Understanding The Potential Mechanisms By Which Peri Vascular Adipose Tissue Pvat Contributes To Obesity Related Cardiovascular Diseases Cvds

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Understanding the Potential Mechanisms by which Peri-vascular Adipose Tissue (PVAT) contributes to obesity-related Cardiovascular Diseases (CVDs)

Author : Dr. Hakim Saboowala
Publisher : Dr.Hakim Saboowala
ISBN 13 :
Total Pages : 70 pages
Book Rating : 4./5 ( download)

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Book Synopsis Understanding the Potential Mechanisms by which Peri-vascular Adipose Tissue (PVAT) contributes to obesity-related Cardiovascular Diseases (CVDs) by : Dr. Hakim Saboowala

Download or read book Understanding the Potential Mechanisms by which Peri-vascular Adipose Tissue (PVAT) contributes to obesity-related Cardiovascular Diseases (CVDs) written by Dr. Hakim Saboowala and published by Dr.Hakim Saboowala. This book was released on 2020-07-02 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the Potential Mechanisms by which Peri-vascular Adipose Tissue (PVAT) contributes to obesity-related Cardiovascular Diseases (CVDs)., Obesity is a fast-growing problem that is reaching epidemic magnitudes worldwide, affecting both children and adults. It is associated with increased risk of: ü premature death, ü morbidity, and ü mortality from several cardiovascular diseases (CVDs), including: ü stroke, ü coronary heart disease (CHD), ü myocardial infarction, and ü congestive heart failure. Although several studies have substantiated that obesity confers an independent and additive risk of all-cause and cardiovascular death, there is significant variability in these associations, with some lean individuals developing diseases and others remaining healthy despite severe obesity, the so-called metabolically healthy obese. Part of this variability has been attributed to the heterogeneity in both the distribution of body fat and the intrinsic properties of adipose tissue depots, including: ü developmental origin, ü adipogenic and proliferative capacity, ü glucose and lipid metabolism, ü hormonal control, ü thermogenic ability, and ü vascularization. In obesity, these depot-specific differences translate into specific fat distribution patterns, which are closely associated with differential cardiometabolic risks. The adventitial fat layer, also known as perivascular adipose tissue (PVAT), is of major importance. Similar to the visceral adipose tissue, PVAT has a pathophysiological role in CVDs. PVAT influences vascular homeostasis by releasing numerous vasoactive factors, cytokines, and adipokines, which can readily target the underlying smooth muscle cell layers, regulating the vascular tone, distribution of blood flow, as well as angiogenesis, inflammatory processes, and redox status. An effort has been made in this Booklet to summarize the current knowledge and discuss the role of PVAT within the scope of adipose tissue as a major contributing factor to obesity-associated cardiovascular risk along with several relevant illustrations. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Perivascular Adipose Tissue (PVAT) in Health and Disease

Author : Stephanie W. Watts
Publisher : Frontiers Media SA
ISBN 13 : 288945603X
Total Pages : 158 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Perivascular Adipose Tissue (PVAT) in Health and Disease by : Stephanie W. Watts

Download or read book Perivascular Adipose Tissue (PVAT) in Health and Disease written by Stephanie W. Watts and published by Frontiers Media SA. This book was released on 2018-10-05 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Contribution of Perivascular Adipose Tissue to Coronary Vascular Dysfunction

Author : Gregory Allen Payne
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.:/5 (76 download)

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Book Synopsis Contribution of Perivascular Adipose Tissue to Coronary Vascular Dysfunction by : Gregory Allen Payne

Download or read book Contribution of Perivascular Adipose Tissue to Coronary Vascular Dysfunction written by Gregory Allen Payne and published by . This book was released on 2010 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epidemic of obesity and associated cardiovascular complications continues to grow at an alarming rate. Currently, obesity is thought to initiate a state of chronic inflammation, which if unresolved potentially causes cardiovascular dysfunction and disease. Although poorly understood, release of inflammatory mediators and other cytokines from adipose tissue (adipocytokines) has been proposed to be the molecular link between obesity and coronary artery disease. Furthermore, the anatomic location of adipose has been increasingly recognized as a potential contributor to vascular disease. Importantly, the development of coronary atherosclerosis, a key component of heart disease, is typically found in segments of coronary arteries surrounded by perivascular adipose tissue. Accordingly, the goal of this project was to determine how perivascular adipose tissue affects coronary artery function and elucidate the critical mechanisms involved. Initial studies assessing arterial function were conducted with and without perivascular adipose tissue. Preliminary results demonstrated that factors released by perivascular adipose tissue effectively impaired coronary endothelial function both in vitro and in vivo. This observation was determined to be caused by direct inhibition of nitric oxide synthase ос), А ЦРИТИЦАЛ ЕНЗЫМЕ ФОР ТХЕ ПРОДУЦТИОН НИТРИЦ ОЬИДЕ. аТТЕНУАТИОН ОФ ЕНДОТХЕЛИУМ-ДЕПЕНДЕНТ ЖАСОДИЛАТИОН ВАС ИНДЕПЕНДЕНТ ОФ ЦХАНГЕС ИН СУПЕРОЬИДЕ ПРОДУЦТИОН, СМООТХ МУСЦЛЕ РЕСПОНСЕ, ОР ПЕРОЬИДЕ-МЕДИАТЕД ЖАСОДИЛАТИОН. аДДИТИОНАЛ СТУДИЕС РЕЖЕАЛЕД ТХАТ ПЕРИЖАСЦУЛАР АДИПОСЕ-ИНДУЦЕД ИМПАИРМЕНТ ОФ нос ВАС ДУЕ ТО ИНЦРЕАСЕД ИНХИБИТОРЫ РЕГУЛАТИОН БЫ ТХЕ �ø ИСОФОРМ ОФ ПРОТЕИН КИНАСЕ ц (пкц-�ø). сПЕЦИФИЦАЛЛЫ, ПЕРИЖАСЦУЛАР АДИПОСЕ-ДЕРИЖЕД ФАЦТОРС ЦАУСЕД СИТЕ СПЕЦИФИЦ ПХОСПХОРЫЛАТИОН ОФ НИТРИЦ ОЬИДЕ СЫНТХАСЕ АТ тХР-495. аДДИТИОНАЛ ЕЬПЕРИМЕНТС ИНЖЕСТИГАТЕД ХОВ ПЕРИЖАСЦУЛАР АДИПОСЕ-ДЕРИЖЕД ФАЦТОРС ЦОНТРИБУТЕД ТО ЦОРОНАРЫ АРТЕРЫ ДИСЕАСЕ ИН АН АНИМАЛ МОДЕЛ ОФ ОБЕСИТЫ. рЕСУЛТС ФРОМ ТХЕСЕ СТУДИЕС ИНДИЦАТЕД ТХАТ ПЕРИЖАСЦУЛАР АДИПОСЕ-ДЕРИЖЕД ЛЕПТИН МАРКЕДЛЫ ЕЬАЦЕРБАТЕД УНДЕРЛЫИНГ ЕНДОТХЕЛИАЛ ДЫСФУНЦТИОН, АНД СИГНИФИЦАНТЛЫ ЦОНТРИБУТЕД ТО ЦОРОНАРЫ ЕНДОТХЕЛИАЛ ДЫСФУНЦТИОН ТХРОУГХ А пкц-�ø ДЕПЕНДЕНТ МЕЦХАНИСМ. фИНДИНГС ФРОМ ТХИС ПРОЙЕЦТ ЦОНФИРМ ЕПИЦАРДИАЛ ПЕРИЖАСЦУЛАР АДИПОСЕ ТИССУЕ АС А ЛОЦАЛ СОУРЦЕ ОФ ХАРМФУЛ АДИПОЦЫТОКИНЕС. иН АДДИТИОН, ПЕРИЖАСЦУЛАР АДИПОСЕ-ДЕРИЖЕД ЛЕПТИН ВАС ДЕМОНСТРАТЕД ТО БЕ А ЦРИТИЦАЛ МЕДИАТОР ОФ ЦОРОНАРЫ ЖАСЦУЛАР ДЫСФУНЦТИОН ИН ОБЕСИТЫ. тОГЕТХЕР, ТХЕ РЕСУЛТС СТРОНГЛЫ СУГГЕСТ ТХАТ ПЕРИЖАСЦУЛАР АДИПОСЕ ТИССУЕ ИС А КЕЫ ЦОНТРИБУТОР ТО ЦОРОНАРЫ АРТЕРЫ ДИСЕАСЕ ИН ОБЕСИТЫ.

Epicardial Adipose Tissue

Author : Gianluca Iacobellis
Publisher : Springer Nature
ISBN 13 : 3030405702
Total Pages : 191 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Epicardial Adipose Tissue by : Gianluca Iacobellis

Download or read book Epicardial Adipose Tissue written by Gianluca Iacobellis and published by Springer Nature. This book was released on 2020-03-25 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease. It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic targets of EAT in atrial fibrillation, heart failure and coronary artery disease. Comprehensive yet focused, Epicardial Adipose Tissue: From Cell to Clinic is an essential resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.

Obesity and Cardiovascular Disease

Author : Gianluca Iacobellis
Publisher : Oxford University Press
ISBN 13 : 019954932X
Total Pages : 293 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Obesity and Cardiovascular Disease by : Gianluca Iacobellis

Download or read book Obesity and Cardiovascular Disease written by Gianluca Iacobellis and published by Oxford University Press. This book was released on 2009-10-08 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This essential book comprehensively covers the diagnosis, treatment and management of cardiovascular disease in obese patients, translating up-to-date clinical research findings into clinical practice.

The ESC Textbook of Vascular Biology

Author : Rob Krams
Publisher : Oxford University Press
ISBN 13 : 0198755775
Total Pages : 347 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis The ESC Textbook of Vascular Biology by : Rob Krams

Download or read book The ESC Textbook of Vascular Biology written by Rob Krams and published by Oxford University Press. This book was released on 2017 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.

Microcirculation in Cardiovascular Diseases

Author : Enrico Agabiti-Rosei
Publisher : Springer Nature
ISBN 13 : 3030478017
Total Pages : 215 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Microcirculation in Cardiovascular Diseases by : Enrico Agabiti-Rosei

Download or read book Microcirculation in Cardiovascular Diseases written by Enrico Agabiti-Rosei and published by Springer Nature. This book was released on 2020-10-03 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers an extensive review of the most recent data on the pathophysiological role of structural and functional alterations in the microcirculation, particularly focusing on hypertension and diabetes. It covers several relevant and innovative aspects, including the possible mechanisms involved in the development of microvascular remodeling and rarefaction, the technical approaches available for the detection of microvascular alterations, including non-invasive evaluations, the prognostic role of changes in small resistance artery structure, the possibility of preventing or regressing such alterations with appropriate treatment, and the potential clinical advantages of such intervention. A number of innovative areas of research are considered, including the role of the immune system, inflammation and oxidative stress in the development of microvascular alterations. Lastly, it examines the availability of recent non-invasive methods for the evaluation of small resistance artery morphology in the retina, which in the near future may provide a useful tool for the stratification of cardiovascular risk and even for clinical decisions regarding drug treatment, thus providing physicians with a clinically relevant instrument for improving and optimizing the management of hypertensive and diabetic patients. The book provides valuable, clinically relevant information for specialists (cardiology, internal medicine, and endocrinology) and general practitioners, and also offers novel and stimulating data to basic and clinical researchers.

Regulation of Coronary Blood Flow

Author : Michitoshi Inoue
Publisher : Springer Science & Business Media
ISBN 13 : 4431683674
Total Pages : 330 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Regulation of Coronary Blood Flow by : Michitoshi Inoue

Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

Diabetes Augmentation on Vascular Disease

Author : Godfrey Getz
Publisher : Frontiers Media SA
ISBN 13 : 2889741540
Total Pages : 117 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Diabetes Augmentation on Vascular Disease by : Godfrey Getz

Download or read book Diabetes Augmentation on Vascular Disease written by Godfrey Getz and published by Frontiers Media SA. This book was released on 2022-01-25 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Vascular Adjustments in Cardiovascular Disorders

Author : Luciana Venturini Rossoni
Publisher : Frontiers Media SA
ISBN 13 : 2889718778
Total Pages : 203 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Vascular Adjustments in Cardiovascular Disorders by : Luciana Venturini Rossoni

Download or read book Vascular Adjustments in Cardiovascular Disorders written by Luciana Venturini Rossoni and published by Frontiers Media SA. This book was released on 2021-12-30 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Textbook of Vascular Medicine

Author : Rhian M. Touyz
Publisher : Springer
ISBN 13 : 3030164810
Total Pages : 503 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Textbook of Vascular Medicine by : Rhian M. Touyz

Download or read book Textbook of Vascular Medicine written by Rhian M. Touyz and published by Springer. This book was released on 2019-08-02 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.

Exploring the Crosstalk Between Adipose Tissue and the Cardiovascular System

Author : Nadia Akawi
Publisher : Frontiers Media SA
ISBN 13 : 2889767647
Total Pages : 106 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Exploring the Crosstalk Between Adipose Tissue and the Cardiovascular System by : Nadia Akawi

Download or read book Exploring the Crosstalk Between Adipose Tissue and the Cardiovascular System written by Nadia Akawi and published by Frontiers Media SA. This book was released on 2022-09-27 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Endothelium

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Endothelium by : Michel Félétou

Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Cardiovascular Pharmacology: Endothelial Control

Author :
Publisher : Academic Press
ISBN 13 : 0123850622
Total Pages : 332 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Cardiovascular Pharmacology: Endothelial Control by :

Download or read book Cardiovascular Pharmacology: Endothelial Control written by and published by Academic Press. This book was released on 2010-12-16 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions. - Contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field

The impact of adipose tissue dysfunction on cardiovascular and renal disease, volume II

Author : Xiaodong Sun
Publisher : Frontiers Media SA
ISBN 13 : 283252852X
Total Pages : 124 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The impact of adipose tissue dysfunction on cardiovascular and renal disease, volume II by : Xiaodong Sun

Download or read book The impact of adipose tissue dysfunction on cardiovascular and renal disease, volume II written by Xiaodong Sun and published by Frontiers Media SA. This book was released on 2023-07-03 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:

PanVascular Medicine

Author : Peter Lanzer
Publisher : Springer
ISBN 13 : 9783642370779
Total Pages : 5004 pages
Book Rating : 4.3/5 (77 download)

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Book Synopsis PanVascular Medicine by : Peter Lanzer

Download or read book PanVascular Medicine written by Peter Lanzer and published by Springer. This book was released on 2015-03-30 with total page 5004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular management and care has become a truly multidisciplinary enterprise as the number of specialists involved in the treatment of patients with vascular diseases has steadily increased. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. Pan Vascular Medicine, 2nd edition has been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.

Visceral and Ectopic Fat

Author : Hildo J. Lamb
Publisher : Elsevier
ISBN 13 : 0128230126
Total Pages : 424 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Visceral and Ectopic Fat by : Hildo J. Lamb

Download or read book Visceral and Ectopic Fat written by Hildo J. Lamb and published by Elsevier. This book was released on 2022-10-28 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the health consequences and mechanisms by which visceral fat causes disease are well-studied, relatively less is known about ectopic fat, its patterns of deposition and its effects on the pathoetiology of type 2 diabetes, atherosclerosis, and cardiovascular disease. Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease covers the wealth of literature that has been amassed over the past decade on this topic. This reference brings all the research and clinical data together in one volume and helps clinicians and academic researchers understand more thoroughly the underlying mechanisms and interrelation between fat depots and ectopic fat stores in relation to health and disease. It showcases some of the recent developments in adipose tissue biology, particularly on the impact of interventional strategies - bariatric surgery, liposuction, physical and dietary intervention - of which information is desired among health specialists and policy makers. - Brings together up-to-date research on imaging, genetics, and risk factors for chronic diseases such as diabetes, heart disease, cancer, and fatty liver disease - Takes a deep dive into the current state of knowledge regarding fat stores, ectopic fat, regulation of fat stores, clinical implications, interventions, and imagining techniques - Provides up-to-date information specifically focused on visceral and ectopic fat. In addition, both pathophysiological and preventive and treatment aspects of the problem will be considered - Covers a broad range of organs - different fat stores such as skeletal muscle, bone marrow, liver and kidney - Discusses potential interventions to reduce abdominal fat