Type I Chaperonins Mechanism And Beyond

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Type I Chaperonins: Mechanism and Beyond

Author : Adina Breiman
Publisher : Frontiers Media SA
ISBN 13 : 2889455750
Total Pages : 104 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Type I Chaperonins: Mechanism and Beyond by : Adina Breiman

Download or read book Type I Chaperonins: Mechanism and Beyond written by Adina Breiman and published by Frontiers Media SA. This book was released on 2018-09-14 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type I chaperonins are key players in maintaining the proteome of bacteria and organelles of bacterial origin. They are well known for their crucial role in mediating protein folding. For almost three decades, the molecular mechanism of chaperonin function has been the subject of intensive research. Still, surprising new mechanistic discoveries are constantly reported. It seems that we are far from having a full understanding of the chaperonin mode of action. Chaperonins are not simply protein folding machines. They also perform diverse extramitochondrial tasks, mainly related to inflammatory and signal transduction processes. This eBook constitutes ten articles highlighting the latest developments related to the divers functions of Type I chaperonins. As its title, mechanism and beyond, the collection starts with mechanistic view, continues with extracellular functions and ends with biotechnological applications of Type I chaperonins.

Protein Folding in the Cell

Author :
Publisher : Elsevier
ISBN 13 : 0080522408
Total Pages : 516 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Protein Folding in the Cell by :

Download or read book Protein Folding in the Cell written by and published by Elsevier. This book was released on 2002-02-20 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Advances in Protein Chemistry provides a broad, yet deep look at the cellular components that assist protein folding in the cell. This area of research is relatively new--10 years ago these components were barely recognized, so this book is a particularly timely compilation of current information. Topics covered include a review of the structure and mechanism of the major chaperone components, prion formation in yeast, and the use of microarrays in studying stress response. Outlines preceding each chapter allow the reader to quickly access the subjects of greatest interest. The information presented in this book should appeal to biochemists, cell biologists, and structural biologists.

Prokaryotic Chaperonins

Author : C. M. Santosh Kumar
Publisher : Springer
ISBN 13 : 9811046514
Total Pages : 172 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Prokaryotic Chaperonins by : C. M. Santosh Kumar

Download or read book Prokaryotic Chaperonins written by C. M. Santosh Kumar and published by Springer. This book was released on 2017-08-30 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on a topical and timely aspect of prokaryotic biology - the biology of prokaryotic multiple chaperonins. Chaperonins are a class of molecular chaperones, the proteins that assist folding of other proteins in the cell. The book begins with an introductory chapter on the structural and functional aspects of chaperonins, followed by an outline on different mechanisms of their regulation. Subsequently, the book provides a comprehensive overview on how the multiple-chaperonins have embraced biological requirements in different classes of microbes, discussing their functional diversity, evolutionary paths and the latest advances in the field. It brings together leading experts from across the globe in offering a detailed account of the structural, biochemical, functional and phylogenetic characteristics of microbial chaperonins for students, researchers and teachers working in the area of microbiology/ biophysics/ parasitology – more specifically, in protein folding pathways.

The Networking of Chaperones by Co-Chaperones

Author : Adrienne L. Edkins
Publisher : Springer Nature
ISBN 13 : 3031147405
Total Pages : 436 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis The Networking of Chaperones by Co-Chaperones by : Adrienne L. Edkins

Download or read book The Networking of Chaperones by Co-Chaperones written by Adrienne L. Edkins and published by Springer Nature. This book was released on 2022-12-15 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is the dynamic integration of the processes of protein folding, degradation and translocation to ensure that cellular function is finely tuned in space and time. This third edition of the book The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by co-chaperones, a diverse cohort of non-client proteins. Since the second edition was released, not only has knowledge deepened on how co-chaperones act as nodes to network and functionalise chaperones, but an understanding of their broader biological function has started to emerge. The third edition provides new and updated chapters highlighting recent developments and emerging themes on co-chaperones, such as their extracellular functions, their role in human disease and their status as putative drug targets. The book is a useful resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.

The Chaperonins

Author : Robert L. Ellis
Publisher : Elsevier
ISBN 13 : 0080528880
Total Pages : 339 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Chaperonins by : Robert L. Ellis

Download or read book The Chaperonins written by Robert L. Ellis and published by Elsevier. This book was released on 1996-04-01 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations. - Origins of the new view of protein folding - Prokaryotic chaperonins - Eukaryotic chaperonins - Evolution of the chaperonins - Refolding of denatured proteins - Organelle biosynthesis - Biomedical aspects

HSF1 and Molecular Chaperones in Biology and Cancer

Author : Marc Laurence Mendillo
Publisher : Springer Nature
ISBN 13 : 3030402045
Total Pages : 185 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis HSF1 and Molecular Chaperones in Biology and Cancer by : Marc Laurence Mendillo

Download or read book HSF1 and Molecular Chaperones in Biology and Cancer written by Marc Laurence Mendillo and published by Springer Nature. This book was released on 2020-04-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Snyder and Champness Molecular Genetics of Bacteria

Author : Tina M. Henkin
Publisher : John Wiley & Sons
ISBN 13 : 1555819753
Total Pages : 644 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Snyder and Champness Molecular Genetics of Bacteria by : Tina M. Henkin

Download or read book Snyder and Champness Molecular Genetics of Bacteria written by Tina M. Henkin and published by John Wiley & Sons. This book was released on 2020-10-27 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: The single most comprehensive and authoritative textbook on bacterial molecular genetics Snyder & Champness Molecular Genetics of Bacteria is a new edition of a classic text, updated to address the massive advances in the field of bacterial molecular genetics and retitled as homage to the founding authors. In an era experiencing an avalanche of new genetic sequence information, this updated edition presents important experiments and advanced material relevant to current applications of molecular genetics, including conclusions from and applications of genomics; the relationships among recombination, replication, and repair and the importance of organizing sequences in DNA; the mechanisms of regulation of gene expression; the newest advances in bacterial cell biology; and the coordination of cellular processes during the bacterial cell cycle. The topics are integrated throughout with biochemical, genomic, and structural information, allowing readers to gain a deeper understanding of modern bacterial molecular genetics and its relationship to other fields of modern biology. Although the text is centered on the most-studied bacteria, Escherichia coli and Bacillus subtilis, many examples are drawn from other bacteria of experimental, medical, ecological, and biotechnological importance. The book's many useful features include Text boxes to help students make connections to relevant topics related to other organisms, including humans A summary of main points at the end of each chapter Questions for discussion and independent thought A list of suggested readings for background and further investigation in each chapter Fully illustrated with detailed diagrams and photos in full color A glossary of terms highlighted in the text While intended as an undergraduate or beginning graduate textbook, Molecular Genetics of Bacteria is an invaluable reference for anyone working in the fields of microbiology, genetics, biochemistry, bioengineering, medicine, molecular biology, and biotechnology. "This is a marvelous textbook that is completely up-to-date and comprehensive, but not overwhelming. The clear prose and excellent figures make it ideal for use in teaching bacterial molecular genetics." —Caroline Harwood, University of Washington Watch an interview with the authors as they discuss their book further: https://www.youtube.com/watch?v=NEl-dfatWUU

Comprehensive Biophysics

Author :
Publisher : Academic Press
ISBN 13 : 0080957188
Total Pages : 3533 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Comprehensive Biophysics by :

Download or read book Comprehensive Biophysics written by and published by Academic Press. This book was released on 2012-04-12 with total page 3533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource

Molecular Chaperones and Human Disease

Author : Graham Chakafana
Publisher : Frontiers Media SA
ISBN 13 : 2832509185
Total Pages : 155 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Molecular Chaperones and Human Disease by : Graham Chakafana

Download or read book Molecular Chaperones and Human Disease written by Graham Chakafana and published by Frontiers Media SA. This book was released on 2022-12-19 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

Author : Peter Csermely
Publisher : Springer Science & Business Media
ISBN 13 : 0387399755
Total Pages : 218 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks by : Peter Csermely

Download or read book Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks written by Peter Csermely and published by Springer Science & Business Media. This book was released on 2007-08-09 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.

Journal of the Royal Society, Interface

Author :
Publisher :
ISBN 13 :
Total Pages : 590 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Journal of the Royal Society, Interface by :

Download or read book Journal of the Royal Society, Interface written by and published by . This book was released on 2008 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cells: Molecules and Mechanisms

Author : Eric Wong
Publisher : Axolotl Academic Publishing
ISBN 13 : 0985226110
Total Pages : 283 pages
Book Rating : 4.9/5 (852 download)

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Book Synopsis Cells: Molecules and Mechanisms by : Eric Wong

Download or read book Cells: Molecules and Mechanisms written by Eric Wong and published by Axolotl Academic Publishing. This book was released on 2009 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.

Mechanisms of Lymphocyte Activation and Immune Regulation VIII

Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1461512433
Total Pages : 138 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Mechanisms of Lymphocyte Activation and Immune Regulation VIII by : Sudhir Gupta

Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation VIII written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies. This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.

Moonlighting Proteins

Author : Brian Henderson
Publisher : John Wiley & Sons
ISBN 13 : 1118951131
Total Pages : 472 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Moonlighting Proteins by : Brian Henderson

Download or read book Moonlighting Proteins written by Brian Henderson and published by John Wiley & Sons. This book was released on 2017-03-14 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science.

Mitochondria and Anaerobic Energy Metabolism in Eukaryotes

Author : William F. Martin
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110612410
Total Pages : 269 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Mitochondria and Anaerobic Energy Metabolism in Eukaryotes by : William F. Martin

Download or read book Mitochondria and Anaerobic Energy Metabolism in Eukaryotes written by William F. Martin and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-12-07 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are sometimes called the powerhouses of eukaryotic cells, because mitochondria are the site of ATP synthesis in the cell. ATP is the universal energy currency, it provides the power that runs all other life processes. Humans need oxygen to survive because of ATP synthesis in mitochondria. The sugars from our diet are converted to carbon dioxide in mitochondria in a process that requires oxygen. Just like a fire needs oxygen to burn, our mitochondria need oxygen to make ATP. From textbooks and popular literature one can easily get the impression that all mitochondria require oxygen. But that is not the case. There are many groups of organismsm known that make ATP in mitochondria without the help of oxygen. They have preserved biochemical relicts from the early evolution of eukaryotic cells, which took place during times in Earth history when there was hardly any oxygen avaiable, certainly not enough to breathe. How the anaerobic forms of mitochondria work, in which organisms they occur, and how the eukaryotic anaerobes that possess them fit into the larger picture of rising atmospheric oxygen during Earth history are the topic of this book.

Alpha-1 Antitrypsin

Author : Adam Wanner
Publisher : Humana Press
ISBN 13 : 3319234498
Total Pages : 181 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Alpha-1 Antitrypsin by : Adam Wanner

Download or read book Alpha-1 Antitrypsin written by Adam Wanner and published by Humana Press. This book was released on 2015-12-18 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive overview of alpha-1 antitrypsin deficiency, an inherited condition that leads to lung disease in adults and liver disease in adults and children and is associated with chronic obstructive lung disease in adults. While it is a rare condition, the mechanisms underlying the clinical manifestations of this deficiency have been largely clarified. Treatment, however, is available only for the lung disease that arises from the condition, thus necessitating continued research into new and alternative therapeutic solutions. The book discusses the biology of alpha-1 antitrypsin, protein misfolding and polymerization, and diagnosis and treatment of alpha-1 antitrypsin deficiency and its associated diseases. It concludes with a discussion of rare disorders linked to alpha-1 antitrypsin deficiency and the role of healthcare organizations in the treatment of these diseases. Written for pulmonary clinicians and scientists, Alpha-1 Antitrypsin: Role in Health and Disease is a valuable resource that sheds light on this rare disease.