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The Synthesis Of A Novel Cubane Based Chiral Ligand And Its Application In Asymmetric Reactions
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Book Synopsis The Synthesis of a Novel Cubane-based Chiral Ligand and Its Application in Asymmetric Reactions by : Michelle L. Ingalsbe
Download or read book The Synthesis of a Novel Cubane-based Chiral Ligand and Its Application in Asymmetric Reactions written by Michelle L. Ingalsbe and published by . This book was released on 2009 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Towards the Synthesis of a Novel Chiral Ligand for Bismuth for Use in Asymmetric Catalysis by : Emily Drew
Download or read book Towards the Synthesis of a Novel Chiral Ligand for Bismuth for Use in Asymmetric Catalysis written by Emily Drew and published by . This book was released on 2014 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chiral Ligands by : Montserrat Diéguez
Download or read book Chiral Ligands written by Montserrat Diéguez and published by CRC Press. This book was released on 2021-05-12 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many new drugs on the market are chiral compounds, that is, they can exist in two non-superimposable mirror-image forms. Asymmetric catalysis encompasses a large variety of processes for obtaining such compounds. The performance of the catalyst in those processes largely depends on the ligand that makes up the catalyst. This book describes the most relevant ligand libraries for some key processes, including an overview of the state of art and the key mechanistic aspects that favor a high catalytic performance. Key Features: The book presents historical content from the time of discovery for each family of ligands. Provides a description of the synthetic route and the ligand library's application in various catalytic asymmetric reactions Suitable as supplementary reading for courses targeting the design, synthesis and application of chiral catalysts, asymmetric catalysis and sustainable production Edited by a distinguished scientist in the field, the book has a diverse audience including research groups in homogeneous catalysis, particularly asymmetric transformations
Book Synopsis Synthesis and Screening of a Novel Cubane Schiff Base Ligand in Asymmetric Catalysis by : Kyle F. Biegasiewicz
Download or read book Synthesis and Screening of a Novel Cubane Schiff Base Ligand in Asymmetric Catalysis written by Kyle F. Biegasiewicz and published by . This book was released on 2010 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Issues in Chemistry and General Chemical Research: 2011 Edition by :
Download or read book Issues in Chemistry and General Chemical Research: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 10508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Chemistry and General Chemical Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chemistry and General Chemical Research. The editors have built Issues in Chemistry and General Chemical Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chemistry and General Chemical Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Chemistry and General Chemical Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Design and Synthesis of Chiral Ligands and Their Applications in Transition Metal-catalyzed Asymmetric Reactions by : Wei Li
Download or read book Design and Synthesis of Chiral Ligands and Their Applications in Transition Metal-catalyzed Asymmetric Reactions written by Wei Li and published by . This book was released on 2012 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Novel Chiral Dipyridylphosphine Ligands and Their Application in Ru- and Rh-catalyzed Asymmetric Hydrogenation Reactions by : Jing Wu
Download or read book Synthesis of Novel Chiral Dipyridylphosphine Ligands and Their Application in Ru- and Rh-catalyzed Asymmetric Hydrogenation Reactions written by Jing Wu and published by . This book was released on 2003 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Novel Chiral Bicyclic Ligands and Their Application in Iridium-catalyzed Reactions by : Anna Trifonova
Download or read book Synthesis of Novel Chiral Bicyclic Ligands and Their Application in Iridium-catalyzed Reactions written by Anna Trifonova and published by . This book was released on 2005 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of a Novel, Cis-decalin Ligand Scaffold and Application of Boron-mediated Reactions to Asymmetric Ligand Evaluation by : Jason W. Skudlarek
Download or read book Synthesis of a Novel, Cis-decalin Ligand Scaffold and Application of Boron-mediated Reactions to Asymmetric Ligand Evaluation written by Jason W. Skudlarek and published by . This book was released on 2000 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook Of Chiral Chemicals by : David John Ager
Download or read book Handbook Of Chiral Chemicals written by David John Ager and published by CRC Press. This book was released on 1999-01-04 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the problems associated with large, commercial-scale syntheses of chiral molecules and the relatively small number of reactions that can be used to achieve these syntheses. The book discusses commercially viable and still-developing methods of compound manufacture, and reviews the best-selling chiral compounds as of 1996.
Book Synopsis Synthesis of a Chiral Ligand and Its Use in Conjugate Addition Reactions by : Vincent Dronnet
Download or read book Synthesis of a Chiral Ligand and Its Use in Conjugate Addition Reactions written by Vincent Dronnet and published by . This book was released on 1993 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Novel Chiral Bipyrimidine Diphosphine and Aminoalcohol Ligands and Their Application in Asymmetric Catalysis by : Gang Chen
Download or read book Synthesis of Novel Chiral Bipyrimidine Diphosphine and Aminoalcohol Ligands and Their Application in Asymmetric Catalysis written by Gang Chen and published by . This book was released on 2003 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis and Evaluation of Chiral Nonracemic Ligands and Catalysts for Asymmetric Synthesis by : Michael P. A. Lyle
Download or read book Design, Synthesis and Evaluation of Chiral Nonracemic Ligands and Catalysts for Asymmetric Synthesis written by Michael P. A. Lyle and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work described in this thesis concerns the design, synthesis and evaluation of new chiral nonracemic ligands and catalysts for use in asymmetric reactions. A series of chiral nonracemic chloroacetals were prepared from 2-chloro-4- methyl-6,7-dihydro-5H-[l]pyrindine-7-one and a variety of C2-symmetric and chiral nonracemic 1,2-ethanediols (R = Me, i-Pr and Ph). These chloroacetals were further elaborated, in a modular fashion, to provide a series of chiral ligands and catalysts. A new class of C2-symmetric 2,2'-bipyridyl ligands were prepared in one step fiom the chloroacetals via a nickel(0)-mediated homo-coupling reaction. These ligands were then evaluated as chiral directors in copper@)-catalyzed asymmetric cyclopropanation reactions of styrene and diazoesters (up to 44% ee). A chiral pyridine N-oxide and a C2-symmetric 2,2'-bipyridyl N, N'-dioxide were also prepared by direct oxidation of the corresponding pyridine and the 2,2'-bipyridine, respectively. These chiral N-oxides were evaluated as chiral catalysts in desymmeterization reactions of cis-stilbene oxide (up to 20% ee). A series of pyridylphosphine ligands (P, N-ligands) were subsequently prepared in two steps from the chloroacetals via a Suzuki coupling reaction with orthofluorophenylboronic and on subsequent displacement of the fluoride with the potassium anion of diphenylphosphine. These ligands were then evaluated in palladium-catalyzed asymmetric allylic substitution reactions of racemic 3-acetoxy-l,3-diphenyl-1-propene with dimethyl malonate. Optimization of the reaction conditions resulted in the formation of the alkylated product in excellent yield (91%) and in high enantiomeric excess (90%). A related chiral nonracemic and C2-symmetric 2,2'-bipyridyl ligand was prepared from 2-chloro-4-methyl-5H-[llpyrindine. This pyrindine was prepared from a common intermediate that was used in the synthesis of the first generation of ligands. The chirality of this second generation ligand was installed by a Sharpless asymmetric dihydroxylation reaction (90% ee). The subsequently elaborated 2,2'-bipyridyl ligand (enriched to>99% ee) was then evaluated in copper(1)-catalyzed asymmetric cyclopropanation reactions of alkenes and diazoesters. In the case of the reaction of para-fluorostyrene and tert-butyl diazoacetate, the corresponding cyclopropane was formed in good diastereoselectivity (92:8) and in excellent enantioselectivity (99% ee). This ligand was also evaluated in copper(I1)-catalyzed asymmetric Friedel-Crafts alkylation reactions of various substituted indoles (up to 90% ee) and in copper(1)- catalyzed asymmetric allylic oxidation reactions of cyclic alkenes with tert-butyl peroxybenzoate (up to 9 1 % ee).
Book Synopsis The Synthesis of Chiral P, N Ligands and Their Applications in Asymmetric Catalysis by : Cian Reid
Download or read book The Synthesis of Chiral P, N Ligands and Their Applications in Asymmetric Catalysis written by Cian Reid and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Synthesis and Application of Bulky S-stereogenic and P- Stereogenic Chiral Ligands by : Seán Doran
Download or read book The Synthesis and Application of Bulky S-stereogenic and P- Stereogenic Chiral Ligands written by Seán Doran and published by . This book was released on 2012 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This doctoral thesis was focused on the design and synthesis of novel chiral ligands for application in asymmetric catalysis. One of the best examples of asymmetric catalysis is the asymmetric hydrogenation reaction for its atom economy, ease of access to both S and R enantiomers and almost ultimate enantiomeric excess obtainable in a multitude of substrates. There has been much investigation into this reaction and there has been a plethora of chiral ligands designed which catalyze this reaction in high enantiomeric excess using metals such as rhodium, iridium and ruthenium. The vast majority of these ligands are diphosphines with their chirality lying either on the backbone of the ligand or on the coordinating phosphorus atom itself. In the beginning of this work investigation was undertook to explore the possibility of successfully employing a new type of ligand class in the asymmetric hydrogenation reaction, namely the N-phosphino sulfinamide or PNSO ligands. PNSO ligands had been successfully applied to the asymmetric Pauson-Khand reaction in the Riera group yielding cyclopentenone Pauson-Khand adducts in high yield and very high enantioselectivity. The family of PNSO ligands prepared in the Riera group was attractive because apart from the high yields and enantioselectivities obtained from the reactions in which they were used, they proved to be easily prepared in short syntheses from commercially available starting materials. It was believed if they could be successfully applied in asymmetric hydrogenation for their ease of preparation they would be an attractive alternative to the diphosphine ligand class. Unfortunately the first two PNSO-Rh complexes successfully prepared provided low enantioselectivities and difficulties were encountered while trying to prepare further analogues. After some time trying to achieve PNSO-Rh complex analogues unsuccessfully the direction of the project was shifted away from the N-phosphino sulfinamide ligand class in asymmetric hydrogenation. The MaxPhos ligand had recently been developed in the group and had proven highly promising. A study was demanded of its substrate scope as applied in rhodium catalyzed asymmetric hydrogenation. Substrates already described in the literature were prepared and the asymmetric hydrogenation of them catalyzed by the MaxPhos-Rh precatalyst was performed and conditions to do so were optimized. Of seven substrates prepared the MaxPhos-Rh proved to hydrogenate five of those with high enantioselectivity. The TOF of the MaxPhos rhodium catalyst applied in the hydrogenation of the Z-MAC substrate was examined by monitoring the flux of hydrogen and was calculated at 0.065 s-1. MaxPhos complexes of cobalt and palladium were prepared to form part of the investigation into widening the reaction scope of the ligand. [(MaxPhos)Co2(CO)4(C2H2)] proved to catalyze the Pauson-Khand reaction of norbornadiene and 1-hexyne with 24 % yield and 28 %, a noteworthy enantiomeric excess for the catalytic asymmetric Pauson-Khand reaction. Chalcogenated derivatives of MaxPhos were prepared. The diselenide was used to explore the electronic nature of the ligand. The MaxPhos-rhodium carbonyl stretching was examined. MaxPhos-BH3 was used to prepare mono-chalcogenated MaxPhos derivatives. They were applied also in asymmetric hydrogenation once complexed to rhodium but enantiomeric excess of no more than 21 % was obtained in the hydrogenation of the substrate Z-MAC. The aminophosphine, a chiral building block and key intermediate in the preparation of the MaxPhos ligand, was used in the attempt to prepare bulky chiral amidine ligands and although two such species were prepared they proved inapplicable in asymmetric catalysis.
Book Synopsis Synthesis of New Chiral Ligands and Their Application in Catalytic Enantioselective Reactions by : Kedar Shankar Karmarkar
Download or read book Synthesis of New Chiral Ligands and Their Application in Catalytic Enantioselective Reactions written by Kedar Shankar Karmarkar and published by . This book was released on 1996 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design and Synthesis of Novel Chiral Bisoxazoline Ligands for the Catalytic Asymmetric Allylic Oxidation by : Davoud Asgari
Download or read book Design and Synthesis of Novel Chiral Bisoxazoline Ligands for the Catalytic Asymmetric Allylic Oxidation written by Davoud Asgari and published by . This book was released on 2001 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: