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The Role Of Aaa Proteins In Protein Repair And Degradation
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Book Synopsis The Role of AAA+ Proteins in Protein Repair and Degradation by : James Shorter
Download or read book The Role of AAA+ Proteins in Protein Repair and Degradation written by James Shorter and published by Frontiers Media SA. This book was released on 2018-12-06 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that are defined by the presence of the AAA+ domain containing canonical Walker A and B motifs required for ATP binding and hydrolysis. Members of this superfamily act on other proteins, DNA, RNA, or multicomponent complexes to affect their conformation or their assembly. There have been substantial advances in understanding the structure and mechanism of function of a large number of AAA+ proteins. In this Research Topic, review articles and original research papers discuss new aspects as well as provide a detailed overview of several AAA+ proteins, namely: ClpXP, Lon, ClpB, Hsp104, p97, AAA+ proteins of the proteasome, Rubisco activases, Torsin, Pontin, and Reptin.
Book Synopsis The Role of AAA+ Proteins in Protein Repair and Degradation by :
Download or read book The Role of AAA+ Proteins in Protein Repair and Degradation written by and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that are defined by the presence of the AAA+ domain containing canonical Walker A and B motifs required for ATP binding and hydrolysis. Members of this superfamily act on other proteins, DNA, RNA, or multicomponent complexes to affect their conformation or their assembly. There have been substantial advances in understanding the structure and mechanism of function of a large number of AAA+ proteins. In this Research Topic, review articles and original research papers discuss new aspects as well as provide a detailed overview of several AAA+ proteins, namely: ClpXP, Lon, ClpB, Hsp104, p97, AAA+ proteins of the proteasome, Rubisco activases, Torsin, Pontin, and Reptin.
Book Synopsis Molecular Nutrition and Mitochondria by : Sergej M. Ostojic
Download or read book Molecular Nutrition and Mitochondria written by Sergej M. Ostojic and published by Academic Press. This book was released on 2022-10-20 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals provides a comprehensive examination of molecular aspects of mitochondrial nutrition and how dietary compounds might impact the treatment of mitochondrial dysfunction. Beginning with an overview of the fundamentals of mitochondria physiology and the methods used to evaluate mitochondrial imbalance in clinical practice, the book goes on to outline nutritional shortfalls in mitochondrial dysfunction and highlights the complex intra-organelle milieu affecting interactions between food compounds and mitochondrial co-factors, metabolites, and signaling molecules. Further sections explore the impact of essential nutrients, such as vitamin E, fatty acids, and complex lipids, on mitochondrial biogenesis, as well as non-essential bioactive compounds originating from food that can be evaluated for their mitochondria-modulating potential, such as mitochondria-targeted small molecule antioxidants, plant-based pigments and organic compounds, nucleotides, non-proteogenic amino acids and derivatives, and mitochondria-specific enzyme mimetics from food. Molecular Nutrition and Mitochondria covers the key impacts of nutrition on mitochondria, and is the ideal reference for researchers, students and clinicians looking to develop an in-depth understanding of how dietary compounds can prevent and treat disorders associated with mitochondrial dysfunction. Describes the fundamentals of mitochondria physiology and considers the methods used to evaluate mitochondrial imbalance in clinical practice Provides broad biochemical and metabolic background on nutritional deficits found in mitochondrial dysfunction Explores the prevention and treatment of various inherited and acquired disorders associated with mitochondrial dysfunction Discusses the link between the dosage for each nutrient (nutritional vs. pharmacological) and the clinical effect Features a dedicated section on whole-diet interventions and mitochondrial function
Book Synopsis Handbook of Cell Signaling by : Ralph A. Bradshaw
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3048 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field
Book Synopsis Regulation of Organelle and Cell Compartment Signaling by : Ralph A. Bradshaw
Download or read book Regulation of Organelle and Cell Compartment Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2011-04-05 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: This must-have cell signaling title will appeal to researchers across molecular biology, biochemistry, cell biology and genetics. The articles are written and edited by experts in the field and emphasize signaling to and from intracellular compartments including transcriptional responses to cytoplasmic and nuclear signaling events, chromatin remodeling and stress responses, the regulation of endoplasmic reticulum function, control of cell cycle progression and apoptosis and the modulation of the activities of mitochondria and other organelles. Articles written and edited by experts in the field Thematic volume covering regulation of endoplasmic reticulum function, regulation of cell cycle progression, and quality control and assurance in mitochondrion events Up-to-date research on events in membrane proteins and proteins of intracellular matrix
Book Synopsis Encyclopedia of Biological Chemistry by :
Download or read book Encyclopedia of Biological Chemistry written by and published by Academic Press. This book was released on 2013-01-08 with total page 3223 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4-volume Encyclopedia of Biological Chemistry, Second Edition, represents the current state of a dynamic and crucial field of study. The Encyclopedia pulls together over 500 articles that help define and explore contemporary biochemistry, with content experts carefully chosen by the Editorial Board to assure both breadth and depth in its coverage. Editors-In-Chief William J. Lennarz and M. Daniel Lane have crafted a work that proceeds from the acknowledgement that understanding every living process-from physiology, to immunology, and genetics-is impossible without a grasp on the basic chemistry that provides its underpinning. Each article in the work provides an up-to-date snapshot of a given topic, written by experts, as well as suggestions for further readings for students and researcher wishing to go into greater depth. Available on-line via SciVerse ScienceDirect, the functionality of the Encyclopedia will provide easy linking to referenced articles, electronic searching, as well an online index and glossary to aid comprehension and searchability. This 4-volume set, thoroughly up-to-date and comprehensive, expertly captures this fast-moving field Curated by two esteemed editors-in-chief and an illustrious team of editors and contributors, representing the state of the field Suggestions for further readings offer researchers and students avenues for deeper exploration; a wide-ranging glossary aids comprehension
Book Synopsis Biotechnological Applications of Photosynthetic Proteins by : Maria Teresa Giardi
Download or read book Biotechnological Applications of Photosynthetic Proteins written by Maria Teresa Giardi and published by Springer Science & Business Media. This book was released on 2007-04-03 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnological Applications of Photosynthetic Proteins: Biochips, Biosensors and Biodevices provides an overview of the recent photosystem II research and the systems available for the bioassay of pollutants using biosensors that are based on the photochemical activity. The data presented in this book serves as a basis for the development of a commercial biosensor for use in rapid pre-screening analyses of photosystem II pollutants, minimising costly and time-consuming laboratory analyses.
Book Synopsis Metabolic Regulation in the Development of Cardiovascular Diseases by : Xiaoqiang Tang
Download or read book Metabolic Regulation in the Development of Cardiovascular Diseases written by Xiaoqiang Tang and published by Frontiers Media SA. This book was released on 2021-12-06 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Errol C. Friedberg Publisher :American Society for Microbiology Press ISBN 13 :1555813194 Total Pages :2587 pages Book Rating :4.5/5 (558 download)
Book Synopsis DNA Repair and Mutagenesis by : Errol C. Friedberg
Download or read book DNA Repair and Mutagenesis written by Errol C. Friedberg and published by American Society for Microbiology Press. This book was released on 2005-11-22 with total page 2587 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.
Book Synopsis Post-Translational Modifications and Compartmentalized Protein Quality Control in Cardiac Muscle and Disease by : Huabo Su
Download or read book Post-Translational Modifications and Compartmentalized Protein Quality Control in Cardiac Muscle and Disease written by Huabo Su and published by Frontiers Media SA. This book was released on 2021-10-18 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Heat Shock Proteins in Neuroscience by : Alexzander A. A. Asea
Download or read book Heat Shock Proteins in Neuroscience written by Alexzander A. A. Asea and published by Springer Nature. This book was released on 2019-10-30 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer’s Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Download or read book DNA Repair written by Francesca Storici and published by BoD – Books on Demand. This book was released on 2011-09-09 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA repair is fundamental to all cell types to maintain genomic stability. A collection of cutting-edge reviews, DNA Repair - On the pathways to fixing DNA damage and errors covers major aspects of the DNA repair processes in a large variety of organisms, emphasizing foremost developments, questions to be solved and new directions in this rapidly evolving area of modern biology. Written by researchers at the vanguard of the DNA repair field, the chapters highlight the importance of the DNA repair mechanisms and their linkage to DNA replication, cell-cycle progression and DNA recombination. Major topics include: base excision repair, nucleotide excision repair, mismatch repair, double-strand break repair, with focus on specific inhibitors and key players of DNA repair such as nucleases, ubiquitin-proteasome enzymes, poly ADP-ribose polymerase and factors relevant for DNA repair in mitochondria and embryonic stem cells. This book is a journey into the cosmos of DNA repair and its frontiers.
Book Synopsis Advances in CNS Repair, Regeneration, and Neuroplasticity: From Basic Mechanisms to Therapeutic Strategies by : Shuxin Li
Download or read book Advances in CNS Repair, Regeneration, and Neuroplasticity: From Basic Mechanisms to Therapeutic Strategies written by Shuxin Li and published by Frontiers Media SA. This book was released on 2022-03-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Macromolecular Protein Complexes II: Structure and Function by : J. Robin Harris
Download or read book Macromolecular Protein Complexes II: Structure and Function written by J. Robin Harris and published by Springer Nature. This book was released on 2020-01-14 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book follows on from Volume 83 in the SCBI series (“Macromolecular Protein Complexes”), and addresses several important topics (such as the Proteasome, Anaphase Promoting Complex, Ribosome and Apoptosome) that were not previously included, together with a number of additional exciting topics in this rapidly expanding field of study. Although the first SCBI Protein Complex book focused on soluble protein complexes, the second (Vol. 87)addressed Membrane Complexes, and the third (Vol. 88) put the spotlight on Viral Protein and Nucleoprotein Complexes, a number of membrane, virus and even fibrillar protein complexes have been be considered for inclusion in the present book. A further book is also under preparation that follows the same pattern, in an attempt to provide a thorough coverage of the subject. Chapter 9 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis The key role of ubiquitination and sumoylation in signaling and cancer by : Hui-Kuan Lin
Download or read book The key role of ubiquitination and sumoylation in signaling and cancer written by Hui-Kuan Lin and published by Frontiers E-books. This book was released on with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ubiquitination and Sumoylation are two important posttranslational modifications that play pivotal roles in a variety of biological functions. Although Ubiquitination is traditionally viewed as a critical mark targeting proteins for proteasome-dependent degradation, recent studies reveal that it also plays nonproteolytic functions. In contrast, Sumoylation is long thought not to target proteins for degradation, accumulating evidence suggests that it can serve a priming effect prerequisite for ubiquitination, thereby inducing protein ubiquitination and degradation. Thus, there is an important cross-talk between sumoylation and ubiquitination in determining protein fate. Deregulation in these two marks may cause aberrant activity of proteins and in turn contributes to cancer development. In this Research Topic, we accept review articles, perspectives, research articles covering any one or both of these two posttranslational modifications in regulating diverse signal transduction pathways and providing the novel insights in unraveling the puzzle as to how they may regulate cancer progression and metastasis.
Book Synopsis Encyclopedia of Genetics, Genomics, Proteomics, and Informatics by : George P. Rédei
Download or read book Encyclopedia of Genetics, Genomics, Proteomics, and Informatics written by George P. Rédei and published by Springer Science & Business Media. This book was released on 2008-04-25 with total page 2139 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new third edition updates a best-selling encyclopedia. It includes about 56% more words than the 1,392-page second edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. It includes approximately 1,800 current databases and web servers. This encyclopedia covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, and patents. Similar integrated information is not available in textbooks or on the Internet.
Book Synopsis Biogenesis of the oxidative phosphorylation machinery in plants. From gene expression to complex assembly by : Daniel H. Gonzalez
Download or read book Biogenesis of the oxidative phosphorylation machinery in plants. From gene expression to complex assembly written by Daniel H. Gonzalez and published by Frontiers Media SA. This book was released on 2014-09-10 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial biogenesis is an extremely complex process. A hint of this complexity is clearly indicated by the many steps and factors required to assemble the respiratory complexes involved in oxidative phosphorylation. These steps include the expression of genes present in both the nucleus and the organelle, intricate post-transcriptional RNA processing events, the coordinated synthesis, transport and assembly of the different subunits, the synthesis and assembly of co-factors and, finally, the formation of supercomplexes or respirasomes. It can be envisaged, and current knowledge supports this view, that plants have evolved specific mechanisms for the biogenesis of respiratory complexes. For example, expression of the mitochondrial genome in plants has special features, not present in other groups of eukaryotes. Moreover, plant mitochondrial biogenesis and function should be considered in the context of the presence of the chloroplast, a second organelle involved in energetic and redox metabolism. It implies the necessity to discriminate between proteins destined for each organelle and requires the establishment of functional interconnections between photosynthesis and respiration. In recent years, our knowledge of the mechanisms involved in these different processes in plants has considerably increased. As a result, the many events and factors necessary for the correct expression of proteins encoded in the mitochondrial genome, the cis acting elements and factors responsible for the expression of nuclear genes encoding respiratory chain components, the signals and mechanisms involved in the import of proteins synthesized in the cytosol and the many factors required for the synthesis and assembly of the different redox co-factors (heme groups, iron-sulfur clusters, copper centers) are beginning to be recognized at the molecular level. However, detailed knowledge of these processes is still not complete and, especially, little is known about how these processes are interconnected. Questions such as how the proteins, once synthesized in the mitochondrial matrix, are inserted into the membrane and assembled with other components, including those imported from the cytosol, how the expression of both genomes is coordinated and responds to changes in mitochondrial function, cellular requirements or environmental cues, or which factors and conditions influence the assembly of complexes and supercomplexes are still open and will receive much attention in the near future. This Research Topic is aimed at establishing a collection of articles that focus on the different processes involved in the biogenesis of respiratory complexes in plants as a means to highlight recent advances. In this way, it intends to help to construct a picture of the whole process and, not less important, to expose the existing gaps that need to be addressed to fully understand how plant cells build and modulate the complex structures involved in respiration.
