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Transporter A Linternational
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Download or read book Drug Transporters written by Guofeng You and published by John Wiley & Sons. This book was released on 2022-04-06 with total page 1269 pages. Available in PDF, EPUB and Kindle. Book excerpt: DRUG TRANSPORTERS Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques. The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases. Reflects the current state of the field and offers perspectives on future directions Covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science Provides up-to-date information on drug transporter families, mechanisms, and clinical implications Includes extensive references and numerous figures and tables throughout Understandable for novices while offering sufficient depth for more experienced researchers, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.
Book Synopsis Antitargets and Drug Safety by : Laszlo Urban
Download or read book Antitargets and Drug Safety written by Laszlo Urban and published by John Wiley & Sons. This book was released on 2015-02-23 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks. Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered.
Author : Publisher :Editions Bréal ISBN 13 :2749521017 Total Pages :395 pages Book Rating :4.7/5 (495 download)
Download or read book written by and published by Editions Bréal. This book was released on with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis General and Molecular Pharmacology by : Francesco Clementi
Download or read book General and Molecular Pharmacology written by Francesco Clementi and published by John Wiley & Sons. This book was released on 2015-08-10 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book
Book Synopsis Official Congressional Directory by : United States. Congress
Download or read book Official Congressional Directory written by United States. Congress and published by . This book was released on 1989 with total page 1246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes maps of the U.S. Congressional districts.
Book Synopsis Advances in Maternal-Fetal Biomedicine by : Marcelo Gonzalez-Ortiz
Download or read book Advances in Maternal-Fetal Biomedicine written by Marcelo Gonzalez-Ortiz and published by Springer Nature. This book was released on 2023-07-19 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volumeaims to describe physiological and pathophysiological mechanisms that underlie human maternal-fetal interactions. The book emphasizes the structure and development of the fetoplacental unit, the endocrine and nutritional regulation of fetal development, nitric oxide signalling, solute carriers function and ion channels regulation in healthy pregnancies and diseases, like preeclampsia, gestational diabetes, and maternal obesity, among others. Also, we highlight novel mechanisms associated with language impairment in children, the use of serotonin inhibitors or cannabis during pregnancy, and maternal conditions' potential impact on cerebrovascular development in newborns and infants. The cellular and molecular understanding of maternal-fetal physiology and pathophysiology will allow the readers to understand the impact of diseases or conditions that are highly prevalent in pregnant women.
Download or read book Drug Delivery written by Binghe Wang and published by John Wiley & Sons. This book was released on 2016-04-18 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery
Download or read book The International Bookbinder written by and published by . This book was released on 1918 with total page 918 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Microbiology by : David H. Persing
Download or read book Molecular Microbiology written by David H. Persing and published by John Wiley & Sons. This book was released on 2020-07-24 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the latest molecular diagnostic techniques in one comprehensive volume The molecular diagnostics landscape has changed dramatically since the last edition of Molecular Microbiology: Diagnostic Principles and Practice in 2011. With the spread of molecular testing and the development of new technologies and their opportunities, laboratory professionals and physicians more than ever need a resource to help them navigate this rapidly evolving field. Editors David Persing and Fred Tenover have brought together a team of experienced researchers and diagnosticians to update this third edition comprehensively, to present the latest developments in molecular diagnostics in the support of clinical care and of basic and clinical research, including next-generation sequencing and whole-genome analysis. These updates are provided in an easy-to-read format and supported by a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors. Molecular Microbiology: Diagnostic Principles and Practice Presents the latest basic scientific theory underlying molecular diagnostics Offers tested and proven applications of molecular diagnostics for the diagnosis of infectious diseases, including point-of-care testing Illustrates and summarizes key concepts and techniques with detailed figures and tables Discusses emerging technologies, including the use of molecular typing methods for real-time tracking of infectious outbreaks and antibiotic resistance Advises on the latest quality control and quality assurance measures Explores the increasing opportunities and capabilities of information technology Molecular Microbiology: Diagnostic Principles and Practice is a textbook for molecular diagnostics courses that can also be used by anyone involved with diagnostic test selection and interpretation. It is also a useful reference for laboratories and as a continuing education resource for physicians. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.
Book Synopsis Proceeding of the 7th International Conference on Logistics Operations Management, GOL’24 by : Youssef Benadada
Download or read book Proceeding of the 7th International Conference on Logistics Operations Management, GOL’24 written by Youssef Benadada and published by Springer Nature. This book was released on with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The International Bookbinder by : James L. Feeney
Download or read book The International Bookbinder written by James L. Feeney and published by . This book was released on 1918 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cation Transporters in Plants by : Santosh Kumar Upadhyay
Download or read book Cation Transporters in Plants written by Santosh Kumar Upadhyay and published by Academic Press. This book was released on 2021-11-19 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cation Transporters in Plants presents expert information on the major cation transporters, along with developments of various new strategies to cope with the adverse effects of abiotic and biotic stresses. The book will serve as a very important repository for the scientist, researcher, academician and industrialist to enhance their knowledge about cation transport in plants. Further, applications listed in the book will facilitate future developments in crop designing strategies. This comprehensive resource provides an alternative strategy for abiotic and biotic stress management in agricultural and horticultural crops. In addition, it will further improve basic knowledge om the origin and mechanism of cation homeostasis and their role in developmental transition and stress regulation. - Contains in-depth knowledge about various cation transporters in plants - Provides information about important macro and micronutrient cation transporters and their applications in the agricultural and biotechnology sectors - Facilitates agricultural scientists and industries in future crop designing strategies - Provides an alternative strategy for abiotic and biotic stress management in agricultural and horticultural crops
Book Synopsis Convention Relating to International Air Navigation by :
Download or read book Convention Relating to International Air Navigation written by and published by . This book was released on 1919 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Blood-Brain Barrier in Drug Discovery by : Li Di
Download or read book Blood-Brain Barrier in Drug Discovery written by Li Di and published by John Wiley & Sons. This book was released on 2015-02-02 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market
Download or read book Public Transport International written by and published by . This book was released on 2000 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Well Production Practical Handbook by : Henri Cholet
Download or read book Well Production Practical Handbook written by Henri Cholet and published by Editions TECHNIP. This book was released on 2008 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complete & Comprehensive overview of field development and well production, providing a wealth of practical information. A reference guide for petroleum engineers + oilfield oerators. Provides readily-available solutions to practical problems. Formulas, charts, 155 figures, 201 tables. Glossary & index.
Book Synopsis The Contract of Carriage by : Paula Bäckdén
Download or read book The Contract of Carriage written by Paula Bäckdén and published by Taylor & Francis. This book was released on 2019-01-28 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Contract of Carriage: Multimodal Transport and Unimodal Regulation provides a new perspective on how to approach the question of multimodal transport regulation regarding liability for goods carried. Unlike previous literature, which has approached the issue of applicability from a strict interpretation-of-the-convention angle, this book will analyse the issue from a law of contracts perspective. If goods are damaged during international transport, the carrier’s liability is governed by rules laid down in international conventions, such as the CMR convention, the Hague–Visby Rules and the Montreal Convention. Such rules apply to certain modes of transport, to contracts for unimodal carriage. When goods are carried under a multimodal contract of carriage, which provides for carriage by more than one mode of transport, the question is whether these rules are applicable to transport under multimodal contracts of carriage. This book investigates the rules of carrier’s liability applicable to unimodal transport, and whether these rules are applicable to carriage under multimodal contracts of carriage, with focus on the actual contract of carriage. This unique text will be of great interest to students, academics, industry professionals, and legal practitioners alike.
