Translational and Clinical Research in Autism Spectrum Disorders

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Author :
Publisher : American Medical Publishers
ISBN 13 : 9781639279029
Total Pages : 0 pages
Book Rating : 4.2/5 (79 download)

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Book Synopsis Translational and Clinical Research in Autism Spectrum Disorders by : Paul Spencer

Download or read book Translational and Clinical Research in Autism Spectrum Disorders written by Paul Spencer and published by American Medical Publishers. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects how a person perceives and interacts with others, leading to problems in social interaction and communication. Limited and repetitive patterns of conduct are also part of the disorder. While autism is a lifelong disease, the extent to which these challenges limit a person's capacity to function varies from person to person. The term 'spectrum disorders' signifies the wide variety of symptoms and severity associated with autism. Genetic factors are primarily the reason for the disorder's occurrence. ASD appears early in childhood and is related to social, scholastic, and occupational challenges. Autism signs appear as early as the first year of life. Some of the complications linked with the disease include difficulties in school and successful learning, work issues, inability to live independently, social isolation, and family stress. This book is a collection of translational and clinical researches on autism. The readers would gain knowledge that would broaden their perspective about autism spectrum disorders.

Translational Approaches to Autism Spectrum Disorder

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Author :
Publisher :
ISBN 13 : 9783319163222
Total Pages : pages
Book Rating : 4.1/5 (632 download)

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Book Synopsis Translational Approaches to Autism Spectrum Disorder by : Maria de los Angeles Robinson-Agramonte

Download or read book Translational Approaches to Autism Spectrum Disorder written by Maria de los Angeles Robinson-Agramonte and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any, proven therapies for the majority of the disorders. Topics addressed in this book include neural plasticity, neuroimmunology, neuroinflammation, neuroimaging, and appropriate animal and genetic models.

Autism Spectrum Disorders

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Author :
Publisher : Oxford University Press
ISBN 13 : 0199707472
Total Pages : 1445 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Autism Spectrum Disorders by : David Amaral

Download or read book Autism Spectrum Disorders written by David Amaral and published by Oxford University Press. This book was released on 2011-05-01 with total page 1445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research. Approximately 1 in 150 children are diagnosed as autistic, so it is also an intense growth area in behavioral and educational treatments. Financial resources have begun to be raised for more comprehensive research and an increasing number of scientists are becoming involved in autism research. In many respects, autism has become a model for conducting translational research on a psychiatric disorder. This text provides a comprehensive summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology. Edited by three leading researchers, this volume contains over 80 chapters and nine shorter commentaries by thought leaders in the field, making the book a virtual "who's who" of autism research. This carefully developed book is a comprehensive and authoritative reference for what we know in this area as well as a guidepost for the next several years in all areas of autism research.

Translational Anatomy and Cell Biology of Autism Spectrum Disorder

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Author :
Publisher : Springer
ISBN 13 : 3319524984
Total Pages : 216 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Translational Anatomy and Cell Biology of Autism Spectrum Disorder by : Michael J. Schmeisser

Download or read book Translational Anatomy and Cell Biology of Autism Spectrum Disorder written by Michael J. Schmeisser and published by Springer. This book was released on 2017-05-25 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational anatomy and cell biology of ASD. International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals. Primary objective is to clarify how anatomical and cell biological phenotypes of ASD will help to translate basic mechanisms to clinical practice and to efficiently treat affected individuals in the near future.

Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m)

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832515681
Total Pages : 153 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m) by : David Quentin Beversdorf

Download or read book Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m) written by David Quentin Beversdorf and published by Frontiers Media SA. This book was released on 2023-04-17 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many therapeutic interventions for autism spectrum disorder fail when they are examined in a clinical trial. Frequently, there is a subset of patients that responds very well to the intervention, while others do not, and the overall result does not yield a positive result. As autism spectrum disorder is highly heterogeneous in its underlying genetics and other etiological risk factors, as well as its heterogeneous phenotypic manifestation, this variability in response to any specific treatment is not entirely surprising. However, it remains a challenge to meaningfully subtype this heterogeneity for targeted treatment. The purpose of this research topic is to solicit articles that address the heterogeneity in autism spectrum disorder in a manner that may meaningfully contribute to targeted treatment approaches. Studies that address the heterogeneity of autism that could theoretically lead to targeted treatment, and studies that more directly address the use of a marker in association with response to a treatment, are both aspects that will contribute to this purpose. It is hoped that this Research Topic will yield articles that can help advance the field towards precision medicine in autism spectrum disorders. Manuscripts that contribute to the specification of the heterogeneity of autism spectrum disorder in a manner that could theoretically lead to targeted treatment would be appropriate for this research topic. Additionally, articles that utilize subtyping in relation to response to treatment would be appropriate for this research topic.

Autism Service Delivery

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Publisher : Springer
ISBN 13 : 149392656X
Total Pages : 495 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Autism Service Delivery by : Florence D. DiGennaro Reed

Download or read book Autism Service Delivery written by Florence D. DiGennaro Reed and published by Springer. This book was released on 2015-09-09 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines ways in which service delivery to individuals with autism can be improved from both ends of the basic-applied research spectrum. It introduces the concept of translational scholarship and examines real-world value in developing relevant interventions. Each area of coverage reviews current findings on autism from basic research and, then, discusses the latest applied research literature to create a roadmap for researchers, clinicians, and scientist-practitioners to develop new, effective strategies as children, adolescents, and adults with autism continue to learn and grow. Featured coverage includes: Why practice needs science and how science informs practice. The social learning disorder of stimulus salience in autism. Assessment and treatment of problem behaviors associated with transitions. Understanding persistence and improving treatment through behavioral momentum theory. The behavioral economics of reinforcer value. Increasing tolerance for delay with children and adults with autism. Autism Service Delivery is an essential resource for researchers, clinicians and scientist-practitioners, and graduate students in the fields of developmental psychology, behavioral therapy, social work, clinical child and school psychology, occupational therapy, and speech pathology.

Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders

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Author :
Publisher : Academic Press
ISBN 13 : 0444641955
Total Pages : 232 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders by :

Download or read book Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders written by and published by Academic Press. This book was released on 2018-11-14 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241 provides the most recent information on the animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, this volume also provides detailed chapters on a variety of specific topics, including An overview of genetic models of ASDs, Phenotypic modeling of ASD symptoms, Molecular mechanisms of NF1 model of ASD symptoms, Ube3a gene dosage disorders: molecular and circuit mechanisms of ASD, Circuit dysfunctions in ASD models, ERK signaling in genetic models of ASD, and more. Presents a timely, comprehensive assessment of the field Includes helpful summaries on current knowledge, gaps and future directions in autism research

Frontiers In Autism Research: New Horizons For Diagnosis And Treatment

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Author :
Publisher : World Scientific
ISBN 13 : 9814602175
Total Pages : 724 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis Frontiers In Autism Research: New Horizons For Diagnosis And Treatment by : Valerie W Hu

Download or read book Frontiers In Autism Research: New Horizons For Diagnosis And Treatment written by Valerie W Hu and published by World Scientific. This book was released on 2014-05-09 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the emerging and expanding areas of research on ASD and their potential to lead to better diagnosis and more effective therapies. These areas include innovative and integrative approaches to genetic/genomic analyses and investigations of epigenetic contributions, including the role of noncoding RNAs, DNA methylation, alternative splicing, RNA editing, and faulty translation in gene regulation and expression, metabolic and immune dysfunction, co-morbidities, as well as hormonal and gene-environment interactions that may increase risk for ASD.Within each chapter, experts review cutting-edge research as well as provide their perspective on the future of research in their respective areas, including the challenges involved and the types of studies or advances that are necessary to move the field forward to achieve predicted translational goals.Contributors: Argel Aguilar-Valles, Evdokia Anagnostou, Emma Ashwin, Bonnie Auyeung, Kelly M Bakulski, Simon Baron-Cohen, Margaret L Bauman, Donna Betts, Chad A Bousman, Daniel B Campbell, Manuel F Casanova, Bhismadev Chakrabarti, Gursharan Chana, Abha Chauhan, Ved Chauhan, Jessica DeWitt, Keith W Dunaway, Alal Eran, Ian P Everall, M Daniele Fallin, Richard E Frye, Piers Gillett, Matthew Ginsberg, Christos G Gkogkas, Rhonda J Greenhaw, Simon G Gregory, Elena L Grigorenko, Feng Gu, Rebecca Harmer, Martha Herbert, Valerie W Hu, Karen L Jones, Petra Kern, Arkady Khoutorsky, Rebecca Knickmeyer, Isaac S Kohane, Louis M Kunkel, Janine M LaSalle, Michael V Lombardo, Deepali Mankad, Marvin Natowicz, Laura Nicholls, Christos Pantelis, Natalia Rakhlin, Radhika Ramadas, Daniel A Rossignol, Tewarit Sarachana, Stephen W Scherer, Gabriela Schmulevich, Ayten Shah, Frank R Sharp, Alison B Singer, Efstratios Skafidas, Estate M Sokhadze, Nahum Sonenberg, Boryana Stamova, Zohreh Talebizadeh, Renee Testa, Judy Van de Water, Irina Voineagu, Daniel Williams, Ryan K C Yuen, Daniela Zantomio.

Advances in Autism Research

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Author :
Publisher : MDPI
ISBN 13 : 3036502025
Total Pages : 434 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Advances in Autism Research by : Antonio Narzisi

Download or read book Advances in Autism Research written by Antonio Narzisi and published by MDPI. This book was released on 2021-06-08 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents one of the most up-to-date collections of articles on clinical practice and research in the field of Autism Spectrum Disorders (ASD). The scholars who contributed to this book are experts in their field, carrying out cutting edge research in prestigious institutes worldwide (e.g., Harvard Medical School, University of California, MIND Institute, King’s College, Karolinska Institute, and many others). The book addressed many topics, including (1) The COVID-19 pandemic; (2) Epidemiology and prevalence; (3) Screening and early behavioral markers; (4) Diagnostic and phenotypic profile; (5) Treatment and intervention; (6) Etiopathogenesis (biomarkers, biology, and genetic, epigenetic, and risk factors); (7) Comorbidity; (8) Adulthood; and (9) Broader Autism Phenotype (BAP). This book testifies to the complexity of performing research in the field of ASD. The published contributions underline areas of progress and ongoing challenges in which more certain data is expected in the coming years. It would be desirable that experts, clinicians, researchers, and trainees could have the opportunity to read this updated text describing the challenging heterogeneity of Autism Spectrum Disorder.

Clinical Assessment and Intervention for Autism Spectrum Disorders

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Author :
Publisher : Elsevier
ISBN 13 : 0080559808
Total Pages : 447 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Clinical Assessment and Intervention for Autism Spectrum Disorders by : Johnny L. Matson

Download or read book Clinical Assessment and Intervention for Autism Spectrum Disorders written by Johnny L. Matson and published by Elsevier. This book was released on 2011-09-02 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorder has received increasing research in recent years, with more information on assessment and treatment than can be readily assimilated from primary literature by clinicians. Clinical Assessment and Intervention for Autism Spectrum Disorders summarizes evidence-based assessments and intervention for Autism across the life-span, providing clinicians with a practical overview of how best to assess and treat this disorder. The book begins with a discussion of what warrants a determination of being "evidence based" and a description of the disorder from a life span perspective. The book also provides a chapter on differential diagnosis of autism relative to other disorders. What follows are separate sections on assessment and intervention. These chapters discuss first how to assess and then separately how to treat behavioral problems, communication and social skills issues, academic and vocational skills, and the use of pharmacology and an assessment of possible pharmacological effects. Intended for practitioners assessing and treating children with developmental delays, the book provides clinicians with best practices for assessing and treating delays associated with autism. Covers the full range of Autism Spectrum Disorders Covers the lifespan Focuses on evidence-based assessment and treatment

Autism Spectrum Disorders: From Genotypes to Phenotypes

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889196801
Total Pages : 95 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Autism Spectrum Disorders: From Genotypes to Phenotypes by : Valsamma Eapen

Download or read book Autism Spectrum Disorders: From Genotypes to Phenotypes written by Valsamma Eapen and published by Frontiers Media SA. This book was released on 2015-12-10 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between key "social brain" regions. These interconnected neural systems can be understood through the relationship between functionally relevant anatomic areas and neurochemical pathways, the programming of which are genetically modulated during neurodevelopment and mediated through a range of epigenetic and environmental modulators. Elucidating the underlying molecular mechanisms can provide an invaluable window for understanding the neural wiring that regulates higher brain functions and consequent clinical phenotypes. In keeping with the multi modal and diverse origins of ASD, this Research Topic explores the genetic underpinnings and environmental modulation in the aetiology; neural substrates, biomarkers and endophenotypes that underlie clinical characteristics; as well as neurochemical pathways and pathophysiological mechanisms that pave the way for therapeutic interventions. Furthermore, since genetically mediated deficits and consequent functional impairments involve activity-dependent synapse development that depends on postnatal learning and experience, the trajectory towards the final clinical expression could be modulated by early interventions that exploit the neuronal maturation and brain plasticity. However, identifying these diverse pathogenetic processes and tailoring interventions would require subtyping ASD into homogeneous subgroups. In this regard, this topic covers the current state of evidence in the literature through topic reviews as well as ongoing original work that provides tangible hypotheses and directions for future research.

Autism in Translation

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Publisher : Springer
ISBN 13 : 3319932934
Total Pages : 311 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Autism in Translation by : Elizabeth Fein

Download or read book Autism in Translation written by Elizabeth Fein and published by Springer. This book was released on 2018-08-28 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is a complex phenomenon that is both individual and social. Showing both robust similarities and intriguing differences across cultural contexts, the autism spectrum raises innumerable questions about self, subjectivity, and society in a globalized world. Yet it is often misrepresented as a problem of broken bodies and disordered brains. So, in 2015, a group of interdisciplinary scholars gathered in Rio de Janeiro, Brazil for an intellectual experiment: a workshop that joined approaches from psychological anthropology to the South American tradition of Collective Health in order to consider autism within social, historical, and political settings. This book is the product of the ongoing conversation emerging from this event. It contains a series of comparative histories of autism policy in Italy, Brazil, and the United States; focuses on issues of voice, narrative, and representation in autism; and examines how the concept of autism shapes both individual lives and broader social and economic systems. Featuring contributions from: Michael Bakan Benilton Bezerra Pamela Block M. Ariel Cascio Jurandir Freire Costa Bárbara Costa Andrada Cassandra Evans Elizabeth Fein Clara Feldman Roy Richard Grinker Rossano Lima Francisco Ortega Dawn Prince-Hughes Clarice Rios Laura Sterponi Thomas S. Weisner Enrico Valtellina

Translational Approaches to Autism Spectrum Disorder

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Author :
Publisher : Springer
ISBN 13 : 3319163213
Total Pages : 222 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Translational Approaches to Autism Spectrum Disorder by : Maria de los Angeles Robinson-Agramonte

Download or read book Translational Approaches to Autism Spectrum Disorder written by Maria de los Angeles Robinson-Agramonte and published by Springer. This book was released on 2015-06-10 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any, proven therapies for the majority of the disorders. Among the topic addressed are neural plasticity, neuroimmunology, neuroinflammation, neuroimaging, and appropriate animal and genetic models.

Behavior Analysis

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Publisher : Guilford Publications
ISBN 13 : 1462553486
Total Pages : 594 pages
Book Rating : 4.4/5 (625 download)

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Book Synopsis Behavior Analysis by : Henry S. Roane

Download or read book Behavior Analysis written by Henry S. Roane and published by Guilford Publications. This book was released on 2024-01-26 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Throughout this text, many of the research paradigms and methodologies across experimental analysis of behavior (EAB) and applied behavior analysis (ABA) are presented within the "bench-to-bedside" approach of translational research described by the National Institutes of Health. The first few chapters of the text introduce underlying core tenets of behaviorism as well as core characteristics and methods that define the field of behavior analysis. The next several chapters of the book introduce the reader to some of the foundational principles of behavior analysis, with coverage from both the EAB and ABA perspectives. The final chapters of the book cover topics for which there has been ample basic, applied, and translational research conducted. The text concludes with a chapter on ethics, which includes content related to ethical issues in research, ethical issues in clinical practice, and the ethical use of nonhuman animals and special populations in research"--

The Molecular Basis of Autism

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Publisher : Springer
ISBN 13 : 1493921908
Total Pages : 438 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis The Molecular Basis of Autism by : S. Hossein Fatemi

Download or read book The Molecular Basis of Autism written by S. Hossein Fatemi and published by Springer. This book was released on 2015-03-20 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive overview of the clinical and scientific aspects of Autism from the leading experts in the field. The clinical section covers everything from epidemiological features to epigenetic regulation to behavioral therapies and much in between. The basic science section presents the latest knowledge on the underlying causes of the disorder including the role of various neurotransmitters, neurexins and neuroligins, reelin, and other proteins. Chapters also explore the cognition and motor control in autism and the connection between oxidative stress and mitochondrial dysfunction and autism. The thorough description of these underlying causes may help researchers and clinicians find more effective treatments and therapies for the 1 in 68 American children who have been diagnosed with Autism.

The Neuroscience of Autism Spectrum Disorders

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Author :
Publisher : Academic Press
ISBN 13 : 012391924X
Total Pages : 494 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis The Neuroscience of Autism Spectrum Disorders by : Joseph D. Buxbaum

Download or read book The Neuroscience of Autism Spectrum Disorders written by Joseph D. Buxbaum and published by Academic Press. This book was released on 2012-10-25 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available

Autism

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Author :
Publisher : Academic Press
ISBN 13 : 0128212438
Total Pages : 404 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Autism by :

Download or read book Autism written by and published by Academic Press. This book was released on 2020-07-23 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism, Volume 173 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. Chapters in this new release include updates on atypical brain development in autism spectrum disorder, predicting early diagnosis of autism spectrum disorder using neural and behavioral measures, the roles of the endocannabinoid system in autism spectrum disorder, the neurobiology of sensory processing in autism spectrum disorder, the effects of oxytocin administration on individuals with ASD, resting-state abnormalities of posterior cingulate in autism spectrum disorder, and more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field