Empirical Likelihood Methods in Biomedicine and Health

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Publisher : CRC Press
ISBN 13 : 1351001515
Total Pages : 300 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Empirical Likelihood Methods in Biomedicine and Health by : Albert Vexler

Download or read book Empirical Likelihood Methods in Biomedicine and Health written by Albert Vexler and published by CRC Press. This book was released on 2018-09-03 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Empirical Likelihood Methods in Biomedicine and Health provides a compendium of nonparametric likelihood statistical techniques in the perspective of health research applications. It includes detailed descriptions of the theoretical underpinnings of recently developed empirical likelihood-based methods. The emphasis throughout is on the application of the methods to the health sciences, with worked examples using real data. Provides a systematic overview of novel empirical likelihood techniques. Presents a good balance of theory, methods, and applications. Features detailed worked examples to illustrate the application of the methods. Includes R code for implementation. The book material is attractive and easily understandable to scientists who are new to the research area and may attract statisticians interested in learning more about advanced nonparametric topics including various modern empirical likelihood methods. The book can be used by graduate students majoring in biostatistics, or in a related field, particularly for those who are interested in nonparametric methods with direct applications in Biomedicine.

Empirical Likelihood

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Publisher : CRC Press
ISBN 13 : 1420036157
Total Pages : 322 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Empirical Likelihood by : Art B. Owen

Download or read book Empirical Likelihood written by Art B. Owen and published by CRC Press. This book was released on 2001-05-18 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Empirical likelihood provides inferences whose validity does not depend on specifying a parametric model for the data. Because it uses a likelihood, the method has certain inherent advantages over resampling methods: it uses the data to determine the shape of the confidence regions, and it makes it easy to combined data from multiple sources. It al

Empirical Likelihood Methods in Biomedicine and Health

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Publisher : CRC Press
ISBN 13 : 1351001507
Total Pages : 149 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Empirical Likelihood Methods in Biomedicine and Health by : Albert Vexler

Download or read book Empirical Likelihood Methods in Biomedicine and Health written by Albert Vexler and published by CRC Press. This book was released on 2018-09-03 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Empirical Likelihood Methods in Biomedicine and Health provides a compendium of nonparametric likelihood statistical techniques in the perspective of health research applications. It includes detailed descriptions of the theoretical underpinnings of recently developed empirical likelihood-based methods. The emphasis throughout is on the application of the methods to the health sciences, with worked examples using real data. Provides a systematic overview of novel empirical likelihood techniques. Presents a good balance of theory, methods, and applications. Features detailed worked examples to illustrate the application of the methods. Includes R code for implementation. The book material is attractive and easily understandable to scientists who are new to the research area and may attract statisticians interested in learning more about advanced nonparametric topics including various modern empirical likelihood methods. The book can be used by graduate students majoring in biostatistics, or in a related field, particularly for those who are interested in nonparametric methods with direct applications in Biomedicine.

The Two-sample Empirical Likelihood Method

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Publisher :
ISBN 13 :
Total Pages : 6 pages
Book Rating : 4.:/5 (221 download)

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Book Synopsis The Two-sample Empirical Likelihood Method by : Bing-Yi Jing

Download or read book The Two-sample Empirical Likelihood Method written by Bing-Yi Jing and published by . This book was released on 1993 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt:

EMPIRICAL LIKELIHOOD TESTS FOR CONSTANT VARIANCE IN THE TWO-SAMPLE PROBLEM

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Publisher :
ISBN 13 :
Total Pages : 19 pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis EMPIRICAL LIKELIHOOD TESTS FOR CONSTANT VARIANCE IN THE TWO-SAMPLE PROBLEM by : Paul Shen

Download or read book EMPIRICAL LIKELIHOOD TESTS FOR CONSTANT VARIANCE IN THE TWO-SAMPLE PROBLEM written by Paul Shen and published by . This book was released on 2019 with total page 19 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, we investigate the problem of testing constant variance. It is an important problem in the field of statistical influence where many methods require the assumption of constant variance. The question of constant variance has to be settled in order to perform a significance test through a Student t-Test or an F-test. Two of most popular tests of constant variance in applications are the classic F-test and the Modified Levene's Test. The former is a ratio of two sample variances. Its performance is found to be very sensitive with the normality assumption. The latter Modified Levene's Test can be viewed as a result of the estimation method through the absolute deviation from the median. Its performance is also dependent upon the distribution shapes to some extent, though not as much as the F-test. We propose an innovative test constructed by the empirical likelihood method through the moment estimation equations appearing in the Modified Levene's Test. The new empirical likelihood ratio test is a nonparametric test and retains the principle of maximum likelihood. As a result, it can be an appropriate alternative to the two traditional tests in applications when underlying populations are skewed. To be specific, the empirical likelihood ratio test of constant variance uses the optimal weights in summing the absolute deviations of observations from the median values, while the Modified Levene's test uses the simple averages. It is thus desired that the empirical likelihood ratio test is more powerful than the Modified Levene's test. Meanwhile, the empirical likelihood ratio test is expected to be as robust as the Modified Levene's test, as the empirical likelihood ratio test is also constructed via the same distance as the Modified Levene's test. A real-life data set is used to illustrate implementation of the empirical likelihood ratio test with comparisons to the classic F-test and the Modified Levene's Test. It is confirmed that the empirical likelihood ratio test performs the best.

Empirical Likelihood Method in Survival Analysis

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Publisher : CRC Press
ISBN 13 : 1466554932
Total Pages : 221 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Empirical Likelihood Method in Survival Analysis by : Mai Zhou

Download or read book Empirical Likelihood Method in Survival Analysis written by Mai Zhou and published by CRC Press. This book was released on 2015-06-17 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Empirical Likelihood Method in Survival Analysis explains how to use the empirical likelihood method for right censored survival data. The author uses R for calculating empirical likelihood and includes many worked out examples with the associated R code. The datasets and code are available for download on his website and CRAN. The book focuses on all the standard survival analysis topics treated with empirical likelihood, including hazard functions, cumulative distribution functions, analysis of the Cox model, and computation of empirical likelihood for censored data. It also covers semi-parametric accelerated failure time models, the optimality of confidence regions derived from empirical likelihood or plug-in empirical likelihood ratio tests, and several empirical likelihood confidence band results. While survival analysis is a classic area of statistical study, the empirical likelihood methodology has only recently been developed. Until now, just one book was available on empirical likelihood and most statistical software did not include empirical likelihood procedures. Addressing this shortfall, this book provides the functions to calculate the empirical likelihood ratio in survival analysis as well as functions related to the empirical likelihood analysis of the Cox regression model and other hazard regression models.

Empirical Likelihood Ratio Tests for Two Sample Comparison Under Current Status Data

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis Empirical Likelihood Ratio Tests for Two Sample Comparison Under Current Status Data by : 侯科宇

Download or read book Empirical Likelihood Ratio Tests for Two Sample Comparison Under Current Status Data written by 侯科宇 and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Sample Surveys: Inference and Analysis

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Publisher : Morgan Kaufmann
ISBN 13 : 0080963544
Total Pages : 667 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Sample Surveys: Inference and Analysis by :

Download or read book Sample Surveys: Inference and Analysis written by and published by Morgan Kaufmann. This book was released on 2009-09-02 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Statistics_29B contains the most comprehensive account of sample surveys theory and practice to date. It is a second volume on sample surveys, with the goal of updating and extending the sampling volume published as volume 6 of the Handbook of Statistics in 1988. The present handbook is divided into two volumes (29A and 29B), with a total of 41 chapters, covering current developments in almost every aspect of sample surveys, with references to important contributions and available software. It can serve as a self contained guide to researchers and practitioners, with appropriate balance between theory and real life applications. Each of the two volumes is divided into three parts, with each part preceded by an introduction, summarizing the main developments in the areas covered in that part. Volume 1 deals with methods of sample selection and data processing, with the later including editing and imputation, handling of outliers and measurement errors, and methods of disclosure control. The volume contains also a large variety of applications in specialized areas such as household and business surveys, marketing research, opinion polls and censuses. Volume 2 is concerned with inference, distinguishing between design-based and model-based methods and focusing on specific problems such as small area estimation, analysis of longitudinal data, categorical data analysis and inference on distribution functions. The volume contains also chapters dealing with case-control studies, asymptotic properties of estimators and decision theoretic aspects. Comprehensive account of recent developments in sample survey theory and practice Covers a wide variety of diverse applications Comprehensive bibliography

Empirical Likelihood Inference for Two-sample Problems

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Publisher :
ISBN 13 :
Total Pages : 40 pages
Book Rating : 4.:/5 (827 download)

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Book Synopsis Empirical Likelihood Inference for Two-sample Problems by : Ying Yan

Download or read book Empirical Likelihood Inference for Two-sample Problems written by Ying Yan and published by . This book was released on 2010 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, we are interested in empirical likelihood (EL) methods for two-sample problems, with focus on the difference of the two population means. A weighted empirical likelihood method (WEL) for two-sample problems is developed. We also consider a scenario where sample data on auxiliary variables are fully observed for both samples but values of the response variable are subject to missingness. We develop an adjusted empirical likelihood method for inference of the difference of the two population means for this scenario where missing values are handled by a regression imputation method. Bootstrap calibration for WEL is also developed. Simulation studies are conducted to evaluate the performance of naive EL, WEL and WEL with bootstrap calibration (BWEL) with comparison to the usual two-sample t-test in terms of power of the tests and coverage accuracies. Simulation for the adjusted EL for the linear regression model with missing data is also conducted.

Empirical Likelihood Ratio Tests with Smoothing Estimators and a Weighted Approach for Two Sample Comparison Under Current Status Data

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (15 download)

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Book Synopsis Empirical Likelihood Ratio Tests with Smoothing Estimators and a Weighted Approach for Two Sample Comparison Under Current Status Data by : 許玳瑜

Download or read book Empirical Likelihood Ratio Tests with Smoothing Estimators and a Weighted Approach for Two Sample Comparison Under Current Status Data written by 許玳瑜 and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Extended Empirical Likelihood

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (91 download)

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Book Synopsis The Extended Empirical Likelihood by : Fan Wu

Download or read book The Extended Empirical Likelihood written by Fan Wu and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The empirical likelihood method introduced by Owen (1988, 1990) is a powerful nonparametric method for statistical inference. It has been one of the most researched methods in statistics in the last twenty-five years and remains to be a very active area of research today. There is now a large body of literature on empirical likelihood method which covers its applications in many areas of statistics (Owen, 2001). One important problem affecting the empirical likelihood method is its poor accuracy, especially for small sample and/or high-dimension applications. The poor accuracy can be alleviated by using high-order empirical likelihood methods such as the Bartlett corrected empirical likelihood but it cannot be completely resolved by high-order asymptotic methods alone. Since the work of Tsao (2004), the impact of the convex hull constraint in the formulation of the empirical likelihood on the finite sample accuracy has been better understood, and methods have been developed to break this constraint in order to improve the accuracy.

Empirical Likelihood Confidence Intervals for the Difference of Two Quantiles with Right Censoring

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (375 download)

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Book Synopsis Empirical Likelihood Confidence Intervals for the Difference of Two Quantiles with Right Censoring by : Crystal Cho Ying Yau

Download or read book Empirical Likelihood Confidence Intervals for the Difference of Two Quantiles with Right Censoring written by Crystal Cho Ying Yau and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, we study two independent samples under right censoring. Using a smoothed empirical likelihood method, we investigate the difference of quantiles in the two samples and construct the pointwise confidence intervals from it as well. The empirical log-likelihood ratio is proposed and its asymptotic limit is shown as a chi-squared distribution. In the simulation studies, in terms of coverage accuracy and average length of confidence intervals, we compare the empirical likelihood and the normal approximation method. It is concluded that the empirical likelihood method has a better performance. At last, a real clinical trial data is used for the purpose of illustration. Numerical examples to illustrate the efficacy of the method are presented.

Two-Step Empirical Likelihood Estimation Under Stratified Sampling When Aggregate Information is Available

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (137 download)

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Book Synopsis Two-Step Empirical Likelihood Estimation Under Stratified Sampling When Aggregate Information is Available by : Esmeralda A. Ramalho

Download or read book Two-Step Empirical Likelihood Estimation Under Stratified Sampling When Aggregate Information is Available written by Esmeralda A. Ramalho and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Empirical likelihood is appropriate to estimate moment condition models when a random sample from the target population is available. However, many economic surveys are subject to some form of stratification, in which case direct application of empirical likelihood will produce inconsistent estimators. In this paper we propose a two-step empirical likelihood estimator to deal with stratified samples in models defined by unconditional moment restrictions in the presence of some aggregate information such as the mean and the variance of the variable of interest. A Monte Carlo simulation study reveals promising results for many versions of the two-step empirical likelihood estimator.

Sampling Theory and Practice

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Publisher : Springer Nature
ISBN 13 : 3030442462
Total Pages : 371 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Sampling Theory and Practice by : Changbao Wu

Download or read book Sampling Theory and Practice written by Changbao Wu and published by Springer Nature. This book was released on 2020-05-15 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three parts of this book on survey methodology combine an introduction to basic sampling theory, engaging presentation of topics that reflect current research trends, and informed discussion of the problems commonly encountered in survey practice. These related aspects of survey methodology rarely appear together under a single connected roof, making this book a unique combination of materials for teaching, research and practice in survey sampling. Basic knowledge of probability theory and statistical inference is assumed, but no prior exposure to survey sampling is required. The first part focuses on the design-based approach to finite population sampling. It contains a rigorous coverage of basic sampling designs, related estimation theory, model-based prediction approach, and model-assisted estimation methods. The second part stems from original research conducted by the authors as well as important methodological advances in the field during the past three decades. Topics include calibration weighting methods, regression analysis and survey weighted estimating equation (EE) theory, longitudinal surveys and generalized estimating equations (GEE) analysis, variance estimation and resampling techniques, empirical likelihood methods for complex surveys, handling missing data and non-response, and Bayesian inference for survey data. The third part provides guidance and tools on practical aspects of large-scale surveys, such as training and quality control, frame construction, choices of survey designs, strategies for reducing non-response, and weight calculation. These procedures are illustrated through real-world surveys. Several specialized topics are also discussed in detail, including household surveys, telephone and web surveys, natural resource inventory surveys, adaptive and network surveys, dual-frame and multiple frame surveys, and analysis of non-probability survey samples. This book is a self-contained introduction to survey sampling that provides a strong theoretical base with coverage of current research trends and pragmatic guidance and tools for conducting surveys.

Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials

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Publisher : CRC Press
ISBN 13 : 1351214527
Total Pages : 218 pages
Book Rating : 4.3/5 (512 download)

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Book Synopsis Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials by : Mark Chang

Download or read book Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials written by Mark Chang and published by CRC Press. This book was released on 2019-03-20 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development.... Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously." Jay Herson, Johns Hopkins University The pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to a more innovative approach in which strategies are employed to compress and optimize the clinical development plan and associated timelines. However, these strategies are generally being considered on an individual trial basis and not as part of a fully integrated overall development program. Such optimization at the trial level is somewhat near-sighted and does not ensure cost, time, or development efficiency of the overall program. This book seeks to address this imbalance by establishing a statistical framework for overall/global clinical development optimization and providing tactics and techniques to support such optimization, including clinical trial simulations. Provides a statistical framework for achieve global optimization in each phase of the drug development process. Describes specific techniques to support optimization including adaptive designs, precision medicine, survival-endpoints, dose finding and multiple testing. Gives practical approaches to handling missing data in clinical trials using SAS. Looks at key controversial issues from both a clinical and statistical perspective. Presents a generous number of case studies from multiple therapeutic areas that help motivate and illustrate the statistical methods introduced in the book. Puts great emphasis on software implementation of the statistical methods with multiple examples of software code (both SAS and R). It is important for statisticians to possess a deep knowledge of the drug development process beyond statistical considerations. For these reasons, this book incorporates both statistical and "clinical/medical" perspectives.

Empirical Likelihood Methods for Pretest-Posttest Studies

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Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4.:/5 (96 download)

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Book Synopsis Empirical Likelihood Methods for Pretest-Posttest Studies by : Min Chen

Download or read book Empirical Likelihood Methods for Pretest-Posttest Studies written by Min Chen and published by . This book was released on 2015 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pretest-posttest trials are an important and popular method to assess treatment effects in many scientific fields. In a pretest-posttest study, subjects are randomized into two groups: treatment and control. Before the randomization, the pretest responses and other baseline covariates are recorded. After the randomization and a period of study time, the posttest responses are recorded. Existing methods for analyzing the treatment effect in pretest-posttest designs include the two-sample t-test using only the posttest responses, the paired t-test using the difference of the posttest and the pretest responses, and the analysis of covariance method which assumes a linear model between the posttest and the pretest responses. These methods are summarized and compared by Yang and Tsiatis (2001) under a general semiparametric model which only assumes that the first and second moments of the baseline and the follow-up response variable exist and are finite. Leon et al. (2003) considered a semiparametric model based on counterfactuals, and applied the theory of missing data and causal inference to develop a class of consistent estimator on the treatment effect and identified the most efficient one in the class. Huang et al. (2008) proposed a semiparametric estimation procedure based on empirical likelihood (EL) which incorporates the pretest responses as well as baseline covariates to improve the efficiency. The EL approach proposed by Huang et al. (2008) (the HQF method), however, dealt with the mean responses of the control group and the treatment group separately, and the confidence intervals were constructed through a bootstrap procedure on the conventional normalized Z-statistic. In this thesis, we first explore alternative EL formulations that directly involve the parameter of interest, i.e., the difference of the mean responses between the treatment group and the control group, using an approach similar to Wu and Yan (2012). Pretest responses and other baseline covariates are incorporated to impute the potential posttest responses. We consider the regression imputation as well as the non-parametric kernel imputation. We develop asymptotic distributions of the empirical likelihood ratio statistic that are shown to be scaled chi-squares. The results are used to construct confidence intervals and to conduct statistical hypothesis tests. We also derive the explicit asymptotic variance formula of the HQF estimator, and compare it to the asymptotic variance of the estimator based on our proposed method under several scenarios. We find that the estimator based on our proposed method is more efficient than the HQF estimator under a linear model without an intercept that links the posttest responses and the pretest responses. When there is an intercept, our proposed model is as efficient as the HQF method. When there is misspecification of the working models, our proposed method based on kernel imputation is most efficient. While the treatment effect is of primary interest for the analysis of pretest-posttest sample data, testing the difference of the two distribution functions for the treatment and the control groups is also an important problem. For two independent samples, the nonparametric Mann-Whitney test has been a standard tool for testing the difference of two distribution functions. Owen (2001) presented an EL formulation of the Mann-Whitney test but the computational procedures are heavy due to the use of a U-statistic in the constraints. We develop empirical likelihood based methods for the Mann-Whitney test to incorporate the two unique features of pretest-posttest studies: (i) the availability of baseline information for both groups; and (ii) the missing by design structure of the data. Our proposed methods combine the standard Mann-Whitney test with the empirical likelihood method of Huang, Qin and Follmann (2008), the imputation-based empirical likelihood method of Chen, Wu and Thompson (2014a), and the jackknife empirical likelihood (JEL) method of Jing, Yuan and Zhou (2009). The JEL method provides a major relief on computational burdens with the constrained maximization problems. We also develop bootstrap calibration methods for the proposed EL-based Mann-Whitney test when the corresponding EL ratio statistic does not have a standard asymptotic chi-square distribution. We conduct simulation studies to compare the finite sample performances of the proposed methods. Our results show that the Mann-Whitney test based on the Huang, Qin and Follmann estimators and the test based on the two-sample JEL method perform very well. In addition, incorporating the baseline information for the test makes the test more powerful. Finally, we consider the EL method for the pretest-posttest studies when the design and data collection involve complex surveys. We consider both stratification and inverse probability weighting via propensity scores to balance the distributions of the baseline covariates between two treatment groups. We use a pseudo empirical likelihood approach to make inference of the treatment effect. The proposed methods are illustrated through an application using data from the International Tobacco Control (ITC) Policy Evaluation Project Four Country (4C) Survey.

Empirical Likelihood and Extremes

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (81 download)

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Book Synopsis Empirical Likelihood and Extremes by : Yun Gong

Download or read book Empirical Likelihood and Extremes written by Yun Gong and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1988, Owen introduced empirical likelihood as a nonparametric method for constructing confidence intervals and regions. Since then, empirical likelihood has been studied extensively in the literature due to its generality and effectiveness. It is well known that empirical likelihood has several attractive advantages comparing to its competitors such as bootstrap: determining the shape of confidence regions automatically using only the data; straightforwardly incorporating side information expressed through constraints; being Bartlett correctable. The main part of this thesis extends the empirical likelihood method to several interesting and important statistical inference situations. This thesis has four components. The first component (Chapter II) proposes a smoothed jackknife empirical likelihood method to construct confidence intervals for the receiver operating characteristic (ROC) curve in order to overcome the computational difficulty when we have nonlinear constrains in the maximization problem. The second component (Chapter III and IV) proposes smoothed empirical likelihood methods to obtain interval estimation for the conditional Value-at-Risk with the volatility model being an ARCH/GARCH model and a nonparametric regression respectively, which have applications in financial risk management. The third component(Chapter V) derives the empirical likelihood for the intermediate quantiles, which plays an important role in the statistics of extremes. Finally, the fourth component (Chapter VI and VII) presents two additional results: in Chapter VI, we present an interesting result by showing that, when the third moment is infinity, we may prefer the Student's t-statistic to the sample mean standardized by the true standard deviation; in Chapter VII, we present a method for testing a subset of parameters for a given parametric model of stationary processes.