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Theoretical And Synthetic Investigations Into The Intramolecular Diels Alder Reaction
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Book Synopsis Theoretical and Synthetic Investigations Into the Intramolecular Diels-Alder Reaction by : Tory Nathan Cayzer
Download or read book Theoretical and Synthetic Investigations Into the Intramolecular Diels-Alder Reaction written by Tory Nathan Cayzer and published by . This book was released on 2004 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies of the Intramolecular Diels-Alder Reaction by : Joseph Scott Warmus Warmus
Download or read book Synthetic Studies of the Intramolecular Diels-Alder Reaction written by Joseph Scott Warmus Warmus and published by . This book was released on 1990 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Diels-Alder Reaction by : Francesco Fringuelli
Download or read book The Diels-Alder Reaction written by Francesco Fringuelli and published by John Wiley & Sons. This book was released on 2002-01-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: 70 Jahre Forschung an der Diels-Alder-Reaktion: Dieses Buch fasst die wichtigsten und beeindruckendsten Ergebnisse in einzigartiger Weise zusammen! Zunächst werden die Grundprinzipien der Reaktion klar und verständlich anhand übersichtlicher Graphiken erläutert. Spezielle Vorschriften und gegebenenfalls ihre industrielle Umsetzung werden anschließend erklärt. Einen Schwerpunkt bilden auch physikalische und katalytische Verfahren zur Steigerung der Selektivität der Reaktion. Cycloadditionen in konventionellen und unkonventionellen Medien werden vorgestellt. Mit über 1.000 Literaturverweisen!
Book Synopsis Studies on the Intramolecular Diels-Alder Reaction by : Geoff T. Halvorsen
Download or read book Studies on the Intramolecular Diels-Alder Reaction written by Geoff T. Halvorsen and published by . This book was released on 2012 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intramolecular Diels-Alder reaction is widely recognized as a powerful and versatile method for the assembly of complex bicyclic structures in synthetic organic chemistry and has been utilized as a key step in the total syntheses of a number of interesting biologically active natural products. We have studied the use of siloxacyclopentene constrained trienes as a method to control diastereofacial selectivity in the intramolecular Diels-Alder reaction. The siloxacyclopentene constraints could be formed under mild conditions and attached to either the diene or dienophile units of a variety of trienes. These constrained trienes underwent intramolecular Diels-Alder reactions to give cycloadducts with the oxygen contained in the siloxacyclopentene exclusively in an anti-configuration relative to the ring fusion proton. Suitably chosen dienophile activating groups and optimized conditions for cyclization allowed for high levels of selectivity for either cis - or trans -fused cycloadducts in the case of siloxacyclopentenes contained within the diene, while siloxacyclopentenes constraints attached at the dienophile gave exclusively the trans-fused cycloadducts. A siloxacyclopentene constrained tetraene was then utilized in a concise, stereoselective synthesis of the decahydrofluorene core common to the hirsutellones. Synthetic efforts targeting the completion of the hirsutellones via a common biosynthetic intermediate were pursued utilizing a macrobenzannulation strategy. This strategy was abandoned due to inability to prepare a suitable benzannulation precursor. Later a strategy of first forming a five membered ring containing analogue was also pursued, but failed due to an inability to convert a suitable ester to the corresponding furan or thiophene.
Book Synopsis Strategic Applications of Named Reactions in Organic Synthesis by : Laszlo Kurti
Download or read book Strategic Applications of Named Reactions in Organic Synthesis written by Laszlo Kurti and published by Elsevier. This book was released on 2005-04-29 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. - The first reference work on named reactions to present colored schemes for easier understanding - 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples - An opening list of abbreviations includes both structures and chemical names - Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works - Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools - Extensive index quickly locates information using words found in text and drawings
Book Synopsis Cycloaddition Reactions in Organic Synthesis by : W. Carruthers
Download or read book Cycloaddition Reactions in Organic Synthesis written by W. Carruthers and published by Elsevier. This book was released on 2013-10-22 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demonstrates the wide scope of cycloaddition reactions, including the Diels-Alder reaction, the ene reaction, 1,3-dipolar cycloadditions and [2+2] cycloadditions in organic synthesis. The author, a leading exponent of the subject, illustrates the ways in which they can be employed in the synthesis of a wide range of carbocyclic and heterocyclic compounds, including a variety of natural products of various types. Special attention is given to intramolecular reactions, which often provide a rapid and efficient route to polycyclic compounds, and to the stereochemistry of the reactions, including recent and developing work on enantioselective synthesis.
Book Synopsis Intramolecular Diels-Alder and Alder Ene Reactions by : Douglass F. Taber
Download or read book Intramolecular Diels-Alder and Alder Ene Reactions written by Douglass F. Taber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Diels-Alder reaction has long been a powerful tool in organic synthesis. In recent years, the Alder ene reaction has also achieved some prominence. From the beginning, it was apparent that the intramolecular variants of these reactions would be feasible. Many such have been reported, but the results are widely scattered in the chemical literature. This volume is an attempt to synthesize results observed to date, and to suggest directions for future development. One of the limiting factors in the application of the intramolecular Diels Alder reaction has been the development of methods for the preparation of the requisite trienes. The fIrst chapter of this volume summarizes methods for the preparation of dienes and dienophiles. Examples representative of every general approach to 1,3-dienes and to dienophilic functional group combinations have been included. There are two questions one might ask in considering the prospective cyclization of a given triene: what are the factors that govern the rate of cyclization? and, for cyclizations that lead to the creation of one or more new chiral centers, what are the factors that govern diastereoselectivity? These questions are addressed in Chapter Two. The third chapter is devoted to the all-carbon intramolecular Alder ene reaction. The tables in that chapter summarize all examples that could be found in the literature through 1981, with several additional examples from 1982. Leading references to heterocyclic ene reactions are also included in this chapter.
Book Synopsis Theoretical Studies on Synthetically Relevant Reactions in Organic Chemistry by : Selina Ching-Hsuan Wang
Download or read book Theoretical Studies on Synthetically Relevant Reactions in Organic Chemistry written by Selina Ching-Hsuan Wang and published by . This book was released on 2008 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Intramolecular Diels-alder Reactions in Organic Synthesis by : Nicholas Blandford Luke Sizemore
Download or read book Intramolecular Diels-alder Reactions in Organic Synthesis written by Nicholas Blandford Luke Sizemore and published by . This book was released on 2014 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intramolecular Diels-Alder (IMDA) reactions are an important class of reactions in synthetic organic chemistry for the rapid construction of polycyclic frameworks. Three classes of IMDA reactions were investigated synthetically and computationally: 1) all-carbon type 1 IMDA reactions, 2) N-acylnitroso type 2 IMDA reactions, and 3) cyano-azadiene IMDA reactions. The first class was implemented in research toward the total synthesis of maoecrystal Z and isopalhinine A. The second class was studied computationally to understand the origins of regio- and stereochemistry in these reactions. The third class was investigated in the context of indolizine and quinolizidine synthesis.
Book Synopsis Synthetic Applications of the Intramolecular Diels-Alder Reaction by : Tadas S. Macas
Download or read book Synthetic Applications of the Intramolecular Diels-Alder Reaction written by Tadas S. Macas and published by . This book was released on 1984 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigations Into the Zipper-mode Domino Intramolecular Diels-Alder Reaction by : Marck Nørret
Download or read book Investigations Into the Zipper-mode Domino Intramolecular Diels-Alder Reaction written by Marck Nørret and published by . This book was released on 2003 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Part I: A Convergent Synthetic Scheme to Quassin by : Colleen Joan Northcott
Download or read book Part I: A Convergent Synthetic Scheme to Quassin written by Colleen Joan Northcott and published by . This book was released on 1983 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Study of the Intramolecular Diels-Alder Reaction and Its Application to the Natural Product Synthesis by : David Tung Mao
Download or read book A Study of the Intramolecular Diels-Alder Reaction and Its Application to the Natural Product Synthesis written by David Tung Mao and published by . This book was released on 1980 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applications of the Type 2 Intramolecular Diels--Alder Reaction by : Ryan Mark Lauchli
Download or read book Applications of the Type 2 Intramolecular Diels--Alder Reaction written by Ryan Mark Lauchli and published by . This book was released on 2007 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis More Dead Ends and Detours by : Miguel A. Sierra
Download or read book More Dead Ends and Detours written by Miguel A. Sierra and published by John Wiley & Sons. This book was released on 2013-07-11 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Success comes in many forms and in synthesis it can be a failure that results in their ultimate successful solutions. This long-awaited sequel to "Dead Ends and Detours" retains the proven concept while featuring over 20 new case studies of failed strategies and their (successful) solutions in natural product total synthesis. Additionally, computational models are used to discuss the problem in much more detail and to provide readers with additional information not found in the primary literature. The topics range from classic synthetic reactions (e.g. Diels Alder reaction), metal-mediated coupling reactions, metathesis, and asymmetric catalysis to the importance of protecting and activating groups. This book will benefit not only graduate students in organic chemistry but also advanced researchers as they gain knowledge derived from the step-by-step analysis of mistakes made in the past and, thus be able to improve their own chemical reaction planning. With its coverage of the most commonly applied reaction types, the book perfectly complements its predecessor, which focuses on general aspects, such as reactivity and selectivity.
Book Synopsis Investigations of the Type II Intramolecular Diels-Alder Reaction Directed Toward Natural Product Synthesis by : Andrew Clive Muscroft-Taylor
Download or read book Investigations of the Type II Intramolecular Diels-Alder Reaction Directed Toward Natural Product Synthesis written by Andrew Clive Muscroft-Taylor and published by . This book was released on 2006 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Deeper Understanding of the Diels-Alder Reaction by : William James Lording
Download or read book A Deeper Understanding of the Diels-Alder Reaction written by William James Lording and published by . This book was released on 2010 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Diels-Alder reaction was discovered in 1928 and has become the most efficient and practical method for the synthesis of six-membered carbocyclic and heterocyclic rings. This thesis comprises three chapters of results and discussion with the Diels-Alder reaction as a theme. Chapter 2 details an investigation of endo:exo selectivity in the Diels-Alder reactions of 1,3-butadiene. Chapter 3 explores aspects of the intramolecular Diels-Alder reactions of some substituted 1,3,8-nonatrienes, and Chapter 4 describes the domino Diels-Alder reactions of 1,4-diiodo-1,3-butadiene. The Diels-Alder reaction is powerful, general, and widely used in chemical synthesis, and it is well known that many Diels-Alder reactions exhibit endo selectivity, in accord with Alder's empirical rule. The origins of endo:exo selectivity in the Diels-Alder reaction, however, are not completely understood and there is a dearth of experimental evidence concerning the Diels-Alder reactions of the archetypal 1,3-diene, 1,3-butadiene. Chapter 2 describes a study of the Diels-Alder reactions of an isotopically labelled 1,3-butadiene with a range of simple dienophiles, allowing the endo:exo selectivities of these important reactions to be determined for the first time. The experimental data shed light on the origins of endo:exo selectivity in the Diels-Alder reaction and will serve as an important reference for future computational investigations in this area. The intramolecular Diels-Alder reaction shares many of the virtues of its intermolecular counterpart, however its use in chemical synthesis is limited because intramolecular Diels-Alder reactivity and stereoselectivity are often governed by subtle factors, and can be very difficult to predict. As part of a comprehensive experimental and computational collaboration, Chapter 3 describes an investigation of the heat and Lewis acid promoted intramolecular Diels-Alder reactions of some ether tethered 1,3,8-nonatrienes. Also presented are the results of a rate study and a kinetic isotope effect study involving the intramolecular Diels-Alder reactions of some 1,3,8-nonatrienes. The experimental data are analysed and compared with predicted stereoselectivities, activation barriers and kinetic isotope effects obtained from computational modelling. Increased efficiency in chemical synthesis conserves resources, reduces waste, and saves time and money. Domino reactions are particularly efficient processes, which can generate complex products from simple reactants. Chapter 4 describes an investigation of the domino Diels-Alder reactions of (1E,3E)-1,4-diiodo-1,3-butadiene with maleimide dienophiles, through which a family of bicyclo[2.2.2]oct-2-ene derivatives are produced in one high yielding and stereoselective synthetic step.
