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Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (19 download)
Download or read book Treatment Strategies for Patients With Peripheral Artery Disease written by and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : U. S. Department of Health and Human Services
Publisher : CreateSpace
ISBN 13 : 9781491081259
Total Pages : 366 pages
Book Rating : 4.0/5 (812 download)
Download or read book Treatment Strategies for Patients with Peripheral Artery Disease written by U. S. Department of Health and Human Services and published by CreateSpace. This book was released on 2013-07 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peripheral artery disease (PAD) refers to chronic narrowing or atherosclerosis of the lower extremities and represents a spectrum of disease severity from asymptomatic disease to intermittent claudication (IC), to critical limb ischemia (CLI). PAD has a similar atherosclerotic process to coronary artery disease and shares similar risk factors: male gender, age, diabetes, smoking, hypertension, high cholesterol, and renal insufficiency. PAD is known to be associated with a reduction in functional capacity and quality of life as well as an increased risk for myocardial infarction (MI), stroke, and death; it is also a major cause of limb amputation. Therefore, the general goals of treatment for PAD are cardiovascular protection, relief of symptoms, preservation of walking and functional status, and prevention of amputation. The optimal treatment for PAD—with specific emphasis on the comparative effectiveness of treatment options—is not known. The backbone of treatment for PAD is smoking cessation, risk factor modification, dietary modification, and increased physical activity. There are three main treatment options for improving functional status and other clinical outcomes in patients with PAD: (1) medical therapy, (2) exercise training, and (3) revascularization. The treatment options offered to PAD patients depend on whether the patient is asymptomatic or symptomatic (with either IC or CLI). The KQs considered in this comparative effectiveness review were: KQ 1. In adults with PAD, including asymptomatic patients and symptomatic patients with atypical leg symptoms, IC, or CLI: a. What is the comparative effectiveness of aspirin and other antiplatelet agents in reducing the risk of adverse cardiovascular events, functional capacity, and quality of life? b. Does the effectiveness of treatments vary according to the patient's PAD classification or by subgroup (age, sex, race, risk factors, or comorbidities)? c. What are the significant safety concerns associated with each treatment strategy? Do the safety concerns vary by subgroup (age, sex, race, risk factors, comorbidities, or PAD classification)? KQ 2. In adults with symptomatic PAD (atypical leg symptoms or IC): a. What is the comparative effectiveness of exercise training, medications (cilostazol, pentoxifylline), endovascular intervention (percutaneous transluminal angioplasty, atherectomy, or stents), and/or surgical revascularization (endarterectomy, bypass surgery) on outcomes including cardiovascular events, amputation, quality of life, wound healing, analog pain scale score, functional capacity, repeat revascularization, and vessel patency? b. Does the effectiveness of treatments vary by use of exercise and medical therapy prior to invasive management or by subgroup (age, sex, race, risk factors, comorbidities, or anatomic location of disease)? c. What are the significant safety concerns associated with each treatment strategy? Do the safety concerns vary by subgroup (age, sex, race, risk factors, comorbidities, anatomic location of disease)? KQ 3. In adults with CLI due to PAD: a. What is the comparative effectiveness of endovascular intervention (percutaneous transluminal angioplasty, atherectomy, or stents) and surgical revascularization (endarterectomy, bypass surgery) for outcomes including cardiovascular events, amputation, quality of life, wound healing, analog pain scale score, functional capacity, repeat revascularization, and vessel patency? b. Does the effectiveness of treatments vary by subgroup (age, sex, race, risk factors, comorbidities, or anatomic location of disease)? c. What are the significant safety concerns associated with each treatment strategy (e.g., adverse drug reactions, bleeding, contrast nephropathy, radiation exposure, infection, and periprocedural complications causing acute limb ischemia)? Do the safety concerns vary by subgroup (age, sex, race, risk factors, comorbidities, or anatomic location of disease)?
Author : Dorairaj Prabhakaran
Publisher : World Bank Publications
ISBN 13 : 1464805202
Total Pages : 948 pages
Book Rating : 4.4/5 (648 download)
Download or read book Disease Control Priorities, Third Edition (Volume 5) written by Dorairaj Prabhakaran and published by World Bank Publications. This book was released on 2017-11-17 with total page 948 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.
Author : W. Schuyler Jones
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (855 download)
Download or read book Treatment Strategies for Patients with Peripheral Artery Disease written by W. Schuyler Jones and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: OBJECTIVES: For patients with peripheral artery disease (PAD), the optimal treatment for cardiovascular protection, symptom relief, preservation of walking and functional status, and prevention of amputation is not known. This review assessed the comparative effectiveness of antiplatelet therapy, medical therapy, exercise, and endovascular and surgical revascularization in PAD patients with intermittent claudication (IC) or critical limb ischemia (CLI). DATA SOURCES: We searched PubMed(r), Embase(r), and the Cochrane Database of Systematic Reviews for relevant English-language studies published since January 1995. REVIEW METHODS: Two investigators screened each abstract and full-text article for inclusion, abstracted the data, and performed quality ratings and evidence grading. Random-effects models were used to compute summary estimates of effects. A meta-analysis of direct comparisons was supplemented by a mixed-treatment analysis to incorporate data from placebo comparisons, head-to-head comparisons, and multiple treatment arms. RESULTS: A total of 83 studies contributed evidence. Eleven studies--10 randomized controlled trials (RCTs), 1 observational study--evaluated the comparative effectiveness of antiplatelet agents. In asymptomatic PAD patients, there was no difference between aspirin and placebo for all-cause mortality, cardiovascular mortality, myocardial infarction (MI), or stroke. In patients with IC, one RCT suggests that aspirin may reduce MI and composite vascular events compared with placebo but was inconclusive for other outcomes of interest. Another RCT involving IC patients suggests that clopidogrel is more effective than aspirin for reducing cardiovascular mortality, nonfatal MI, and composite vascular events. Clopidogrel and aspirin appear to be equivalent for prevention of nonfatal stroke, but the confidence interval was wide, making this conclusion less certain. In symptomatic (92% IC) and asymptomatic (8%) PAD patients, dual antiplatelet therapy (DAPT)--clopidogrel plus aspirin--had no impact on composite or individual outcomes. Similarly, in IC or CLI patients after unilateral bypass graft, one RCT showed no difference between DAPT and aspirin alone on nonfatal stroke and composite vascular events and was inconclusive for other outcomes. In patients with IC or CLI after an endovascular procedure, one RCT showed no difference between DAPT and aspirin alone in cardiovascular events or mortality at 6 months but was underpowered for those outcomes. Four additional studies assessed other antiplatelet comparisons but were too small to make any meaningful conclusions about effectiveness. Seven RCTs reported different types of bleeding events, and the use of antiplatelet agents was associated with higher rates of minor and moderate bleeding compared with placebo. Thirty-five studies (27 RCTs, 8 observational) evaluated the comparative effectiveness of cilostazol, pentoxifylline, exercise therapy, endovascular revascularization, or surgical revascularization in IC patients, with the majority of the studies comparing one intervention with either placebo or one other intervention. In order to place all treatments in a common framework for comparison, we created a network meta-analysis. Although the data were still too sparse to definitively conclude which treatment is most effective, we were able to depict relative effect sizes and identify which treatments are clearly superior to placebo for which outcomes. No specific treatment had a statistically significant effect on all-cause mortality (12 RCTs). Exercise training improved maximal walking distance (16 RCTs), and exercise training and endovascular intervention improved initial claudication distance (12 RCTs) compared with usual care. Quality-of-life scores (10 RCTs) showed a significant improvement from cilostazol, exercise training, endovascular intervention, and surgical intervention compared with usual care. Seventeen RCTs reported safety concerns. Cilostazol was associated with higher rates of headache, dizziness, and diarrhea, while endovascular interventions were associated with more transfusions, arterial dissections/perforations, and hematomas compared with the usual care groups. Twenty-three studies (1 RCT, 22 observational) in CLI patients and 12 studies (2 RCTs, 10 observational) in IC or CLI patients evaluated the comparative effectiveness of endovascular or surgical treatments. Long-term amputation-free survival and all-cause mortality were not different between the two treatments in the CLI population. Primary patency varied, but secondary patency rates appeared to favor endovascular interventions in the CLI population. In four observational studies comparing endovascular interventions with usual care, there was insufficient evidence on the comparative effect for all clinical outcomes. In observational studies of the IC-CLI population, there were fewer periprocedural complications from endovascular interventions, while RCTs showed lower rates in the surgical intervention arm. CONCLUSIONS: From a limited number of studies, it appears that aspirin has no benefit over placebo in the asymptomatic PAD patient; clopidogrel monotherapy is more beneficial than aspirin in the IC patient; and DAPT is not significantly better than aspirin at reducing cardiovascular events in patients with IC or CLI. For IC patients, exercise therapy, cilostazol, and endovascular intervention all had an effect on improving functional status and quality of life; the impact of these therapies on cardiovascular events and mortality is uncertain. The comparisons of endovascular and surgical revascularization in CLI are primarily from observational studies, and the heterogeneity of the results makes conclusions for all clinical outcomes less certain. Several advances in care in both medical therapy and invasive therapy have not been rigorously tested and thus provide an impetus for further research.
Author : Jay D. Coffman
Publisher : Humana Press
ISBN 13 : 9781468497502
Total Pages : 356 pages
Book Rating : 4.4/5 (975 download)
Download or read book Peripheral Arterial Disease written by Jay D. Coffman and published by Humana Press. This book was released on 2014-03-06 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 030915698X
Total Pages : 304 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cardiovascular Disability written by Institute of Medicine and published by National Academies Press. This book was released on 2010-12-04 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Author : Dennis G. Caralis
Publisher : Springer Science & Business Media
ISBN 13 : 1592598811
Total Pages : 311 pages
Book Rating : 4.5/5 (925 download)
Download or read book Lower Extremity Arterial Disease written by Dennis G. Caralis and published by Springer Science & Business Media. This book was released on 2007-11-15 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review the state-of-the-art in atherosclerosis of the arteries of the legs and feet. The authors discuss in detail the primary symptom-claudication-an intermittent pain in the leg or foot while walking, its predisposing factors, the current diagnostic methodologies, the impressive advances in the therapeutic armamentarium, and the need to screen for co-existing coronary artery disease. Additional chapters describe cutting-edge noninvasive angiography and vascular flow studies, specific drug therapy for claudication, regression of atherosclerosis therapy, gene therapy, and drug eluting stents for peripheral arterial disease. The authors also examine the epidemiology of LEAD, the effects of smoking and effective smoking cessation programs, its pathogenesis and its association with lipid abnormalities and hypertension, aggressive risk factor modification, and the need to measure the ankle brachial index of every patient over 45.
Author : Emile R. Mohler
Publisher : John Wiley & Sons
ISBN 13 : 1118776070
Total Pages : 207 pages
Book Rating : 4.1/5 (187 download)
Download or read book Peripheral Artery Disease written by Emile R. Mohler and published by John Wiley & Sons. This book was released on 2017-07-13 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, quick-reference guide to the diagnosis and management of peripheral artery disease for non-specialists With an aging population subject to an increasing number of health risks, peripheral artery disease (PAD) is on the rise throughout the world. Because of PAD's direct links to heart attack and stroke, it is critical that internists, surgeons, cardiologists, radiologists, gerontologists, GPs, and family practitioners know how to recognize it and make the best treatment recommendations for their patients. This book provides all the expert, practical information and guidance they need to do just that. Edited by two thought leaders in PAD diagnosis and treatment, and comprising chapters written by subject matter experts, Peripheral Artery Disease, Second Edition provides clinicians with guidance on how to diagnose and treat one of the most under-diagnosed conditions affecting millions of patients. This updated and revised edition of the popular guide distills the complexities of PAD into clear, actionable advice for busy medical practitioners, providing them with the information they need—when they need it. Provides clinicians with essential information for recognizing and treating this under-diagnosed condition that affects millions of patients Distills the complexities of PAD, from diagnosis to traditional and emerging treatment options, into clear, actionable advice for clinicians Covers PAD epidemiology, office examination, imaging, laboratory evaluation, medical therapy, surgical interventions, endovascular treatments, and much more Reflects the latest PAD Guidelines and Performance Measures established by leading specialty societies Features contributions from internists and surgeons, all recognized experts in PAD Peripheral Artery Disease, Second Edition is an important working reference for internists, cardiologists, radiologists, and surgeons, as well as fellows and residents in those fields.
Author : Tulio Pinho Navarro
Publisher : Springer Nature
ISBN 13 : 3030569543
Total Pages : 425 pages
Book Rating : 4.0/5 (35 download)
Download or read book Stem Cell Therapy for Vascular Diseases written by Tulio Pinho Navarro and published by Springer Nature. This book was released on 2020-11-05 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers.
Author : Richard C. Becker
Publisher : Professional Communications
ISBN 13 : 1932610634
Total Pages : 466 pages
Book Rating : 4.9/5 (326 download)
Download or read book Antithrombotic Therapy written by Richard C. Becker and published by Professional Communications. This book was released on 2010-12-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical application of antithrombotic therapy in both arterial disease (acute coronary syndromes, acute MI, peripheral arterial disease, valvular heart disease, atrial fibrillation) and venous disease, (venous thromboembolic disease and pulmonary embolism). Results of major clinical trials and their implications for clinical practice.
Author : Robert Hinchliffe
Publisher : JP Medical Ltd
ISBN 13 : 1907816623
Total Pages : 18 pages
Book Rating : 4.9/5 (78 download)
Download or read book The Diabetic Foot written by Robert Hinchliffe and published by JP Medical Ltd. This book was released on 2014-09-08 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: The incidence of diabetes is increasing both in the western world and in developing countries; type 2 diabetes increase is partly the result of greater obesity. Diabetes can cause two major problems to the foot – diabetic neuropathy resulting in nerve damage and peripheral vascular disease reducing the flow of blood. These can result in ulceration of the foot which needs careful management to avoid the possibility of amputation. This management is best undertaken by multidisciplinary teams using the latest evidence to support their practice. This book presents a comprehensive and authoritative coverage of the latest evidence-based investigations, techniques and management of the diabetic foot. Evidenced-based management of the diabetic foot International, multidisciplinary team of editors and contributors Comprehensive reference for all health professionals involved in the care of diabetic foot problems
Author : Jose M. Wiley
Publisher : John Wiley & Sons
ISBN 13 : 1119283515
Total Pages : 328 pages
Book Rating : 4.1/5 (192 download)
Download or read book Endovascular Interventions written by Jose M. Wiley and published by John Wiley & Sons. This book was released on 2019-01-18 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical resource covering both elective and emergency procedures for the practicing vascular and endovascular clinician This book provides medical professionals (vascular surgeons, interventional cardiologists, interventional radiologists, endovascular neurologists, vascular medicine specialists) with a reference guide to the most common and accepted approach to endovascular management of peripheral vascular disease. It also addresses urgent interventions in the acute setting of the various vascular beds, and covers emerging areas such as stroke intervention and endovascular treatment of pulmonary embolism and vascular trauma. Edited by a multidisciplinary team, Endovascular Interventions offers in-depth coverage of the field in seven parts: Overview; Supra-Aortic Intervention in High Risk Patients: Innominate, Subclavian, Carotid, Vertebral and Intracranial Interventions; Interventions of the Aorta; Renal and Mesenteric Interventions; Lower Extremity Interventions; Venous Disease; and Vascular Trauma. Each section covers the technical aspects of the procedures as well as the fundamental clinical aspects which are necessary in the evaluation of patients considered for interventions. Chapters feature illustrations, case studies, key learning points, equipment lists, and sample questions and answers which can be used for Board exam practice. Practical review of vascular and endovascular medicine covering both elective and emergency procedures Illustrated, templated chapters provide rapid answers to questions and include case studies, key learning points, and equipment lists Includes sample questions and answers that are handy for Board exam practice Edited by multidisciplinary experts Endovascular Interventions is an excellent review book for all practicing and aspiring vascular and endovascular specialists.
Author : Bernardo Cortese
Publisher : Springer
ISBN 13 : 3319926004
Total Pages : 234 pages
Book Rating : 4.3/5 (199 download)
Download or read book Drug-Coated Balloons written by Bernardo Cortese and published by Springer. This book was released on 2019-06-19 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, up-to-date summary of drug-coated balloon (DCB) technology and the role of DCBs in the treatment of coronary and peripheral arterial disease. In addition to clear explanation of how DCBs works, readers will find an enlightening analysis of the mistakes and successes of the past decade and the emergence of the latest delivery systems, which combine a more deliverable device with much improved drug delivery to the vessel wall. The full range of current applications of DCBs are reviewed in detail, drawing on the latest scientific evidence. Due attention is paid to newer devices, with provision of technical insights and documentation of the available clinical data. Ongoing research projects, remaining technical challenges, likely future directions, and reimbursement issues are also carefully considered. This book will be a useful tool for any interventional cardiologist, interventional radiologist, or vascular surgeon who wishes to acquire a deep knowledge of this technology and its application in both coronary and peripheral interventions.
Author : Yoshiaki Yokoi
Publisher : BoD – Books on Demand
ISBN 13 : 9535129678
Total Pages : 160 pages
Book Rating : 4.5/5 (351 download)
Download or read book Angiography and Endovascular Therapy for Peripheral Artery Disease written by Yoshiaki Yokoi and published by BoD – Books on Demand. This book was released on 2017-03-22 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook on Angiography and Endovascular Therapy for Peripheral Artery Disease provides a comprehensive angiographic approach to assess and determine optimal treatment strategies for peripheral artery disease (PAD). Each chapter focuses on angiography as it relates to the outcomes of endovascular work. It is an overview of the results obtained from a large number of actual cases with over 100 angiographic images of aortoiliac, femoropopliteal, below-the-knee, and below-the-ankle artery disease. Diagnostic and angiographic images of nonatherosclerotic PAD are also included. Anyone who is engaged in or preparing to engage in endovascular work for PAD should find this book useful as a reference and as an instruction material.
Author : Jean-Pierre Michel
Publisher : Oxford University Press
ISBN 13 : 0198701594
Total Pages : 1393 pages
Book Rating : 4.1/5 (987 download)
Download or read book Oxford Textbook of Geriatric Medicine written by Jean-Pierre Michel and published by Oxford University Press. This book was released on 2018 with total page 1393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of the definitive international reference book on all aspects of the medical care of older persons will provide every physician involved in the care of older patients with a comprehensive resource on all the clinical problems they are likely to encounter, as well as on related psychological, philosophical, and social issues.
Author : Michael R. Jaff, DO
Publisher : Cardiotext Publishing
ISBN 13 : 1935395610
Total Pages : 602 pages
Book Rating : 4.9/5 (353 download)
Download or read book Vascular Disease: Diagnostic and Therapeutic Approaches written by Michael R. Jaff, DO and published by Cardiotext Publishing. This book was released on 2011-04-01 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patients with vascular disease offer great challenges to physicians of multiple backgrounds. The rapid improvement in multimodal imaging and the growth of endovascular strategies for treatment of peripheral vascular disease have resulted in an explosion in interest in these patients. But patients and physicians often misdiagnose vascular disease as normal signs of aging, resulting in presentation to specialists at the end stage of the disease process. This textbook, edited by two recognized experts in the field, is designed to offer unique and comprehensive information on the diagnostic approach to and state-of-the-art treatment of arterial and venous diseases. This multispecialty textbook will be a critical addition to the practicing clinician's library. "This is a well-conceived and well-executed text dealing with the full gamut of peripheral vascular diseases, their diagnosis, and treatment... While other texts are similar with respect to content and intended audience, Vascular Disease is unique at least in its organization of the subject matter. By uniting pathophysiology, risk factors, diagnosis, and medical and surgical treatment of each anatomic distribution in one chapter of section, the editors have provided a facile reference. A particular chapter will inform the physician's or nurse's care of an individual patient, without that medical profession having to skip around - using the index - to garner or refresh their expertise in, say, the 'contemporary management of superior vena cava syndrome.'" - Benjamin M. Jackson, MD (Ann Thorac Surg 2011;92:1555)
Author : Stefanie Martina Odilia Peeters Weem
Publisher :
ISBN 13 : 9789462332386
Total Pages : 203 pages
Book Rating : 4.3/5 (323 download)
Download or read book Evolving Strategies for the Optimal Treatment of Peripheral Arterial Disease written by Stefanie Martina Odilia Peeters Weem and published by . This book was released on 2016 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt:
