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Download or read book The Ubiquitin System in Health and Disease (2009). written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stefan Jentsch
Publisher : Springer Science & Business Media
ISBN 13 : 3540851070
Total Pages : 203 pages
Book Rating : 4.5/5 (48 download)
Download or read book The Ubiquitin System in Health and Disease written by Stefan Jentsch and published by Springer Science & Business Media. This book was released on 2008-11-14 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. An understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention. This work covers the developments in this field.
Author : Milton J. Schlesinger
Publisher : Cold Spring Harbor Laboratory Press
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.:/5 (319 download)
Download or read book The Ubiquitin System written by Milton J. Schlesinger and published by Cold Spring Harbor Laboratory Press. This book was released on 1988 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tomoaki Ishigami
Publisher : MDPI
ISBN 13 : 3036505466
Total Pages : 292 pages
Book Rating : 4.0/5 (365 download)
Download or read book Ubiquitination in Health and Diseases written by Tomoaki Ishigami and published by MDPI. This book was released on 2021-05-18 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled “Ubiquitination in Health and Disease” successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.
Author : Thibault Mayor
Publisher : Humana
ISBN 13 : 9781493993710
Total Pages : 413 pages
Book Rating : 4.9/5 (937 download)
Download or read book The Ubiquitin Proteasome System written by Thibault Mayor and published by Humana. This book was released on 2019-10-06 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: “This volume explores numerous techniques used to study the ubiquitin proteasome system. The chapters in this book are organized into five parts and cover topics such as determining the mechanisms of action for E2s, E3s, and DUB enzymes; the latest advances to study the formation of poly-ubiquitin chains as well as their linkage types; the binding partners of proteins in the UPS; methods for structure determination by x-ray crystallography, cryo electron microscopy and SAXS; screening assays to select for degrons or modulators of E3s and DUBs; proteomics approaches in the ubiquitin field and methods to study 26S proteasome function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, The Ubiquitin Proteasome System: Methods and Protocols is a valuable resource for both experienced and novice scientists who are interested in expanding their knowledge in this field.
Author : Lucio G Costa
Publisher : Royal Society of Chemistry
ISBN 13 : 1782622381
Total Pages : 655 pages
Book Rating : 4.7/5 (826 download)
Download or read book Manganese in Health and Disease written by Lucio G Costa and published by Royal Society of Chemistry. This book was released on 2014-11-27 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Manganese in the diet is nutritionally essential for normal physiologic functioning. However, excessive exposure to manganese has been associated with developmental, neurodegenerative and other disorders. The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and chapters cover the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases. A large section devoted to health effects presents the latest research that associates manganese exposure to potential human diseases. Any scientists, health professional or regulator involved with metal exposure and toxicology should find this volume essential reading. Students and researchers in neurotoxicology will also find this book a useful reference.
Author : Peter Zwickl
Publisher : Springer Science & Business Media
ISBN 13 : 364259414X
Total Pages : 222 pages
Book Rating : 4.6/5 (425 download)
Download or read book The Proteasome — Ubiquitin Protein Degradation Pathway written by Peter Zwickl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gives an overview of pro tea some-mediated protein degradation and the regulatory role of the ubiquitin system in cellular proteolysis. The first chapter describes the molecular evolution of the proteasome and its associated activators, i. e. , the 20S core, the base and the lid of the 19S cap, and the 11 S regulator. The ensuing chapter gives an overview of the structure and assembly of the 20S proteasome and the regulation of the archaeal proteasome by PAN. The third contribution summarizes our knowledge on the eukaryotic 26S proteasome and its regulation by the 19S regu lator, followed by a chapter devoted to the llS regulator, which elucidates the structural basis for the 11 S-mediated activation of the 20S proteasome. The fifth chapter reviews in detail the role of the proteasome in the immune response. The subsequent chapter of the natural substrates of the gives a comprehensive description proteasome and their recognition by the enzymes of the ubiqui tination machinery. The penultimate chapter rounds up the in formation on intracellular distribution of proteasomes in yeast and mammalian cells, while the last contribution highlights proteasome inhibitors, tools which proved to be very valuable for dissecting the cellular roles of the proteasome and which might turn out to be of pharmacological importance.
Author : Jonas H. Ellenberg
Publisher : CRC Press
ISBN 13 : 9780824788230
Total Pages : 600 pages
Book Rating : 4.7/5 (882 download)
Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)
Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Author : Michael Karin
Publisher : Springer Science & Business Media
ISBN 13 : 3642160174
Total Pages : 273 pages
Book Rating : 4.6/5 (421 download)
Download or read book NF-kB in Health and Disease written by Michael Karin and published by Springer Science & Business Media. This book was released on 2011-04-26 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival, growth, and proliferation
Author : Astrid Sigel
Publisher : Springer Science & Business Media
ISBN 13 : 9400775008
Total Pages : 603 pages
Book Rating : 4.4/5 (7 download)
Download or read book Interrelations between Essential Metal Ions and Human Diseases written by Astrid Sigel and published by Springer Science & Business Media. This book was released on 2014-01-27 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.
Author : Bruce Beutler
Publisher : Springer Science & Business Media
ISBN 13 : 354075203X
Total Pages : 230 pages
Book Rating : 4.5/5 (47 download)
Download or read book Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology written by Bruce Beutler and published by Springer Science & Business Media. This book was released on 2008-06-20 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph deals with the impact of classical genetics in immunology, prov- ing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who do not fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists. They may hold the opinion that genetics has run its course since Mendel read his paper on peas in 1865. “Why bother with classical genetics,” they may ask. “Won’t all genes be knocked out soon anyway?” Or they are intimidated by genetics, with its heavy reliance on model organisms that seem so alien. “What has C. elegans to do with me?” the questioning might go. “It doesn’t even have lymphocytes. ” Such skeptics may be unaware that the mouse is fast becoming as tractable a model organism as the fly, and that humans may not be too far behind. So I would like to introduce the topic with a few words about the power of genetics, and why it has contributed so much to immunology, and to bi- ogy in general. Genetics, as the word is used here, is not merely the science of heredity, but much more than that. It is the science of exceptions: the science that takes note of heritable variation and seeks to explain it at the most fundamental level.
Author : Andre Zelanis
Publisher : Academic Press
ISBN 13 : 0323856977
Total Pages : 308 pages
Book Rating : 4.3/5 (238 download)
Download or read book Proteolytic Signaling in Health and Disease written by Andre Zelanis and published by Academic Press. This book was released on 2021-10-13 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events. Examines biological events triggered by proteolytic enzyme activity across human development and pathologies Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types Features methods and protocols supporting further study of proteolytic signaling events Includes chapter contributions from international leaders in the field
Author : Nina Papavasiliou
Publisher : World Scientific
ISBN 13 : 1908977949
Total Pages : 232 pages
Book Rating : 4.9/5 (89 download)
Download or read book Dna Deamination And The Immune System: Aid In Health And Disease written by Nina Papavasiliou and published by World Scientific. This book was released on 2010-10-27 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted into actually fixing mutations into the genome? These questions, among others, will be addressed in this monograph from various perspectives. Being leading experts in their respective fields, the contributors of this highly valued title summarize current research in the field of AID and put forth hypotheses in order to provide a platform for future experiments./a
Author : Sten Orrenius
Publisher : CRC Press
ISBN 13 : 1439880026
Total Pages : 530 pages
Book Rating : 4.4/5 (398 download)
Download or read book Mitochondrial Signaling in Health and Disease written by Sten Orrenius and published by CRC Press. This book was released on 2012-06-20 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Author : Suresh I. S. Rattan
Publisher : CRC Press
ISBN 13 : 1482205467
Total Pages : 378 pages
Book Rating : 4.4/5 (822 download)
Download or read book Hormesis in Health and Disease written by Suresh I. S. Rattan and published by CRC Press. This book was released on 2014-05-16 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some mild stresses have positive effects on survival and aging as shown in animal models. There is also a large body of research that demonstrates these hormetic effects on aging, health, and resistance to severe stresses and diseases in human beings. However, the data are dispersed in the literature and are not always interpreted as hormetic effec
Author : Paolo Bernardi
Publisher : Frontiers Media SA
ISBN 13 : 2889712516
Total Pages : 299 pages
Book Rating : 4.8/5 (897 download)
Download or read book Mitochondria in Health and Disease written by Paolo Bernardi and published by Frontiers Media SA. This book was released on 2021-09-01 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial biology reinvented itself and became a new world that has attracted new scientists influencing every field of biomedical research. Mitochondrial research is growing and changing, as reflected by the exponential rise in the number of conferences covering mitochondrial biology and the role of mitochondria in diseases ranging from neurodegenerative diseases,metabolic diseases and genetic muscular dystrophies toimmunopathologies and cancer. As the awareness of the essential role of mitochondria in pathology rose, a demand for new approaches to measure mitochondrial function resulted in the robust development of new forms of microscopy and spectroscopy that opened windows into previously unknown aspects of mitochondrial biology. Two Conferences provided an outstanding representation of this state of affairs, the Gordon Research Conference Mitochondrial Dynamics and Signaling (Ventura, California March 17-22, 2019) and the FASEB Conference Mitochondrial Biogenesis and Dynamics in Health and Disease (Palm Springs, California May 19-24, 2019). These conferences well reflected the explosion of the field of mitochondrial communication within the cell, between cells and across organs, as well as the budding of a new field on the definition of individual mitochondria and the identification of subtypes with diverse structural features that may serve different specific functions. Through our participation in these meetings, we conceived the idea to cover some of these topics in the Research Topic “Mitochondria in Health and Disease” of Frontiers in Physiology - Mitochondrial Research Specialty Section. Fitting the tradition of Frontiers, our contributors have generated a platform incuding both solid data and new concepts, as radical and courageous as they can be. We are pleased with the outcome and we hope that our readers will share our enthusiasm.
