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Download or read book Ultrasound Assisted Non - Seeded Method on Surface Modification of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging Probe written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Esther Amstad
Publisher : Sudwestdeutscher Verlag Fur Hochschulschriften AG
ISBN 13 : 9783838117218
Total Pages : 388 pages
Book Rating : 4.1/5 (172 download)
Download or read book Surface Modification of Superparamagnetic Iron Oxide Nanoparticles written by Esther Amstad and published by Sudwestdeutscher Verlag Fur Hochschulschriften AG. This book was released on 2012 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical applications of superparamagnetic iron oxide nanoparticles (NPs) for therapeutic and diagnostic purposes require NPs to be stable under physiologic conditions. This can only be achieved if NPs are sterically stabilized with appropriate dispersants that bind irreversibly to the iron oxide surface. Tight control over the dispersant layer not only prevents NP agglomeration but additionally paves the way to tailor NP size, charge, the type and density of functionalities presented at the NP surface. These factors are especially important for the in vivo performance of NPs. One possibility to sterically stabilize NPs is to graft low molecular weight dispersants to these surfaces. Stabilization of NPs with low molecular weight dispersants relies on high affinity anchors that firmly bind spacers and functionalities to the NP surface at high density. This thesis compares the ability of different anchors to firmly bind low molecular weight dispersants to Fe3O4 NP surfaces and investigates the stability of NPs sterically stabilized with different dispersants. Furthermore, the performance of these sterically stabilized iron oxide NPs in selected biomedical applications is addressed.
Author : Juanye Zhang
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)
Download or read book Surface Modifications of Iron Oxide Nanoparticles for Magnetic Imaging and Diagnosis written by Juanye Zhang and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contrast agents are commonly used in magnetic resonance imaging (MRI) for their ability to selectively highlight or darken image brightness from different tissue components depending on their chemical nature. This work explores and discusses potential of colloidal iron oxide nanoparticles as non-toxic MRI contrast agents for diagnosis. Novel single-nanometer iron oxide (SNIO) nanoparticles exhibited contrast enhancement in T1-weighted MRI superior than commercially used gadolinium-based contrast agents, with unprecedentedly fast and clean renal clearance in inorganic colloidal nanoparticles. An approach for size determination based on small-angle X-ray scattering (SAXS) was developed, and understanding of particle size distribution led to successful development of alkyne-functionalized nanoparticles allowing for conjugation with biological cargos, creating a novel vehicle for drug delivery. SNIO-CBP, product from conjugating functionalized SNIO nanoparticles with a nature-inspired cyclic collagen-binding peptide (CBP) through newly developed preparatory copper-catalyzed alkyne-azide coupling CuAAC, exhibited binding affinity towards type I collagen, a natural indicator of fibrosis abundant in the extracellular matrix. SNIO-CBP was able to quickly detect hepatotoxin-induced and diet-induced non-alcoholic steatohepatitis (NASH) in mice through T1-weighted MRI upon intravenous administration. New formulations of hydrophilic iron oxide nanoparticles were explored. Tailored for quantitative ultra-short time-to-echo contrast-enhanced (QUTE-CE) MRI, catechol-coated iron oxide with 10 nm mean diameter was optimized; carboxymethyl dextran as a new ligand system was developed on SNIO and formation of nanoparticle clusters was observed, implying its potential for the emergent preclinical technique of magnetic particle imaging (MPI).
Author : Numpon Insin
Publisher :
ISBN 13 :
Total Pages : 192 pages
Book Rating : 4.:/5 (716 download)
Download or read book Surface Modifications of Iron Oxide Nanoparticles for Biological Applications written by Numpon Insin and published by . This book was released on 2011 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron oxides magnetic nanoparticles (MPs) of high crystallinity, high magnetization, and size-monodispersity were synthesized with oleic acid as their native ligands. These hydrophobic and non-functionalized MPs have magnetic properties that are suitable for various biological applications. Surface modifications were studied for transferring these MPs into biological environments as well as transforming them into functional nanoparticles. Certain surface modifications of MPs, such as attaching silane groups and silica coating, lead to formation of more complex structures of superparamagnetic and fluorescent silica microspheres and nanostructures. These microspheres and nanostructures comprising MPs and semiconductor quantum dots (QDs) are useful tools for biological applications such as for magnetically controlling with fluorescent tracking of particles and for bimodal imaging. Surface modifications of MPs with hydrophobically-modified polyacrylic acid (mPAA) amphiphilic polymer and catechol-derivative surfactants resulted in hydrophilic MPs that are stable in physiological environment and small in their hydrodynamic size. These MPs are also designed to possess active functional groups that are necessary for further conjugations with proteins and molecules of interest. These hydrophilic and functional MPs are useful in biological applications such as magnetic resonance imaging and sensing applications.
Author : Morteza Mahmoudi
Publisher :
ISBN 13 : 9781616689643
Total Pages : 0 pages
Book Rating : 4.6/5 (896 download)
Download or read book Superparamagnetic Iron Oxide Nanoparticles written by Morteza Mahmoudi and published by . This book was released on 2010-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the fabrication of nanoparticles and exploration of their properties have attracted the attention of physicists, chemists, biologists and engineers. Interest in nanoparticles arise from the fact that the mechanical, chemical, electrical, optical, magnetic, electro-optical and magneto-optical properties of these particles are different from their bulk properties and depend on the particle size. There are numerous areas where nanoparticulate systems are of scientific and technological interest. This book reviews research on the various components of superparamagnetic iron oxide nanoparticles.
Author : Morteza Mahmoudi
Publisher :
ISBN 13 : 9781617286315
Total Pages : 225 pages
Book Rating : 4.2/5 (863 download)
Download or read book Superparamagnetic Iron Oxide Nanoparticles written by Morteza Mahmoudi and published by . This book was released on 2011 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Abhilasha Mukherjee
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.:/5 (576 download)
Download or read book Uptake of Surface Modified Superparamagnetic Iron Oxide Nanoparticles by Human Aortic Endothelial Cells written by Abhilasha Mukherjee and published by . This book was released on 2004 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sophie Laurent
Publisher : Elsevier
ISBN 13 : 0081012756
Total Pages : 336 pages
Book Rating : 4.0/5 (81 download)
Download or read book Iron Oxide Nanoparticles for Biomedical Applications written by Sophie Laurent and published by Elsevier. This book was released on 2017-10-20 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine. Unlocks the potential of iron oxide nanoparticles to transform diagnostic imaging techniques Contains full coverage of new developments and recent research, making this essential reading for researchers and engineers alike Explains the synthesis, processing and characterization of iron oxide nanoparticles with a view to their use in biomedicine
Author : A. K. Peacock
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book Surface Modified Superparamagnetic Iron Oxide Nanoparticles for Long Term Stem Cell Tracking written by A. K. Peacock and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chuansong Duanmu
Publisher :
ISBN 13 :
Total Pages : 116 pages
Book Rating : 4.:/5 (637 download)
Download or read book Expanding Applications of Iron Oxide Nanoparticles by Surface Functionalization written by Chuansong Duanmu and published by . This book was released on 2009 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this dissertation, research efforts mainly focused on exploring the applications of superparamagnetic iron oxide nanoparticles (SPIONs) in MR imaging and nanocatalysis via surface functionalization.
Author : Jaison Darson
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)
Download or read book Iron Oxide Nanoparticles and Nano-Composites written by Jaison Darson and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, functional Iron oxides nanoparticles and nano-composites have gained a special traction in the field of nano-biomedicine, owing to their multifunctional capabilities that includes the inherent magnetic resonance imaging, magnetic bioseparation, cargo delivery and magnetic hyperthermia behavior. Interestingly, there are various forms of iron oxides available, with each form having their own specific characteristics. The different polymorphic forms of iron oxides are obtained through various synthetic routes and are usually surface modified to prevent their oxidation. The chapter shall encompass the synthesis and surface modification of Iron oxides nanoparticles, physicochemical properties, and theranostic application of the magnetic iron oxide nanoparticles in cancer. Also, the future directions of Iron oxide nanoparticles and nano-composites towards the achievement of clinically realizable nanoformulation for cancer theranostic applications were highlighted.
Author : Richard Hoff
Publisher :
ISBN 13 :
Total Pages : 65 pages
Book Rating : 4.:/5 (128 download)
Download or read book Iron Oxide Nanoparticle Surface Modification written by Richard Hoff and published by . This book was released on 2019 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional nanomaterials can be engineered to aid in the diagnosis of diseases, enable efficient drug delivery, monitor treatment progress over time, and evaluate treatment outcomes. This strategy, known as theranostics, focuses on the combination of diagnostic and therapeutic techniques to provide new clinically safe and efficient personalized treatments. The evaluation of different nanomaterials' properties and their customization for specific medical applications has therefore been a significant area of interest within the scientific community. Iron oxide nanoparticles, specifically those based on iron (II, III) oxide (magnetite, Fe3O4), have been prominently investigated for biomedical, theranostic applications due to their documented superparamagnetism, high biocompatibility, and other unique physicochemical properties. The aim of this thesis is to establish a viable set of methods for preparing magnetite (iron oxide) nanoparticles through hydrothermal synthesis and modifying their surfaces with organic functional groups in order to both modulate surface chemistry and facilitate the attachment of molecules such as peptides via covalent bond formations. Modifying their surfaces with biomolecules such as peptides can further increase their uptake into cells, which is a necessary step in the mechanisms of their desired biomedical applications. The methods of nanoparticle synthesis, surface functionalization, and characterization involving electron microscopy (e.g., SEM, TEM), zeta potential measurements, size analysis (i.e., DLS), and FT-IR spectroscopy will be presented.
Author : Carlos Bárcena
Publisher :
ISBN 13 :
Total Pages : 216 pages
Book Rating : 4.:/5 (231 download)
Download or read book Novel Superparamagnetic Nanoparticles as MRI Contrast Agents written by Carlos Bárcena and published by . This book was released on 2008 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, magnetic nanoparticles have played an increasing role in biomedical applications and have been the subject of extensive research investigations. Physical properties, including nanoparticle size, composition and surface chemistry, vary widely and influence their biological and pharmacological properties and, ultimately, their clinical applications and utilities. Among different magnetic nanoparticles, superparamagnetic iron oxide nanoparticles (SPIOs) were found non-toxic and used in multiple applications including magnetic resonance imaging (MRI) contrast agents, molecular and cellular imaging, and potential therapeutic options. Herein, a mixed spinel strategy was devised to increase the magnetization of SPIO by incorporation of non-magnetic Zn 2+ . Addition of a normal spinel (ZnFe 2 O 4) to an inverse spinel (Fe 3 O 4) results in a magnetic disorder which leads to increased magnetization. Hydrophobic Zn x Fe 1-x O Fe 2 O 3 (x = 0.34) nanoparticles encapsulated in polymeric micelles exhibited increased T 2 relaxivity and sensitivity of detection over commercially used Feridex ® sample. The superb MR relaxivity of these Zn-SPIO nanoparticles and stability of micellar carriers make them excellent candidates for in vivo MR imaging of cancer.
Author : Jatuporn Salaklang
Publisher :
ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.:/5 (729 download)
Download or read book Advanced Surface Derivatization of Superparamagnetic Iron Oxide Nanoparticles in a Fixed Bed Magnetic Reactor for Bio-application written by Jatuporn Salaklang and published by . This book was released on 2009 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Haotian Wang
Publisher :
ISBN 13 :
Total Pages : 57 pages
Book Rating : 4.:/5 (948 download)
Download or read book In Vivo Stability and Biodistribution of Superparamagnetic Iron Oxide Nanoparticles Radiolabeled with Indium-111 written by Haotian Wang and published by . This book was released on 2014 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticles of various kinds have generated considerable excitement as vehicles for drug delivery, and as imaging agents (Yen, 2013). Magnetic nanoparticles are of particular interest since their distribution in the body can be manipulated using magnetic fields, and they can also act as highly sensitive contrast agents in magnetic resonance imaging (MRI) (Bonnemain, 1998; Wang, Hussain, & Krestin, 2001). For some applications, radionuclide imaging (Positron emission tomography (PET) or Single-photon emission computed tomography (SPECT)) offers advantages when used in conjunction with MRI, since the strengths of the two modalities, higher spatial resolution for MRI, but better quantification for PET or SPECT, are complementary (Bouziotis et al., 2012). On the other hand, the validity of dual modality imaging requires that the association between radioactive label and magnetic label remains intact in the human or animal body during the period of study. Evaluation of the extent to which this requirement is true for PEGylated nanoparticles containing a core of superparamagnetic iron oxide (SPION), and also labeled with a radioactive metal which is commonly used in nuclear medicine, indium-111, is a major component of this proposal. In the present study, we prepared SPIONs using co-precipitation of iron oxide, complexation with oleic acid, and final coating of the particles with DSPE-PEG plus DMPE-DTPA using the lipid rehydration technique. We radiolabeled the particles by introducing iron-59 ferric chloride or carbon-14 oleic acid during their preparation, and by forming a chelate between the anchored DTPA and indium-111. We conducted biodistribution studies in mice with particles labeled with each radionuclide, and also with indium-111 labeled indium citrate, indium-DTPA, and DMPE-DTPA-indium, and with carbon-14 oleic acid. We found that that the radioactivity from radioindium labeled SPIONs was, as hypothesized, preferentially localized in liver, spleen and bone associated with trapping of colloids by reticuloendothelial cells. However, radioactivity from SPIONs labeled with iron-59 was accumulated in liver, spleen and bone to a greater extent than from indium-111 labeled SPIONs, showing that the association of indium with the particles is not completely maintained in vivo. Radioactivity from SPIONs labeled with carbon-14 oleic acid exhibited a quite different distribution pattern to iron-59 or indium-111, and so does not remain with the iron oxide core after injection into mice.
Author : Sneha Bhagyaraj
Publisher : Woodhead Publishing
ISBN 13 : 0081019769
Total Pages : 314 pages
Book Rating : 4.0/5 (81 download)
Download or read book Synthesis of Inorganic Nanomaterials written by Sneha Bhagyaraj and published by Woodhead Publishing. This book was released on 2018-06-29 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Inorganic Nanomaterials: Advances and Key Technologies discusses the latest advancements in the synthesis of various types of nanomaterials. The book's main objective is to provide a comprehensive review regarding the latest advances in synthesis protocols that includes up-to-date data records on the synthesis of all kinds of inorganic nanostructures using various physical and chemical methods. The synthesis of all important nanomaterials, such as carbon nanostructures, Core-shell Quantum dots, Metal and metal oxide nanostructures, Nanoferrites, polymer nanostructures, nanofibers, and smart nanomaterials are discussed, making this a one-stop reference resource on research accomplishments in this area. Leading researchers from industry, academia, government and private research institutions across the globe have contributed to the book. Academics, researchers, scientists, engineers and students working in the field of polymer nanocomposites will benefit from its solutions for material problems. Provides an up-to-date data record on the synthesis of all kinds of organic and inorganic nanostructures using various physical and chemical methods Presents the latest advances in synthesis protocols Includes the latest techniques used in the physical and chemical characterization of nanomaterials Covers the characterization of all the important materials groups, such as carbon nanostructures, core-shell quantum dots, metal and metal oxide nanostructures, Nano ferrites, polymer nanostructures and nanofibers
Author : He Wei (Ph.D.)
Publisher :
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.:/5 (95 download)
Download or read book Synthesis and Development of Hydrophilic Iron Oxide Nanoparticles for Biomedical Applications written by He Wei (Ph.D.) and published by . This book was released on 2014 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uniformly sized superparamagnetic iron oxide nanoparticles (SPIONs) with inorganic diameters of 3-35 nm were synthesized. New surface ligand coatings were designed and synthesized, and the resulting hydrophilic SPIONs in biological buffers were found to be compact, stable, highly magnetic, and biocompatible. Furthermore, the hydrophilic SPIONs were stable in vitro in serums and cells as well as in vivo in mice. Functionalized SPIONs demonstrated the ability of specific labeling. Finally, the hydrophilic SPIONs have potential as a non-toxic alternative to Gadolinium based contrast agents for T1-weighted magnetic resonance imaging (MRI) and they have shown potential in multicolor MRI as well as magnetic particle imaging.
