Tumor Models In Cancer Research

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Tumor Models in Cancer Research

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
ISBN 13 : 1592591000
Total Pages : 745 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Tumor Models in Cancer Research by : Beverly A. Teicher

Download or read book Tumor Models in Cancer Research written by Beverly A. Teicher and published by Springer Science & Business Media. This book was released on 2001-11-07 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Animal Models in Cancer Drug Discovery

Author : Asfar Azmi
Publisher : Academic Press
ISBN 13 : 0128147059
Total Pages : 470 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Animal Models in Cancer Drug Discovery by : Asfar Azmi

Download or read book Animal Models in Cancer Drug Discovery written by Asfar Azmi and published by Academic Press. This book was released on 2019-04-16 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Tumor Models in Cancer Research

Author : Beverly A. Teicher
Publisher : Humana Press
ISBN 13 : 9781475768824
Total Pages : 690 pages
Book Rating : 4.7/5 (688 download)

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Book Synopsis Tumor Models in Cancer Research by : Beverly A. Teicher

Download or read book Tumor Models in Cancer Research written by Beverly A. Teicher and published by Humana Press. This book was released on 2013-04-03 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Cancer Models

Author : Michael Breitenbach
Publisher : Frontiers Media SA
ISBN 13 : 288945701X
Total Pages : 176 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Cancer Models by : Michael Breitenbach

Download or read book Cancer Models written by Michael Breitenbach and published by Frontiers Media SA. This book was released on 2019-02-05 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer research, like research on other diseases, highly depends on representative and reliable model systems. In the Research Topic “Cancer Models”, we collected original papers and review articles addressing the topic of tumor modeling from molecular biology, biochemistry, microorganisms, cells and organoids, fishes, animals and xenografts, up to computational cancer models and patient data analysis. This representative eBook describes that there is not a single molecular defined tumor but rather a heterogenic and highly variable complex of different individual diseases. This is what makes research on cancer so difficult, expensive, and explains the broad number of models needed for research. Our authors describe new next-generation sequencing-based methods to analyze complex patterns of chromosomal aberrations in order to understand the molecular biology of tumorigenesis as well as the role of cellular senescence and dormancy in the aetiology of tumor formation and development of therapy resistance of tumors. The current developments on 3D cultures are thoroughly reviewed, as these models help to overcome the current limitations of cell cultures and allow a more accurate mimicry of the native cancer tissue, including cellular heterogeneity and restore specific biochemical and morphological. Reviews about tumor models in zebrafish, different transgenic mouse strains and pigs conclude the book. In the final two chapters of this volume, the authors discuss the theoretical and mathematical models developed in cancer research.

Patient Derived Tumor Xenograft Models

Author : Rajesh Uthamanthil
Publisher : Academic Press
ISBN 13 : 0128040610
Total Pages : 486 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Patient Derived Tumor Xenograft Models by : Rajesh Uthamanthil

Download or read book Patient Derived Tumor Xenograft Models written by Rajesh Uthamanthil and published by Academic Press. This book was released on 2016-10-13 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory. Offers guidance on data interpretation and regulatory aspects Provides useful techniques and strategies for working with PDX models Includes practical tools and potential pitfalls for best practices Compiles all knowledge of PDX models research in one resource Presents the results of first ever global survey on standards of PDX development and usage in academia and industry

Alternatives to Animal Testing

Author : Hajime Kojima
Publisher : Springer
ISBN 13 : 9811324476
Total Pages : 130 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Alternatives to Animal Testing by : Hajime Kojima

Download or read book Alternatives to Animal Testing written by Hajime Kojima and published by Springer. This book was released on 2018-12-27 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.

Medical Physics

Author : Anna Bajek
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110662345
Total Pages : 317 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Medical Physics by : Anna Bajek

Download or read book Medical Physics written by Anna Bajek and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-08-02 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern cancer research is a high-tech undertaking, overlapping with many fields in the physical sciences. These include nanotechnology, engineering, immunology, and bioinformatics. This book focuses on the science and technology underlying the diagnosis and treatement of cancer. The authors offer insights into technologies including radiotherapy, modelling, and drug encapsulation.

The Drosophila Model in Cancer

Author : Wu-Min Deng
Publisher : Springer Nature
ISBN 13 : 3030236293
Total Pages : 251 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis The Drosophila Model in Cancer by : Wu-Min Deng

Download or read book The Drosophila Model in Cancer written by Wu-Min Deng and published by Springer Nature. This book was released on 2019-09-13 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.

Immunodeficient Animals

Author : Wolfgang Arnold
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 252 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Immunodeficient Animals by : Wolfgang Arnold

Download or read book Immunodeficient Animals written by Wolfgang Arnold and published by S. Karger AG (Switzerland). This book was released on 1996 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The classic immunodeficient mutants nude, scid and rnu have an important function in experimental cancer research: they allow unique methods of investigation and provide data of clinical relevance. This volume presents the state of the art of research work based on the use of these immunodeficient animal models. One section is dedicated to the biological aspects and immunological properties of immunodeficient mutants. Another part includes articles on xenogenous transplantation of human tumors, focusing on the establishment of transplantable lines, growth characteristics and tumor markers. Special attention is given to new approaches in the fields of chemotherapy, radiation therapy and immunotherapy. Various contributors consider in vitro methods as alternative models. In addition to current data, this publication contains useful technical and methodological information and is therefore valuable not only for specialists but also for scientists entering the field of experimental cancer research.

Genetically Engineered Mice for Cancer Research

Author : Jeffrey E. Green
Publisher : Springer Science & Business Media
ISBN 13 : 0387698051
Total Pages : 639 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Genetically Engineered Mice for Cancer Research by : Jeffrey E. Green

Download or read book Genetically Engineered Mice for Cancer Research written by Jeffrey E. Green and published by Springer Science & Business Media. This book was released on 2011-12-09 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials.

Patient-Derived Mouse Models of Cancer

Author : Robert M. Hoffman
Publisher : Humana
ISBN 13 : 9783319861586
Total Pages : 0 pages
Book Rating : 4.8/5 (615 download)

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Book Synopsis Patient-Derived Mouse Models of Cancer by : Robert M. Hoffman

Download or read book Patient-Derived Mouse Models of Cancer written by Robert M. Hoffman and published by Humana. This book was released on 2018-06-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems

An Introduction to Physical Oncology

Author : Vittorio Cristini
Publisher : CRC Press
ISBN 13 : 1315356880
Total Pages : 303 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis An Introduction to Physical Oncology by : Vittorio Cristini

Download or read book An Introduction to Physical Oncology written by Vittorio Cristini and published by CRC Press. This book was released on 2017-06-26 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical oncology has the potential to revolutionize cancer research and treatment. The fundamental rationale behind this approach is that physical processes, such as transport mechanisms for drug molecules within tissue and forces exchanged by cancer cells with tissue, may play an equally important role as biological processes in influencing progression and treatment outcome. This book introduces the emerging field of physical oncology to a general audience, with a focus on recent breakthroughs that help in the design and discovery of more effective cancer treatments. It describes how novel mathematical models of physical transport processes incorporate patient tissue and imaging data routinely produced in the clinic to predict the efficacy of many cancer treatment approaches, including chemotherapy and radiation therapy. By helping to identify which therapies would be most beneficial for an individual patient, and quantifying their effects prior to actual implementation in the clinic, physical oncology allows doctors to design treatment regimens customized to each patient’s clinical needs, significantly altering the current clinical approach to cancer treatment and improving the outcomes for patients.

Multiscale Modeling of Cancer

Author : Vittorio Cristini
Publisher : Cambridge University Press
ISBN 13 : 1139491504
Total Pages : 299 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Multiscale Modeling of Cancer by : Vittorio Cristini

Download or read book Multiscale Modeling of Cancer written by Vittorio Cristini and published by Cambridge University Press. This book was released on 2010-09-09 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field.

Animal Models of Brain Tumors

Author : Ricardo Martínez Murillo
Publisher : Humana Press
ISBN 13 : 9781627032087
Total Pages : 0 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Animal Models of Brain Tumors by : Ricardo Martínez Murillo

Download or read book Animal Models of Brain Tumors written by Ricardo Martínez Murillo and published by Humana Press. This book was released on 2012-11-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. Animal Models of Brain Tumors brings together developments and discoveries in “in vivo” experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results. Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.

Biomaterials for 3D Tumor Modeling

Author : Subhas C. Kundu
Publisher : Elsevier
ISBN 13 : 012818129X
Total Pages : 773 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biomaterials for 3D Tumor Modeling by : Subhas C. Kundu

Download or read book Biomaterials for 3D Tumor Modeling written by Subhas C. Kundu and published by Elsevier. This book was released on 2020-08-22 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Relevance of Tumor Models for Anticancer Drug Development

Author : H. H. Fiebig
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 480 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Relevance of Tumor Models for Anticancer Drug Development by : H. H. Fiebig

Download or read book Relevance of Tumor Models for Anticancer Drug Development written by H. H. Fiebig and published by S. Karger AG (Switzerland). This book was released on 1999 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, large-scale 'disease-oriented' and 'target-oriented' screening procedures have transformed anticancer drug discovery. As a result several novel therapeutic agents and strategies, aimed to combat cancer via a molecular approach, are being evaluated for their possible clinical benefit. The main topics of this volume address the challenges for current drug development and the available preclinical in vivo and in vitro model systems. Special new techniques to mimic the clinical situation in the mouse, models to evaluate metastasis and angiogenesis inhibitors, new molecular targets for anticancer drug development and their preclinically/clinically examined inhibitors or modulators are described. Furthermore, the recent testing procedures for the discovery of novel therapeutic agents employed at the US National Cancer Institute (e.g. Hollow Fiber Assay) and at the European Organization for Research and Treatment of Cancer (EORTC) - Screening and Pharmacology Group (SPG) - are reviewed. This volume will provide a comprehensive overview of the up-to-date drug discovery and development strategies for medical oncologists, experimental cancer researchers, cancer research institutions, and the pharmaceutical industry.

“Humanized” Large Animal Cancer Models: Accelerating Time and Effectiveness of Clinical Trials

Author : Kyle M. Schachtschneider
Publisher : Frontiers Media SA
ISBN 13 : 2889632490
Total Pages : 113 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis “Humanized” Large Animal Cancer Models: Accelerating Time and Effectiveness of Clinical Trials by : Kyle M. Schachtschneider

Download or read book “Humanized” Large Animal Cancer Models: Accelerating Time and Effectiveness of Clinical Trials written by Kyle M. Schachtschneider and published by Frontiers Media SA. This book was released on 2019-12-23 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook provides futuristic perspectives with respect to the emerging requirements of large animal cancer models to address unmet clinical needs. As the vast majority of drugs tested in small animal cancer models fail in human clinical trials, there is a need for large animal models to translate results obtained in small animal models to human clinical practice.