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Author : Alice Mae Berglund
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.:/5 (234 download)
Download or read book Type II Spiral Ganglion Neurons of the Mammalian Cochlea written by Alice Mae Berglund and published by . This book was released on 1990 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alain Dabdoub
Publisher : Springer
ISBN 13 : 1493930311
Total Pages : 300 pages
Book Rating : 4.4/5 (939 download)
Download or read book The Primary Auditory Neurons of the Mammalian Cochlea written by Alain Dabdoub and published by Springer. This book was released on 2015-10-06 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details the essential role of the spiral ganglion neurons. The volume elucidates and characterizes their development, their environment, their electrophysiological characteristics, their connectivity to their targets in the inner ear and the brain, and discusses the potential for their regeneration. A comprehensive review about the spiral ganglion neurons is important for researchers not only in the inner ear field but also in development, neuroscience, biophysics as well as neural networks researchers. The chapters are authored by leading researchers in the field.
Author : Miguel A. Merchán
Publisher : Springer Science & Business Media
ISBN 13 : 1461529328
Total Pages : 525 pages
Book Rating : 4.4/5 (615 download)
Download or read book The Mammalian Cochlear Nuclei written by Miguel A. Merchán and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: The presence of sophisticated auditory processing in mammals has permitted perhaps the most significant evolutionary development in humans: that of language. An understanding of the neural basis of hearing is thus a starting point for elucidating the mechanisms that are essential to human communication. The cochlear nucleus is the first region of the brain to receive input from the inner ear and is therefore the earliest stage in the central nervous system at which auditory signals are processed for distribution to higher centers. Clarifying its role in the central auditory pathway is crucial to our knowledge of how the brain deals with complex stimuli such as speech, and is also essential for understanding the central effects of peripheral sensorineural hearing loss caused by, for example, aging, ototoxic drugs, and noise. Ambitious new developments to assist people with total sensorineural deafness, including both cochlear and cochleus nuclear implants, require a detailed knowledge of the neural signals received by the brainstem and how these are processed. Recently, many new data have been obtained on the structure and function of the cochlear nucleus utilizing combinations of anatomical, physiological, pharmacological and molecular biological procedures. Approaches such as intracellular dye-filling of physiologically identified neurons, localization of classical neurotransmitters, peptides, receptors and special proteins, or gene expression have opened the door to novel morphofunctional correlations.
Author : Jean-Daniel Horisberger
Publisher : R. G. Landes
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.F/5 ( download)
Download or read book The Na, K-ATPase written by Jean-Daniel Horisberger and published by R. G. Landes. This book was released on 1994 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text addresses the question, How does the sodium pump pump'. A variety of primary structure information is available, and progress has been made in the functional characterization of the Na, K-pump, making the answer to this question possible, within reach of currently used techniques
Author :
Publisher :
ISBN 13 :
Total Pages : 89 pages
Book Rating : 4.:/5 (858 download)
Download or read book Function of Cochlear Spiral Ganglion Neurons and Effects of Neurotrophic Factors on Their Development written by and published by . This book was released on 2006 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: The spiral ganglion neurons (SGN) in the mammalian inner ear play a key role in transferring the neural activity transduced by the hair cells to the central auditory system. The neurophysiological properties of the SGN are determined in large part by the voltage-gated and ligand-gated ion channels. There is a growing awareness that the voltage-gated and ligand-gated ion channels which are expressed on neurons throughout the brain undergo significant modifications during early postnatal life and following damage and recovery. This is a process often referred to as neural plasticity. The SGN are anatomically difficult to access, therefore relatively little is known about the changes in the SGN's voltage and ligand gated ion channels during early postnatal life. Recent studies indicate that the survival of SGN can be profoundly altered by neurotrophic factor 3 (NT-3) and brain derived neurotrophic factor (BDNF) released by hair cells of the inner ear. However, it is unclear how NT-3 and BDNF affect the development of voltage and ligand gated channels expressed on SGN. To address the lack of knowledge in this area, the whole-cell patch clamp recording was utilized in order to study the early postnatal changes which occur in several voltage and ligand gated channels of SGN. Since preliminary studies have shown that NT-3 and BDNF can influence the survival and function of SGN, I also studied their affects on the developmental changes. Using whole cell patch clamp recording, I found that the amplitude of the voltage-gated potassium current increased significantly during early postnatal development (P1-P5). However, when isolated SGN were maintained in culture from 1 to 28 days (C1-C28), the voltage-gated potassium current remained relatively constant while the voltage-gated sodium current increased significantly. During C1-C28 the firing pattern of action potentials evoked by suprathreshold current shifted from fast adapting to slow adapting. The developmental changes seen in the voltage gated potassium channels are likely to contribute to this shift in SGN action potential firing pattern. Glutamate receptors are believed to be the dominant excitatory neurotransmitter receptors of SGN. To investigate the development of glutamate receptors, I applied kainic acid (KA), a non- N -methyl-D-aspartic acid (non-NMDA) glutamate receptor agonist to the SGN. KA induced a robust current in nearly all SGN cultured in neurotrophin free medium for short term (
Author : David R. Moore
Publisher : Oxford University Press, USA
ISBN 13 : 0199233284
Total Pages : 592 pages
Book Rating : 4.1/5 (992 download)
Download or read book The Oxford Handbook of Auditory Science: The Auditory Brain written by David R. Moore and published by Oxford University Press, USA. This book was released on 2010-01-21 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 1: The Ear (edited by Paul Fuchs) Volume 2: The Auditory Brain (edited by Alan Palmer and Adrian Rees) Volume 3: Hearing (edited by Chris Plack) Auditory science is one of the fastest growing areas of biomedical research. There are now around 10,000 researchers in auditory science, and ten times that number working in allied professions. This growth is attributable to several major developments: Research on the inner ear has shown that elaborate systems of mechanical, transduction and neural processes serve to improve sensitivity, sharpen frequency tuning, and modulate response of the ear to sound. Most recently, the molecular machinery underlying these phenomena has been explored and described in detail. The development, maintenance, and repair of the ear are also subjects of contemporary interest at the molecular level, as is the genetics of hearing disorders due to cochlear malfunctions.
Author : Geoffrey A. Manley
Publisher : Springer
ISBN 13 : 3319520733
Total Pages : 361 pages
Book Rating : 4.3/5 (195 download)
Download or read book Understanding the Cochlea written by Geoffrey A. Manley and published by Springer. This book was released on 2017-08-30 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This SHAR volume serves to expand, supplement, and update the original "Cochlea" volume in the series. The book aims to highlight the power of diverse modern approaches in cochlear research by focusing on advances in those fields over the last two decades. It also provides insights into where cochlear research is going, including new hearing prostheses for the deaf that will most likely soon enter the phase of clinical trials. The book will appeal to a broad, interdisciplinary readership, including neuroscientists and clinicians in addition to the more specific auditory community.
Author : Mark E. Warchol
Publisher : Springer Nature
ISBN 13 : 3031206614
Total Pages : 242 pages
Book Rating : 4.0/5 (312 download)
Download or read book Hair Cell Regeneration written by Mark E. Warchol and published by Springer Nature. This book was released on 2023-04-27 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a detailed update on progress in the field of hair cell regeneration. This topic is of considerable interest to academicians, clinicians, and commercial entities, including students of auditory and vestibular neuroscience, audiologists, otologists, and industry, all of whom may have interest in hair cell regeneration as a potential future therapy for hearing and balance dysfunction. In 2008, Springer published a SHAR volume on this subject (Hair Cell Regeneration, Repair, and Protection, Editors Richard Salvi and Richard Fay). Since that time, there has been considerable advancement in this field.This book provides a historical perspective on the field, but the emphasis is on more "prospective" views of the various facets of regeneration research, in the hope that the volume will stimulate new projects and approaches, focusing on the limitations of current knowledge and describing promising strategies for future work. The book will include the following key features of hair cell regeneration: • Cellular and molecular control hair cell regeneration in non-mammalian species (in particular zebrafish and chickens) • Our current understanding of the capacity for hair cell replacement in mammals (rodents and humans). • Signals controlling pro-regenerative behaviors in supporting cells, the hair cell progenitors. • New techniques that have been applied to study the genetic and epigenetic regulation of hair cell regeneration in mammals and non-mammals. • Contributions of stem cells toward building new tools to explore how hair cell regeneration is controlled and toward developing cells and tissue for therapeutic transplantation. • Studies that have applied gene and drug therapy to promote regeneration in mammals.
Author : Douglas B Webster
Publisher : Springer Science & Business Media
ISBN 13 : 1461244161
Total Pages : 494 pages
Book Rating : 4.4/5 (612 download)
Download or read book The Mammalian Auditory Pathway: Neuroanatomy written by Douglas B Webster and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Auditory Research presents a series of com prehensive and synthetic reviews of the fundamental topics in modem auditory research. It is aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes will introduce new investigators to important aspects of hearing science and will help established inves tigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume is intended to present a particular topic comprehensively, and each chapter will serve as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The series focusses on topics that have developed a solid data and con ceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.
Author : Matthew Kelley
Publisher : Springer Science & Business Media
ISBN 13 : 0387306781
Total Pages : 250 pages
Book Rating : 4.3/5 (873 download)
Download or read book Development of the Inner Ear written by Matthew Kelley and published by Springer Science & Business Media. This book was released on 2006-03-04 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Auditory Research presents a series of compreh- sive and synthetic reviews of the fundamental topics in modern auditory - search. The volumes are aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to betterunderstandthefundamentaltheoriesanddatain?eldsofhearingthatthey may not normally follow closely. Each volume presents a particular topic comprehensively, and each servesas a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature. Eachvolumeintheseriesconsistsofafewsubstantialchaptersonaparticular topic. In some cases, the topics will be ones of traditional interest for which there is a substantial body of data and theory, such as auditory neuroanatomy (Vol. 1) and neurophysiology (Vol. 2). Other volumes in the series deal with topics that have begun to mature more recently, suchasdevelopment,plasticity, and computational models of neural processing. In many cases, the series - itorsarejoinedbyaco-editorhavingspecialexpertiseinthetopicofthevolume.
Author : Richard J. Salvi
Publisher : Springer Science & Business Media
ISBN 13 : 0387733647
Total Pages : 323 pages
Book Rating : 4.3/5 (877 download)
Download or read book Hair Cell Regeneration, Repair, and Protection written by Richard J. Salvi and published by Springer Science & Business Media. This book was released on 2008-03-15 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not male pattern baldness, but the loss of sensory hair, is a very serious topic. Sensory hair cells convert sound and motion into our sense of hearing, movement, and head position. In mammals, the loss of hair cells is irreversible. Or is it? Hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. This book provides a comprehensive survey of the regeneration of sensory hair cells.
Author : David J. Lim
Publisher : Springer Science & Business Media
ISBN 13 : 1461542235
Total Pages : 274 pages
Book Rating : 4.4/5 (615 download)
Download or read book Cell and Molecular Biology of the Ear written by David J. Lim and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Howard House, founder of the House Ear Institute and House Ear Clinic often uses the analogy of planting a seed when referring to establishing the House Ear Institute in 1946. Two grateful patients of Dr. House put forth the idea that his knowledge and innovative skills could be used to expand the understanding of hearing impairment and its treatment. Those two early patients provided the "seed money" to begin the Institute. Since that time, the growth has been phenomenal from a one-man laboratory to a multidisciplinary facility boasting over 175 scien tists, physicians, and support staff, all dedicated to the advancement of otologic research and education. Six years ago after a half-century of remarkable success with prosthetic and device research, the Institute began cultivating a new field of endeavor-cell and molecular biology. Don Nielsen, then the Institute's Executive Vice President for Research and Scientific Director, began exploring the potential for hair cell regen eration and presented his ideas to the Board of Trustees. For a period of six months, we did a lot of fact finding to assess what role the Institute might take in this excit ing new field.
Author : Aage Moller
Publisher : Elsevier
ISBN 13 : 0323141935
Total Pages : 956 pages
Book Rating : 4.3/5 (231 download)
Download or read book Basic Mechanisms in Hearing written by Aage Moller and published by Elsevier. This book was released on 2012-12-02 with total page 956 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Mechanisms in Hearing is a collection of papers that discusses the function of the auditory system covering its ultrastructure, physiology, and the mechanism's connection with experimental psychology. Papers review the mechanics, morphology, and physiology of the cochlear, including the physiology of individual hair cells and their synapses. One paper examines the combined physiological and anatomical studies of stimulus coding in the mammalian auditory nervous system. The results of these studies pertain to the latency, frequency selectivity, and time pattern of responses to short tone bursts. Other research compare the cochlear nerve, behavioral, and psychophysical frequency selectivity which show that frequency selectivity of the auditory system occurs at the level of the cochlear nerve, becoming downgraded in end-organ deafness. Other papers discuss neural coding at higher levels such as the feature extraction in the auditory system of bats. Some papers also analyze the specialized hearing mechanisms in animals, for example, the echolocation of bats and in some insects, the function of the swimbladder in fish hearing, as well as the "invertebrate frequency analyzer" in the locust ear. Physiologists, neurophysiologists, neurobiologists, general medical practioners, and EENT specialists will find this collection valuable.
Author : Raymond Romand
Publisher : Academic Press
ISBN 13 : 0124081088
Total Pages : 563 pages
Book Rating : 4.1/5 (24 download)
Download or read book Development of Auditory and Vestibular Systems written by Raymond Romand and published by Academic Press. This book was released on 2014-05-23 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of Auditory and Vestibular Systems fourth edition presents a global and synthetic view of the main aspects of the development of the stato-acoustic system. Unique to this volume is the joint discussion of two sensory systems that, although close at the embryological stage, present divergences during development and later reveal conspicuous functional differences at the adult stage. This work covers the development of auditory receptors up to the central auditory system from several animal models, including humans. Coverage of the vestibular system, spanning amphibians to effects of altered gravity during development in different species, offers examples of the diversity and complexity of life at all levels, from genes through anatomical form and function to, ultimately, behavior. The new edition of Development of Auditory and Vestibular Systems will continue to be an indispensable resource for beginning scientists in this area and experienced researchers alike. Full-color figures illustrate the development of the stato-acoustic system pathway Covers a broad range of species, from drosophila to humans, demonstrating the diversity of morphological development despite similarities in molecular processes involved at the cellular level Discusses a variety of approaches, from genetic-molecular biology to psychophysics, enabling the investigation of ontogenesis and functional development
Author : Peter Dallos
Publisher : Springer Science & Business Media
ISBN 13 : 1461207576
Total Pages : 561 pages
Book Rating : 4.4/5 (612 download)
Download or read book The Cochlea written by Peter Dallos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge about the structure and function of the inner ear is vital to an understanding of vertebrate hearing. This volume presents a detailed overview of the mammalian cochlea from its anatomy and physiology to its biophysics and biochemistry. The nine review chapters, written by internationally distinguished auditory researchers, provide a detailed and unified introduction to sound processing in the cochlea and the steps by which the ensuing signals are prepared for the central nervous system.
Author : Bernat Soria
Publisher :
ISBN 13 :
Total Pages : 498 pages
Book Rating : 4.3/5 (91 download)
Download or read book Ion Channel Pharmacology written by Bernat Soria and published by . This book was released on 1998 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The improved understanding of ion channel structure, achieved through the use of molecular biology techniques, has opened the way for the development of new drugs targeted at specific types of ion channels. This book provides a comprehensive, single-volume overview of the effects of different drugs and toxins on ionic channels. The first part of the book deals with the development of ion channels, while subsequent chapters detail the electrophysiological properties and pharmacology of eight different types of ion channels, including intracellular, cyclic nucleotide-gated, and receptor operated channels. Drug effects in various cell types, along with the potential use of channels in therapeutics, are discussed for each channel type. Comprehensive and up-to-date, Ion Channel Pharmacology is an essential reference for every investigator in this fast-growing area of research.
Author : George Paxinos
Publisher : Academic Press
ISBN 13 : 0323139892
Total Pages : 1211 pages
Book Rating : 4.3/5 (231 download)
Download or read book The Human Nervous System written by George Paxinos and published by Academic Press. This book was released on 2012-12-02 with total page 1211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Nervous System is a definitive account of human neuroanatomy, with a comprehensive coverage of the brain, spinal cord, and peripheral nervous system. The cytoarchitecture, chemoarchitecture, connectivity, and major functions of neuronal structures are examined by acknowledged authorities in the field, such as: Alheid, Amaral, Armstrong, Beitz, Burke, de Olmos, Difiglia, Garey, Gerrits, Gibbins, Holstege, Kaas, Martin, McKinley, Norgren, Ohye, Paxinos, Pearson, Pioro, Price, Saper, Sasaki, Schoenen, Tadork, Voogd, Webster, Zilles, and their associates. Large, clearly designed 8-1/2" x 11" format 35 information-packed chapters 500 photomicrographs and diagrams 6,200 bibliographic entries Table of contents for every chapter Exceptionally cross-referenced Detailed subject index Substantial original research work Mini atlases of some brain regions
