Toxicity Report On Toxicity Studies Of Wy 14643 Cas No 50892 23 4 Administered In Feed To Male Sprague Dawley Rats B6c3f1 Mice And Syrian Hamsters

Author : Michael L. Cunningham
Publisher : DIANE Publishing
ISBN 13 : 1428988130
Total Pages : 90 pages
Book Rating : 4.4/5 (289 download)

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Download or read book Toxicity Report on Toxicity Studies of Wy-14,643 (CAS NO. 50892-23-4) Administered in Feed to Male Sprague-Dawley Rats, B6C3F1 Mice, and Syrian Hamsters written by Michael L. Cunningham and published by DIANE Publishing. This book was released on 2008-03 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wyeth-14,643 is a chemical that was developed by the pharmaceutical industry to lower serum cholesterol. It is not used in clinical applications. This study examined the effects of Wyeth-14,643 on rats, mice, & hamsters because it was known that this chemical promotes the production of peroxisomes, organelles that contain a variety of enzymes involved in metabolism of lipids & cholesterols. Results show that exposure to Wyeth-14,6453 caused changes in the livers of male rats, mice, & hamsters, including increased liver weights, increases in cytoplasmic alteration of the liver, & some liver foci. Wyeth-14,643 also had effects on the testes of exposed male rodents, decreasing the spermatid counts & the weights of the cauda epididymis. Illus.