Trapping and Manipulation of Micron and Submicron Particles

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (114 download)

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Book Synopsis Trapping and Manipulation of Micron and Submicron Particles by : Mohammad Asif Zaman

Download or read book Trapping and Manipulation of Micron and Submicron Particles written by Mohammad Asif Zaman and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Micro/nano trapping and manipulation techniques have applications ranging from examining bacteria and exploring biochemistry at the cellular level to condensed matter physics. While conventional optical trapping techniques are widely used, their diffraction limited resolution and non-planar nature make them unsuitable for some applications. Near-field trapping techniques involving plasmonic structures can be used to address some of these issues. These structures can create a near-field spot size smaller than what is possible using diffraction limited optics. The small spot size makes it possible to manipulate subwavelength-sized objects. Their planar nature also makes parallelization easier for lab-on-a-chip applications. Another method having some of the same benefits is dielectrophoresis. Dielectrophoretic methods use electrical excitation of micro-electrodes at radio/microwave frequencies instead of optical excitation to create the trapping/manipulation force. Though lacking the resolution of near-field schemes, dielectrophoretic methods have longer range, material selectivity, and the ability to apply both attractive and repulsive forces. While near-field methods and dielectrophoretic methods both have been applied for trapping micro-/nano-sized objects, their application in controlled motion/manipulation of objects has not been widely investigated. My work involved designing devices which utilize these schemes and are capable of controlled manipulation of micron and submicron-sized objects. The developed technology is aimed towards biochemistry applications. In this thesis, I start with an overview of conventional particle manipulation schemes. Some theoretical discussions on gradient forces and the mathematics used for calculating those forces are presented. A Brownian dynamics model used for analyzing the behavior of colloidal particles in the force-field is also discussed. Next, I present my work on plasmonic C-shaped engravings/apertures for trapping and manipulating nanoparticles. The electromagnetic response of the plasmonic structure, profile of the generated force, and the behavior of a colloidal particle near the structure are discussed. Experimental results of particle manipulation are presented. Some of the limitations of this scheme are mentioned prior to introducing dielectrophoretic manipulation techniques. Dielectrophoresis solves many of the challenges associated with near-field methods at the cost of resolution. I present dielectrophoretic devices which are capable of moving a micro-particle over a distance of hundreds of microns. Controlled motion along a straight line and along a curved path is achieved by using micro-electrode arrays with appropriate electrical switching routines. Lastly, I discuss optically induced dielectrophoresis which incorporates aspects of both optical schemes and dielectrophoretic schemes. Rather than using physical micro-electrodes, the designs use optical illumination to excite photoconductors which behave like virtual electrodes to produce dielectrophoretic forces. The photoconductor can be selectively excited using focused lasers or plasmonic apertures. A hybrid approach utilizing the high resolution of plasmonic C-apertures and the long range of dielectrophoretic forces is developed. Particle manipulations using these techniques are discussed. Finally, concluding remarks are made and potential future works are listed.

Optical Trapping And Manipulation Of Neutral Particles Using Lasers: A Reprint Volume With Commentaries

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Publisher : World Scientific
ISBN 13 : 9814494348
Total Pages : 941 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Optical Trapping And Manipulation Of Neutral Particles Using Lasers: A Reprint Volume With Commentaries by : Arthur Ashkin

Download or read book Optical Trapping And Manipulation Of Neutral Particles Using Lasers: A Reprint Volume With Commentaries written by Arthur Ashkin and published by World Scientific. This book was released on 2006-12-29 with total page 941 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important volume contains selected papers and extensive commentaries on laser trapping and manipulation of neutral particles using radiation pressure forces. Such techniques apply to a variety of small particles, such as atoms, molecules, macroscopic dielectric particles, living cells, and organelles within cells. These optical methods have had a revolutionary impact on the fields of atomic and molecular physics, biophysics, and many aspects of nanotechnology.In atomic physics, the trapping and cooling of atoms down to nanokelvins and even picokelvin temperatures are possible. These are the lowest temperatures in the universe. This made possible the first demonstration of Bose-Einstein condensation of atomic and molecular vapors. Some of the applications are high precision atomic clocks, gyroscopes, the measurement of gravity, cryptology, atomic computers, cavity quantum electrodynamics and coherent atom lasers.A major application in biophysics is the study of the mechanical properties of the many types of motor molecules, mechanoenzymes, and other macromolecules responsible for the motion of organelles within cells and the locomotion of entire cells. Unique in vitro and in vivo assays study the driving forces, stepping motion, kinetics, and efficiency of these motors as they move along the cell's cytoskeleton. Positional and temporal resolutions have been achieved, making possible the study of RNA and DNA polymerases, as they undergo their various copying, backtracking, and error correcting functions on a single base pair basis.Many applications in nanotechnology involve particle and cell sorting, particle rotation, microfabrication of simple machines, microfluidics, and other micrometer devices. The number of applications continues to grow at a rapid rate.The author is the discoverer of optical trapping and optical tweezers. With his colleagues, he first demonstrated optical levitation, the trapping of atoms, and tweezer trapping and manipulation of living cells and biological particles.This is the only review volume covering the many fields of optical trapping and manipulation. The intention is to provide a selective guide to the literature and to teach how optical traps really work.

Micro-Nanorobotic Manipulation Systems and Their Applications

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Publisher : Springer Science & Business Media
ISBN 13 : 3642363911
Total Pages : 347 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Micro-Nanorobotic Manipulation Systems and Their Applications by : Toshio Fukuda

Download or read book Micro-Nanorobotic Manipulation Systems and Their Applications written by Toshio Fukuda and published by Springer Science & Business Media. This book was released on 2013-02-28 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Micro/Nano Robotics and Automation technologies have rapidly grown associated with the growth of Micro and Nanotechnologies. This book presents a summary of fundamentals in micro-nano scale engineering and the current state of the art of these technologies. “Micro-Nanorobotic Manipulation Systems and their Applications” introduces these advanced technologies from the basics and applications aspects of Micro/Nano-Robotics and Automation from the prospective micro/nano-scale manipulation. The book is organized in 9 chapters including an overview chapter of Micro/Nanorobotics and Automation technology from the historical view and important related research works. Further chapters are devoted to the physics of micro-nano fields as well as to material and science, microscopes, fabrication technology, importance of biological cell, and control techniques. Furthermore important examples, applications and a concise summary of Micro-Nanorobotics and Automation technologies are given.

Manipulation of Particles by Optical Trapping

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Publisher :
ISBN 13 :
Total Pages : 146 pages
Book Rating : 4.:/5 (12 download)

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Book Synopsis Manipulation of Particles by Optical Trapping by : Boya Zhang

Download or read book Manipulation of Particles by Optical Trapping written by Boya Zhang and published by . This book was released on 2017 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Optical Trapping and Manipulation of Neutral Particles Using Lasers

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Publisher : World Scientific Publishing Company Incorporated
ISBN 13 : 9789810240578
Total Pages : 915 pages
Book Rating : 4.2/5 (45 download)

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Book Synopsis Optical Trapping and Manipulation of Neutral Particles Using Lasers by : Arthur Ashkin

Download or read book Optical Trapping and Manipulation of Neutral Particles Using Lasers written by Arthur Ashkin and published by World Scientific Publishing Company Incorporated. This book was released on 2006 with total page 915 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important volume contains selected papers and extensive commentaries on laser trapping and manipulation of neutral particles using radiation pressure forces. Such techniques apply to a variety of small particles, such as atoms, molecules, macroscopic dielectric particles, living cells, and organelles within cells. These optical methods have had a revolutionary impact on the fields of atomic and molecular physics, biophysics, and many aspects of nanotechnology.In atomic physics, the trapping and cooling of atoms down to nanokelvins and even picokelvin temperatures are possible. These are the lowest temperatures in the universe. This made possible the first demonstration of Bose-Einstein condensation of atomic and molecular vapors. Some of the applications are high precision atomic clocks, gyroscopes, the measurement of gravity, cryptology, atomic computers, cavity quantum electrodynamics and coherent atom lasers.A major application in biophysics is the study of the mechanical properties of the many types of motor molecules, mechanoenzymes, and other macromolecules responsible for the motion of organelles within cells and the locomotion of entire cells. Unique in vitro and in vivo assays study the driving forces, stepping motion, kinetics, and efficiency of these motors as they move along the cell's cytoskeleton. Positional and temporal resolutions have been achieved, making possible the study of RNA and DNA polymerases, as they undergo their various copying, backtracking, and error correcting functions on a single base pair basis.Many applications in nanotechnology involve particle and cell sorting, particle rotation, microfabrication of simple machines, microfluidics, and other micrometer devices. The number of applications continues to grow at a rapid rate.The author is the discoverer of optical trapping and optical tweezers. With his colleagues, he first demonstrated optical levitation, the trapping of atoms, and tweezer trapping and manipulation of living cells and biological particles.This is the only review volume covering the many fields of optical trapping and manipulation. The intention is to provide a selective guide to the literature and to teach how optical traps really work.

High Efficiency Three-dimensional Manipulation of Sub-micron Particles and DNA Molecules

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Publisher :
ISBN 13 :
Total Pages : 186 pages
Book Rating : 4.:/5 (769 download)

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Book Synopsis High Efficiency Three-dimensional Manipulation of Sub-micron Particles and DNA Molecules by : Alexander Leroy Teeter

Download or read book High Efficiency Three-dimensional Manipulation of Sub-micron Particles and DNA Molecules written by Alexander Leroy Teeter and published by . This book was released on 2006 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Micro Total Analysis Systems 2000

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Publisher : Springer Science & Business Media
ISBN 13 : 9401722641
Total Pages : 639 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Micro Total Analysis Systems 2000 by : Albert van den Berg

Download or read book Micro Total Analysis Systems 2000 written by Albert van den Berg and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the fourth international symposium on Micro Total Analysis Systems (muTAS 2000). Cutting-edge research of all invited and contributed papers presented by the world’s leading muTAS groups provides the state of the art of this electrifying, multidisciplinary field.

Nanoelectromechanics in Engineering and Biology

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Publisher : CRC Press
ISBN 13 : 1420058363
Total Pages : 344 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Nanoelectromechanics in Engineering and Biology by : Michael Pycraft Hughes

Download or read book Nanoelectromechanics in Engineering and Biology written by Michael Pycraft Hughes and published by CRC Press. This book was released on 2018-10-03 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The success, growth, and virtually limitless applications of nanotechnology depend upon our ability to manipulate nanoscale objects, which in turn depends upon developing new insights into the interactions of electric fields, nanoparticles, and the molecules that surround them. In the first book to unite and directly address particle electrokinetics and nanotechnology, Nanoelectromechanics in Engineering and Biology provides a thorough grounding in the phenomena associated with nanoscale particle manipulation. The author delivers a wealth of application and background knowledge, from using electric fields for particle sorting in lab-on-a-chip devices to electrode fabrication, electric field simulation, and computer analysis. It also explores how electromechanics can be applied to sorting DNA molecules, examining viruses, constructing electronic devices with carbon nanotubes, and actuating nanoscale electric motors. The field of nanotechnology is inherently multidisciplinary-in its principles, in its techniques, and in its applications-and meeting its current and future challenges will require the kind of approach reflected in this book. Unmatched in its scope, Nanoelectromechanics in Engineering and Biology offers an outstanding opportunity for people in all areas of research and technology to explore the use and precise manipulation of nanoscale structures.

Optical Tweezers

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Publisher : CRC Press
ISBN 13 : 1420074148
Total Pages : 510 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Optical Tweezers by : Miles J. Padgett

Download or read book Optical Tweezers written by Miles J. Padgett and published by CRC Press. This book was released on 2010-06-02 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: The technical development of optical tweezers, along with their application in the biological and physical sciences, has progressed significantly since the demonstration of an optical trap for micron-sized particles based on a single, tightly focused laser beam was first reported more than twenty years ago. Bringing together many landmark papers on

Manipulating and Characterizing Nanoscale Particles Using Near-field Optical Forces

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Publisher :
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis Manipulating and Characterizing Nanoscale Particles Using Near-field Optical Forces by : Dakota Lee O'Dell

Download or read book Manipulating and Characterizing Nanoscale Particles Using Near-field Optical Forces written by Dakota Lee O'Dell and published by . This book was released on 2017 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the three decades since the development of optical tweezers, optical trapping has become an invaluable technique for particle manipulation and is used widely in biology as well as material science. In more recent years, there has been a significant effort to integrate optical traps directly with microfluidics on-chip to produce stronger optical forces and manipulate even smaller particles. This is often achieved through the use of near-field forces produced by subwavelength optical confinement. By leveraging techniques and designs from photonics, near-field optics can generate very strong piconewton forces that act over nanometer length scales. This dissertation aims to exploit these unique features of near-field optical forces-- their strength, tunability, and precise localization-- to build new nanostructures, develop new optical spectroscopy techniques, and probe the fundamental nature of particles and their interactions on the nanoscale. In the first half of this work, I focus on using optical gradient forces to drive the assembly of hybrid photonic-plasmonic resonators and using the amplified forces from these resonators to trap, manipulate, and bind other nanoparticles. These resonators are then used to optically drive the adsorption of individual proteins as a way of measuring the activation energy barrier of those adsorption reactions. While colloidal nanoparticles are critical in a wide range of fields and industries, there is still no reliable theoretical framework to describe their behavior in realistic solution conditions. This issue is compounded by the difficulty of directly measuring nanoscale particles with conventional optical tools. In the latter half of this work, I have demonstrated that near-field optical forces, which operate at similar magnitudes and length scales as colloidal forces, can be used to study the properties of nanoparticles directly. By applying a known optical force to a particle with an optical waveguide, the size and properties of the particle can be extracted from its dynamic response to that applied force. This technique leverages the unique advantages of localized optical forces and allows for direct measurement of single nanoparticles at high throughput. Combined with the previous section on binding and assembly, this dissertation lays the groundwork for future work on near-field optical forces which has great potential for improving our understanding of physics at the nanoscale. ...

The Supercontinuum Laser Source

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Publisher : Springer
ISBN 13 : 1493933264
Total Pages : 452 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis The Supercontinuum Laser Source by : Robert R. Alfano

Download or read book The Supercontinuum Laser Source written by Robert R. Alfano and published by Springer. This book was released on 2016-02-10 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the third edition of a well-known classic on ultrafast nonlinear and linear processes responsible for supercontinuum generation. Part I of the book reviews the progress achieved in experimental and theoretical understanding of the field, and goes over the applications developed since the discovery of the supercontinuum effect. The second part of the book covers recent research activity on supercontinuum phenomena and advances achieved since the publication of the previous edition. The new chapters specifically focus on: normal dispersion photonic band gap fibers; coherence in the supercontinuum; supercontinuum in the UV, NIR, and IR; and supercontinuum in XUV and X-rays for attosecond pulses. The Supercontinuum Laser Source is a definitive work by one of the discoverers of the white light effect. It is indispensable reading for any researcher or student working in the field of ultrafast laser physics.

Engineering of Submicron Particles

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Publisher : John Wiley & Sons
ISBN 13 : 1119296463
Total Pages : 220 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Engineering of Submicron Particles by : Jayanta Chakraborty

Download or read book Engineering of Submicron Particles written by Jayanta Chakraborty and published by John Wiley & Sons. This book was released on 2019-08-05 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brings together in one place the fundamental theory and models, and the practical aspects of submicron particle engineering This book attempts to resolve the tricky aspects of engineering submicron particles by discussing the fundamental theories of frequently used research tools—both theoretical and experimental. The first part covers the Fundamental Models and includes sections on nucleation, growth, inter-molecular and inter-particle forces, colloidal stability, and kinetics. The second part examines the Modelling of a Suspension and features chapters on fundamental concepts of particulate systems, writing the number balance, modelling systems with particle breakage and aggregation, and Monte Carlo simulation. The book also offers plenty of diagrams, software, examples, brief experimental demonstrations, and exercises with answers. Engineering of Submicron Particles: Fundamental Concepts and Models offers a lengthy discussion of classical nucleation theory, and introduces other nucleation mechanisms like organizer mechanisms. It also looks at older growth models like diffusion controlled or surface nucleation controlled growth, along with new generation models like connected net analysis. Aggregation models and inter-particle potentials are touched upon in a prelude on intermolecular and surface forces. The book also provides analytical and numerical solutions of population balance models so readers can solve basic population balance equations independently. Presents the fundamental theory, practical aspects, and models of submicron particle engineering Teaches readers to write number balances for their own system of interest Provides software with open code for solution of population balance model through discretization Filled with diagrams, examples, demonstrations, and exercises Engineering of Submicron Particles: Fundamental Concepts and Models will appeal to researchers in chemical engineering, physics, chemistry, engineering, and mathematics concerned with particulate systems. It is also a good text for advanced students taking particle technology courses.

Microfluidics Based Microsystems

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Publisher : Springer Science & Business Media
ISBN 13 : 9048190312
Total Pages : 622 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Microfluidics Based Microsystems by : S. Kakaç

Download or read book Microfluidics Based Microsystems written by S. Kakaç and published by Springer Science & Business Media. This book was released on 2010-09-10 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains an archival record of the NATO Advanced Study Institute on Microfluidics Based Microsystems – Fundamentals and App- cations held in Çe ?me-Izmir, Turkey, August 23–September 4, 2009. ASIs are intended to be high-level teaching activity in scientific and technical areas of current concern. In this volume, the reader may find interesting chapters and various microsystems fundamentals and applications. As the world becomes increasingly concerned with terrorism, early - spot detection of terrorist’s weapons, particularly bio-weapons agents such as bacteria and viruses are extremely important. NATO Public Diplomacy division, Science for Peace and Security section support research, Advanced Study Institutes and workshops related to security. Keeping this policy of NATO in mind, we made such a proposal on Microsystems for security. We are very happy that leading experts agreed to come and lecture in this important NATO ASI. We will see many examples that will show us Microfluidics usefulness for rapid diagnostics following a bioterrorism attack. For the applications in national security and anti-terrorism, microfluidic system technology must meet the challenges. To develop microsystems for security and to provide a comprehensive state-of-the-art assessment of the existing research and applications by treating the subject in considerable depth through lectures from eminent professionals in the field, through discussions and panel sessions are very beneficial for young scientists in the field.

Method for Sampling Sub-micron Particles

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (873 download)

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Book Synopsis Method for Sampling Sub-micron Particles by :

Download or read book Method for Sampling Sub-micron Particles written by and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Apparatus and method steps for collecting sub-micron sized particles include a collection chamber and cryogenic cooling. The cooling is accomplished by coil tubing carrying nitrogen in liquid form, with the liquid nitrogen changing to the gas phase before exiting from the collection chamber in the tubing. Standard filters are used to filter out particles of diameter greater than or equal to 0.3 microns; however the present invention is used to trap particles of less than 0.3 micron in diameter. A blower draws air to said collection chamber through a filter which filters particles with diameters greater than or equal to 0.3 micron. The air is then cryogenically cooled so that moisture and sub-micron sized particles in the air condense into ice on the coil. The coil is then heated so that the ice melts, and the liquid is then drawn off and passed through a Buchner funnel where the liquid is passed through a Nuclepore membrane. A vacuum draws the liquid through the Nuclepore membrane, with the Nuclepore membrane trapping sub-micron sized particles therein. The Nuclepore membrane is then covered on its top and bottom surfaces with sheets of Mylar. RTM. and the assembly is then crushed into a pellet. This effectively traps the sub-micron sized particles for later analysis.

Optical Nano and Micro Actuator Technology

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Publisher : CRC Press
ISBN 13 : 1439840547
Total Pages : 666 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Optical Nano and Micro Actuator Technology by : George K. Knopf

Download or read book Optical Nano and Micro Actuator Technology written by George K. Knopf and published by CRC Press. This book was released on 2017-12-19 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Optical Nano and Micro Actuator Technology, leading engineers, material scientists, chemists, physicists, laser scientists, and manufacturing specialists offer an in-depth, wide-ranging look at the fundamental and unique characteristics of light-driven optical actuators. They discuss how light can initiate physical movement and control a variety of mechanisms that perform mechanical work at the micro- and nanoscale. The book begins with the scientific background necessary for understanding light-driven systems, discussing the nature of light and the interaction between light and NEMS/MEMS devices. It then covers innovative optical actuator technologies that have been developed for many applications. The book examines photoresponsive materials that enable the design of optically driven structures and mechanisms and describes specific light-driven technologies that permit the manipulation of micro- and nanoscale objects. It also explores applications in optofluidics, bioMEMS and biophotonics, medical device design, and micromachine control. Inspiring the next generation of scientists and engineers to advance light-driven technologies, this book gives readers a solid grounding in this emerging interdisciplinary area. It thoroughly explains the scientific language and fundamental principles, provides a holistic view of optical nano and micro actuator systems, and illustrates current and potential applications of light-driven systems.

Lab-on-Chips for Cellomics

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Publisher : Springer Science & Business Media
ISBN 13 : 1402029756
Total Pages : 373 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Lab-on-Chips for Cellomics by : Albert Berg

Download or read book Lab-on-Chips for Cellomics written by Albert Berg and published by Springer Science & Business Media. This book was released on 2007-09-07 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is volume entirely dedicated to microfabricated cell-based systems. It will provide readers with a quick introduction to the field as well as with a variety of specific examples of such Lab-on-Chip systems for cellomics applications. It will give investigators inspiration for innovative research topics, whereas end users will be surprised about the wide variety of new and exciting applications.

Trapping and Guiding Microscopic Particles with Light-induced Forces

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (144 download)

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Book Synopsis Trapping and Guiding Microscopic Particles with Light-induced Forces by : Niko Oliver Eckerskorn

Download or read book Trapping and Guiding Microscopic Particles with Light-induced Forces written by Niko Oliver Eckerskorn and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contact-free trapping and manipulation of light absorbing micrometer and nanometer-scale particles in air and in vacuum utilises radiation pressure, which results from momentum transfer from photons, and a pressure-dependent thermal force, caused by momentum transfer from gas molecules to the confined particles. Both forces are linearly proportional to the illuminating laser intensity, and both push the particles towards regions of lower intensity. While the radiation pressure of light was predicted and described more than a century ago, the theory of thermal forces, the so called photophoretic force, is still under development. It depends on a number of poorly described factors, such as the temperature gradient across the illuminated particle and thermal creep of heated gas along the particle surface due to temperature and pressure gradients. In this thesis I use doughnut-shaped structured laser beams to levitate and guide light-absorbing micron-size particles aiming to uncover the optically induced forces in air at variable pressure ranging from 10-2000 millibar. First, I designed and built a counter-propagating optical pipeline to uncover the influence of polarisation on the particle movement. Second, I designed and constructed a vertically directed diverging vortex beam trap, a 'funnel' trap, to conduct a quantitative evaluation of the photophoretic force and trapping stiffness by levitating graphite particles and carbon-coated glass shells of calibrated sizes in a carefully characterised vortex beam. Third, from the measured size of the particles and the position of the particle in the beam on the one hand, and the known density of the particles and the intensity distribution of the funnel trap on the other hand, I characterised the optically induced thermal forces in the axial and transverse directions. Fourth, I compared the contribution of thermal force to the light-pressure force and their dependence on atmospheric pressure. Based on the results of my experiments I determined the parameter space for guiding particles with hollow-core vortex and Bessel beams, taking into account the particle speed, size, and offset from the laser axis, all linked to the optical beam properties such as beam divergence, optical polarisation and power. The results of this thesis are used in the development of a touch-free optical system for pin-point delivery of macromolecules to the X-ray focal spot at the Free Electron Laser facility at the DESY (Deutsches Elektronen-Synchrotron) synchrotron in Hamburg, Germany, for coherent diffractive imaging experiments on nanometer-scale morphology. I conclude with a discussion of avenues for future work in contact-free manipulating of particles with structured laser beams to enhance significantly the efficiency of nanometer-scale morphology of proteins and biomolecules.