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Translational Neuropsychopharmacology
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Book Synopsis Translational Neuropsychopharmacology by : Trevor W. Robbins
Download or read book Translational Neuropsychopharmacology written by Trevor W. Robbins and published by Springer. This book was released on 2016-09-22 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.
Book Synopsis Artificial Intelligence for Translational Pharmacology by : Zhi-Liang Ji
Download or read book Artificial Intelligence for Translational Pharmacology written by Zhi-Liang Ji and published by Frontiers Media SA. This book was released on 2020-07-28 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neuropsychopharmacology by : Kenneth L. Davis
Download or read book Neuropsychopharmacology written by Kenneth L. Davis and published by Lippincott Williams & Wilkins. This book was released on 2002 with total page 1964 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of all neuropsychiatric disorders. Nine sections focus on specific groups of disorders, covering clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
Book Synopsis Introduction to Neuropsychopharmacology by : Leslie Iversen
Download or read book Introduction to Neuropsychopharmacology written by Leslie Iversen and published by Oxford University Press. This book was released on 2009 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The text ranges from drugs that affect the mood and behavior to hypnotics, narcotics, anticonvulsants, and analgesics, as well as a variety of drugs that affect the autonomic nervous system and psychoactive drugs used for non-medical reasons - nicotine, alcohol, opiates, psychostimulants and cannabis."--BOOK JACKET.
Book Synopsis Neuropsychopharmacology by : Jahangir Moini
Download or read book Neuropsychopharmacology written by Jahangir Moini and published by Elsevier. This book was released on 2023-05-10 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropsychopharmacology reviews the principles of pharmacology with a focus on the central nervous system and autonomic nervous system. Beyond autonomic and central nervous system pharmacology, this volume uniquely discusses psychiatric disorders and the pharmacological interventions that are available for conditions including depression, schizophrenia and anxiety disorders. With a focus on these specific body systems, readers will see end-of-chapter questions that offer real-world case studies, as well as multiple-choice questions for further learning. Beneficial features and content also include two extensive examination tests, which each contain 100 questions for better learning or to be used in teaching, and a glossary. Helpful appendices cover high-alert medications and toxicology effects on the nervous system. Each chapter will contain classifications of medications, pharmacokinetics, mechanism of action, clinical indications and toxicities. - Describes pharmacology principles pertaining to the central and autonomic nervous system - Identifies pharmacological interventions for psychiatric disorders including current evidence-based interventions for depression, schizophrenia and anxiety disorders - Features chapter outlines, end-of-chapter questions, real-world case studies and examinations for deeper learning or teaching
Book Synopsis Conn's Translational Neuroscience by : P. Michael Conn
Download or read book Conn's Translational Neuroscience written by P. Michael Conn and published by Academic Press. This book was released on 2016-09-28 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. - Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance - Features contributions from leading global basic and clinical investigators in the field - Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes - Relates and translates the current science to the understanding of neurological disorders and their treatment
Book Synopsis Improving the Utility and Translation of Animal Models for Nervous System Disorders by : Institute of Medicine
Download or read book Improving the Utility and Translation of Animal Models for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2013-04-25 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.
Book Synopsis Translational Neuroimaging by : Robert A. McArthur
Download or read book Translational Neuroimaging written by Robert A. McArthur and published by Academic Press. This book was released on 2012-10-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders.
Book Synopsis Translational Medicine in CNS Drug Development by : George G. Nomikos
Download or read book Translational Medicine in CNS Drug Development written by George G. Nomikos and published by Academic Press. This book was released on 2019-06-18 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. - Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development - Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders - Includes chapters written by international experts from industry and academia
Book Synopsis New frontiers in the neuropsychopharmacology of mental illness by : Thibault Renoir
Download or read book New frontiers in the neuropsychopharmacology of mental illness written by Thibault Renoir and published by Frontiers Media SA. This book was released on 2015-01-28 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, mental illnesses have become recognized as a huge emotional and financial burden to the individual, their relatives and society at large. Stress-related and mood disorders as well as psychoactive substance abuse are among the disorders associated with most disability in high income countries. Suicide, which is often attributed to some underlying mental disorders, is a leading cause of death among teenagers and young adults. At the same time, mental disorders pose some of the toughest challenges in neuroscience research. There are many different categories of mental disorder as defined and classified by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) and the International Statistical Classification of Diseases 10th Revision (ICD-10). Despite the ongoing improvements of those widely used manuals, the validity and reliability of their diagnoses remain a constant debate. However, it has now become accepted by the scientific community that mental disorders can arise from multiple sources. In that regard, both clinical and animal studies looking at gene-environment interactions have helped to better understand the mechanisms involved in the pathophysiology as well as the discovery of treatments for mental disorders. This Research Topic aims to cover recent progress in research studying how genetic make-up and environmental factors (such as stress paradigm or pharmacological treatment) can contribute to the development of mental disorders such as anxiety, depression, and schizophrenia. This Research Topic also seeks to highlight studies looking at affective-like disorders following the intake of drugs of abuse. We also welcome all research articles, review papers, brief communications, and commentary on topics related to the broad field of Neuropsychopharmacology.
Book Synopsis Interpretational Processing Biases in Emotional Psychopathology by : Marcella L. Woud
Download or read book Interpretational Processing Biases in Emotional Psychopathology written by Marcella L. Woud and published by Springer Nature. This book was released on 2023-03-28 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary aim of this book is to bridge the gap between lab-based and clinical research by disseminating the latest interdisciplinary scientific findings on interpretational processing biases in the context of emotional psychopathology. It is designed to help the practitioner by drawing explicit links between the basic science and implications for clinical practice. This enables an enhanced interaction between science and practice, strengthening bi-directional translational links, and the potential to produce more meaningful and significant advances in the treatment of emotional psychopathology. This in turn will facilitate an innovative step-change in the area of both research and clinical practice. The book focuses on cognitive processing biases that are common across a wide range of psychological disorders, meaning that the conclusions drawn have relevance across the whole spectrum of psychopathology and will stimulate and inspire a broad range of discussions and future work. From the foreword by Nikolaos Kazantzis: "The practice of CBT is complex and requires a tailored approach. Every technique has a specific target but may be used for multiple purposes simultaneously in support of the client’s therapeutic goals. The purpose of Dr. Woud’s book is to elucidate the ways in which interpretational biases can be a focus of intervention for CBT therapists at all stages of professional development, from those undertaking training to master clinicians. Dr. Woud has succeeded admirably in this regard."
Book Synopsis Toxicity and Autophagy in Neurodegenerative Disorders by : José M. Fuentes
Download or read book Toxicity and Autophagy in Neurodegenerative Disorders written by José M. Fuentes and published by Springer. This book was released on 2015-05-04 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.
Book Synopsis Neuroscience of Enduring Change by : Richard D. Lane
Download or read book Neuroscience of Enduring Change written by Richard D. Lane and published by Oxford University Press, USA. This book was released on 2020 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience of Enduring Change is founded on the premise that all major psychotherapy modalities producing enduring change do so by virtue of corrective emotional experiences that alter problematic memories through the process of reconsolidation. This book is unique in linking basic science concepts to clinical research and clinical application. Experts in each area address each of the basic science and clinical topics. No other book addresses a general mechanism of change in psychotherapy in combination with the basic science underpinning it. This book is also unique in bringing the latest neuroimaging evidence and cutting-edge conceptual approaches to bear in understanding how psychological and behavioral treatment approaches bring about lasting change in the brain. Clinicians will benefit from the detailed discussion of basic mechanisms that underpin their clinical interventions and will be challenged to consider how their approach to therapy might be adjusted to optimize the opportunities for enduring change. Researchers will benefit from authoritative reviews of extant knowledge and a clear description of the research agenda going forward. The cross-fertilization between the research and clinical domains is evident throughout.
Book Synopsis The Sage Handbook of Cognitive and Systems Neuroscience by : Gregory J. Boyle
Download or read book The Sage Handbook of Cognitive and Systems Neuroscience written by Gregory J. Boyle and published by SAGE Publications Limited. This book was released on 2023-11-15 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cognitive neuroscience is the interdisciplinary study of how cognitive and intellectual functions are processed and represented within the brain, which is critical to building understanding of core psychological and behavioural processes such as learning, memory, behaviour, perception, and consciousness. Understanding these processes not only offers relevant fundamental insights into brain-behavioural relations, but may also lead to actionable knowledge that can be applied in the clinical treatment of patients with various brain-related disabilities. This Handbook examines complex cognitive systems through the lens of neuroscience, as well as providing an overview of development and applications within cognitive and systems neuroscience research and beyond. Containing 35 original, state of the art contributions from leading experts in the field, this Handbook is essential reading for researchers and students of cognitive psychology, as well as scholars across the fields of neuroscientific, behavioural and health sciences. Part 1: Attention, Learning and Memory Part 2: Language and Communication Part 3: Emotion and Motivation Part 4: Social Cognition Part 5: Cognitive Control and Decision Making Part 6: Intelligence
Book Synopsis Anhedonia: Preclinical, Translational, and Clinical Integration by : Diego A. Pizzagalli
Download or read book Anhedonia: Preclinical, Translational, and Clinical Integration written by Diego A. Pizzagalli and published by Springer Nature. This book was released on 2022-08-08 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anhedonia is a key symptom (and often risk factor) for various neuropsychiatric disorders, including depression, schizophrenia, substance use disorders, post-traumatic stress disorders, and Parkinson's Disease, among others. Across disorders, anhedonia has been associated with worse disease course, including poor response to pharmacological, psychological and neurostimulation treatments as well as completed suicide. Mounting evidence emerging from preclinical and translational sciences has clarified that "anhedonia" can be parsed into partially independent subcomponents, including incentive motivation, consummatory pleasure, reward learning, and effort-based decision making, pointing to distinct neurobiological substrates that could underlie anhedonic phenotypes. Taking an integrative approach that emphasizes cross-species integration and dimensional conceptualization of mental illnesses (e.g., Research Domain Criteria (RDoC)), this book represents the most comprehensive evaluation, synthesis and integration of theories and empirical findings focused on anhedonia. Organized across five parts, the handbook starts with chapters on the history, etiology, and assessments of anhedonia (Part I), followed by a section on the role of anhedonia in psychiatric and neurological disorders (Part II). Using the RDoC Matrix as a guide, Part III presents chapters synthetizing preclinical and clinical findings on different reward processing subdomains (e.g., reward responsiveness, reward valuation, reward learning). Part IV is focused on selected special topics, including historical and current perspectives on the transdiagnostic nature and importance of social anhedonia, the role of inflammation in the pathophysiology of anhedonia, the use of computational modeling to “dissect” anhedonia and improve its understanding, and links between anhedonia and suicide. Finally, Part V includes chapters on pharmacological, psychological and neurostimulation treatments for anhedonia.
Book Synopsis Advances in Bioengineering Research and Application: 2012 Edition by :
Download or read book Advances in Bioengineering Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 1665 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Bioengineering Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bioengineering. The editors have built Advances in Bioengineering Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bioengineering in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Bioengineering Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Behavioral Pharmacology of Drug Abuse: Current Status by :
Download or read book Behavioral Pharmacology of Drug Abuse: Current Status written by and published by Academic Press. This book was released on 2022-03-25 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Behavioral Pharmacology of Drug Abuse: Current Status, Volume 93 provides an update on our current understanding of animal and human behavioral pharmacology in major classes of drugs of abuse, including nicotine, alcohol, opioids, psychostimulants, and hallucinogens, drug-environment interactions, neurochemical mechanisms and medications developments. This volume updates the field of behavioral pharmacology based on new knowledge gained in the past decade. - Provides accurate and updated reviews from selected experts on covered topics - Presents useful graphic material for ease of reading - Covers a wide range of topics that are highly integral to offer a panoramic view of the field of behavioral pharmacology
