The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure. (Revised Reprint from Methods of Biochemical Analysis, Edited by David Glick, Volume 13, Pages 113-239.).

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Book Synopsis The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure. (Revised Reprint from Methods of Biochemical Analysis, Edited by David Glick, Volume 13, Pages 113-239.). by : K. C. Holmes

Download or read book The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure. (Revised Reprint from Methods of Biochemical Analysis, Edited by David Glick, Volume 13, Pages 113-239.). written by K. C. Holmes and published by . This book was released on 1966 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure

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ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure by : Kenneth Charles Holmes

Download or read book The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure written by Kenneth Charles Holmes and published by . This book was released on 1966 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure

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ISBN 13 :
Total Pages : 127 pages
Book Rating : 4.:/5 (181 download)

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Book Synopsis The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure by : David M. Blow

Download or read book The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure written by David M. Blow and published by . This book was released on 1966 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Principles of Protein X-ray Crystallography

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Publisher : Springer Science & Business Media
ISBN 13 : 1475730926
Total Pages : 355 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Principles of Protein X-ray Crystallography by : Jan Drenth

Download or read book Principles of Protein X-ray Crystallography written by Jan Drenth and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: New textbooks at all levels of chemistry appear with great regularity. Some fields such as basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research that is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive intro ductions to their fields. These should serve the needs of one-semester or one-quarter graduate courses in chemistry and biochemistry. In some cases, the availability of texts in active research areas should help stimulate the creation of new courses. Charles R. Cantor v Preface to the Second Edition Since the publication of the previous edition in 1994, X-ray crystallography of proteins has advanced by improvements in existing techniques and by addition of new techniques.

The use of x-ray diffraction in study of protein and nucleic acid structure

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)

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Book Synopsis The use of x-ray diffraction in study of protein and nucleic acid structure by : K. C. Holmes

Download or read book The use of x-ray diffraction in study of protein and nucleic acid structure written by K. C. Holmes and published by . This book was released on 1966 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure [by] K. C. Holmes and D. M. Blow

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ISBN 13 :
Total Pages : 127 pages
Book Rating : 4.:/5 (859 download)

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Book Synopsis The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure [by] K. C. Holmes and D. M. Blow by : K. C. Holmes

Download or read book The Use of X-ray Diffraction in the Study of Protein and Nucleic Acid Structure [by] K. C. Holmes and D. M. Blow written by K. C. Holmes and published by . This book was released on 1966 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Crystals, X-rays and Proteins

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Publisher : Oxford University Press
ISBN 13 : 019955904X
Total Pages : 640 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Crystals, X-rays and Proteins by : Dennis Sherwood

Download or read book Crystals, X-rays and Proteins written by Dennis Sherwood and published by Oxford University Press. This book was released on 2011 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information derived from X-ray crystal structures of biological molecules allows us to explain their functions in living organisms in extraordinary detail, and to develop drugs to treat disease. This book describes the principles and practice of X-ray diffraction as a key technique at the forefront of new discoveries in biology and medicine.

Protein-Nucleic Acid Interactions

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Publisher : Royal Society of Chemistry
ISBN 13 : 1847558267
Total Pages : 416 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Protein-Nucleic Acid Interactions by : Phoebe A Rice

Download or read book Protein-Nucleic Acid Interactions written by Phoebe A Rice and published by Royal Society of Chemistry. This book was released on 2008-04-22 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid 1980s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite frequently. High-resolution structures of protein-RNA complexes were relatively rare until the last decade. Propelled by advances in technology as well as the realization of RNA's importance to biology, the number of example structures has ballooned in recent years. New insights are now being gained from comparative studies only recently made possible due to the size of the database, as well as from careful biochemical and biophysical studies. As a result of the explosion of research in this area, it is no longer possible to write a comprehensive review. Instead, current review articles tend to focus on particular subtopics of interest. This makes it difficult for newcomers to the field to attain a solid understanding of the basics. One goal of this book is therefore to provide in-depth discussions of the fundamental principles of protein-nucleic acid interactions as well as to illustrate those fundamentals with up-to-date and fascinating examples for those who already possess some familiarity with the field. The book also aims to bridge the gap between the DNA- and the RNA- views of nucleic acid - protein recognition, which are often treated as separate fields. However, this is a false dichotomy because protein - DNA and protein - RNA interactions share many general principles. This book therefore includes relevant examples from both sides, and frames discussions of the fundamentals in terms that are relevant to both. The monograph approaches the study of protein-nucleic acid interactions in two distinctive ways. First, DNA-protein and RNA-protein interactions are presented together. Second, the first half of the book develops the principles of protein-nucleic acid recognition, whereas the second half applies these to more specialized topics. Both halves are illustrated with important real life examples. The first half of the book develops fundamental principles necessary to understand function. An introductory chapter by the editors reviews the basics of nucleic acid structure. Jen-Jacobsen and Jacobsen discuss how solvent interactions play an important role in recognition, illustrated with extensive thermodynamic data on restriction enzymes. Marmorstein and Hong introduce the zoology of the DNA binding domains found in transcription factors, and describe the combinational recognition strategies used by many multiprotein eukaryotic complexes. Two chapters discuss indirect readout of DNA sequence in detail: Berman and Lawson explain the basic principles and illustrate them with in-depth studies of CAP, while in their chapter on DNA bending and compaction Johnson, Stella and Heiss highlight the intrinsic connections between DNA bending and indirect readout. Horvath lays out the fundamentals of protein recognition of single stranded DNA and single stranded RNA, and describes how they apply in a detailed analysis of telomere end binding proteins. Nucleic acids adopt more complex structures - Lilley describes the conformational properties of helical junctions, and how proteins recognize and cleave them. Because RNA readily folds due to the stabilizing role of its 2'-hydroxyl groups, Li discusses how proteins recognize different RNA folds, which include duplex RNA. With the fundamentals laid out, discussion turns to more specialized examples taken from important aspects of nucleic acid metabolism. Schroeder discusses how proteins chaperone RNA by rearranging its structure into a functional form. Berger and Dong discuss how topoisomerases alter the topology of DNA and relieve the superhelical tension introduced by other processes such as replication and transcription. Dyda and Hickman show how DNA transposes mediate genetic mobility and Van Duyne discusses how site-specific recombinases "cut" and "paste" DNA. Horton presents a comprehensive review of the structural families and chemical mechanisms of DNA nucleases, whereas Li in her discussion of RNA-protein recognition also covers RNA nucleases. Lastly, FerrÚ-D'AmarÚ shows how proteins recognize and modify RNA transcripts at specific sites. The book also emphasises the impact of structural biology on understanding how proteins interact with nucleic acids and it is intended for advanced students and established scientists wishing to broaden their horizons.

Introduction to Biophysical Methods for Protein and Nucleic Acid Research

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Publisher : Academic Press
ISBN 13 : 0080534988
Total Pages : 528 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Introduction to Biophysical Methods for Protein and Nucleic Acid Research by : Jay A. Glasel

Download or read book Introduction to Biophysical Methods for Protein and Nucleic Acid Research written by Jay A. Glasel and published by Academic Press. This book was released on 1995-11-20 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, Introduction to Biophysical Methods for Protein and Nucleic Acid Research serves as a text for the experienced researcher and student requiring an introduction to the field. Each chapter presents a description of the physical basis of the method, the type of information that may be obtained with the method, how data should be analyzed and interpreted and, where appropriate, practical tips about procedures and equipment. Key Features* Modern Use of Mass Spectroscopy* NMR Spectroscopy* Molecular Modeling and Graphics* Macintosh and DOS/Windows 3.x disks

Protein-Nucleic Acids Interactions

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Publisher : Elsevier
ISBN 13 : 0124116280
Total Pages : 211 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Protein-Nucleic Acids Interactions by :

Download or read book Protein-Nucleic Acids Interactions written by and published by Elsevier. This book was released on 2013-06-19 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Structural Studies of Protein-Nucleic Acid Interaction

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Publisher : CUP Archive
ISBN 13 : 9780521414890
Total Pages : 108 pages
Book Rating : 4.4/5 (148 download)

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Book Synopsis Structural Studies of Protein-Nucleic Acid Interaction by : Thomas A. Steitz

Download or read book Structural Studies of Protein-Nucleic Acid Interaction written by Thomas A. Steitz and published by CUP Archive. This book was released on 1993-09-16 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this 1993 text, Nobel Prize winner Professor Steitz reviews the wide-ranging research in structural studies of DNA-binding proteins and their complexes with DNA. The author clearly and concisely describes the uses of techniques in molecular genetics, DNA synthesis, protein crystallography and nuclear magnetic response.

Protein Crystallography

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Publisher : JHU Press
ISBN 13 : 0801888085
Total Pages : 149 pages
Book Rating : 4.8/5 (18 download)

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Book Synopsis Protein Crystallography by : Eaton E. Lattman

Download or read book Protein Crystallography written by Eaton E. Lattman and published by JHU Press. This book was released on 2008-04-28 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein’s three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.

Molecular Biotechnology

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ISBN 13 :
Total Pages : 724 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Molecular Biotechnology by : Bernard R. Glick

Download or read book Molecular Biotechnology written by Bernard R. Glick and published by . This book was released on 1998 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition explains the principles of recombinant DNA technology as well as other important techniques such as DNA sequencing, the polymerase chain reaction, and the production of monclonal antibodies.

X-Ray Crystallography of Biomacromolecules

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Publisher : John Wiley & Sons
ISBN 13 : 3527609679
Total Pages : 318 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis X-Ray Crystallography of Biomacromolecules by : Albrecht Messerschmidt

Download or read book X-Ray Crystallography of Biomacromolecules written by Albrecht Messerschmidt and published by John Wiley & Sons. This book was released on 2007-02-27 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by one of the most significant contributors to the progress of protein crystallography, this practical guide contains case studies, a troubleshooting section and pointers on data interpretation. It covers the theory, practice and latest achievements in x-ray crystallography, such that any researcher in structural biology will benefit from this extremely clearly written book. Part A covers the theoretical basis and such experimental techniques as principles of x-ray diffraction, solutions for the phase problem and time-resolved x-ray crystallography. Part B includes case studies for different kinds of x-ray crystal structure determination, such as the MIRAS and MAD techniques, molecular replacement, and the difference Fourier technique.

Diffraction of X-rays by Proteins, Nucleic Acids and Viruses

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ISBN 13 :
Total Pages : 164 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Diffraction of X-rays by Proteins, Nucleic Acids and Viruses by : Herbert Rees Wilson

Download or read book Diffraction of X-rays by Proteins, Nucleic Acids and Viruses written by Herbert Rees Wilson and published by . This book was released on 1966 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

USE OF X-RAY DIFFRACTION IN THE STU- DY OF PROTEIN AND NUCLEIC

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ISBN 13 :
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Book Rating : 4.:/5 (14 download)

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Book Synopsis USE OF X-RAY DIFFRACTION IN THE STU- DY OF PROTEIN AND NUCLEIC by :

Download or read book USE OF X-RAY DIFFRACTION IN THE STU- DY OF PROTEIN AND NUCLEIC written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Structural Biology Using Electrons and X-rays

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Publisher : Academic Press
ISBN 13 : 0080919456
Total Pages : 451 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Structural Biology Using Electrons and X-rays by : Michael F Moody

Download or read book Structural Biology Using Electrons and X-rays written by Michael F Moody and published by Academic Press. This book was released on 2011-03-03 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural Biology Using Electrons and X-Rays discusses the diffraction and image-based methods used for the determination of complex biological macromolecules. The book focuses on the Fourier transform theory, which is a mathematical function that is computed to transform signals between time and frequency domain. Composed of five parts, the book examines the development of nuclear magnetic resonance (NMR), which allows the calculation of the images of a certain protein. Parts 1 to 4 provide the basic information and the applications of Fourier transforms, as well as the different methods used for image processing using X-ray crystallography and the analysis of electron micrographs. Part 5 focuses entirely on the mathematical aspect of Fourier transforms. In addition, the book examines detailed structural analyses of a specimen’s symmetry (i.e., crystals, helices, polyhedral viruses and asymmetrical particles). This book is intended for the biologist or biochemist who is interested in different methods and techniques for calculating the images of proteins using nuclear magnetic resonance (NMR). It is also suitable for readers without a background in physical chemistry or mathematics. Emphasis on common principles underlying all diffraction-based methods Thorough grounding in theory requires understanding of only simple algebra Visual representations and explanations of challenging content Mathematical detail offered in short-course form to parallel the text