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The Single Neuron Theory
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Book Synopsis The Single-Neuron Theory by : Steven Sevush
Download or read book The Single-Neuron Theory written by Steven Sevush and published by Springer. This book was released on 2016-08-31 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an engaging account of a provocative new theory which explores how our brain generates conscious experience and where this occurs. It suggests that conscious experience happens not at the whole brain level but at the level of individual nerve cells. The notion that the brain as a whole is sentient is an illusion created by the exquisite organization of the individually conscious neurons. Despite appearances to the contrary, conscious behavior that seems to be the product of a single macroscopic mind is actually the integrated output of a chorus of microscopic minds, each associated with an individual neuron. The result is a theory that revolutionizes our conception of who and what we are.
Book Synopsis Single Neuron Studies of the Human Brain by : Itzhak Fried
Download or read book Single Neuron Studies of the Human Brain written by Itzhak Fried and published by MIT Press. This book was released on 2014-06-13 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foundational studies of the activities of spiking neurons in the awake and behaving human brain and the insights they yield into cognitive and clinical phenomena. In the last decade, the synergistic interaction of neurosurgeons, engineers, and neuroscientists, combined with new technologies, has enabled scientists to study the awake, behaving human brain directly. These developments allow cognitive processes to be characterized at unprecedented resolution: single neuron activity. Direct observation of the human brain has already led to major insights into such aspects of brain function as perception, language, sleep, learning, memory, action, imagery, volition, and consciousness. In this volume, experts document the successes, challenges, and opportunity in an emerging field. The book presents methodological tutorials, with chapters on such topics as the surgical implantation of electrodes and data analysis techniques; describes novel insights into cognitive functions including memory, decision making, and visual imagery; and discusses insights into diseases such as epilepsy and movement disorders gained from examining single neuron activity. Finally, contributors consider future challenges, questions that are ripe for investigation, and exciting avenues for translational efforts. Contributors Ralph Adolphs, William S. Anderson, Arjun K. Bansal, Eric J. Behnke, Moran Cerf, Jonathan O. Dostrovsky, Emad N. Eskandar, Tony A. Fields, Itzhak Fried, Hagar Gelbard-Sagiv, C. Rory Goodwin, Clement Hamani, Chris Heller, Mojgan Hodaie, Matthew Howard III, William D. Hutchison, Matias Ison, Hiroto Kawasaki, Christof Koch, Rüdiger Köhling, Gabriel Kreiman, Michel Le Van Quyen, Frederick A. Lenz, Andres M. Lozano, Adam N. Mamelak, Clarissa Martinez-Rubio, Florian Mormann, Yuval Nir, George Ojemann, Shaun R. Patel, Sanjay Patra, Linda Philpott, Rodrigo Quian Quiroga, Ian Ross, Ueli Rutishauser, Andreas Schulze-Bonhage, Erin M. Schuman, Demetrio Sierra-Mercado, Richard J. Staba, Nanthia Suthana, William Sutherling, Travis S. Tierney, Giulio Tononi, Oana Tudusciuc, Charles L. Wilson
Book Synopsis Single Neuron Computation by : Thomas M. McKenna
Download or read book Single Neuron Computation written by Thomas M. McKenna and published by Academic Press. This book was released on 2014-05-19 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real neurons is essential to the design of enhanced processor elements for use in the next generation of ANNs. The book covers computation in dendrites and spines, computational aspects of ion channels, synapses, patterned discharge and multistate neurons, and stochastic models of neuron dynamics. It is the most up-to-date presentation of biophysical and computational methods.
Book Synopsis Neuronal Dynamics by : Wulfram Gerstner
Download or read book Neuronal Dynamics written by Wulfram Gerstner and published by Cambridge University Press. This book was released on 2014-07-24 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.
Book Synopsis Biophysics of Computation by : Christof Koch
Download or read book Biophysics of Computation written by Christof Koch and published by Oxford University Press. This book was released on 2004-10-28 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes.Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive and active dendritic trees; the Hodgkin-Huxley model of action potential generation and propagation; phase space analysis; linking stochastic ionic channels to membrane-dependent currents; calcium and potassium currents and their role in information processing; the role of diffusion, buffering and binding of calcium, and other messenger systems in information processing and storage; short- and long-term models of synaptic plasticity; simplified models of single cells; stochastic aspects of neuronal firing; the nature of the neuronal code; and unconventional models of sub-cellular computation.Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical and computer engineering, and physics.
Book Synopsis Spiking Neuron Models by : Wulfram Gerstner
Download or read book Spiking Neuron Models written by Wulfram Gerstner and published by Cambridge University Press. This book was released on 2002-08-15 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an introduction to spiking neurons for advanced undergraduate or graduate students. It can be used with courses in computational neuroscience, theoretical biology, neural modeling, biophysics, or neural networks. It focuses on phenomenological approaches rather than detailed models in order to provide the reader with a conceptual framework. No prior knowledge beyond undergraduate mathematics is necessary to follow the book. Thus it should appeal to students or researchers in physics, mathematics, or computer science interested in biology; moreover it will also be useful for biologists working in mathematical modeling.
Book Synopsis The Feeling of Life Itself by : Christof Koch
Download or read book The Feeling of Life Itself written by Christof Koch and published by MIT Press. This book was released on 2019-09-24 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thought-provoking argument that consciousness—more widespread than previously assumed—is the feeling of being alive, not a type of computation or a clever hack In The Feeling of Life Itself, Christof Koch offers a straightforward definition of consciousness as any subjective experience, from the most mundane to the most exalted—the feeling of being alive. Psychologists study which cognitive operations underpin a given conscious perception. Neuroscientists track the neural correlates of consciousness in the brain, the organ of the mind. But why the brain and not, say, the liver? How can the brain—three pounds of highly excitable matter, a piece of furniture in the universe, subject to the same laws of physics as any other piece—give rise to subjective experience? Koch argues that what is needed to answer these questions is a quantitative theory that starts with experience and proceeds to the brain. In The Feeling of Life Itself, Koch outlines such a theory, based on integrated information. Koch describes how the theory explains many facts about the neurology of consciousness and how it has been used to build a clinically useful consciousness meter. The theory predicts that many, and perhaps all, animals experience the sights and sounds of life; consciousness is much more widespread than conventionally assumed. Contrary to received wisdom, however, Koch argues that programmable computers will not have consciousness. Even a perfect software model of the brain is not conscious. Its simulation is fake consciousness. Consciousness is not a special type of computation—it is not a clever hack. Consciousness is about being.
Book Synopsis Discovering the Brain by : National Academy of Sciences
Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Book Synopsis From Neurons to Neighborhoods by : National Research Council
Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
Download or read book A Thousand Brains written by Jeff Hawkins and published by Basic Books. This book was released on 2021-03-02 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: A bestselling author, neuroscientist, and computer engineer unveils a theory of intelligence that will revolutionize our understanding of the brain and the future of AI. For all of neuroscience's advances, we've made little progress on its biggest question: How do simple cells in the brain create intelligence? Jeff Hawkins and his team discovered that the brain uses maplike structures to build a model of the world—not just one model, but hundreds of thousands of models of everything we know. This discovery allows Hawkins to answer important questions about how we perceive the world, why we have a sense of self, and the origin of high-level thought. A Thousand Brains heralds a revolution in the understanding of intelligence. It is a big-think book, in every sense of the word. One of the Financial Times' Best Books of 2021 One of Bill Gates' Five Favorite Books of 2021
Book Synopsis The Handbook of Brain Theory and Neural Networks by : Michael A. Arbib
Download or read book The Handbook of Brain Theory and Neural Networks written by Michael A. Arbib and published by MIT Press (MA). This book was released on 1998 with total page 1118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Choice Outstanding Academic Title, 1996. In hundreds of articles by experts from around the world, and in overviews and "road maps" prepared by the editor, The Handbook of Brain Theory and Neural Networks charts the immense progress made in recent years in many specific areas related to great questions: How does the brain work? How can we build intelligent machines? While many books discuss limited aspects of one subfield or another of brain theory and neural networks, the Handbook covers the entire sweep of topics—from detailed models of single neurons, analyses of a wide variety of biological neural networks, and connectionist studies of psychology and language, to mathematical analyses of a variety of abstract neural networks, and technological applications of adaptive, artificial neural networks. Expository material makes the book accessible to readers with varied backgrounds while still offering a clear view of the recent, specialized research on specific topics.
Book Synopsis The Myth of Mirror Neurons: The Real Neuroscience of Communication and Cognition by : Gregory Hickok
Download or read book The Myth of Mirror Neurons: The Real Neuroscience of Communication and Cognition written by Gregory Hickok and published by W. W. Norton & Company. This book was released on 2014-08-18 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential reconsideration of one of the most far-reaching theories in modern neuroscience and psychology. In 1992, a group of neuroscientists from Parma, Italy, reported a new class of brain cells discovered in the motor cortex of the macaque monkey. These cells, later dubbed mirror neurons, responded equally well during the monkey’s own motor actions, such as grabbing an object, and while the monkey watched someone else perform similar motor actions. Researchers speculated that the neurons allowed the monkey to understand others by simulating their actions in its own brain. Mirror neurons soon jumped species and took human neuroscience and psychology by storm. In the late 1990s theorists showed how the cells provided an elegantly simple new way to explain the evolution of language, the development of human empathy, and the neural foundation of autism. In the years that followed, a stream of scientific studies implicated mirror neurons in everything from schizophrenia and drug abuse to sexual orientation and contagious yawning. In The Myth of Mirror Neurons, neuroscientist Gregory Hickok reexamines the mirror neuron story and finds that it is built on a tenuous foundation—a pair of codependent assumptions about mirror neuron activity and human understanding. Drawing on a broad range of observations from work on animal behavior, modern neuroimaging, neurological disorders, and more, Hickok argues that the foundational assumptions fall flat in light of the facts. He then explores alternative explanations of mirror neuron function while illuminating crucial questions about human cognition and brain function: Why do humans imitate so prodigiously? How different are the left and right hemispheres of the brain? Why do we have two visual systems? Do we need to be able to talk to understand speech? What’s going wrong in autism? Can humans read minds? The Myth of Mirror Neurons not only delivers an instructive tale about the course of scientific progress—from discovery to theory to revision—but also provides deep insights into the organization and function of the human brain and the nature of communication and cognition.
Book Synopsis The Neuron in Context by : Vanessa Lux
Download or read book The Neuron in Context written by Vanessa Lux and published by Springer. This book was released on 2024-04-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience has largely abandoned its localizationist and mechanistic framework of the 20th century. The plastic, embodied, and network character of our nervous system is widely acknowledged and systems theory approaches to consciousness dominate the field. However, the underlying neuron theory has not changed. The neuron doctrine, conceptualizing the single neuron as atomistic, one-directional source of neural function, still provides the template for our understanding of these basic elements of our nervous system and the material foundation of consciousness. Yet, the single neuron does not exist as an isolated unit. It is embedded within multiple cellular, structural, and functional contexts, and highly depends on them for its development, neural activity, and survival. The book discusses the constraints of the neuron doctrine and its pragmatic reductionism in the light of the growing knowledge about the brain’s connectivity, plasticity, and systemic and embodied nature. To overcome these constraints, the author argues for a new neuron theory, depicting the neuron as bidirectional hub which is at the same time source and product of neural function. This bidirectionality is further characterized by spatial and time dimensions, placing the neuron within a multi-level pathway model of psychobiological development from the perspective of Developmental Embodiment Research. Furthermore, the author discusses the potential of neuroepigenetic markers to characterize the neuron and its range of plasticity within this developmental perspective.With its focus on neuroepigenetics, the book addresses a knowledge gap in the current study of the neural foundations of psychological functions. The multi-level and bidirectional perspective is already realized in approaches coming from developmental systems theory, which model neural function at the connectome level, and it also fits with approaches investigating feedback loops underlying neural activity at the single cell level. At both these levels, the spatial and the time dimensions are well characterized, either as changing connectivity patterns across different age groups, or as synaptic feedback loops underlying neural activation patterns. However, for the intermediate level of small neural populations, which is currently the main target for studies investigating the neural basis of specific psychological functions, this characterization turned out to be more challenging. Multi-cell recordings have provided a first glimpse into the complex interaction patterns of these small neural networks, but they are limited to the recording period and do not provide information about the long-term developmental and activation history. Here, neuroepigenetic markers could be of use. Due to their relative stability and, at the same time, environmental sensitivity, neuroepigenetic markers represent an additional layer of information in which, to a certain degree, the cell’s metabolic and activation history is aggregated over time. This information is available at the single neuron level but could also be modeled as aggregated information for small neural populations and the supporting cellular context. Looking through this “epigenetic lens” adds to our understanding of the neuron as bidirectional hub by emphasizing the molecular correlates of functional stabilization and their contextual prerequisites. These prerequisites reach from the immediate cellular context to the social-cultural contexts which shape the culturally specific modes of acquisition of psychological functions throughout the lifespan. Accounting for this multilayered contextuality of the neuron and its function affords to repositions the relationship between neuroscience and psychology in their joint effort to unravel the material basis of consciousness. This provides new challenges but also new perspectives for theoretical psychology. The book presents these current developments and debates to researchers, graduate students, and interested professionals and practitioners working in neuroscience, epigenetics, psychiatry, psychology and psychotherapy. It also provides a basic introduction into neuroepigenetics, its mechanisms, and first findings for graduate students as well as interested professionals and practitioners working in psychiatry, psychology, and psychotherapy.
Book Synopsis I of the Vortex by : Rodolfo R. Llinas
Download or read book I of the Vortex written by Rodolfo R. Llinas and published by MIT Press. This book was released on 2002-02-22 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: A highly original theory of how the mind-brain works, based on the author's study of single neuronal cells. In I of the Vortex, Rodolfo Llinas, a founding father of modern brain science, presents an original view of the evolution and nature of mind. According to Llinas, the "mindness state" evolved to allow predictive interactions between mobile creatures and their environment. He illustrates the early evolution of mind through a primitive animal called the "sea squirt." The mobile larval form has a brainlike ganglion that receives sensory information about the surrounding environment. As an adult, the sea squirt attaches itself to a stationary object and then digests most of its own brain. This suggests that the nervous system evolved to allow active movement in animals. To move through the environment safely, a creature must anticipate the outcome of each movement on the basis of incoming sensory data. Thus the capacity to predict is most likely the ultimate brain function. One could even say that Self is the centralization of prediction. At the heart of Llinas's theory is the concept of oscillation. Many neurons possess electrical activity, manifested as oscillating variations in the minute voltages across the cell membrane. On the crests of these oscillations occur larger electrical events that are the basis for neuron-to-neuron communication. Like cicadas chirping in unison, a group of neurons oscillating in phase can resonate with a distant group of neurons. This simultaneity of neuronal activity is the neurobiological root of cognition. Although the internal state that we call the mind is guided by the senses, it is also generated by the oscillations within the brain. Thus, in a certain sense, one could say that reality is not all "out there," but is a kind of virtual reality.
Download or read book Consciousness written by Christof Koch and published by MIT Press. This book was released on 2012-03-09 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fascinating exploration of the human brain that combines “the leading edge of consciousness science with surprisingly personal and philosophical reflection . . . shedding light on how scientists really think”—this is “science writing at its best” (Times Higher Education). In which a scientist searches for an empirical explanation for phenomenal experience, spurred by his instinctual belief that life is meaningful. What links conscious experience of pain, joy, color, and smell to bioelectrical activity in the brain? How can anything physical give rise to nonphysical, subjective, conscious states? Christof Koch has devoted much of his career to bridging the seemingly unbridgeable gap between the physics of the brain and phenomenal experience. This engaging book—part scientific overview, part memoir, part futurist speculation—describes Koch’s search for an empirical explanation for consciousness. Koch recounts not only the birth of the modern science of consciousness but also the subterranean motivation for his quest—his instinctual (if “romantic”) belief that life is meaningful. Koch describes his own groundbreaking work with Francis Crick in the 1990s and 2000s and the gradual emergence of consciousness (once considered a “fringy” subject) as a legitimate topic for scientific investigation. Present at this paradigm shift were Koch and a handful of colleagues, including Ned Block, David Chalmers, Stanislas Dehaene, Giulio Tononi, Wolf Singer, and others. Aiding and abetting it were new techniques to listen in on the activity of individual nerve cells, clinical studies, and brain-imaging technologies that allowed safe and noninvasive study of the human brain in action. Koch gives us stories from the front lines of modern research into the neurobiology of consciousness as well as his own reflections on a variety of topics, including the distinction between attention and awareness, the unconscious, how neurons respond to Homer Simpson, the physics and biology of free will, dogs, Der Ring des Nibelungen, sentient machines, the loss of his belief in a personal God, and sadness. All of them are signposts in the pursuit of his life's work—to uncover the roots of consciousness.
Book Synopsis Neural Control Engineering by : Steven J. Schiff
Download or read book Neural Control Engineering written by Steven J. Schiff and published by MIT Press. This book was released on 2022-11-01 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: How powerful new methods in nonlinear control engineering can be applied to neuroscience, from fundamental model formulation to advanced medical applications. Over the past sixty years, powerful methods of model-based control engineering have been responsible for such dramatic advances in engineering systems as autolanding aircraft, autonomous vehicles, and even weather forecasting. Over those same decades, our models of the nervous system have evolved from single-cell membranes to neuronal networks to large-scale models of the human brain. Yet until recently control theory was completely inapplicable to the types of nonlinear models being developed in neuroscience. The revolution in nonlinear control engineering in the late 1990s has made the intersection of control theory and neuroscience possible. In Neural Control Engineering, Steven Schiff seeks to bridge the two fields, examining the application of new methods in nonlinear control engineering to neuroscience. After presenting extensive material on formulating computational neuroscience models in a control environment—including some fundamentals of the algorithms helpful in crossing the divide from intuition to effective application—Schiff examines a range of applications, including brain-machine interfaces and neural stimulation. He reports on research that he and his colleagues have undertaken showing that nonlinear control theory methods can be applied to models of single cells, small neuronal networks, and large-scale networks in disease states of Parkinson's disease and epilepsy. With Neural Control Engineering the reader acquires a working knowledge of the fundamentals of control theory and computational neuroscience sufficient not only to understand the literature in this trandisciplinary area but also to begin working to advance the field. The book will serve as an essential guide for scientists in either biology or engineering and for physicians who wish to gain expertise in these areas.
Book Synopsis From Neurons to Self-consciousness by : Bernard Korzeniewski
Download or read book From Neurons to Self-consciousness written by Bernard Korzeniewski and published by Gateway Bookshelf. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the end, the author suggests that as more is learned about the working of the brain, philosophical problems that have caused centuries of speculation will simply be resolved by the facts of neurophysiology. --Book Jacket.
