Author : Ian Bass Seiple
Publisher :
ISBN 13 :
Total Pages : 1460 pages
Book Rating : 4.:/5 (79 download)
Book Synopsis The Pursuit of Palau'amine by : Ian Bass Seiple
Download or read book The Pursuit of Palau'amine written by Ian Bass Seiple and published by . This book was released on 2011 with total page 1460 pages. Available in PDF, EPUB and Kindle. Book excerpt: These total syntheses were enabled by a catalytic, enantioselective Diels-Alder reaction and by the invention of a chemoselective silver(II)-mediated oxidation, which inspired an investigation into unexplored domains of silver-mediated chemistry. The discovery that a silver(I)/persulfate system can effect the radical deborylation of aryl- and alkylboronic acids led to new practical methods for the C-H functionalization of heterocycles and quinones. This discovery further prompted the reinvestigation of other underutilized methods for radical functionalization, namely radical trifluoromethylation of heterocyles. This thesis will show how an endeavor in total synthesis, namely the pursuit of palau'amine, can lead to discoveries and inventions that transcend its original goals and lead to lasting lessons in science.