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The Synthesis Of Triazole Peptidomimetics
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Book Synopsis Advances in Triazole Chemistry by : Tahir Farooq
Download or read book Advances in Triazole Chemistry written by Tahir Farooq and published by Elsevier. This book was released on 2020-11-28 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Triazole Chemistry reviews the ever-widening scope of triazole chemistry. Triazole is an exceptional structural motif with a range of applications across scientific disciplines, including materials science, organocatalysis, agrochemicals, and medicinal chemistry. These many applications of different classes of triazoles have promoted the development of a range of synthetic strategies over the past few years, which are presented here along with recent and ecofriendly methods for the synthesis of all types of triazoles. The book also reviews the recent notable applications in chemical ligation, peptidomimetics, carbohydrate chemistry, nanotechnology, and polymer and materials science. This comprehensive resource is ideal for researchers using triazoles in various disciplines, as well as chemists working in the pharmaceutical, polymer, and agrochemical industries. - Includes coverage of the role triazoles play in DNA synthesis - Features comprehensive information on 1,2,3-triazoles and 1,2,4-triazoles and their subclasses, synthesis, and applications - Serves as an ideal reference for researchers and chemists interested in using triazole chemistry for functionalization, modification, and development of target products
Book Synopsis Peptidomimetics in Organic and Medicinal Chemistry by : Antonio Guarna
Download or read book Peptidomimetics in Organic and Medicinal Chemistry written by Antonio Guarna and published by John Wiley & Sons. This book was released on 2014-04-07 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
Book Synopsis Bioisosteres in Medicinal Chemistry by : Nathan Brown
Download or read book Bioisosteres in Medicinal Chemistry written by Nathan Brown and published by John Wiley & Sons. This book was released on 2012-06-18 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
Book Synopsis Peptidomimetics I by : William D. Lubell
Download or read book Peptidomimetics I written by William D. Lubell and published by Springer. This book was released on 2017-06-29 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.
Book Synopsis Room Temperature Organic Synthesis by : Goutam Brahmachari
Download or read book Room Temperature Organic Synthesis written by Goutam Brahmachari and published by Elsevier. This book was released on 2015-03-19 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a gap in the scientific literature, Room Temperature Organic Synthesis is unique in its authoritative, thorough, and applied coverage of a wide variety of "green" organic synthetic methodologies. The book describes practical, feasible protocols for room temperature reactions to produce carbon-carbon and carbon-heteroatom bond formations including aliphatic, aromatic, alicyclic, heterocycles, and more. Consistently organized for easy access, each selected reaction is discussed in a very compact and structured manner including: reaction type, reaction condition, reaction strategy, catalyst, keywords, general reaction scheme, mechanism (in selected cases), representative entries, experimental procedure, characterization data of representative entries, and references. This book will be a valuable resource for synthetic organic, natural products, medicinal, and biochemists as well as those working in the pharmaceutical and agrochemical industry. - Includes more than 300 protocols for a green approach to organic synthesis - Provides specific detail about experimental conditions - Increases efficiency in the laboratory by eliminating time-consuming literature searches
Book Synopsis Synthesis of Peptides and Peptidomimetics by : Murray Goodman
Download or read book Synthesis of Peptides and Peptidomimetics written by Murray Goodman and published by . This book was released on 2003 with total page 882 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Science of Synthesis: Click Chemistry by : Floris P. J. T. Rutjes
Download or read book Science of Synthesis: Click Chemistry written by Floris P. J. T. Rutjes and published by Thieme. This book was released on 2021-11-24 with total page 750 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work presents the state-of-the-art in the field of click chemistry, collecting the most useful, practical, and reliable methods. Click chemistry is a discipline that has grown rapidly since the introduction of this term by Barry Sharpless and Huisgen approximately two decades ago. Initially, click reactions mostly involved copper-catalyzed azide-alkyne cycloadditions and their applications to connect molecules, but gradually new types of click reactions were developed which also allowed a much wider range of applications throughout the chemical, biological, and materials sciences. This volume provides an overview of the most widely used click reactions and their scope and limitations. Written by pioneers and leaders in the field and including representative applications and experimental procedures. Newcomers to the field are enabled to instantly apply these reactions in synthesis.
Book Synopsis Isocyanide Chemistry by : V. Nenajdenko
Download or read book Isocyanide Chemistry written by V. Nenajdenko and published by John Wiley & Sons. This book was released on 2012-06-04 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in different branches of organic, inorganic, coordination, combinatorial and medicinal chemistry. This invaluable reference is the only book to cover the topic in such depth, presenting all aspects of synthetic isonitrile chemistry. The highly experienced and internationally renowned editor has brought together an equally distinguished team of authors who cover multicomponent reactions, isonitriles in total synthesis, isonitriles in polymer chemistry and much more.
Book Synopsis Click Reactions in Organic Synthesis by : Srinivasan Chandrasekaran
Download or read book Click Reactions in Organic Synthesis written by Srinivasan Chandrasekaran and published by John Wiley & Sons. This book was released on 2016-09-13 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endlich ein Buch zu Click-Reaktionen mit Schwerpunkt auf der organischen Synthese. Beschrieben werden das Click-Konzept, die zugrunde liegenden Mechanismen und Hauptanwendungsgebiete. NÜTZLICH: Die Click-Chemie ist ein wirkungsvoller Ansatz, um auf einfache Weise komplexe organische Moleküle aus verfügbaren Ausgangsmaterialien zu erzeugen ? der Traum jedes Organikers. EINZIGARTIGER SCHWERPUNKT: Aufgrund des besonderen Schwerpunkts auf der organischen Synthese ist dieses Buch für jeden Synthesechemiker von hohem Interesse. HILFREICH: Click-Reaktionen sind stereospezifisch, einfach durchzuführen, hoch ergiebig und lassen sich in einfach zu entfernenden oder nicht schädlichen Lösungsmitteln durchführen. INTERDISZIPLINÄR: Das Click-Konzept ist bei der Herstellung natürlicher Produkte, bioaktiver Verbindungen, von Kohlenhydraten, Arzneimitteln, Polymeren, supramolekularer Strukturen und Materialien weit verbreitet.
Book Synopsis Chemistry of Peptide Synthesis by : N. Leo Benoiton
Download or read book Chemistry of Peptide Synthesis written by N. Leo Benoiton and published by CRC Press. This book was released on 2016-04-19 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather th
Book Synopsis Progress in Heterocyclic Chemistry by : Gordon Gribble
Download or read book Progress in Heterocyclic Chemistry written by Gordon Gribble and published by Elsevier. This book was released on 2009-06-16 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the 20th annual volume of Progress in Heterocyclic Chemistry, which covers the literature published during 2007. As with previous volumes in the series, Volume 20 will enable the reader to keep abreast of developments in heterocyclic chemistry in an effortless way.* A critical review of the heterocyclic literature published during 2007 * Presents specialized reviews * Chapters all written by leading researchers in their field
Book Synopsis Energetic Nanomaterials by : Vladimir E Zarko
Download or read book Energetic Nanomaterials written by Vladimir E Zarko and published by Elsevier. This book was released on 2016-01-21 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Energetic Nanomaterials: Synthesis, Characterization, and Application provides researchers in academia and industry the most novel and meaningful knowledge on nanoenergetic materials, covering the fundamental chemical aspects from synthesis to application. This valuable resource fills the current gap in book publications on nanoenergetics, the energetic nanomaterials that are applied in explosives, gun and rocket propellants, and pyrotechnic devices, which are expected to yield improved properties, such as a lower vulnerability towards shock initiation, enhanced blast, and environmentally friendly replacements of currently used materials. The current lack of a systematic and easily available book in this field has resulted in an underestimation of the input of nanoenergetic materials to modern technologies. This book is an indispensable resource for researchers in academia, industry, and research institutes dealing with the production and characterization of energetic materials all over the world. - Written by high-level experts in the field of nanoenergetics - Covers the hot topic of energetic nanomaterials, including nanometals and their applications in nanoexplosives - Fills a gap in energetic nanomaterials book publications
Book Synopsis Advances in Organic Synthesis: Volume 17 by : Atta-ur-Rahman
Download or read book Advances in Organic Synthesis: Volume 17 written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2022-07-13 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field. Contents of this volume include these 6 reviews: - Multicomponent synthesis of heterocycles by microwave irradiation - Stereoselective procedures for the synthesis of olefines - Advanced microwave assisted organic synthesis method in organic chemistry - Five and six-membered n-heterocycle rings from diaminomaleonitrile - Peptidomimetics: current and future perspectives on hiv protease inhibitors - A review on synthesis, chemistry, and medicinal properties of benzothiazines and their related scaffolds
Download or read book Click Triazoles written by Janez Košmrlj and published by Springer. This book was released on 2012-05-30 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: B. R. Buckley and H. Heaney: Mechanistic Investigations of Copper(I)- Catalyzed Alkyne–Azide Cycloaddition Reactions.- J. D. Crowley and D. A. McMorran: “Click-Triazole” Coordination Chemistry: Exploiting 1,4-Disubstituted-1,2,3-Triazoles as Ligands.- S. Lee and A. H. Flood: Binding Anions in Rigid and Reconfigurable Triazole Receptors.- M. Watkinson: Click Triazoles as Chemosensors.- H.-F. Chow, C.-M. Lo and Y. Chen: Triazole-Based Polymer Gels.- T. Zheng, S. H. Rouhanifard, A. S. Jalloh, P. Wu: Click Triazoles for Bioconjugation.- S. Mignani, Y. Zhou, T. Lecourt and L. Micouin: Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles.
Book Synopsis Chemistry of 1,2,3-triazoles by : Wim Dehaen
Download or read book Chemistry of 1,2,3-triazoles written by Wim Dehaen and published by Springer. This book was released on 2014-10-20 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.
Book Synopsis Solid-Phase Peptide Synthesis by : Gregg B. Fields
Download or read book Solid-Phase Peptide Synthesis written by Gregg B. Fields and published by Academic Press. This book was released on 1997-10-21 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of peptides for structural and biological studies * Characterization of synthetic peptides
Book Synopsis High Throughput Screening Methods by : Joshua A. Bittker
Download or read book High Throughput Screening Methods written by Joshua A. Bittker and published by Royal Society of Chemistry. This book was released on 2016-12-08 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.
