Two Faces Of Evil Cancer And Neurodegeneration

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Two Faces of Evil: Cancer and Neurodegeneration

Author : Thomas Curran
Publisher : Springer Science & Business Media
ISBN 13 : 3642166024
Total Pages : 171 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Two Faces of Evil: Cancer and Neurodegeneration by : Thomas Curran

Download or read book Two Faces of Evil: Cancer and Neurodegeneration written by Thomas Curran and published by Springer Science & Business Media. This book was released on 2010-12-16 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes

In Pursuit of Memory

Author : Joseph Jebelli
Publisher : Little, Brown Spark
ISBN 13 : 0316398969
Total Pages : 293 pages
Book Rating : 4.3/5 (163 download)

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Book Synopsis In Pursuit of Memory by : Joseph Jebelli

Download or read book In Pursuit of Memory written by Joseph Jebelli and published by Little, Brown Spark. This book was released on 2017-10-31 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: For readers of Atul Gawande, Siddhartha Mukherjee, and Henry Marsh, a riveting, gorgeously written biography of one of history's most fascinating and confounding diseases -- Alzheimer's -- from its discovery more than 100 years ago to today's race towards a cure. Alzheimer's is the great global epidemic of our time, affecting millions worldwide -- there are more than 5 million people diagnosed in the US alone. And as our population ages, scientists are working against the clock to find a cure. Neuroscientist Joseph Jebelli is among them. His beloved grandfather had Alzheimer's and now he's written the book he needed then -- a very human history of this frightening disease. But In Pursuit of Memory is also a thrilling scientific detective story that takes you behind the headlines. Jebelli's quest takes us from nineteenth-century Germany and post-war England, to the jungles of Papua New Guinea and the technological proving grounds of Japan; through America, India, China, Iceland, Sweden, and Colombia. Its heroes are scientists from around the world -- many of whom he's worked with -- and the brave patients and families who have changed the way that researchers think about the disease. This compelling insider's account shows vividly why Jebelli feels so hopeful about a cure, but also why our best defense in the meantime is to understand the disease. In Pursuit of Memory is a clever, moving, eye-opening guide to the threat one in three of us faces now.

Proteopathic Seeds and Neurodegenerative Diseases

Author : Mathias Jucker
Publisher : Springer Science & Business Media
ISBN 13 : 3642354912
Total Pages : 163 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Proteopathic Seeds and Neurodegenerative Diseases by : Mathias Jucker

Download or read book Proteopathic Seeds and Neurodegenerative Diseases written by Mathias Jucker and published by Springer Science & Business Media. This book was released on 2013-03-27 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer ́s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society.

International Seminar On Nuclear War And Planetary Emergencies - 46th Session: The Role Of Science In The Third Millennium

Author : Richard C Ragaini
Publisher : World Scientific
ISBN 13 : 9814623458
Total Pages : 540 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis International Seminar On Nuclear War And Planetary Emergencies - 46th Session: The Role Of Science In The Third Millennium by : Richard C Ragaini

Download or read book International Seminar On Nuclear War And Planetary Emergencies - 46th Session: The Role Of Science In The Third Millennium written by Richard C Ragaini and published by World Scientific. This book was released on 2014-07-07 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 46th Session of the International Seminars on Nuclear War and Planetary Emergencies held in Erice, Sicily. This Seminar has again gathered, in 2013, over 100 scientists from 43 countries in an interdisciplinary effort that has been going on for the last 32 years, to examine and analyze planetary problems which had been followed up, all year long, by the World Federation of Scientists' Permanent Monitoring Panels.

The Neuroscience of Dementia

Author : Colin R Martin
Publisher : Academic Press
ISBN 13 : 0128160446
Total Pages : 1866 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Neuroscience of Dementia by : Colin R Martin

Download or read book The Neuroscience of Dementia written by Colin R Martin and published by Academic Press. This book was released on 2020-12-23 with total page 1866 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. This foundational, comprehensive book compiles the latest understanding on all forms of dementia and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers comprehensive coverage of a broad range of topics related to dementia - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a "one-stop" source for everything you need to know about dementia

Genetics, Neurology, Behavior, and Diet in Dementia

Author : Colin R Martin
Publisher : Academic Press
ISBN 13 : 0128158697
Total Pages : 954 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genetics, Neurology, Behavior, and Diet in Dementia by : Colin R Martin

Download or read book Genetics, Neurology, Behavior, and Diet in Dementia written by Colin R Martin and published by Academic Press. This book was released on 2020-08-11 with total page 954 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers comprehensive coverage of a broad range of topics related to dementia - Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a "one-stop" source for everything you need to know about dementia

Neurocognitive Development: Normative Development

Author :
Publisher : Elsevier
ISBN 13 : 0444641513
Total Pages : 534 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Neurocognitive Development: Normative Development by :

Download or read book Neurocognitive Development: Normative Development written by and published by Elsevier. This book was released on 2019-09-22 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is one of a two-volume work on neurocognitive development, focusing separately on normative and non-normative development. The normative volume focuses on neurology, biology, genetics, and psychology of normative cognitive development. It covers the development of intellectual abilities, visual perception, motor function, language, memory, attention, executive function, social cognition, learning abilities, and affect and behavior. The book identifies when and how these functions develop, the genetics and neurophysiology of their operation, and their evaluation and assessment in clinical practice. This book will serve as a comprehensive reference to researchers in cognitive development in neuroscience, psychology, and medicine, as well as to clinicians and allied health professionals focused on developmental disabilities (child neurologists, pediatric neuropsychologists, child psychiatrists, speech and language therapists, and occupational therapists.) - Summarizes research on normative neurocognitive development - Includes intellectual abilities, language, memory, attention, motor function, and more - Discusses genetics and environmental influences on development - Provides interdisciplinary information of use to both researchers and clinicians

Sleep and Brain Injury

Author : Crawford M. Thomas
Publisher : Routledge
ISBN 13 : 0429581564
Total Pages : 177 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Sleep and Brain Injury by : Crawford M. Thomas

Download or read book Sleep and Brain Injury written by Crawford M. Thomas and published by Routledge. This book was released on 2021-11-22 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This ground-breaking book binds together a contemporary understanding of sleep and brain injury, pairing empirical understanding through clinical practice with extensive up-to-date research, to provide a deeply considered approach to these overlapping topics. Firstly, the author discusses the neuroanatomy and architecture of sleep, including the need for sleep, definitions of good sleep, and what can go wrong with sleep. The focus then moves to the neuroanatomical damage and dysfunction from brain injury, and the resultant functional effects. The author then adroitly fuses the two streams of coverage together, focusing on the neurobiological, neurochemical, and functional aspects of both sleep and brain injury to offer new insights as to how they interrelate. The book then looks towards the applied aspects of treatment and rehabilitation, bringing further thoughts of how, because of this new understanding, we can potentially offer novel treatments for brain injury recovery and sleep problems. In this final practical part, four sleep foundations are given, necessary to optimize the three most common sleep problems and their treatments after brain injury. This new approach highlights how sleep can affect the specific functional effects of brain injury and how brain injury can exacerbate some of the specific functional effects of sleep problems, thus having the potential to transform the field of neurorehabilitation. It is essential reading for professionals working with brain injury and postgraduate students in clinical neuropsychology.

Alzheimer's Disease and Air Pollution

Author : L. Calderón-Garcidueñas
Publisher : IOS Press
ISBN 13 : 1643681591
Total Pages : 616 pages
Book Rating : 4.6/5 (436 download)

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Book Synopsis Alzheimer's Disease and Air Pollution by : L. Calderón-Garcidueñas

Download or read book Alzheimer's Disease and Air Pollution written by L. Calderón-Garcidueñas and published by IOS Press. This book was released on 2021-05-03 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most people think of Alzheimer’s disease as a condition which predominately affects elderly people, but an increasing amount of evidence indicates that in populations exposed to high concentration of air pollutants, Alzheimer’s disease development and progression can be identified in pediatric and young adulthood ages. Cognitive, olfactory, gait, equilibrium and auditory alterations are seen early, thus the concept of decades-long asymptomatic period prior to clinical cognitive impairment does not apply to the millions of people exposed day in and day out to polluted environments. This book Alzheimer's Disease and Air Pollution – The Development and Progression of a Fatal Disease from Childhood and the Opportunities for Early Prevention is a compilation of work by researchers intent on revealing the links between air pollution and neurodegeneration. The book is divided into 6 sections. It includes a section describing the ways in which air pollution from traffic and tobacco smoke can damage the brain; epidemiological studies establishing a strong link between dementia and particulate matter and ozone; papers explaining the properties of pollution; and works describing the intricate pathways which transform normal neurons into ghost tangles surrounded by a devastated brain. Air pollution is complex; different pollutants, different sizes and shapes and different portals of entry, play different roles, but their capacity to damage neural tissue is abundantly illustrated in this book, which highlights the need for preventive measures to protect the millions of people currently exposed to air pollutants, and the need to ameliorate their harmful effects.

Nanocarriers in Neurodegenerative Disorders

Author : Wael Mohamed
Publisher : CRC Press
ISBN 13 : 1040105181
Total Pages : 366 pages
Book Rating : 4.0/5 (41 download)

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Book Synopsis Nanocarriers in Neurodegenerative Disorders by : Wael Mohamed

Download or read book Nanocarriers in Neurodegenerative Disorders written by Wael Mohamed and published by CRC Press. This book was released on 2024-09-30 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the lack of secure, efficient, and patient-friendly therapies for neurodegenerative disorders, there is a rising demand for innovative approaches. Despite the limited number of nanocarriers approved for human use, they have demonstrated significant potential in preclinical and, in some instances, clinical trials. In alignment with this objective, the chapters of the book are structured to offer a comprehensive overview of recent advancements in medication and dosage form development, specifically emphasizing the nanoparticulate system for targeting the brain. This book aims to furnish readers with a thorough understanding of the clinical application of nanocarrier systems for treating neurodegenerative disorders, encompassing the latest developments, challenges, safety concerns, toxicity issues, regulatory considerations, prospects, and limitations. Individuals in academia, the scientific community, business, and education seeking a more effective approach to target the brain will find valuable insights in this resource. Key Features Provides a comparative perspective of various nanocarrier systems, therefore facilitating the researcher's selection of appropriate nanoparticulate carriers Highlights the related restrictions of brain delivery and current available medicines Includes information on the advantages and disadvantages of various biomaterials utilized in the development of nanocarriers for brain targeting Emphasizes distinct facets of surface functionalization according to the brain area of interest Presents the current advances, preclinical and clinical development, and the future potential of multiple brain-targeting technologies

The Great Influenza

Author : John M. Barry
Publisher : Penguin
ISBN 13 : 9780143036494
Total Pages : 580 pages
Book Rating : 4.0/5 (364 download)

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Book Synopsis The Great Influenza by : John M. Barry

Download or read book The Great Influenza written by John M. Barry and published by Penguin. This book was released on 2005-10-04 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 New York Times bestseller “Barry will teach you almost everything you need to know about one of the deadliest outbreaks in human history.”—Bill Gates "Monumental... an authoritative and disturbing morality tale."—Chicago Tribune The strongest weapon against pandemic is the truth. Read why in the definitive account of the 1918 Flu Epidemic. Magisterial in its breadth of perspective and depth of research, The Great Influenza provides us with a precise and sobering model as we confront the epidemics looming on our own horizon. As Barry concludes, "The final lesson of 1918, a simple one yet one most difficult to execute, is that...those in authority must retain the public's trust. The way to do that is to distort nothing, to put the best face on nothing, to try to manipulate no one. Lincoln said that first, and best. A leader must make whatever horror exists concrete. Only then will people be able to break it apart." At the height of World War I, history’s most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease.

Systems Biology of Free Radicals and Antioxidants

Author : Ismail Laher
Publisher : Springer
ISBN 13 : 9783642300172
Total Pages : 0 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Systems Biology of Free Radicals and Antioxidants by : Ismail Laher

Download or read book Systems Biology of Free Radicals and Antioxidants written by Ismail Laher and published by Springer. This book was released on 2014-06-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.

Women in Gastrointestinal Cancers, volume II: 2022

Author : Nadia M. Hamdy
Publisher : Frontiers Media SA
ISBN 13 : 2832525636
Total Pages : 134 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Women in Gastrointestinal Cancers, volume II: 2022 by : Nadia M. Hamdy

Download or read book Women in Gastrointestinal Cancers, volume II: 2022 written by Nadia M. Hamdy and published by Frontiers Media SA. This book was released on 2023-06-08 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Devalued and Distrusted

Author : John L. LaMattina
Publisher : John Wiley & Sons
ISBN 13 : 1118511255
Total Pages : 173 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Devalued and Distrusted by : John L. LaMattina

Download or read book Devalued and Distrusted written by John L. LaMattina and published by John Wiley & Sons. This book was released on 2012-12-10 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: An expert's view on solving the challenges confronting today's pharmaceutical industry Author John LaMattina, a thirty-year veteran of the pharmaceutical industry and former president of Pfizer's Global R&D Division, is internationally recognized as an expert on the pharmaceutical industry. His first book, Drug Truths: Dispelling the Myths About Pharma R&D, was critically acclaimed for clearing up misconceptions about the pharmaceutical industry and providing an honest account of the contributions of pharmaceutical research and development to human health and well-being. As he toured the country discussing Drug Truths, Dr. LaMattina regularly came across people who were filled with anger, accusing the pharmaceutical industry of making up diseases, hiding dangerous side effects, and more. This book was written in response to that experience, critically examining public perceptions and industry realities. Starting with "4 Secrets that Drug Companies Don't Want You to Know," Devalued and Distrusted provides a fact-based account of how the pharmaceutical industry works and the challenges it faces. It addresses such critical issues as: Why pharmaceutical R&D productivity has declined Where pharmaceutical companies need to invest their resources What can be done to solve core health challenges, including cancer, diabetes, and neurodegenerative diseases How the pharmaceutical industry can regain public trust and resuscitate its image Our understanding of human health and disease grows daily; however, converting science into medicine is increasingly challenging. Reading Devalued and Distrusted, you'll not only gain a greater appreciation of those challenges, but also the role that the pharmaceutical industry currently plays and can play in solving those challenges. Get to know the author: Read an interview with John LaMattina or watch a video on ChemistryViews! Interview: John LaMattina: 30 Years in Pharma Video: Can the Pharmaceutical Industry Restory its Broken Image?

Laboratory Dogs Rescued

Author : Ellie Hansen
Publisher : McFarland
ISBN 13 : 1476685010
Total Pages : 249 pages
Book Rating : 4.4/5 (766 download)

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Book Synopsis Laboratory Dogs Rescued by : Ellie Hansen

Download or read book Laboratory Dogs Rescued written by Ellie Hansen and published by McFarland. This book was released on 2021-11-19 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal testing is a controversy that has raged for hundreds of years. Some people view experiments on dogs as necessary for human medical progress, while others argue that the practice is barbaric. When the author adopted Marty--a beagle rescued from a research laboratory--she found herself rehabilitating a terrified dog with a traumatic past. She soon discovered the well-kept secret of painful and often fatal testing on dogs. This book details what the author has learned about the past and present of laboratory testing on dogs, life after laboratories and the hope for a future without animal testing. Interviews with rescue organizers and adoptive families reveal the struggles of removing dogs from laboratories and acclimating them to daily life. Scientists discuss the ethics of dog research and advocate for new biomedical technologies. Fundamental change is brewing, with the public, scientists and governments urging the use of new technologies that can replace testing on animals and yield better results.

The Neurology of Religion

Author : Alasdair Coles
Publisher : Cambridge University Press
ISBN 13 : 1107082609
Total Pages : 319 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis The Neurology of Religion by : Alasdair Coles

Download or read book The Neurology of Religion written by Alasdair Coles and published by Cambridge University Press. This book was released on 2019-11-07 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines what can be learnt about the brain mechanisms underlying religious practice from studying people with neurological disorders.

A Tattoo on my Brain

Author : Daniel Gibbs
Publisher : Cambridge University Press
ISBN 13 : 1009333585
Total Pages : 227 pages
Book Rating : 4.0/5 (93 download)

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Book Synopsis A Tattoo on my Brain by : Daniel Gibbs

Download or read book A Tattoo on my Brain written by Daniel Gibbs and published by Cambridge University Press. This book was released on 2023-03-16 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr Daniel Gibbs is one of 50 million people worldwide with an Alzheimer's disease diagnosis. Unlike most patients with Alzheimer's, however, Dr Gibbs worked as a neurologist for twenty-five years, caring for patients with the very disease now affecting him. Also unusual is that Dr Gibbs had begun to suspect he had Alzheimer's several years before any official diagnosis could be made. Forewarned by genetic testing showing he carried alleles that increased the risk of developing the disease, he noticed symptoms of mild cognitive impairment long before any tests would have alerted him. In this highly personal account, Dr Gibbs documents the effect his diagnosis has had on his life and explains his advocacy for improving early recognition of Alzheimer's. Weaving clinical knowledge from decades caring for dementia patients with his personal experience of the disease, this is an optimistic tale of one man's journey with early-stage Alzheimer's disease. Soon to be a documentary film on MTV/Paramount +.