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Author : PJ. LEWI
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)
Download or read book TOXICOLOGY REFERENCE DATA: WISTAR RAT (Volume 4). written by PJ. LEWI and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul J. Lewi
Publisher : Elsevier-North-Holland Biomedical Press
ISBN 13 : 9780444803429
Total Pages : 358 pages
Book Rating : 4.8/5 (34 download)
Download or read book Toxicology Reference Data, Wistar Rat written by Paul J. Lewi and published by Elsevier-North-Holland Biomedical Press. This book was released on 1981-01-01 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul J. Lewi
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (163 download)
Download or read book Toxicology reference data - wistar rat. Body and organ weights, biochem. determinations, hematology and urinalysis, compiled at Janssen Pharmaceutica written by Paul J. Lewi and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Andrew W. Suttie
Publisher : Academic Press
ISBN 13 : 0123914892
Total Pages : 750 pages
Book Rating : 4.1/5 (239 download)
Download or read book Boorman's Pathology of the Rat written by Andrew W. Suttie and published by Academic Press. This book was released on 2017-12-01 with total page 750 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. Contains full, four color photographs from the NTP archive and database and coverage of all rat strains Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes Includes comprehensive and detailed background incidence data Presents detailed descriptive content regarding changes in rat models during research
Author : Mary J Tucker
Publisher : CRC Press
ISBN 13 : 0748405216
Total Pages : 269 pages
Book Rating : 4.7/5 (484 download)
Download or read book Dieseases of the Wistar Rat written by Mary J Tucker and published by CRC Press. This book was released on 1997-05-21 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a complete account of this particular rat strain. The book includes extensive data on reproductive indices, congenital abnormalities, growth, clinical signs, mortality, organ weights and chemical pathology. The data are derived from around 9000 control animals used in toxicology studies of two weeks to two years duration, completed between 1960 and 1992, and include 24 two-year studies and one life-span study of a 51 month duration. These extended periods of study have shown that many diseases are seen more frequently in later years.; Diseases are dealt with by body system and include clinical signs, macroscopic features and histopathology illustrations of the important or unusual diseases. Incidence levels are provided for all diseases and these are compared with published data for other rat strains.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309171474
Total Pages : 167 pages
Book Rating : 4.3/5 (91 download)
Download or read book Microbial Status and Genetic Evaluation of Mice and Rats written by National Research Council and published by National Academies Press. This book was released on 2000-10-30 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: US/Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US/Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes. In addition to these publications, the meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats. In cooperation with the Comparative Medicine section of NCRR/NIH, the ILAR Council and staff are pleased to become the host for this important annual meeting and look forward to participating in future meetings. The support and sponsorship of NCRR (P40 RR 11611) in the United States and the Central Institute for Experimental Animals in Japan are gratefully acknowledged. Bringing together the leading scientists in the field of laboratory animal care has resulted in increased understanding of American and Japanese approaches to laboratory animal science and should continue to strengthen efforts to harmonize approaches aimed at resolving common challenges in the use of animal models for biomedical research and testing. This effort to improve understanding and cooperation between Japan and the United States should also be useful in developing similar interaction with other regions of the world including Europe, Australia, and Southeast Asia.
Author : Fritz P. Gluckstein
Publisher :
ISBN 13 :
Total Pages : 28 pages
Book Rating : 4.:/5 (319 download)
Download or read book Reference Data of Common Laboratory Animals written by Fritz P. Gluckstein and published by . This book was released on 1987 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael J. Paidas
Publisher : John Wiley & Sons
ISBN 13 : 1444347926
Total Pages : 232 pages
Book Rating : 4.4/5 (443 download)
Download or read book Hemostasis and Thrombosis in Obstetrics and Gynecology written by Michael J. Paidas and published by John Wiley & Sons. This book was released on 2011-07-05 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproductive hemostasis: A global approach to a global challenge A hemostatic change in women through their reproductive lifetime is emerging as an issue of global importance. No wonder, as obstetric hemorrhage remains a major cause of maternal mortality in both developed and developing countries. Thrombophilias and pulmonary embolisms are a threat to maternal and fetal well-being. Hemostasis and Thrombosis in Obstetrics & Gynecology provides a framework for assessing and managing hemostatic disorders in women. Written by an international team, it provides globally applicable guidelines for obstetric hematology. The practical approach to clinical management includes: Hematologic changes in pregnancy Red cell disorders Platelet disorders Inherited and acquired thrombophilia Inherited bleeding disorders Postpartum hemorrhage Blood and bleeding disorders in women can be managed by obstetrician-gynecologists or hematologists, separately or together. Hemostasis and Thrombosis in Obstetrics & Gynecology provides specialists from both disciplines with the information necessary to manage their patients effectively.
Author : Elizabeth Fiona McInnes
Publisher : Elsevier Health Sciences
ISBN 13 : 0702049247
Total Pages : 256 pages
Book Rating : 4.7/5 (2 download)
Download or read book Background Lesions in Laboratory Animals E-Book written by Elizabeth Fiona McInnes and published by Elsevier Health Sciences. This book was released on 2011-10-24 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals a chapter on common artifacts that may be observed in histological glass slides extensive references to each lesion described aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies
Author : P.L. Chambers
Publisher : Springer Science & Business Media
ISBN 13 : 3642685110
Total Pages : 398 pages
Book Rating : 4.6/5 (426 download)
Download or read book New Toxicology for Old written by P.L. Chambers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system is in the most cases a likely target for the untoward effects of chemicals. The harmful consequences affect primarily the individual but may also considerably strain the whole society. The consumption of ethanol is a glaring example (National Institute on Alcohol Abuse and Alcoholism 1978). As ethanol, many organic liquids have similar immediate effects on the nervous system. The rapidity of the response suggests the involvement of the neuronal communication. The nervous system is also vulnerable to the depletion of oxygen, another common cause for the rapid deterioration of the brain function. It is quite impossible to list all the effects produced by the very large number of the individual chemicals. It would be more fruitful to try to understand the characteristics of the nervous system and the biochemical toxic mechanisms in the evaluation of the neurotoxicity of chemicals. Transfer of Xenobiotics in the Brain The adult central nervous system displays a functional barrier toward the blood-borne chemicals so that water-soluble compounds with an approximate molecular weight above 100 are largely prevented from directly entering the brain (Bradbury 1979). The functional barrier has morphological features typical to it and has a very close association of adjacent capillary cells separated by clefts of 12 A wide (Jacobs 1978). The nervous system capillaries are enveloped by glial cell tongues, and these pericytes contain contractile elements (Le Beux and Willemot 1978a, b) so that the capillaries can be constricted.
Author : Robert L. Maynard
Publisher : Academic Press
ISBN 13 : 0128118717
Total Pages : 378 pages
Book Rating : 4.1/5 (281 download)
Download or read book Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research written by Robert L. Maynard and published by Academic Press. This book was released on 2019-02-08 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research presents the detailed systematic anatomy of the rat, with a focus on toxicological needs. Most large works dealing with the laboratory rat provide a chapter on anatomy, but fall far short of the detailed account in this book which also focuses on the needs of toxicologists and others who use the rat as a laboratory animal. The book includes detailed guides on dissection methods and the location of specific tissues in specific organ systems. Crucially, the book includes classic illustrations from Miss H. G. Q. Rowett, along with new color photo-micrographs. Written by two of the top authors in their fields, this book can be used as a reference guide and teaching aid for students and researchers in toxicology. In addition, veterinary/medical students, researchers who utilize animals in biomedical research, and researchers in zoology, comparative anatomy, physiology and pharmacology will find this book to be a great resource. Illustrated with over 100 black and white and color images to assist understanding Contains detailed descriptions and explanations to accompany all images, thus helping with self-study Designed for toxicologic research for people from diverse backgrounds, including biochemistry, pharmacology, physiology, immunology and general biomedical sciences
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309051266
Total Pages : 188 pages
Book Rating : 4.3/5 (9 download)
Download or read book Nutrient Requirements of Laboratory Animals, written by National Research Council and published by National Academies Press. This book was released on 1995-02-01 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309171938
Total Pages : 534 pages
Book Rating : 4.3/5 (91 download)
Download or read book Toxicological Risks of Selected Flame-Retardant Chemicals written by National Research Council and published by National Academies Press. This book was released on 2000-07-06 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ignition of upholstered furniture by small open flames from matches, cigarette lighters, and candles is one of the leading causes of residential-fire deaths in the United States. These fires accounted for about 16% of civilian fire deaths in 1996. On average, each year since 1990, about 90 deaths (primarily of children), 440 injuries, and property losses amounting to 50 million dollars have resulted from fires caused by the ignition of upholstered furniture by small open flames. Certain commercial seating products (such as aircraft and bus seats) are subject to flammability standards and sometimes incorporate FR-treated upholstery cover materials, but there is no federal-government requirement for residential upholstered furniture, and it is generally not treated with FR chemicals. It is estimated that less than 0.2% of all U.S. residential upholstery fabric is treated with flame-retardant (FR) chemicals. The Consumer Product Safety Act of 1972 created the U.S. Consumer Product Safety Commission (CPSC) as an independent federal regulatory agency whose mission is to protect the public from unreasonable risks of injury and death associated with consumer products. CPSC also administers the Flammable Fabrics Act, under which it regulates flammability hazards and the Federal Hazardous Substances Act (FHSA), which regulates hazardous substances including chemicals. In 1993, the National Association of State Fire Marshals petitioned CPSC to issue a performance-based flammability standard for upholstered furniture to reduce the risk of residential fires. The Commission granted that portion of the petition relating to small open flame ignition risks. In response to concerns regarding the safety of FR chemicals, Congress, in the fiscal year 1999 appropriations report for CPSC, requested that the National Research Council conduct an independent study of the health risks to consumers posed by exposure to FR chemicals that are likely to be used in residential upholstered furniture to meet a CPSC standard. The National Research Council assigned the project to the Committee on Toxicology (COT) of the Commission on Life Sciences' Board on Environmental Studies and Toxicology. COT convened the Subcommittee on Flame-Retardant Chemicals, which prepared this report. Subcommittee members were chosen for their recognized expertise in toxicology, pharmacology, epidemiology, chemistry, exposure assessment, risk assessment, and biostatistics. Toxicological Risks of Selected Flame-Retardant Chemicals is organized into 18 chapters and two appendices. Chapter 2 describes the risk assessment process used by the subcommittee in determining the risk associated with potential exposure to the various FR chemicals. Chapter 3 describes the method the subcommittee used to measure and estimate the intensity, frequency, extent, and duration of human exposure to FR chemicals. Chapters 4-19 provide the subcommittee's review and assessment of health risks posed by exposure to each of the 16 FR chemicals. Data gaps and research needs are provided at the end of these chapters.
Author :
Publisher :
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.3/5 (91 download)
Download or read book Toxicological Profile for Nitrophenols written by and published by . This book was released on 1992 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Byron J. T. Morgan
Publisher : Oxford University Press
ISBN 13 : 9780198523291
Total Pages : 250 pages
Book Rating : 4.5/5 (232 download)
Download or read book Statistics in Toxicology written by Byron J. T. Morgan and published by Oxford University Press. This book was released on 1996 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of papers on aspects of statistics in toxicology is will be of interest to all medical statisticians. It offers findings from numerous leading experts from around the world including A. Whitehead and R. N. Connor (University of Reading), L. Ryan (Harvard), A. P. Grieve (Pfizer Research), K.J. Risko (Northern Telecom), and B.H. Margolin (University of North Carolina). This is the latest in the popular Royal Statistical Society Lecture Series, and will be essential reading for all those involved in this area.
Author : C. Gopinath
Publisher : Springer Science & Business Media
ISBN 13 : 9400931891
Total Pages : 448 pages
Book Rating : 4.4/5 (9 download)
Download or read book Atlas of Experimental Toxicological Pathology written by C. Gopinath and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our aim in producing a colour atlas of toxicological guidelines itemize the investigations to be carried out pathology was to present a catalogue of histopathologi during the course of the study and they normally include: cal lesions which we had encountered over the years in clinical observations and behaviour; food intake and body various laboratory animal species exposed to a vast weight measurements; serum biochemistry; haema range of pharmaceuticals, agrochemicals and industrial tology; ECG and ophthalmology. At the end of a study, chemicals. While we believe a colour atlas is the ideal full macroscopic and microscopic examinations of the way to share our experiences with others, it quickly organ weight analyses together with tissues are essen became clear to us that for the atlas to be meaningful tial. By far the greater part of the material used in this the associated text must be comprehensive and contain book is from toxicity studies conducted in recent years ample literature references. and performed in compliance with the Good Laboratory The atlas is intended for both the trainee and the Practice standards of governmental regulatory bodies in experienced toxicological pathologist working with lab Europe, Japan and North America. oratory animals in the pharmaceutical, agrochemical or Toxicity studies are commonly carried out in rats, chemical environment.
Author : R. Greger
Publisher : Springer Science & Business Media
ISBN 13 : 3642681476
Total Pages : 325 pages
Book Rating : 4.6/5 (426 download)
Download or read book Renal Transport of Organic Substances written by R. Greger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of reviews on the renal transport of organic substances. The first chapters deal with general aspects of the topic. The following articles treat the present knowledge on the renal trans port of specific compounds or classes of organic substances, whereas the fmal chapter on comparative physiology deals with the renal trans port of organic substances in non-mammalian vertebrates. The articles of this volume were presented in an abbreviated form as introductory lectures at a recent Symposium on Renal Transport of Organic Substances. This conference was organized by Prof. Deetjen and the editors, and was held in Innsbruck, Austria, in July 1980 at the Department of Physiology of the University of Innsbruck. During this conference the authors of the free communications (published as abstracts ill Renal Physiology, 2 (3), pp 135-166 (1980) as well as Drs. C. Gottschalk, T. Hoshi, K.C. Huang, J.P. Kokko, Ch. de Rouffignac, K. Scharer, BM. Schmidt-Nielsen, and J.A. Young, who acted as chair persons at the meeting, were invaluable contributors to the discussions of the topics reviewed in this volume. We hope that the book will be of value to nephrologists, to renal physiologists, and to those who are involved in teaching physiology, pharmacology, and internal medicine.
