Traité d'imagerie médicale - Volume 1 - 2e éd.

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Publisher : Lavoisier
ISBN 13 : 2257705815
Total Pages : 840 pages
Book Rating : 4.2/5 (577 download)

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Book Synopsis Traité d'imagerie médicale - Volume 1 - 2e éd. by : NAHUM Henri

Download or read book Traité d'imagerie médicale - Volume 1 - 2e éd. written by NAHUM Henri and published by Lavoisier. This book was released on 2013-12-12 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exhaustive et très richement illustrée, cette deuxième édition entièrement en couleur aborde de manière toujours claire et précise les méthodes et les résultats de l’imagerie de l’ensemble du corps humain. Chaque section présente de façon systématique : Les différentes techniques d’imagerie disponibles, des plus classiques au plus innovantes. Les principales stratégies diagnostiques pour toutes les pathologies de la région explorée. L’ensemble des chapitres a été actualisé et les chapitres de neurocardiologie et d'imagerie cardiovasculaire ont été totalement réécrits pour tenir compte des nouveaux apports de l’imagerie et des plus récents développements technologiques.

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Author :
Publisher : Odile Jacob
ISBN 13 : 2738172733
Total Pages : 223 pages
Book Rating : 4.7/5 (381 download)

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Book Synopsis by :

Download or read book written by and published by Odile Jacob. This book was released on with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Les médicaments psychotropes : les thymorégulateurs

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Publisher : Lavoisier
ISBN 13 : 2257705440
Total Pages : 297 pages
Book Rating : 4.2/5 (577 download)

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Book Synopsis Les médicaments psychotropes : les thymorégulateurs by : VERDOUX Hélène

Download or read book Les médicaments psychotropes : les thymorégulateurs written by VERDOUX Hélène and published by Lavoisier. This book was released on 2013-12-16 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: La classe des médicaments thymorégulateurs s’est longtemps résumée au seul lithium, avant de s’élargir aux anticonvulsivants. Plus récemment, avec les modifications intervenues dans le profil des molécules regroupées dans cette classe médicamenteuse et la remise en cause de la distinction entre antipsychotiques et thymorégulateurs, différentes définitions ont émergé, selon les critères retenus et l’accent sur l’efficacité préventive ou curative. Ces interrogations sur la définition de la classe des thymorégulateurs s’accompagnent d’un questionnement sur l’évolution des modèles nosographiques et donc des stratégies thérapeutiques. Ainsi l’ouvrage a-t-il pour objectif d’apporter les informations nécessaires à une prescription raisonnée de thymorégulateurs : - les bases fondamentales : mécanismes neurobiologiques, pharmacocinétique, pharmacodynamie, pharmacogénétique, effets sur les processus cognitifs et émotionnels ; - les modalités de prescription : incluant l’instauration, la surveillance, l’arrêt du traitement ainsi que les effets secondaires et les complications, pour le lithium, les anticonvulsivants et les antipsychotiques ; - l’éducation thérapeutique du patient. - les indications : trouble bipolaire, dépression, troubles psychotiques, troubles de la personnalité, addictions, prescriptions dimensionnelles ; - les spécificités liées aux populations et aux situations : association de plusieurs thymorégulateurs ou à un antidépresseur ou à l’ECT, utilisation chez les enfants et les adolescents, chez la femme enceinte ou allaitant, chez les personnes âgées. Réunissant une cinquantaine de spécialistes reconnus, riche d’une trentaine de tableaux et schémas explicatifs et d’un index détaillé, cet ouvrage est la référence indispensable pour tous les praticiens devant prescrire des thymorégulateurs.

The Psychology of Good and Evil

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Publisher : Oxford University Press
ISBN 13 : 0190250666
Total Pages : 265 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis The Psychology of Good and Evil by : Laurent Bègue

Download or read book The Psychology of Good and Evil written by Laurent Bègue and published by Oxford University Press. This book was released on 2016 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Psychology of Good and Evil expertly analyzes the shape that morality takes in our minds, its consequences in our lives, and how it affects our relationships with others. By exploring the core of human nature, Laurent Bègue uncovers the hidden mechanisms underlying the moral self, the apprenticeship of morality, how we relate to social norms, and the foundations of our beliefs.

Les antipsychotiques : Les médicaments psychotropes

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Publisher : Lavoisier
ISBN 13 : 2257705416
Total Pages : 266 pages
Book Rating : 4.2/5 (577 download)

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Book Synopsis Les antipsychotiques : Les médicaments psychotropes by : THOMAS Pierre

Download or read book Les antipsychotiques : Les médicaments psychotropes written by THOMAS Pierre and published by Lavoisier. This book was released on 2013-12-16 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Le développement des antipsychotiques a marqué une nouvelle ère thérapeutique après la découverte du premier neuroleptique dans les années 1950. Leur principale indication demeure les symptômes psychotiques, même s’ils offrent également de nouvelles perspectives de traitement pour certains troubles de la personnalité ou du comportement. Cependant, l’image négative qu’ont longtemps eue les neuroleptiques n’est pas totalement effacée, et cet ouvrage a pour but d’apporter toutes les informations nécessaires aux prescripteurs pour rationaliser leur choix thérapeutique et favoriser le meilleur usage possible des antipsychotiques : - les bases fondamentales : pharmacologie, pharmacogénétique, effets métaboliques et cognitifs ; - les aspects cliniques : épisodes aigus de schizophrénie, troubles bipolaires, troubles affectifs non bipolaires, TOC et affections neurologiques, tolérance des antipsychotiques et molécules à action prolongée ; - les spécificités liées aux populations : enfants et adolescents, période périnatale, personnes âgées, situations d’urgence ; - le bon usage et l’éducation thérapeutique du patient. Réunissant une quarantaine de spécialistes reconnus, riche d’une cinquantaine de tableaux et schémas explicatifs et d’un index détaillé, cet ouvrage est la référence indispensable pour tous les praticiens devant prescrire des antipsychotiques.

Les troubles anxieux

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Publisher : Lavoisier
ISBN 13 : 2257704088
Total Pages : 344 pages
Book Rating : 4.2/5 (577 download)

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Book Synopsis Les troubles anxieux by : BOULENGER Jean-Philippe

Download or read book Les troubles anxieux written by BOULENGER Jean-Philippe and published by Lavoisier. This book was released on 2014-04-04 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Depuis les premières descriptions cliniques datant de la fin du XIXe siècle, montrant l’intérêt médical relativement récent pour l’anxiété, les symptômes anxieux et les troubles anxieux, les concepts ont considérablement évolué au cours du XXe siècle pour aboutir aux classifications syndromiques en vigueur dans la nosographie actuelle. Pourtant, un certain nombre de questions demeurent, par exemple sur l’existence d’un continuum entre une anxiété normale et adaptative et une anxiété pathologique, la nature de la réactivité émotionnelle dans les troubles anxieux par rapport à celle décrite dans les troubles bipolaires, etc... La première partie d’ouvrage présente les diverses approches actuelles pour comprendre les troubles anxieux : modèles émotionnels, approche évolutionniste, psychodynamique, théorie de l’attachement, génétique, neurobiologie, neuropsychologie, électrophysiologie et neuro-imagerie. Sont ensuite exposés les différents troubles anxieux (attaque de panique, phobie sociale, trouble anxieux généralisé, hypocondrie, état de stress post-traumatique, TOC, etc.) et les associations co-morbides (dépression, conduites suicidaires, troubles bipolaires, addictions, etc...). Réunissant plus d’une quarantaine de spécialistes reconnus, riche d’une trentaine tableaux et schémas explicatifs et d’un index détaillé, cet ouvrage offre un état des connaissances et des recherches sur les troubles anxieux. Jean-Pierre Lépine, Professeur des Universités, Praticien hospitalier, service de Psychiatrie Adultes, hôpital Lariboisière, Paris. Jean-Philippe Boulenger, Professeur des Universités, Praticien hospitalier, service de Psychiatrie Adultes, CHU, Montpellier.

Troubles de l'apprentissage chez l'enfant

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Publisher : Lavoisier
ISBN 13 : 225770584X
Total Pages : 206 pages
Book Rating : 4.2/5 (577 download)

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Book Synopsis Troubles de l'apprentissage chez l'enfant by : LENOBLE Evelyne

Download or read book Troubles de l'apprentissage chez l'enfant written by LENOBLE Evelyne and published by Lavoisier. This book was released on 2014-01-15 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Les chemins qu’empruntent les enfants pour apprendre gardent toujours une part de mystère et réservent nombre de surprises, le plus souvent fort agréables. Lorsque des embûches se présentent, lorsque l’enfant peine pour apprendre, les parents, l’entourage familial ou éducatif au sens large ainsi que les enseignants, sont bien souvent pris au dépourvu. L’appel aux professionnels de santé est devenu un recours incontournable, dès que des « difficultés d’apprentissage » sont repérées chez un enfant. Écouter, observer... pour pouvoir aider au mieux, voici le défi auquel sont confrontés les soignants en collaboration avec la famille et l’équipe enseignante. Les auteurs de cet ouvrage – pédopsychiatres, psychologues, orthophonistes – s’appuient sur une longue expérience clinique de consultation hospitalière spécialisée dédiée aux troubles du langage et des apprentissages chez l’enfant (centre référent). L’enjeu d’un bilan pluridisciplinaire réalisé dans ce cadre est de proposer une analyse approfondie des difficultés, et de dégager, à partir des observations recueillies, des points d’appui et des leviers afin d’orienter les actions thérapeutiques et les remédiations dont pourra bénéficier l’enfant en difficulté. Les nombreuses vignettes cliniques décrivant le parcours des enfants au sein de ce centre référent ainsi que la description des outils de travail clinique utilisés, feront partager au lecteur l’expérience quotidienne de l’équipe d’auteurs cliniciens. Largement illustré par des cas cliniques évocateurs, ce livre intéressera tous les acteurs du soin – équipes de proximité (CMP, CMPP, SESSAD... ), équipes hospitalières spécialisées et praticiens libéraux (orthophonistes, psychologues, psychomotriciens, ergothérapeutes, psychopédagogues, pédiatres, pédopsychiatres, neuropédiatres...) – ainsi que les acteurs des champs pédagogique, éducatif et associatif, engagés auprès des enfants, sans oublier les familles.

Eating Disorders in Contemporary French Women’s Writing

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Publisher : Liverpool University Press
ISBN 13 : 1802076484
Total Pages : 320 pages
Book Rating : 4.8/5 (2 download)

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Book Synopsis Eating Disorders in Contemporary French Women’s Writing by : Lucille Cairns

Download or read book Eating Disorders in Contemporary French Women’s Writing written by Lucille Cairns and published by Liverpool University Press. This book was released on 2023-05-15 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eating Disorders in Contemporary French Women’s Writing examines the most common types of Eating Disorders (EDs) - anorexia nervosa, bulimia nervosa/bulimarexia, and binge eating disorder - as represented in contemporary French women’s literature. The primary corpus comprises 40 autobiographical (and very occasionally autofictional) texts complemented by ample reference, and sometimes challenge, to clinical, medically-researched based, or theoretical publications on EDs.

Dual Disorders (Addictive and Concomitant Psychiatric Disorders): Mechanisms and Treatment

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Publisher : Frontiers Media SA
ISBN 13 : 2889769305
Total Pages : 137 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Dual Disorders (Addictive and Concomitant Psychiatric Disorders): Mechanisms and Treatment by : Georges Brousse

Download or read book Dual Disorders (Addictive and Concomitant Psychiatric Disorders): Mechanisms and Treatment written by Georges Brousse and published by Frontiers Media SA. This book was released on 2022-09-12 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Routledge Handbook of Philosophy and Science of Addiction

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Publisher : Routledge
ISBN 13 : 1317423410
Total Pages : 580 pages
Book Rating : 4.3/5 (174 download)

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Book Synopsis The Routledge Handbook of Philosophy and Science of Addiction by : Hanna Pickard

Download or read book The Routledge Handbook of Philosophy and Science of Addiction written by Hanna Pickard and published by Routledge. This book was released on 2018-06-13 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: The problem of addiction is one of the major challenges and controversies confronting medicine and society. It also poses important and complex philosophical and scientific problems. What is addiction? Why does it occur? And how should we respond to it, as individuals and as a society? The Routledge Handbook of Philosophy and Science of Addiction is an outstanding reference source to the key topics, problems and debates in this exciting subject. It spans several disciplines and is the first collection of its kind. Organised into three clear parts, forty-five chapters by a team of international contributors examine key areas, including: the meaning of addiction to individuals conceptions of addiction varieties and taxonomies of addiction methods and models of addiction evolution and addiction history, sociology and anthropology population distribution and epidemiology developmental processes vulnerabilities and resilience psychological and neural mechanisms prevention, treatment and spontaneous recovery public health and the ethics of care social justice, law and policy. Essential reading for students and researchers in addiction research and in philosophy, particularly philosophy of mind and psychology and ethics, The Routledge Handbook of Philosophy and Science of Addiction will also be of great interest to those in related fields, such as medicine, mental health, social work, and social policy.

Adverse Syndromes and Psychiatric Drugs

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Publisher : Oxford University Press
ISBN 13 : 0198527489
Total Pages : 334 pages
Book Rating : 4.1/5 (985 download)

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Book Synopsis Adverse Syndromes and Psychiatric Drugs by : Peter Haddad

Download or read book Adverse Syndromes and Psychiatric Drugs written by Peter Haddad and published by Oxford University Press. This book was released on 2004-05-27 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacotherapy is an important part of the treatment of major phychiatric disorders. Although psychiatric drugs can have benefits for patients, adverse syndromes are common, causing distress for patients. This book will help psychiatrists, GPs pharmacists and nurses manage adverse syndromes associated with psychiatric drugs.

Meta-organizations

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Publisher : Edward Elgar Publishing
ISBN 13 : 1848442653
Total Pages : 201 pages
Book Rating : 4.8/5 (484 download)

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Book Synopsis Meta-organizations by : Göran Ahrne

Download or read book Meta-organizations written by Göran Ahrne and published by Edward Elgar Publishing. This book was released on 2008-01-01 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: A growing number of organizations are meta-organizations; rather than individuals they have other organizations as their members. This comprehensive book explains, in-depth, the unique way in which meta-organizations function, how they differ from organizations with individual membership, and how they are crucial agents in the process of globalization. Göran Ahrne and Nils Brunsson combine the fields of organization theory and international relations in a new way. They portray a theory based on insights from organization studies that is also used to explain and understand international organizations. This theory creates new possibilities to analyze meta-organizations such as the EU and the UN and compare them to other meta-organizations such as national trade associations, sport federations and international non-governmental organizations. The authors point out striking similarities between all these organizations that have never been discovered before, including the conditions for membership, identity formation and decision-making. The book opens a whole new area for organizational research. It will be essential reading for researchers and postgraduate students interested in organization theory, globalization, politics and organizations, or international organizations.

Cognition and Addiction

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Publisher : Academic Press
ISBN 13 : 0128152990
Total Pages : 444 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Cognition and Addiction by : Antonio Verdejo García

Download or read book Cognition and Addiction written by Antonio Verdejo García and published by Academic Press. This book was released on 2019-09-29 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cognition and Addiction: A Researcher's Guide from Mechanisms Towards Interventions provides researchers with a guide to recent cognitive neuroscience advances in addiction theory, phenotyping, treatments and new vistas, including both substance and behavioral addictions. This book focuses on "what to know and "how to apply information, prioritizing novel principles and delineating cutting-edge assessment, phenotyping and treatment tools. Written by world renowned researcher Antonio Verdejo-Garcia, this resource will become a go-to guide for researchers in the field of cognitive neuroscience and addiction. - Examines cognitive neuroscience advances in addiction theory, including both substance and behavioral addictions - Discusses primary principles of cutting-edge assessment, phenotyping and treatment tools - Includes detailed chapters on neuro-epidemiology and genetic imaging

Guidelines for the Treatment of Alcohol Problems

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Publisher : Specialty of Addiction Medicine, Faculty of Medicine and Health, The University of Sydney
ISBN 13 : 1742104894
Total Pages : 408 pages
Book Rating : 4.7/5 (421 download)

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Book Synopsis Guidelines for the Treatment of Alcohol Problems by : Paul S. Haber

Download or read book Guidelines for the Treatment of Alcohol Problems written by Paul S. Haber and published by Specialty of Addiction Medicine, Faculty of Medicine and Health, The University of Sydney. This book was released on 2021-04-01 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Australian Guidelines for the Treatment of Alcohol Problems have been periodically developed over the past 25 years. In 1993, the first version of these guidelines, titled: ‘An outline for the management of alcohol problems: Quality assurance in the treatment of drug dependence project’ was published (Mattick & Jarvis 1993). The Australian Government commissioned an update a decade later (Shand et al. 2003) and a further edition in 2009 to integrate the Guidelines with the Australian Guidelines to Reduce Health Risks from Drinking Alcohol (National Health and Medical Research Council, NHMRC 2009; Haber et al., 2009). The present version of the Guidelines was also commissioned by the Commonwealth of Australia to remain current and integrated with the updated NHMRC consumption guidelines (2020). In order to ensure that guidelines remain relevant, the next set of guidelines should be updated in 2025, consistent with NHMRC recommendation that guidelines be updated every five years. These guidelines aim to provide up-to-date, evidence-based information to clinicians on available treatments for people with alcohol problems and are largely directed towards individual clinicians in practice, such as primary care physicians (general practitioners, nursing staff), specialist medical practitioners, psychologists and other counsellors, and other health professionals. Some chapters highlight service or system level issues that impact on clinicians and their patients. These include recommendations concerning Aboriginal and Torres Strait Islander peoples, culturally and linguistically diverse groups, stigma, and discrimination. Elsewhere, organisation capacity is implied, such as medical resources for withdrawal management where recommendations indicate use of medications. As all forms of treatment will not be readily available or suitable for all populations or settings, these guidelines may require interpretation and adaptation.

Internet Gaming Disorder

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Publisher : Academic Press
ISBN 13 : 0128129255
Total Pages : 296 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Internet Gaming Disorder by : Daniel King

Download or read book Internet Gaming Disorder written by Daniel King and published by Academic Press. This book was released on 2018-07-18 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Internet Gaming Disorder: Theory, Assessment, Treatment, and Prevention is an informative and practical introduction to the topics of Internet gaming disorder and problematic gaming. This book provides mental health clinicians with hands-on assessment, prevention, and treatment techniques for clients with problematic gaming behaviors and Internet gaming disorder. It provides an overview of the existing research on epidemiology, risk and protective factors, and discusses the distinct cognitive features that distinguish gaming from gambling and other related activities and disorders. Clinicians will find interest in discussion of the latest developments in cognitive-behavioral approaches to gaming disorder as well as the best structure for clinical interviews. Included in clinical sections are details of the key indicators of harm and impairment associated with problem gaming and how these might present in clinical cases. Internet Gaming Disorder is strongly evidence-based, draws extensively upon the latest international research literature, and provides insights into the likely future developments in this emerging field both in terms of technological development and new research approaches. - Discusses the conceptual basis of Internet gaming disorder as a behavioral addiction - Provides screening approaches for measuring excessive gaming - Details a structured clinical interview approach for assessing gaming disorder - Provides evidence-based clinical strategies for prevention and treatment - Covers cognitive behavioral therapy and harm reduction strategies

Textbook of Addiction Treatment

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Publisher : Springer Nature
ISBN 13 : 3030363910
Total Pages : 1512 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Textbook of Addiction Treatment by : Nady el-Guebaly

Download or read book Textbook of Addiction Treatment written by Nady el-Guebaly and published by Springer Nature. This book was released on 2020-11-03 with total page 1512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addiction is increasingly being recognized as a major global public health issue, and an ever-growing number of medical specialties, psychological and social science training programs, and professional associations are including addiction as part of their training and continuing education curricula. The first edition of this book presented an overview of the spectrum of addiction-related problems across different cultures around the globe. Sharing the experience and wisdom of more than 260 leading experts in the field, and promoted by the International Society of Addiction Medicine, it compared and contrasted clinical practices in the field of addiction medicine on the basis of neurobiological similarities as well as epidemiological and socio-cultural differences. Building on the success of this inaugural edition, and taking into account the formal and informal comments received as well as an assessment of current need, this textbook presents general updated information while retaining the most requested sections of the first edition as demonstrated by the number of chapter downloads. It also provides a basic text for those preparing for the ISAM annual certification exam. Written by some 220 international experts, it is a valuable reference resource for anyone interested in medicine, psychology, nursing, and social science.

Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis

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Publisher : Frontiers Media SA
ISBN 13 : 2889459500
Total Pages : 189 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis by : Karl Bechter

Download or read book Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis written by Karl Bechter and published by Frontiers Media SA. This book was released on 2019-08-12 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.