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Author : Philip L. Chambers
Publisher : Springer Science & Business Media
ISBN 13 : 3642731139
Total Pages : 469 pages
Book Rating : 4.6/5 (427 download)
Download or read book The Target Organ and the Toxic Process written by Philip L. Chambers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : European Society of Toxicology. Meeting
Publisher : Springer Verlag
ISBN 13 : 9780387185125
Total Pages : 462 pages
Book Rating : 4.1/5 (851 download)
Download or read book The Target Organ and the Toxic Process written by European Society of Toxicology. Meeting and published by Springer Verlag. This book was released on 1988-01-01 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : P K Gupta
Publisher : Springer Nature
ISBN 13 : 3030504093
Total Pages : 338 pages
Book Rating : 4.0/5 (35 download)
Download or read book Problem Solving Questions in Toxicology: written by P K Gupta and published by Springer Nature. This book was released on 2020-10-19 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides easy-to-understand diverse specialized topics in toxicology using self- study questions and answers. The answers are in the form of text along with custom made diagrams and explanations that help the student audience to understand and grasp the matter easily. It is written specifically as a study guide for the toxicology board and other examinations.
Author : Cohen
Publisher : CRC-Press
ISBN 13 : 9780849357756
Total Pages : 240 pages
Book Rating : 4.3/5 (577 download)
Download or read book TARGET ORGAN TOXICITY written by Cohen and published by CRC-Press. This book was released on 1986-08-31 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.
Author : Philip C. Burcham
Publisher : Springer Science & Business Media
ISBN 13 : 144715553X
Total Pages : 338 pages
Book Rating : 4.4/5 (471 download)
Download or read book An Introduction to Toxicology written by Philip C. Burcham and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960’s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that “unpack” the concepts being discussed in the text.
Author :
Publisher :
ISBN 13 :
Total Pages : 233 pages
Book Rating : 4.:/5 (853 download)
Download or read book Target Organ Toxicity written by and published by . This book was released on 1986 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cohen
Publisher : CRC Press
ISBN 13 : 9780849357756
Total Pages : 246 pages
Book Rating : 4.3/5 (577 download)
Download or read book Target Organ Toxicity written by Cohen and published by CRC Press. This book was released on 1986-08-31 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.
Author : Gerald M. Cohen
Publisher : Taylor & Francis
ISBN 13 : 1000807932
Total Pages : 488 pages
Book Rating : 4.0/5 (8 download)
Download or read book Target Organ Toxicity written by Gerald M. Cohen and published by Taylor & Francis. This book was released on 2022-07-30 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1986: The purpose of this 2 volume set is to provide a valuable reference for established investigators and postgraduate students in toxicology.
Author : Gerald M. Cohen
Publisher : CRC Press
ISBN 13 : 1000722368
Total Pages : 246 pages
Book Rating : 4.0/5 (7 download)
Download or read book Target Organ Toxicity, Volume I written by Gerald M. Cohen and published by CRC Press. This book was released on 2020-01-29 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.
Author : Elizabeth McInnes
Publisher : John Wiley & Sons
ISBN 13 : 1118755413
Total Pages : 210 pages
Book Rating : 4.1/5 (187 download)
Download or read book Pathology for Toxicologists written by Elizabeth McInnes and published by John Wiley & Sons. This book was released on 2017-05-01 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity. Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes: Colour diagrams explaining how lesions are caused by either external compounds or spontaneously The anatomic variations and background lesions of laboratory animals Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data A chapter on the haematology and biochemistry of laboratory animals Full colour photographs of common macroscopic lesions encountered in laboratory animals A comprehensive glossary
Author : Cohen, James Rab
Publisher : CRC-Press
ISBN 13 : 9780849357695
Total Pages : 488 pages
Book Rating : 4.3/5 (576 download)
Download or read book Target Organ Toxicity written by Cohen, James Rab and published by CRC-Press. This book was released on 2000-12-01 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set provides essential information on the general principles of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modification and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharmacologists, biochemists, and environmental toxicologists.
Author : Daniel Schlenk
Publisher : CRC Press
ISBN 13 : 0203361407
Total Pages : 426 pages
Book Rating : 4.2/5 (33 download)
Download or read book Target Organ Toxicity in Marine and Freshwater Teleosts written by Daniel Schlenk and published by CRC Press. This book was released on 2003-09-02 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing the numerous gaps in current information, Target Organ Toxicology in Marine and Freshwater Teleosts is an essential resource for researchers and professionals in aquatic toxicology and environmental risk assessment. All the chapters are written by researchers who are internationally recognised for their work in mechanistic aspects of aquatic toxicology. Each chapter focuses on a specific target organ or physiological system and describes how various agents disrupt the normal physiological system and processes. This volume is devoted to specific organs with coverage of the gill, kidney, skin, liver and gut. The companion volume, Systems, provides coverage of toxic effects in the central nervous, immune, neurobehavioural and reproductive systems as well as describing general mechanisms of toxicity.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309044375
Total Pages : 224 pages
Book Rating : 4.3/5 (9 download)
Download or read book Monitoring Human Tissues for Toxic Substances written by National Research Council and published by National Academies Press. This book was released on 1991-02-01 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.
Author : Philip W. Harvey
Publisher : CRC Press
ISBN 13 : 0748403302
Total Pages : 331 pages
Book Rating : 4.7/5 (484 download)
Download or read book Adrenal in Toxicology written by Philip W. Harvey and published by CRC Press. This book was released on 1996-03-28 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The adrenal gland is vitally important to health and secretes hormones that control many bodily processes ranging from normal metabolism to the response to stressful circumstances. The corticosteroid hormones are the basis for anti-inflammatory medicines and are very widely prescribed. Changes in the function of the adrenal gland, either naturally through stress or disease, or through the action of drugs and chemicals, can have a major impact on the body.; This text focuses on adrenal toxicity, examining how drugs and chemicals can directly and indirectly affect this gland. Coverage includes: classification of the types of adrenal and endocrine toxicity; the mechanistic and molecular basis of toxicity; reasons why the adrenal is the most common target organ in the endocrine system; drug toxicity specific to patients with adrenal disorders; drug- corticosteroid interactions; adverse drug reactions; and how the adrenal gland is vital in tolerance to toxic insult.
Author : William Hughes
Publisher : CRC Press
ISBN 13 : 0203362799
Total Pages : 189 pages
Book Rating : 4.2/5 (33 download)
Download or read book Essentials Of Environmental Toxicology written by William Hughes and published by CRC Press. This book was released on 2003-09-02 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introductory text addresses the principles and mechanisms of toxicology as applied to environmentally-encountered toxic agents. Each chapter concludes with review questions that may be used for student self-testing and topics covered include dose response, hazards and risk assessment, determination of toxicity, pesticides, metals, plastics, organic solvents, environmental carcinogens, teratogens and mutagens.
Author : Daniel Schlenk
Publisher : CRC Press
ISBN 13 : 1351612492
Total Pages : 383 pages
Book Rating : 4.3/5 (516 download)
Download or read book Target Organ Toxicity in Marine and Freshwater Teleosts written by Daniel Schlenk and published by CRC Press. This book was released on 2017-03-27 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing the numerous gaps in current information, Target Organ Toxicology in Marine and Freshwater Teleosts is an essential resource for researchers and professionals in aquatic toxicology and environmental risk assessment. All the chapters are written by researchers who are internationally recognised for their work in mechanistic aspects of aquatic toxicology. Each chapter focuses on a specific target organ or physiological system and describes how various agents disrupt the normal physiological system and processes. This volume is devoted to specific organs with coverage of the gill, kidney, skin, liver and gut. The companion volume, Systems, provides coverage of toxic effects in the central nervous, immune, neurobehavioural and reproductive systems as well as describing general mechanisms of toxicity.
Author : Franz-Xaver Reichl
Publisher : Springer
ISBN 13 : 9783642353734
Total Pages : 0 pages
Book Rating : 4.3/5 (537 download)
Download or read book Regulatory Toxicology written by Franz-Xaver Reichl and published by Springer. This book was released on 2014-03-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference.
