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The Role Of Prostaglandins In Mouse Skin Tumor Promotion And The Tumor Promoting Phorbol Ester Receptor Protein
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Book Synopsis The Role of Prostaglandins in Mouse Skin Tumor Promotion and the Tumor Promoting Phorbol Ester Receptor Protein by : Curtis L. Ashendel
Download or read book The Role of Prostaglandins in Mouse Skin Tumor Promotion and the Tumor Promoting Phorbol Ester Receptor Protein written by Curtis L. Ashendel and published by . This book was released on 1982 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prostaglandins in Cancer Research by : Enrico Garaci
Download or read book Prostaglandins in Cancer Research written by Enrico Garaci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arachidonic acid metabolites are known to playa regulatory role in a number of biological systems, in which they function as microenviron mental hormones and intracellular signal mediators. One of the most exciting areas of research of these compounds is the one that studies the relationship between prostaglandins and tumor cell growth and function. In the last few years there has been an extraordinary evolution of data on prostaglandins (and related compounds) and cancer. This vol ume is based on papers presented at the 1986 International Confer ence on Prostaglandins and Cancer organized by the Italian National Research Council and the II University of Rome, and held in Rome, Italy, in June, 1986. This Conference brought together oncologists and specialists in the areas of prostaglandin chemistry, biochemistry, pharmacology, physiology, cellular and molecular biology to overview the actual state of knowledge on the role of eicosanoids in cancer and to focus on the key questions that need to be answered. The picture that comes out of this book describes a very complicated network of interactions between arachidonic acid metabolites and different as pects of the complex phenomenon "cancer". Eicosanoids participate in carcinogenesis initiation and promotion, and their relationship with tumor promoters and growth factors is well established. During cancer growth, different prostaglandins can have different roles in the regulation of cell proliferation and differentiation and in metastasis formation; meanwhile evidence is accumulating for a pos sible use of some of these compounds as antineoplastic agents.
Book Synopsis The Role of EP1 Receptor for Prostaglandin E2 in Mouse Skin Carcinogenesis by : In Ok Surh
Download or read book The Role of EP1 Receptor for Prostaglandin E2 in Mouse Skin Carcinogenesis written by In Ok Surh and published by . This book was released on 2009 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandin E2 (PGE2), the most abundant prostaglandin in mouse skin, has been shown to promote skin tumor development. EP1 is one of four PGE2 receptors. EP1 mRNA levels analyzed by a quantitative real-time polymerase chain reaction were increased after treatments of 12-O-tetradecanoylphorbol 13-acetate (TPA) or ultraviolet light on skin as well as in 7,12 dimethylbenz[a]anthracene (DMBA)/TPA or UV-induced skin tumors. To determine whether the EP1 receptor levels affect skin tumor development, we generated BK5. EP1 transgenic mice which overexpress EP1 in the basal layer of the epidermis. The skins of these mice are histologically indistinguishable from wild type mice. To determine the role of EP1 in skin tumor development, a DMBA/TPA skin carcinogenesis protocol was used. EP1 transgenic mice had a reduced tumor multiplicity and a reduced tumor incidence compared to wild type mice, but had a higher papilloma to carcinoma conversion rate. In a DMBA-only skin carcinogenesis protocol, EP1 transgenic mice developed more tumors than wild type mice. The effect of EP1 on cell proliferation was measured in vivo. After TPA treatment, cell proliferation was induced in both EP1 transgenic mice and wild type mice to a similar extent. However, 5 days after DMBA treatment, there were about 2-fold more proliferating cells in the basal layer of the epidermis of EP1 transgenic mouse skin than in wild type mice. To confirm that the enhanced tumor formation in transgenic mice is in fact PGE2 dependent, EP1 transgenic mice were administered the selective cyclooxygenase-2 inhibitor Celecoxib or a control diet starting 1 week before DMBA treatment. Surprisingly, there was no lesion development on mice that were fed Celecoxib. Histological sections of skin from Celecoxib-fed mice showed a fairly normal skin histology 2 weeks after DMBA treatment compared to the pronounced pseudocarcinomatous hyperplasia observed in control diet mice. Therefore, it can be concluded that EP1 signaling increases PGE2 production through COX-2 induction and promotes tumor development.
Book Synopsis Phospholipid Metabolism and the Involvement of Membranes in the Promotion of Tumor Formation in Mouse Skin by : Larry Ray Rohrschneider
Download or read book Phospholipid Metabolism and the Involvement of Membranes in the Promotion of Tumor Formation in Mouse Skin written by Larry Ray Rohrschneider and published by . This book was released on 1973 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Role of the epidermal growth factor receptor in mouse skin tumor promotion by : Wenjuan Xian
Download or read book Role of the epidermal growth factor receptor in mouse skin tumor promotion written by Wenjuan Xian and published by . This book was released on 1996 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular Interactions by Environmental Tumor Promoters by : Hirota Fujiki
Download or read book Cellular Interactions by Environmental Tumor Promoters written by Hirota Fujiki and published by VSP. This book was released on 1984-12 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable progress in our understanding of tumor promotion has been made by cancer researchers throughout the world. In addition, scientists in several other disciplines have made significant contributions in elucidating the pleiotropic effects of tumor promotion. This international symposium was specifically convened to review research progress in these areas and to consider the relevance of these findings to human cancer causation and prevention. The proceedings include the contributions of leading researchers from Europe, Japan and the USA. Several papers report the exciting progress made in understanding how tumor promoters act at the cellular and biochemical levels. Elsewhere attention is focused on tumor promotion as an important phase in the occurrence of certain human tumors. It is hoped that advances in the understanding of the mechanism of tumor promotion in experimental systems will lead to new and effective approaches to human cancer prevention. The proceedings will be of interest and value to researchers working in cancer research, biochemistry, molecular genetics, mutagenesis and cell biology.
Book Synopsis Mechanisms of Tumor Promotion: Tumor promotion and carcinogenesis in vitro by :
Download or read book Mechanisms of Tumor Promotion: Tumor promotion and carcinogenesis in vitro written by and published by . This book was released on 1983 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Eicosanoids and the Skin by : Thomas Ruzicka
Download or read book Eicosanoids and the Skin written by Thomas Ruzicka and published by CRC Press. This book was released on 1990-03-30 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication summarizes the increasing knowledge in eicosanoid research. It provides a detailed overview of this rapidly expanding field. The text contains sections on general aspects of arachidonic acid metabolism, the role of eicosanoids in skin diseases, and their biological and biochemical effects in skin. Also included is a section on inhibitors of arachidonic acid metabolism with particular reference to use in dermatology. New concepts covered are: possible physiological role of lipoxygenase products in cutaneous wound healing, restoration and maintenance of cutaneous integrity, and the recently recognized protective function of prostaglandins in skin. It is an invaluable resource for individuals involved with dermatology, pharmacology, inflammation, immunology, biochemistry, physiology, internal medicine and therapeutics.
Book Synopsis Mechanisms of Tumor Promotion: Cellular responses to tumor promoters by :
Download or read book Mechanisms of Tumor Promotion: Cellular responses to tumor promoters written by and published by . This book was released on 1984 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Journal of the National Cancer Institute by :
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1999 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1993 with total page 1488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Awards Index written by and published by . This book was released on 1988 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mech Tumor Promotion Tumor PROM in Internal Organs by : Thomas J. Slaga
Download or read book Mech Tumor Promotion Tumor PROM in Internal Organs written by Thomas J. Slaga and published by Springer. This book was released on 1983-11-07 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Journal of Cancer Research and Clinical Oncology by :
Download or read book Journal of Cancer Research and Clinical Oncology written by and published by . This book was released on 1990 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Prevention written by H.-J. Senn and published by Springer Science & Business Media. This book was released on 2007-05-26 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the main proceedings of the fourth international conference on "Cancer Prevention 2006," which was held during February 16–18, 2006, in St. Gallen, Switzerland. Written by international experts in the field, the book comprises a comprehensive update on the most recent developments in the upsurging fields of molecular biology and cancer genetics and their interactions with clinical epidemiology and cancer prevention at various levels.
Book Synopsis Environmental Health Perspectives by :
Download or read book Environmental Health Perspectives written by and published by . This book was released on 1993 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Tumor Promotion: Tumor promotion and skin carcinogenesis by :
Download or read book Mechanisms of Tumor Promotion: Tumor promotion and skin carcinogenesis written by and published by . This book was released on 1984 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
