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Toward A Total Synthesis Of Amphidinolide P And Related Studies
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Book Synopsis Toward a Total Synthesis of (+)-amphidinolide P and Related Studies by : Jens-Martin Herold
Download or read book Toward a Total Synthesis of (+)-amphidinolide P and Related Studies written by Jens-Martin Herold and published by . This book was released on 2008 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Finally, novel palladium-catalyzed conjugate additions of organozinc reagents to alpha,beta-unsaturated aldehydes are discussed. This methodology can be diastereoselective and can be used for the selective preparation of (E)-silyl enol ethers. The palladium-catalyzed reaction is also compared to its copper-catalyzed counterpart.
Book Synopsis Studies Toward the Synthesis of the Amphidinolides by : Brian J. Myers
Download or read book Studies Toward the Synthesis of the Amphidinolides written by Brian J. Myers and published by . This book was released on 2000 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of Amphidinolides O and P by : Matthew A. Foster
Download or read book Studies Towards the Total Synthesis of Amphidinolides O and P written by Matthew A. Foster and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis of Amphidinolide B1 by : Wei Zhang
Download or read book Synthetic Studies Toward the Total Synthesis of Amphidinolide B1 written by Wei Zhang and published by . This book was released on 2006 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward Total Synthesis of Amphidinolide A by : Yan Yu
Download or read book Studies Toward Total Synthesis of Amphidinolide A written by Yan Yu and published by . This book was released on 2001 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of the Amphidinolide C Family of Natural Products by : Andrew P. Osnowski
Download or read book Studies Towards the Total Synthesis of the Amphidinolide C Family of Natural Products written by Andrew P. Osnowski and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Towards the Total Synthesis of Amphidinolide F. by : Daniel A. Mills
Download or read book Towards the Total Synthesis of Amphidinolide F. written by Daniel A. Mills and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Total Syntheses of Amphidinolides C and F by : Michael J. McCoy
Download or read book Studies Toward the Total Syntheses of Amphidinolides C and F written by Michael J. McCoy and published by . This book was released on 2007 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Towards the Total Synthesis and Structural Assignment of Amphidinolide N and Caribenolide I by : William E. Brenzovich (Jr.)
Download or read book Progress Towards the Total Synthesis and Structural Assignment of Amphidinolide N and Caribenolide I written by William E. Brenzovich (Jr.) and published by . This book was released on 2008 with total page 916 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis of the Hydrophobic Domain of the Amphidinolide B-type Isomers by : Hugo M. Eng
Download or read book Synthetic Studies Toward the Total Synthesis of the Hydrophobic Domain of the Amphidinolide B-type Isomers written by Hugo M. Eng and published by . This book was released on 1994 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Towards the Total Synthesis of Amphidinolide T Family by : Flavien Labre
Download or read book Towards the Total Synthesis of Amphidinolide T Family written by Flavien Labre and published by . This book was released on 2012 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amphidinolides T are challenging natural targets for the total synthesis community because of their unique structural architecture. This thesis describes the investigations of the establishment of a novel and convenient route to synthesise four members of the natural product family, amphidinolides T1 and T3-5, from a common late-stage intermediate. The key transformations towards the synthetic pathway are ring formation reactions. The trans-tetrahydrofuran ring is forged efficiently via diastereoselective [2,3]-sigmatropic rearrangement of an oxonium ylide from diazo-generated metal carbenoids. Coupling of a side chain is achieved using a sequence of esterification and RCM reactions. Alternatively, a one-pot RCM followed by hydrogenation is described to shorten the synthetic route.
Book Synopsis Progress Towards the Total Synthesis of the Potent Antitumor Antibiotic Amphidinolide C by : Jesse D. Carrick
Download or read book Progress Towards the Total Synthesis of the Potent Antitumor Antibiotic Amphidinolide C written by Jesse D. Carrick and published by . This book was released on 2004 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Directed Toward the Total Synthesis of Pseudolarolide E by : Matthieu Barragué
Download or read book Studies Directed Toward the Total Synthesis of Pseudolarolide E written by Matthieu Barragué and published by . This book was released on 2001 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applied Cross-Coupling Reactions by : Yasushi Nishihara
Download or read book Applied Cross-Coupling Reactions written by Yasushi Nishihara and published by Springer Science & Business Media. This book was released on 2012-12-14 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Applied Cross-Coupling Reactions” provides students and teachers of advanced organic chemistry with an overview of the history, mechanisms and applications of cross-coupling reactions. Since the discovery of the transition-metal-catalyzed cross-coupling reactions in 1972, numerous synthetic uses and industrial applications have been developed. The mechanistic studies of the cross-coupling reactions have disclosed that three fundamental reactions: oxidative addition, transmetalation, and reductive elimination, are involved in a catalytic cycle. Cross-coupling reactions have allowed us to produce a variety of compounds for industrial purposes, such as natural products, pharmaceuticals, liquid crystals and conjugate polymers for use in electronic devices. Indeed, the Nobel Prize for Chemistry in 2010 was awarded for work on cross-coupling reactions. In this book, the recent trends in cross-coupling reactions are also introduced from the point of view of synthesis design and catalytic activities of transition-metal catalysts.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2006 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Part I: Total Synthesis of Marine Macrolide Amphidinolide F and Synthetic Studies Toward Amphidinolide C by : Subham Mahapatra
Download or read book Part I: Total Synthesis of Marine Macrolide Amphidinolide F and Synthetic Studies Toward Amphidinolide C written by Subham Mahapatra and published by . This book was released on 2013 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework of amphidinolide C has been synthesized. During endeavor toward the total syntheses of amphidinolides F / C, we have uncovered a "hidden symmetry element" present in the northern and southern domains of amphidinolides F / C. The southern C1-C and northern C1-C25 tetrahydrofuran segments were derived from a common intermediate. A scalable silver-catalyzed isomerization / cyclization on propargyl-benzoate / diol furnished the common intermediate in multigram quantity. The common intermediate provided access to over half of carbon backbone of the macrocycle as well as majority of stereochemistry present in amphidinolides F / C. Two strategically different techniques have been developed for the C9-C11 diene preparation. A metal-catalyst free Weinreb amide-vinyl lithium coupling / methylenation sequence furnished the diene motif. Alternately, diastereoselective addition of a dienyl iodide derived 2-lithio-1,3-diene species to an [alpha]-oxy aldehyde installed the C9-C11 diene and secured the C8 stereochemistry in single operation. The dienyl iodide was prepared via a regioselective hydrostannylation on an enyne. A challenging alkylation between an [alpha]-branched sulfone and an [alpha]-silyloxy iodide generated the all-carbon frameworks of amphidinolides F / C. An efficient oxidative desulfurization incorporated the carbonyl moiety at C15. The protecting group on C18 alcohol was found to have significant effect on the sulfone-iodide alkylation / oxidative desulfurization sequence. Installation of chelating ethoxyethyl ether on C18 alcohol helped the successful incorporation of C15 ketone and solved the deprotection problem in advanced stage of synthesis. A detailed analytical and computational study on proline sulfonamide-catalyzed aldol reactions has been performed. The pKa value of a proline sulfonamide catalyst was determined experimentally via NMR titration technique. Computational study revealed the origin of enhanced stereoselectivity by proline sulfonamide catalysts over parent proline. The non-classical hydrogen bonding interactions were found to be responsible for improved diastereoselectivity.
Book Synopsis Part One. Studies Directed Toward a Total Synthesis of (±)-dendrobine by : David N. Ridge
Download or read book Part One. Studies Directed Toward a Total Synthesis of (±)-dendrobine written by David N. Ridge and published by . This book was released on 1976 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
