system is a key modulator of central nervous function. This volume, essential reading for interested neuroscientists, provides in-depth coverage of the roles of the endocannabinoid signaling system in the neurobiology of behavior.

Stoned

Author : David Casarett M.D.
Publisher : Penguin
ISBN 13 : 0698186648
Total Pages : 306 pages
Book Rating : 4.6/5 (981 download)

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Book Synopsis Stoned by : David Casarett M.D.

Download or read book Stoned written by David Casarett M.D. and published by Penguin. This book was released on 2015-07-14 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: A doctor discovers the surprising truth about marijuana No substance on earth is as hotly debated as marijuana. Opponents claim it’s dangerous, addictive, carcinogenic, and a gateway to serious drug abuse. Fans claim it as a wonder drug, treating cancer, anorexia, AIDS, chronic pain, glaucoma, arthritis, migraines, PTSD, and insomnia. Patients suffering from these conditions need—and deserve—hard facts based on medical evidence, not hysteria and superstition. In Stoned, palliative care physician Dr. David Casarett sets out to do anything—including experimenting on himself—to find evidence of marijuana’s medical potential. He smears mysterious marijuana paste on his legs and samples pot wine. He poses as a patient at a seedy California clinic and takes lessons from an artisanal hash maker. In conversations with researchers, doctors, and patients around the world he learns how marijuana works—and doesn’t—in the real world. Dr. Casarett unearths tales of near-miraculous success, such as a child with chronic seizures who finally found relief in cannabidiol oil. In Tel Aviv, he learns of a nursing home that’s found success giving marijuana to dementia patients. On the other hand, one patient who believed marijuana cured her lung cancer has clearly been misled. As Casarett sifts the myth and misinformation from the scientific evidence, he explains, among other things: • Why marijuana might be the best treatment option for some types of pain • Why there’s no significant risk of lung damage from smoking pot • Why most marijuana-infused beer or wine won’t get you high Often humorous, occasionally heartbreaking, and full of counterintuitive conclusions, Stoned offers a compassionate and much-needed medical practitioner’s perspective on the potential of this misunderstood plant.

Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE)

Author : Sudie E. Back
Publisher : Oxford University Press, USA
ISBN 13 : 019933451X
Total Pages : 193 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE) by : Sudie E. Back

Download or read book Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE) written by Sudie E. Back and published by Oxford University Press, USA. This book was released on 2014-10-08 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE) is a cognitive-behavioral psychotherapy program designed for patients who have posttraumatic stress disorder (PTSD) and a co-occurring alcohol or drug use disorder. COPE represents an integration of two evidence-based treatments: Prolonged Exposure (PE) therapy for PTSD and Relapse Prevention for substance use disorders. COPE is an integrated treatment, meaning that both the PTSD and substance use disorder are addressed concurrently in therapy by the same clinician, and patients can experience substantial reductions in both PTSD symptoms and substance use severity. Patients use the COPE Patient Workbook while their clinician uses the Therapist Guide to deliver treatment. The program is comprised of 12 individual, 60 to 90 minute therapy sessions. The program includes several components: information about how PTSD symptoms and substance use interact with one another; information about the most common reactions to trauma; techniques to help the patient manage cravings and thoughts about using alcohol or drugs; coping skills to help the patient prevent relapse to substances; a breathing retraining relaxation exercise; and in vivo (real life) and imaginal exposures to target the patient's PTSD symptoms.

Prolonged Exposure Therapy for PTSD

Author : Edna Foa
Publisher : Oxford University Press
ISBN 13 : 019988580X
Total Pages : 175 pages
Book Rating : 4.1/5 (998 download)

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Book Synopsis Prolonged Exposure Therapy for PTSD by : Edna Foa

Download or read book Prolonged Exposure Therapy for PTSD written by Edna Foa and published by Oxford University Press. This book was released on 2007-03-22 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: An estimated 70% of adults in the United States have experienced a traumatic event at least once in their lives. Though most recover on their own, up to 20% develop chronic Posttraumatic Stress Disorder. For these people, overcoming PTSD requires the help of a professional. This guide gives clinicians the information they need to treat clients who exhibit the symptoms of PTSD. It is based on the principles of Prolonged Exposure Therapy, the most scientifically-tested and proven treatment that has been used to effectively treat victims of all types of trauma. Whether your client is a veteran of combat, a victim of a physical or sexual assault, or a casualty of a motor vehicle accident, the techniques and strategies outlined in this book will help. In this treatment clients are exposed to imagery of their traumatic memories, as well as real-life situations related to the traumatic event in a step-by-step, controllable way. Through these exposures, your client will learn to confront the trauma and begin to think differently about it, leading to a marked decrease in levels of anxiety and other PTSD symptoms. Clients are provided education about PTSD and other common reactions to traumatic events. Breathing retraining is taught as a method for helping the client manage anxiety in daily life. Designed to be used in conjunction with the corresponding client workbook, this therapist guide includes all the tools necessary to effectively implement the prolonged exposure program including assessment measures, session outlines, case studies, sample dialogues, and homework assignments. This comprehensive resource is an exceptional treatment manual that is sure to help you help your clients reclaim their lives from PTSD. TreatmentsThatWorkTM represents the gold standard of behavioral healthcare interventions! · All programs have been rigorously tested in clinical trials and are backed by years of research · A prestigious scientific advisory board, led by series Editor-In-Chief David H. Barlow, reviews and evaluates each intervention to ensure that it meets the highest standard of evidence so you can be confident that you are using the most effective treatment available to date · Our books are reliable and effective and make it easy for you to provide your clients with the best care available · Our corresponding workbooks contain psychoeducational information, forms and worksheets, and homework assignments to keep clients engaged and motivated · A companion website (www.oup.com/us/ttw) offers downloadable clinical tools and helpful resources · Continuing Education (CE) Credits are now available on select titles in collaboration with PsychoEducational Resources, Inc. (PER)

Use of Cannabis in the treatment of post-traumatic stress disorder

Author : Pharmacology University
Publisher : Pharmacology University
ISBN 13 :
Total Pages : 26 pages
Book Rating : 4./5 ( download)

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Book Synopsis Use of Cannabis in the treatment of post-traumatic stress disorder by : Pharmacology University

Download or read book Use of Cannabis in the treatment of post-traumatic stress disorder written by Pharmacology University and published by Pharmacology University. This book was released on 2021-12-19 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: An event that had an impact on you, an accident, the traumas of war...are situations that could cause anxiety, fear, insecurities, stress, among others. Millions of people have the well-known post-traumatic stress disorder and cannabis could be an ally in its treatment. The scientific understanding of psychological trauma has witnessed a constant evolution since the 19th century to the present day, several terms have been created in the effort to categorize this phenomenon, as well as multiple explicatory theories often contradictory between each other. In 1889, Herman Oppenheim, a German neurologist, introduced the term "traumatic neurosis". This condition was explained in an organicist manner, by subtle changes at the molecular level in the nervous system. In 1904, Pierre Janet proposed the first explanation of what we today know as PTSD, caused by a failure in memory integration due to extreme emotional arousal. Post-traumatic stress disorder is defined as an exposure to a highly traumatic event, be it a bombing, rape, assault, kidnapping, accident, and more; where the lives of the people in the event are at risk. The images of the traumatic situation are experienced over and over again (flashback), against one's will and despite the time, it remains present and is manifested by intense anxiety reactions such as: worry, intense fear, lack of control, high physiological activation and others. This generates stress, exhaustion, intense emotions and irrational thoughts that increase in intensity. Currently, cannabinoids -substances derived from the cannabis plant- have been involved in modulating the stress response in various animal models in which some degree of stress has been generated. It has also been shown that corticosterone facilitates the synthesis and release of endocannabinoids. In addition, systemic or direct administration in the amygdala reduces stress in fear conditioning models. The recent knowledge about cannabinoids provides a novel therapeutic window for many mental disorders including post-traumatic stress disorder. Preliminary data indicate that medical cannabis and its compounds can manage symptoms of post-traumatic stress disorder related to hyper-excitability. Anxious responses to exteroceptive stimuli and trauma experiences that are context-dependent. While these clinical observations need to be sustained and replicated in larger populations, they provide a clue to the calming effects that cannabis may have on stress and anxiety behaviors. (Patel et al. 2017) The rapid progress that medical research has had to determine the therapeutic properties of cannabis derivatives and the medicinal use of this plant, has generated hope for improving the quality of life of people suffering from various diseases; this based on the beneficial effects that phytocannabinoids have shown against many disorders such as PTSD. In this book that Pharmacology University brings to you, we will explore in more detail what this disorder consists of, what are its clinical manifestations, how the endocannabinoid system acts, as well as the role that cannabinoids can have on the stress and fear experienced by people who suffer from the dreaded post-traumatic stress disorder.