The Relationship Of Metabotropic Glutamate Receptor Type 5 Mglur5 Availability With Hypometabolism In Mesial Temporal Lobe Epilepsy

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The Relationship of Metabotropic Glutamate Receptor Type 5 (MgluR5) Availability with Hypometabolism in Mesial Temporal Lobe Epilepsy

Author : Jackie Lam
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis The Relationship of Metabotropic Glutamate Receptor Type 5 (MgluR5) Availability with Hypometabolism in Mesial Temporal Lobe Epilepsy by : Jackie Lam

Download or read book The Relationship of Metabotropic Glutamate Receptor Type 5 (MgluR5) Availability with Hypometabolism in Mesial Temporal Lobe Epilepsy written by Jackie Lam and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "[18F]FDG positron emission tomography (PET) imaging in mesial temporal lobe epilepsy (MTLE) patients identifies glucose hypometabolism in the epileptic focus and beyond, including the temporal neocortex. However, the mechanisms underlying this phenomenon are still poorly understood. It is thought disruptions of glutamate cycling, which is coupled to glucose utilization, may be related. Metabotropic glutamate receptor 5 (mGluR5) is a G-protein coupled receptor that shows upregulation in immunohistochemistry studies of hippocampi resected from MTLE patients. However, ex vivo studies are limited as they are conducted in drug-resistant patients needing surgery and convey information only on the seizure focus. [11C]ABP688 is a PET radioligand specific for the allosteric site of mGluR5, allowing for non-invasive in vivo whole brain quantification of mGluR5 availability. In this study, we determined if [11C]ABP688 binding abnormalities are more specific and focal than hypometabolism within the epileptic focus of MTLE patients and whether [11C]ABP688 binding abnormalities can be detected at a higher magnification in different hippocampal subfields as described in a immunohistochemistry study by Kandratavicius et al., 2013. Thirty one unilateral MTLE patients (13 right; 24 female; 40±14 yrs) and 30 healthy controls (12 female; 47±18 yrs) underwent structural magnetic resonance imaging and PET imaging with injection of [11C]ABP688; a subset of 15 patients also underwent [18F]FDG PET. Patients were classified as "normal volume" (NV) or "hippocampal atrophy" (HA) based on their degree of hippocampal volume and asymmetry. We compared partial volume corrected [11C]ABP688 non-displaceable binding potentials (BPND) between patients and controls in regions of interest (ROIs) in mesial temporal structures, temporal neocortex, and hippocampal subfields. For the subset of patients with [18F]FDG data, we performed asymmetry analyses and correlated [11C]ABP688 BPND and [18F]FDG standard uptake value ratios (SUVr) to determine if changes in one are associated with changes in the other. Finally, we compared mGluR5 availability with mGluR5 immunoreactivity (IR) in hippocampal subfields.mGluR5 availability was reduced in the hippocampal head and amygdala of patients compared to controls, with reductions also seen in the temporal neocortex in HA patients only. Patients who were seizure-free following surgery had lower [11C]ABP688 BPND in the ipsilateral hippocampal head and entorhinal cortex than patients who were not seizure-free. [18F]FDG hypometabolism was widespread in ROIs ipsilateral to the focus, while [11C]ABP688 BPND reductions were more prominent and more focal in the hippocampal head. Correlation between [11C]ABP688 BPND and [18F]FDG SUVr in presumably healthy supramarginal gyrus was low, while trends for positive correlations in both ipsilateral and contralateral mesial temporal and cortical regions were found, significant only in contralateral entorhinal cortex and in ipsilateral insula and temporal lobe. [11C]ABP688 PET subfield analyses demonstrated that in vivo reduced mGluR5 availability contrasted to reported ex vivo increased mGluR5 IR. This study is among the first to characterize mGluR5 availability in MTLE patients using [11C]ABP688 PET. [11C]ABP688 BPND reductions in the epileptic focus contrasting to previously reported increased mGluR5 IR in resected tissue suggests that overexpressed mGluR5 in the focus might be internalized or subject to other conditions impacting the binding of the radioligand to the allosteric site. Prominent and focal [11C]ABP688 BPND abnormalities supports mGluR5 imaging as a more specific biomarker for the seizure focus than hypometabolism that may help to predict post-surgical success. Trends for positive association between [18F]FDG SUVr and mGluR5 availability within the MTLE network might further support post-synaptic glutamatergic neurotransmission modulation underlying hypometabolism in MTLE." --

MGluR5 Imaging in the Clinical Investigation of Patients with TLE with Bilateral EEG Or Non-contributory MRI Findings. A Proof-of-concept Retrospective Study

Download MGluR5 Imaging in the Clinical Investigation of Patients with TLE with Bilateral EEG Or Non-contributory MRI Findings. A Proof-of-concept Retrospective Study PDF Online Free

Author : Siavash Kermani Koosheh
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (131 download)

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Book Synopsis MGluR5 Imaging in the Clinical Investigation of Patients with TLE with Bilateral EEG Or Non-contributory MRI Findings. A Proof-of-concept Retrospective Study by : Siavash Kermani Koosheh

Download or read book MGluR5 Imaging in the Clinical Investigation of Patients with TLE with Bilateral EEG Or Non-contributory MRI Findings. A Proof-of-concept Retrospective Study written by Siavash Kermani Koosheh and published by . This book was released on 2022 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Epilepsy is a neurological condition characterized by recurrent seizures. The most frequent type of focal epilepsy in adults is temporal lobe epilepsy (TLE). For patients with TLE in whom the focus location is known, surgical intervention can be a potentially curative option. Localization of the epileptogenic zone (EZ) for "clinically complex" TLE patients (i.e., bilateral foci, neocortical generator) often requires intracranial electroencephalography (iEEG) recordings to determining surgical candidacy. Epilepsy is characterized by aberrant neuronal excitability, generating seizures and EEG epileptiform abnormalities. Glutamate has been shown to contribute to excitotoxicity and hyperexcitability in the epileptic focus. Metabotropic glutamate receptor 5 (mGluR5) is a postsynaptic receptor shown to be implicated in the EZ. [11C]ABP688 is a non-competitive antagonist which can be used as a positron emission tomography (PET) radioligand. It is highly specific for the transmembrane allosteric site of mGluR5, allowing for non-invasive in vivo quantification of mGluR5 availability. The aim of this proof-of-concept study was to test whether [11C]ABP688 PET could provide additional information for patients in whom localization of the EZ is more challenging in the presurgical work up. Ten patients who had undergone [11C]ABP688 PET and magnetic resonance imaging (MRI) were retrospectively selected. [11C]ABP688 binding potential (BPND) maps were generated using the cerebellum as reference region, and qualitatively analyzed for abnormalities within the mesial and neocortical temporal structures. [11C]ABP688 binding reduction concordant with the clinical hypothesis was observed in presumed seizure onset areas and variable degrees of reduction in [11C]ABP688 BPND were observed in all 10 patients when visually analyzing the mesial temporal structures such as the amygdala and hippocampus as well as the neocortex. This is one of the first studies that has observed [11C]ABP688 BPND reductions in both mesial and neocortical temporal lobe epilepsy. This proof-of-concept study successfully demonstrated the value of mGluR5 imaging, providing preliminary results to support larger scale studies on the yield of [11C]ABP688 PET in the presurgical work up or in the investigation of more clinically complex cases"--

In Vivo Assessment of Metabotropic Glutamate Receptor Type 5 Abnormalities in Patients with Focal Cortical Dysplasia

Author : Jonathan DuBois
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (18 download)

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Book Synopsis In Vivo Assessment of Metabotropic Glutamate Receptor Type 5 Abnormalities in Patients with Focal Cortical Dysplasia by : Jonathan DuBois

Download or read book In Vivo Assessment of Metabotropic Glutamate Receptor Type 5 Abnormalities in Patients with Focal Cortical Dysplasia written by Jonathan DuBois and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Rationale: Focal cortical dysplasia (FCD) is a malformation of cortical development, which is characterized histologically by cortical dyslamination and the presence of dysmorphic neurons, including balloon cells. Metabotropic glutamate receptor type 5 (mGluR5) is a postsynaptic G-protein coupled receptor that modulates neuronal excitability and plays a key role in cortical development. In addition to several lines of evidence that support a role of mGluR5 in epileptogenesis, surgical specimens resected from patients with FCD show mGluR5 abnormalities in dysmorphic neurons and balloon cells. However, it is unknown whether mGluR5 abnormalities could be a diffuse cortical characteristic of patients with FCD or limited within the boundaries of the epileptogenic lesion.Methods: In order to characterize whole-brain mGluR5 abnormalities in patients with FCD, we utilized the positron emission tomography (PET) ligand [11C]ABP688, which binds selectively to the mGluR5 allosteric site. In addition, we developed a surface-based analysis and data-driven partial volume correction method to ensure accurate comparisons between the FCD lesion and healthy control cortex. Using these methods, we carried out the following projects: 1) Evaluation of regional differences related to mGluR5 availability in healthy controls; 2) Assessment of in vivo mGluR5 abnormalities in patients with FCD; 3) Characterization of the mGluR5 network in patients with FCD.Results: In study 1, we observed a heterogeneous distribution of mGluR5 availability across cortical and subcortical structures, with the highest binding in association cortices. In addition, we found that mGluR5 availability was stable across the healthy adult lifespan and between sexes. In study 2, we demonstrated that mGluR5 availability was reduced within the MRI positive dysplastic lesion. In the majority of patients, mGluR5 abnormalities were also found in perilesional and remote areas of the cortex. In study 3, patients with FCD showed reduced mGluR5 network efficiency and resilience in both the ipsilateral and contralateral hemispheres, suggesting widespread reorganization of the mGluR5 network.Conclusions: First, we developed methods to accurately measure mGluR5 availability and provided a detailed assessment of the distribution throughout the brain in a large sample of healthy control subjects. In patients with FCD, we demonstrated for the first time, in vivo evidence of abnormal mGluR5 availability both within the dysplastic lesion and at the network level. These findings may suggest a role of mGluR5 in the epileptogenicity attributed to FCD. In addition, this work may provide novel insights into the distribution of mGluR5 availability in healthy controls and patients with FCD, which may contribute to future diagnostic and therapeutic applications targeting the mGluR5 pathway." --

The Role of Metabotropic Glutamate Receptor 5 in Cerebral Ischemia

Author : Hsin-Yun Lin
Publisher :
ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.:/5 (987 download)

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Book Synopsis The Role of Metabotropic Glutamate Receptor 5 in Cerebral Ischemia by : Hsin-Yun Lin

Download or read book The Role of Metabotropic Glutamate Receptor 5 in Cerebral Ischemia written by Hsin-Yun Lin and published by . This book was released on 2014 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Group I metabotropic glutamate receptor 5 (mGluR5), belongs to G-protein coupled receptors family and plays important roles in CNS disorders including Fragile X syndrome, drug addiction, epilepsy and stroke. Our previous study showed that inhibition of Group I mGluRs, including mGluR1 and mGluR5, can reduce acute brain damage and improve long-term outcomes after ischemia. However, the contribution of mGluR5 to ischemic injury remains to be determined. In this study, we used mGluR5 knockout (KO) mice to examine whether genetic deletion of mGluR5 will affect brain damage and functional recovery following stroke. Using a photothrombosis induced ischemia model, we found that female mGluR5 KO mice exhibited larger infarct volume after ischemia compared to wild type females, whereas male wild type and mGluR5 KO mice have similar infarctions. Consistently, behavioral assessments following ischemia indicated that female mGluR5 KO mice showed worse performance in hanging wire test and adhesive removal test while there is no significant difference in these tests between male wild type and mGluR5 KO mice. In addition, we observed a difference in neuronal degeneration in female wild type and mGluR5 KO mice but no difference in apoptosis between wild type and mGluR5 KO mice from both genders. Taken together, our results demonstrate that mGluR5 plays an important role in ischemia in female mice and suggest that male and female may function differently after ischemia.

Glutamate and Neuropsychiatric Disorders

Author : Zoran M. Pavlovic
Publisher : Springer Nature
ISBN 13 : 303087480X
Total Pages : 623 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Glutamate and Neuropsychiatric Disorders by : Zoran M. Pavlovic

Download or read book Glutamate and Neuropsychiatric Disorders written by Zoran M. Pavlovic and published by Springer Nature. This book was released on 2022-04-10 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.

Jasper's Basic Mechanisms of the Epilepsies

Author : Jeffrey Noebels
Publisher : OUP USA
ISBN 13 : 0199746540
Total Pages : 1258 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Progressive Brain Disorders in Childhood

Author : Juan M. Pascual
Publisher : Cambridge University Press
ISBN 13 : 1107042054
Total Pages : 507 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Progressive Brain Disorders in Childhood by : Juan M. Pascual

Download or read book Progressive Brain Disorders in Childhood written by Juan M. Pascual and published by Cambridge University Press. This book was released on 2017-04-20 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.

Autoimmune Neurology

Author :
Publisher : Elsevier
ISBN 13 : 0444634460
Total Pages : 569 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Autoimmune Neurology by :

Download or read book Autoimmune Neurology written by and published by Elsevier. This book was released on 2016-03-11 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Voltage Gated Sodium Channels

Author : Peter C. Ruben
Publisher : Springer Science & Business Media
ISBN 13 : 3642415881
Total Pages : 328 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Voltage Gated Sodium Channels by : Peter C. Ruben

Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Neuroimmunology

Author : Amanda L. Piquet
Publisher : Springer Nature
ISBN 13 : 3030618838
Total Pages : 536 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Neuroimmunology by : Amanda L. Piquet

Download or read book Neuroimmunology written by Amanda L. Piquet and published by Springer Nature. This book was released on 2021-03-08 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a clinical focus on neuroinflammatory diseases as well as a review in pathophysiology and treatment approaches. Organized into six parts, the book begins with a basic review of the immune system and concepts for learning and treating neuroimmune conditions. The next four sections cover specific subfields of neuroimmunology and autoimmune neurology - the clinical and diagnostic features of multiple sclerosis, other autoimmune conditions of the central nervous system, autoimmune conditions of the peripheral nervous system, and systemic autoimmune conditions that affect the nervous system. To conclude, Section six discusses various clinical approaches to specific presentations in neuroimmunology, including pediatric demyelinating diseases. These sections provide practical clinical information to improve the reader’s knowledge in this complex field. The chapters are written by world renown authors with extensive knowledge to help provide up to date information. The full scope of autoimmune neurology is discussed, which is a unique feature of this book. Neuroimmunology serves as a resource for those in training including residents and fellows to provide clear clinical reasoning and background in a rapidly advancing field.

PET and SPECT in Neurology

Author : Rudi A.J.O. Dierckx
Publisher : Springer
ISBN 13 : 3642543073
Total Pages : 1103 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis PET and SPECT in Neurology by : Rudi A.J.O. Dierckx

Download or read book PET and SPECT in Neurology written by Rudi A.J.O. Dierckx and published by Springer. This book was released on 2014-06-02 with total page 1103 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and SPECT in Neurology highlight the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable not only to neurologists and radiologists/nuclear medicine specialists but also to interested general practitioners and geriatricians. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.

Intractable Seizures

Author : W. McIntyre Burnham
Publisher : Springer
ISBN 13 : 9781461355038
Total Pages : 0 pages
Book Rating : 4.3/5 (55 download)

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Book Synopsis Intractable Seizures by : W. McIntyre Burnham

Download or read book Intractable Seizures written by W. McIntyre Burnham and published by Springer. This book was released on 2012-10-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: About 20% of people with epilepsy have seizures which are resistant to anticonvulsant medications. These drug-resistant seizures are called `intractable', and the patients who have them - about 1 in 500 of the general population - present a major challenge to neurologists and epilepsy associations. The present volume describes the symptomatology of the major `intractable' syndromes, the most appropriate drugs for each, and the possibilities for surgical control. Research related to the causes and effects of unchecked seizures is presented, and new directions in prevention and therapy are discussed.

Neurorheumatology

Author : Tracey A. Cho
Publisher : Springer
ISBN 13 : 3030169286
Total Pages : 293 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Neurorheumatology by : Tracey A. Cho

Download or read book Neurorheumatology written by Tracey A. Cho and published by Springer. This book was released on 2019-06-29 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed, practical textbook focuses on immune mediated disorders of the nervous system with particular focus on systemic autoimmune disorders. Divided into three sections, the first discusses the neuroanatomical and pathophysiologic basis of immune mediated disorders of the nervous system. Following this are 25 chapters devoted to individual clinical conditions. To conclude, the final section explains what is known about the mechanisms of immunomodulatory treatments and practical points about monitoring patients on these treatments. Neurorheumatology: A Comprehensive Guide to Immune Mediated Disorders of the Nervous System bridges the gaps among different branches of medicine and is an indispensable resource for rheumatologists and neurologists looking to develop a firm understanding of these dynamic disorders

Pediatric Neuropsychiatry

Author : Aaron J. Hauptman
Publisher : Springer
ISBN 13 : 3319949985
Total Pages : 326 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Pediatric Neuropsychiatry by : Aaron J. Hauptman

Download or read book Pediatric Neuropsychiatry written by Aaron J. Hauptman and published by Springer. This book was released on 2018-10-26 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adult neuropsychiatry is now a well-established field with numerous reputable references. Practitioners who work with children routinely note how references and practitioners knowledgeable in the equivalent work in the pediatric world are rare. Child psychiatrists and neurologists frequently work with individuals struggling with these conditions and would strongly benefit from such a reference that incorporates medical work-up, psychopharmacological recommendations, family/support recommendations and theoretical pathophysiology. Pediatricians and developmental pediatricians often treat children with behavioral and neuropsychiatric sequelae, but are not well-trained in the neuropsychiatric management of these cases. Neuropsychologists and educational psychologists working with children and adults with pediatric-onset conditions will also find the text helpful to contextualize their cases, better-understand the medical evaluation and management and perhaps adjust recommendations that would supplement their own testing methods. Finally, sub-specialists in adult neurology, psychiatry and neuropsychiatry often find themselves working with these children by default as there are few pediatric subspecialists who are available to accept them into practice. When facing complex neuropsychiatric illness in children, many clinicians are stymied because they may have “never seen a case like that”. This text fills the wide gap that currently exists and helps move this field forward. The approach utilized in adult neuropsychiatry that is both clear and accessible does not yet have an equivalent in the pediatric realm, but there is tremendous interest in its development. Children and adolescents with neuropsychiatric conditions are very common and they and their caregivers often struggle to find professionals well educated in this field. Ultimately, a wide range of clinicians will find this text to be a very helpful resource for diagnosis and management in the spectrum of pediatric neuropsychiatric conditions. The case-based approach is also unique with respect to neuropsychiatric approaches, and the clear cut, reader-friendly approach of such a format would likely be well-received among physicians looking for a resource on this issue.

Clinical Genetics and Genomics of Aging

Author : Juan Carlos Gomez-Verjan
Publisher : Springer Nature
ISBN 13 : 3030409554
Total Pages : 274 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Clinical Genetics and Genomics of Aging by : Juan Carlos Gomez-Verjan

Download or read book Clinical Genetics and Genomics of Aging written by Juan Carlos Gomez-Verjan and published by Springer Nature. This book was released on 2020-04-13 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.

Imaging Biomarkers in Epilepsy

Author : Andrea Bernasconi
Publisher : Cambridge University Press
ISBN 13 : 1107108357
Total Pages : 263 pages
Book Rating : 4.1/5 (71 download)

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Book Synopsis Imaging Biomarkers in Epilepsy by : Andrea Bernasconi

Download or read book Imaging Biomarkers in Epilepsy written by Andrea Bernasconi and published by Cambridge University Press. This book was released on 2019-01-10 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembles world-class expertise on clinical and molecular imaging-derived biomarkers, presenting neuroimaging in epilepsy in a broad neuroscientific context.

Neuroimaging Techniques in Clinical Practice

Author : Manoj Mannil
Publisher : Springer Nature
ISBN 13 : 303048419X
Total Pages : 340 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Neuroimaging Techniques in Clinical Practice by : Manoj Mannil

Download or read book Neuroimaging Techniques in Clinical Practice written by Manoj Mannil and published by Springer Nature. This book was released on 2020-08-11 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise overview of emerging technologies in the field of modern neuroimaging. Fundamental principles of the main imaging modalities are described as well as advanced imaging techniqes including diffusion weighted imaging, perfusion imaging, arterial spin labeling, diffusion tensor imaging, intravoxel incoherent motion, MR spectroscopy, functional MRI, and artificial intelligence. The physical concepts underlying each imaging technique are carefully and clearly explained in a way suited to a medical audience without prior technical knowledge. In addition, the clinical applications of the various techniques are described with the aid of illustrative clinical examples. Helpful background information is also presented on the core principles of MRI and the evolution of neuroimaging, and important references to current medical research are highlighted. The book will meet the needs of a range of non-technological professionals with an interest in advanced neuroimaging, including radiology researchers and clinicians in the fields of neurology, neurosurgery, and psychiatry.