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Theoretical And Experimental Insights Into Immunology
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Book Synopsis Theoretical and Experimental Insights into Immunology by : Alan S. Perelson
Download or read book Theoretical and Experimental Insights into Immunology written by Alan S. Perelson and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology is largely a science of observation and experimentation, and these approaches have lead to great increases in our knowledge of the genes, molecules and cells of the immune system. This book is an up-to-date discussion of the current state of modelling and theoretical work in immunology, of the impact of theory on experiment, and of future directions for theoretical research. Among the topics discussed are the function and evolution of the immune system, computer modelling of the humoral immune response and of idiotypic networks and idiotypic mimicry, T-cell memory, cryptic peptides, new views and models of AIDS and autoimmunity, and the shaping of the immune repertoire by early presented antigens and self immunoglobulin.
Book Synopsis Immunology: The Making of a Modern Science by : Richard B. Gallagher
Download or read book Immunology: The Making of a Modern Science written by Richard B. Gallagher and published by Elsevier. This book was released on 1995-07-14 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology has progressed in spectacular fashion in the last four decades. Studies of the response to infectious agents, transplanted organs and tumours (and the potential to manipulate that response), and the study of the immune system as a model system in molecular cell biology have yielded dramatic advances in our understanding of the mechanisms of immunity.The field has attracted a continuous stream of the brightest theoretical and experimental scientists for over forty years. This book conveys the philosophies and approaches of sixteen of the most successful of these scientists in the form of a series of narratives that describe the circumstances that led to a major discovery in immunology. Contributors not only recall an exciting period of research that helped shape modern immunology, but set it in the personal context of place and time. Jacques Miller, for example, describes the discovery of the function of the thymus, Rolf Zinkernagel explains how experiments on viral immunity led to the discovery of MHC restriction and Susumu Tonegawa provides an account of how antibody gene structure was defined. Medically-important discoveries include descriptions of early studies of autoimmunity by Noel Rose and of tumour immunology by George and Eva Klein.Far from being a collection of disinterested, historical accounts, this volume comprises a series of passionately biographical, personal essays that provide an unusually intimate insight into the scientific process. This book will be essential, and fascinating, reading for all those with an interest in immunology, and in the life sciences in general. For students and teachers, this will provide the background necessary for a true understanding of immunology, and to place subsequent discoveries in perspective.
Book Synopsis Theoretical Immunology, Part One by : Alan S. Perelson
Download or read book Theoretical Immunology, Part One written by Alan S. Perelson and published by CRC Press. This book was released on 2018-03-05 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomena in different ways, the Sante Fe Institute and the Theoretical Division of Los Alamos National Laboratory cosponsored a workshop entitled "Theoretical Immunology". The workshop focused on themes spanning the field of immunology, with emphasis on areas where the theorists have made the most progress. This book covers the discussions a that workshop on the topics of immune surveillance, mathematical models of HIV infection, complexities of antigen-antibody systems, immune suppression and tolerance, and idiotypie networks. In each of these areas there is reason to believe that advances can be made either through interactions among experimentalists and theorists or through the critical look experimentalists and theorists will bring to bear upon one another's work.
Book Synopsis Rediscovering the Immune System as an Integrated Organ by : Peter Bretscher
Download or read book Rediscovering the Immune System as an Integrated Organ written by Peter Bretscher and published by FriesenPress. This book was released on 2016-01-29 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mainstream view of the immune system is concerned with molecular and cellular details resulting in a picture of immense complexity. Many immunologists live with this complexity, hoping that a series of breakthroughs will eventually add up to a greater insight. However, the forest is ignored for the trees and a ‘Systems Approach’ is vital for a better understanding. Peter Bretscher develops here a unique perspective on how the immune system functions as an integrated organ, by taking account of observations and concepts at the ‘level of system’ that are often half forgotten or ignored. A colleague, on reading this book, wrote: “Those who have followed Peter’s work these past 50 years will recognize this book for what it really is — a rare achievement, a scientific masterpiece. It is a must read for all those Immunologists and Clinicians who want to find effective immunological cures for the many debilitating health issues that confront us. Peter Bretscher has produced a lucid and logical exposition of the rules governing how the adaptive immune system responds to all foreign antigens whether bacterial, viral or modifications of the self, which emerge in cancer or autoimmune conditions. This book is a testament to Louis Pasteur’s dictum that there is no applied science, just the application of basic science.” Rediscovering the Immune System is written in a jargon-free and accessible style. This personal perspective is an ideal guide to the immune system for students, researchers and the engaged, general reader alike.
Book Synopsis Systems Theory in Immunology by : C. Bruni
Download or read book Systems Theory in Immunology written by C. Bruni and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume collects the contributions presented at the "Working Conference on System Theory in Immunology", held in Rome, May 1978. The aim of the Conference was to bring together immunologists on one side and experts in system theory and applied mathematics on the other, in order to identify problems of common interest and to establish a network of joint effort toward their solution. The methodologies of system theory for processing experimental data and for describing dynamical phenomena could indeed contribute significantly to the under standing of basic immunological facts. Conversely, the complexity of experimental results and of interpretative models should stimulate mathematicians to formulate new problems and to design appropriate procedures of analysis. The multitude of scientific publications in theoretical biology, appeared in recent years, confirms this trend and calls for extensive interaction between mat- matics and immunology. The material of this volume is divided into five sections, along the scheme of the Conference program.
Book Synopsis A Historical Perspective on Evidence-Based Immunology by : Edward J. Moticka
Download or read book A Historical Perspective on Evidence-Based Immunology written by Edward J. Moticka and published by Newnes. This book was released on 2015-11-25 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. - Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles - Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology - Presents concepts such as the division of lymphocytes into functionally different populations in their historical context - Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells
Book Synopsis Theoretical Immunology (part I) by : Alan Perelson
Download or read book Theoretical Immunology (part I) written by Alan Perelson and published by Westview Press. This book was released on 1988-01-21 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomen
Book Synopsis MATHEMATICAL MODELS OF LIFE SUPPORT SYSTEMS - Volume II by : Valeri I. Agoshko
Download or read book MATHEMATICAL MODELS OF LIFE SUPPORT SYSTEMS - Volume II written by Valeri I. Agoshko and published by EOLSS Publications. This book was released on 2009-10-10 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical Models of Life Support Systems is a component of Encyclopedia of Mathematical Sciences in which is part of the global Encyclopedia of Life Support Systems (EOLSS), an integrated compendium of twenty one Encyclopedias. The Theme is organized into several topics which represent the main scientific areas of the theme: The first topic, Introduction to Mathematical Modeling discusses the foundations of mathematical modeling and computational experiments, which are formed to support new methodologies of scientific research. The succeeding topics are Mathematical Models in - Water Sciences; Climate; Environmental Pollution and Degradation; Energy Sciences; Food and Agricultural Sciences; Population; Immunology; Medical Sciences; and Control of Catastrophic Processes. These two volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.
Book Synopsis Killer Cell Dynamics by : Dominik Wodarz
Download or read book Killer Cell Dynamics written by Dominik Wodarz and published by Springer Science & Business Media. This book was released on 2007-04-05 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews how mathematical and computational approaches can be useful to help us understand how killer T-cell responses work to fight viral infections. It also demonstrates, in a writing style that exemplifies the point, that such mathematical and computational approaches are most valuable when coupled with experimental work through interdisciplinary collaborations. Designed to be useful to immunoligists and viroligists without extensive computational background, the book covers a broad variety of topics, including both basic immunological questions and the application of these insights to the understanding and treatment of pathogenic human diseases.
Book Synopsis Theory And Control Of Dynamical Systems: Applications To Systems In Biology by : Stig I Andersson
Download or read book Theory And Control Of Dynamical Systems: Applications To Systems In Biology written by Stig I Andersson and published by World Scientific. This book was released on 1992-05-26 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the mathematical modeling of complex system behavior, dynamical systems play an increasing role. The flexibility and very rich phenomenology exhibited by such systems make them indispensible in this context. Control theory for dynamical systems is also a highly active field of research where a number of important results have been achieved recently.This combined course and workshop deals with recent results regarding dynamical systems and control theory, primarily in differential geometric terms as well as the applications of these fields to biological systems, with an emphasis on various aspects of the immune system and on neural networks.
Book Synopsis Handbook of Research on Artificial Immune Systems and Natural Computing: Applying Complex Adaptive Technologies by : Mo, Hongwei
Download or read book Handbook of Research on Artificial Immune Systems and Natural Computing: Applying Complex Adaptive Technologies written by Mo, Hongwei and published by IGI Global. This book was released on 2009-04-30 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book offers new ideas and recent developments in Natural Computing, especially on artificial immune systems"--Provided by publisher.
Book Synopsis Environmental Radiation Effects on Mammals by : Olga A. Smirnova
Download or read book Environmental Radiation Effects on Mammals written by Olga A. Smirnova and published by Springer. This book was released on 2016-10-14 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Smirnova's updated text is devoted to the theoretical studies of radiation effects on mammals. It summarizes 35 years of results the author obtained from analyzing dose rate equivalents for the Galactic Cosmic Rays (GCR) and for Solar Particles Events (SPE). This edition also includes two new chapters on skin epidermal epithelium and risk assessment for myeloid leukemia, as well as extended revisions addressing the radiation effects on the blood-forming system. Mathematical models are used to explain the effects of both acute and chronic irradiation on the dynamics of vital body systems, like the hematopoietic system, the development of autoimmune diseases, and the mortality dynamics in homogeneous and nonhomogeneous mammalian populations. The proposed methodology of these studies, the models themselves, and the obtained results are of a great theoretical significance and can find wide practical use.
Book Synopsis Mathematical Modeling of the Immune System in Homeostasis, Infection and Disease by : Gennady Bocharov
Download or read book Mathematical Modeling of the Immune System in Homeostasis, Infection and Disease written by Gennady Bocharov and published by Frontiers Media SA. This book was released on 2020-02-24 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system provides the host organism with defense mechanisms against invading pathogens and tumor development and it plays an active role in tissue and organ regeneration. Deviations from the normal physiological functioning of the immune system can lead to the development of diseases with various pathologies including autoimmune diseases and cancer. Modern research in immunology is characterized by an unprecedented level of detail that has progressed towards viewing the immune system as numerous components that function together as a whole network. Currently, we are facing significant difficulties in analyzing the data being generated from high-throughput technologies for understanding immune system dynamics and functions, a problem known as the ‘curse of dimensionality’. As the mainstream research in mathematical immunology is based on low-resolution models, a fundamental question is how complex the mathematical models should be? To respond to this challenging issue, we advocate a hypothesis-driven approach to formulate and apply available mathematical modelling technologies for understanding the complexity of the immune system. Moreover, pure empirical analyses of immune system behavior and the system’s response to external perturbations can only produce a static description of the individual components of the immune system and the interactions between them. Shifting our view of the immune system from a static schematic perception to a dynamic multi-level system is a daunting task. It requires the development of appropriate mathematical methodologies for the holistic and quantitative analysis of multi-level molecular and cellular networks. Their coordinated behavior is dynamically controlled via distributed feedback and feedforward mechanisms which altogether orchestrate immune system functions. The molecular regulatory loops inherent to the immune system that mediate cellular behaviors, e.g. exhaustion, suppression, activation and tuning, can be analyzed using mathematical categories such as multi-stability, switches, ultra-sensitivity, distributed system, graph dynamics, or hierarchical control. GB is supported by the Russian Science Foundation (grant 18-11-00171). AM is also supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER grant no. SAF2016-75505-R, the “María de Maeztu” Programme for Units of Excellence in R&D (MDM-2014-0370) and the Russian Science Foundation (grant 18-11-00171).
Book Synopsis Immunity to Change by : Robert Kegan
Download or read book Immunity to Change written by Robert Kegan and published by Harvard Business Press. This book was released on 2009-02-15 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlock your potential and finally move forward. A recent study showed that when doctors tell heart patients they will die if they don't change their habits, only one in seven will be able to follow through successfully. Desire and motivation aren't enough: even when it's literally a matter of life or death, the ability to change remains maddeningly elusive. Given that the status quo is so potent, how can we change ourselves and our organizations? In Immunity to Change, authors Robert Kegan and Lisa Lahey show how our individual beliefs--along with the collective mind-sets in our organizations--combine to create a natural but powerful immunity to change. By revealing how this mechanism holds us back, Kegan and Lahey give us the keys to unlock our potential and finally move forward. And by pinpointing and uprooting our own immunities to change, we can bring our organizations forward with us. This persuasive and practical book, filled with hands-on diagnostics and compelling case studies, delivers the tools you need to overcome the forces of inertia and transform your life and your work.
Book Synopsis Mathematical Modelling of Immune Response in Infectious Diseases by : Guri I. Marchuk
Download or read book Mathematical Modelling of Immune Response in Infectious Diseases written by Guri I. Marchuk and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning his work on the monograph to be published in English, this author tried to present more or less general notions of the possibilities of mathematics in the new and rapidly developing science of infectious immunology, describing the processes of an organism's defence against antigen invasions. The results presented in this monograph are based on the construc tion and application of closed models of immune response to infections which makes it possible to approach problems of optimizing the treat ment of chronic and hypertoxic forms of diseases. The author, being a mathematician, had creative long-Iasting con tacts with immunologists, geneticist, biologists, and clinicians. As far back as 1976 it resulted in the organization of a special seminar in the Computing Center of Siberian Branch of the USSR Academy of Sci ences on mathematical models in immunology. The seminar attracted the attention of a wide circle of leading specialists in various fields of science. All these made it possible to approach, from a more or less united stand point, the construction of models of immune response, the mathematical description of the models, and interpretation of results.
Book Synopsis Artificial Immune Systems by : Leandro N. de Castro
Download or read book Artificial Immune Systems written by Leandro N. de Castro and published by Springer. This book was released on 2007-08-28 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 6th International Conference on Artificial Immune Systems, ICARIS 2007, held in Santos, Brazil, August 2007. The papers are organized in topical sections on search and optimization, classification and clustering, anomaly detection and negative selection, robotics, control and electronics. Modeling papers, conceptual papers, and technical papers and general applications are also included.
Book Synopsis Recent Developments in Biologically Inspired Computing by : Leandro N. De Castro
Download or read book Recent Developments in Biologically Inspired Computing written by Leandro N. De Castro and published by IGI Global. This book was released on 2005-01-01 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Developments in Biologically Inspired Computing is necessary reading for undergraduate and graduate students, and researchers interested in knowing the most recent advances in problem solving techniques inspired by nature. This book covers the most relevant areas in computational intelligence, including evolutionary algorithms, artificial neural networks, artificial immune systems and swarm systems. It also brings together novel and philosophical trends in the exciting fields of artificial life and robotics. This book has the advantage of covering a large number of computational approaches, presenting the state-of-the-art before entering into the details of specific extensions and new developments. Pseudocodes, flow charts and examples of applications are provided so as to help newcomers and mature researchers to get the point of the new approaches presented.
