The Promise And Peril Of Crispr

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The Promise and Peril of CRISPR

Author : Neal Baer
Publisher : JHU Press
ISBN 13 : 1421449315
Total Pages : 196 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis The Promise and Peril of CRISPR by : Neal Baer

Download or read book The Promise and Peril of CRISPR written by Neal Baer and published by JHU Press. This book was released on 2024-07-02 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely collection of essays on the pressing possibilities and risks of gene-editing technology. Scientists and genetic engineers are becoming increasingly adept at editing the human genome. How far can—and should—they go in editing future generations? In The Promise and Peril of CRISPR, editor Neal Baer brings together a timely collection of essays by influential bioethicists, philosophers, and geneticists to explore the moral, ethical, and policy challenges posed by CRISPR technology. We are at a technological and ethical crossroads in grappling with the impacts of genetic editing. Gene-editing technology holds the promise of curing more than 7,000 known genetic diseases. Yet with that promise comes the peril of using CRISPR to edit the human genome, which could not only lead to manipulating human evolution, but also to creating and releasing pathogens capable of wreaking havoc on human, animal, and plant life. Although CRISPR has already cured several genetic diseases, it could also be used to design biological weapons or to edit the embryos of people who can afford to purchase genetic "enhancements" for their children. What role can and should the public play in discussing the far-reaching implications of gene editing? What oversights should be put in place to prevent a rogue scientist from engineering another baby – as was recently done with twins in China? Essay contributors offer informed predictions and guidelines for how the uses of CRISPR today will affect life in the future. Decisions we make now may have unpredictable consequences for future generations. For anyone concerned about the uses and potential abuses of gene editing, these essays provide a critical and comprehensive discussion of the central issues surrounding CRISPR technology. Contributors: Florence Ashley, R. Alta Charo, Marcy Darnovsky, Kevin Doxzen, Rosemarie Garland-Thomson, Gigi Kwik Gronvall, Jodi Halpern, Katie Hasson, Andrew C. Heinrich, Jacqueline Humphries, J. Benjamin Hurlbut, Ellen D. Jorgensen, Peter F. R. Mills, Carol Padden, Marcus Schultz-Bergin, Robert Sparrow, Sandra Sufian, Krystal Tsosie, Ethan Weiss, Rachel M. West

CRISPR Chronicles

Author : James Ellis
Publisher : Rockwood Publishing
ISBN 13 :
Total Pages : 121 pages
Book Rating : 4./5 ( download)

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Book Synopsis CRISPR Chronicles by : James Ellis

Download or read book CRISPR Chronicles written by James Ellis and published by Rockwood Publishing. This book was released on 2023-10-31 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Welcome to the dawn of the genetic age: a revolutionary epoch where the very code of life can be edited at will. As humanity stands on the brink of a genetic revolution, "CRISPR Chronicles: Navigating the Ethics, Promises, and Perils of Gene Editing" presents an engaging and comprehensive exploration of the revolutionary CRISPR technology. With this book as your guide, you'll embark on an intriguing journey through the wonders of genetic engineering, uncovering the fascinating science behind CRISPR and its real-world applications. From eradicating diseases and feeding a growing population sustainably, to groundbreaking developments in biofuels and materials, the possibilities are astounding. But with great power comes profound ethical dilemmas. We explore the controversial boundaries between medical treatment and genetic enhancement, and the moral conundrums they raise. Is it right to edit the genes of unborn children? How can we distinguish between beneficial treatment and controversial enhancement? Who will have access to this technology, and how will it reshape society? With expert opinions, thought-provoking hypothetical scenarios, and a look at the roles of media and public perception, "CRISPR Chronicles" is not just about understanding the science; it's about confronting the critical societal and ethical issues and reflecting on how we, as a society, will shape and be shaped by the genetic revolution. This is your guidebook at the crossroads of destiny, where science, ethics, and society converge, and in doing so will define the trajectory of humanity's future.

The Promise and Peril of CRISPR

Author : Neal Baer
Publisher : JHU Press
ISBN 13 : 1421449307
Total Pages : 269 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis The Promise and Peril of CRISPR by : Neal Baer

Download or read book The Promise and Peril of CRISPR written by Neal Baer and published by JHU Press. This book was released on 2024-07-02 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Comprising eight revised essays and seven new pieces, this work provides a comprehensive resource for students, scientists, bioethicists, physicians, and laypeople to better understand and discuss the ethical issues underlying this technology that has the potential to forever change the world"--

Heritable Human Genome Editing

Author : The Royal Society
Publisher : National Academies Press
ISBN 13 : 0309671132
Total Pages : 239 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Heritable Human Genome Editing by : The Royal Society

Download or read book Heritable Human Genome Editing written by The Royal Society and published by National Academies Press. This book was released on 2021-01-16 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

A Crack In Creation

Author : Jennifer A. Doudna
Publisher : HarperCollins
ISBN 13 : 0544716965
Total Pages : 307 pages
Book Rating : 4.5/5 (447 download)

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Book Synopsis A Crack In Creation by : Jennifer A. Doudna

Download or read book A Crack In Creation written by Jennifer A. Doudna and published by HarperCollins. This book was released on 2017-06-13 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY | Finalist for the Los Angeles Times Book Prize “A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. “The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas “An invaluable account . . . We owe Doudna several times over.” — Guardian

Designing Our Descendants

Author : Audrey R. Chapman
Publisher : JHU Press
ISBN 13 : 0801881293
Total Pages : 385 pages
Book Rating : 4.8/5 (18 download)

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Book Synopsis Designing Our Descendants by : Audrey R. Chapman

Download or read book Designing Our Descendants written by Audrey R. Chapman and published by JHU Press. This book was released on 2004-12-01 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Genome Project, discoveries in molecular biology, and new reproductive technologies have advanced our understanding of how genetic science may be used to treat persons with genetic disorders. Greater knowledge may also make possible genetic interventions to "enhance" normal human characteristics, such as height, hair or eye color, strength, or memory, as well as the transmittal of such modifications to future generations. The prospect of inheritable genetic modifications, or IGMs, whether for therapeutic or enhancement purposes, raises complex scientific, ethical, and regulatory issues. Designing Our Descendants presents twenty essays by physicians, scientists, philosophers, theologians, lawyers, and policy analysts addressing these issues from diverse perspectives. In three sections, the authors discuss the short- and long-term scientific feasibility of IGM technology; ethical and religious issues related to safety, justice, morality, reproductive rights, and enhancement; and regulatory issues including the necessity of public input and oversight and the influence of commercialization. Their goal is to open a dialogue engaging not only scholars and scientists but also government officials and concerned citizens. The authors conclude that while IGM cannot be carried out safely and responsibly on humans utilizing current methods, it is important to begin public discussion now to determine whether, and if so how, to proceed.

A Crack in Creation

Author : Jennifer Doudna
Publisher : Vintage
ISBN 13 : 9781784702762
Total Pages : 304 pages
Book Rating : 4.7/5 (27 download)

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Book Synopsis A Crack in Creation by : Jennifer Doudna

Download or read book A Crack in Creation written by Jennifer Doudna and published by Vintage. This book was released on 2018-06-14 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: A handful of discoveries have changed the course of human history. This book is about the most recent and potentially the most powerful and dangerous of them all. It is an invention that allows us to rewrite the genetic code that shapes and controls all living beings with astonishing accuracy and ease. Thanks to it, the dreams of genetic manipulation have become a stark reality: the power to cure disease and alleviate suffering, to create new sources of food and energy, as well as to re-design any species, including humans, for our own ends. Jennifer Doudna is the co-inventor of this technology - known as CRISPR - and a scientist of worldwide renown. Writing with fellow researcher Samuel Sternberg, here she provides the definitive account of her discovery, explaining how this wondrous invention works and what it is capable of. She also asks us to consider what our new-found power means: how do we enjoy its unprecedented benefits while avoiding its equally unprecedented dangers? The future of humankind - and of all life on Earth - is at stake. This book is an essential guide to the path that now lies ahead.

The Code Breaker

Author : Walter Isaacson
Publisher : Simon and Schuster
ISBN 13 : 1982115874
Total Pages : 560 pages
Book Rating : 4.9/5 (821 download)

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Book Synopsis The Code Breaker by : Walter Isaacson

Download or read book The Code Breaker written by Walter Isaacson and published by Simon and Schuster. This book was released on 2021-03-09 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Best Book of 2021 by Bloomberg BusinessWeek, Time, and The Washington Post The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies. When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would. Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his codiscovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is an “enthralling detective story” (Oprah Daily) that involves the most profound wonders of nature, from the origins of life to the future of our species.

The Palgrave Handbook of Philosophy and Public Policy

Author : David Boonin
Publisher : Springer
ISBN 13 : 3319939076
Total Pages : 836 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis The Palgrave Handbook of Philosophy and Public Policy by : David Boonin

Download or read book The Palgrave Handbook of Philosophy and Public Policy written by David Boonin and published by Springer. This book was released on 2018-10-08 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together a large and diverse collection of philosophical papers addressing a wide variety of public policy issues. Topics covered range from long-standing subjects of debate such as abortion, punishment, and freedom of expression, to more recent controversies such as those over gene editing, military drones, and statues honoring Confederate soldiers. Part I focuses on the criminal justice system, including issues that arise before, during, and after criminal trials. Part II covers matters of national defense and sovereignty, including chapters on military ethics, terrorism, and immigration. Part III, which explores political participation, manipulation, and standing, includes discussions of issues involving voting rights, the use of nudges, and claims of equal status. Part IV covers a variety of issues involving freedom of speech and expression. Part V deals with questions of justice and inequality. Part VI considers topics involving bioethics and biotechnology. Part VII is devoted to beginning of life issues, such as cloning and surrogacy, and end of life issues, such as assisted suicide and organ procurement. Part VIII navigates emerging environmental issues, including treatments of the urban environment and extraterrestrial environments.

Gene Drives on the Horizon

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309437873
Total Pages : 231 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Gene Drives on the Horizon by : National Academies of Sciences, Engineering, and Medicine

Download or read book Gene Drives on the Horizon written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Fables and Futures

Author : George Estreich
Publisher : MIT Press
ISBN 13 : 0262039567
Total Pages : 239 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Fables and Futures by : George Estreich

Download or read book Fables and Futures written by George Estreich and published by MIT Press. This book was released on 2019-03-19 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: How new biomedical technologies—from prenatal testing to gene-editing techniques—require us to imagine who counts as human and what it means to belong. From next-generation prenatal tests, to virtual children, to the genome-editing tool CRISPR-Cas9, new biotechnologies grant us unprecedented power to predict and shape future people. That power implies a question about belonging: which people, which variations, will we welcome? How will we square new biotech advances with the real but fragile gains for people with disabilities—especially when their voices are all but absent from the conversation? This book explores that conversation, the troubled territory where biotechnology and disability meet. In it, George Estreich—an award-winning poet and memoirist, and the father of a young woman with Down syndrome—delves into popular representations of cutting-edge biotech: websites advertising next-generation prenatal tests, feature articles on “three-parent IVF,” a scientist's memoir of constructing a semisynthetic cell, and more. As Estreich shows, each new application of biotechnology is accompanied by a persuasive story, one that minimizes downsides and promises enormous benefits. In this story, people with disabilities are both invisible and essential: a key promise of new technologies is that disability will be repaired or prevented. In chapters that blend personal narrative and scholarship, Estreich restores disability to our narratives of technology. He also considers broader themes: the place of people with disabilities in a world built for the able; the echoes of eugenic history in the genomic present; and the equation of intellect and human value. Examining the stories we tell ourselves, the fables already creating our futures, Estreich argues that, given biotech that can select and shape who we are, we need to imagine, as broadly as possible, what it means to belong.

The Gene Machine

Author : Bonnie Rochman
Publisher : Scientific American / Farrar, Straus and Giroux
ISBN 13 : 0374713960
Total Pages : 289 pages
Book Rating : 4.3/5 (747 download)

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Book Synopsis The Gene Machine by : Bonnie Rochman

Download or read book The Gene Machine written by Bonnie Rochman and published by Scientific American / Farrar, Straus and Giroux. This book was released on 2017-02-28 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A sharp-eyed exploration of the promise and peril of having children in an age of genetic tests and interventions Is screening for disease in an embryo a humane form of family planning or a slippery slope toward eugenics? Should doctors tell you that your infant daughter is genetically predisposed to breast cancer? If tests revealed that your toddler has a genetic mutation whose significance isn’t clear, would you want to know? In The Gene Machine, the award-winning journalist Bonnie Rochman deftly explores these hot-button questions, guiding us through the new frontier of gene technology and how it is transforming medicine, bioethics, health care, and the factors that shape a family. Rochman tells the stories of scientists working to unlock the secrets of the human genome; genetic counselors and spiritual advisers guiding mothers and fathers through life-changing choices; and, of course, parents (including Rochman herself) grappling with revelations that are sometimes joyous, sometimes heartbreaking, but always profound. She navigates the dizzying and constantly expanding array of prenatal and postnatal tests, from carrier screening to genome sequencing, while considering how access to more tests is altering perceptions of disability and changing the conversation about what sort of life is worth living and who draws the line. Along the way, she highlights the most urgent ethical quandary: Is this technology a triumph of modern medicine or a Pandora’s box of possibilities? Propelled by human narratives and meticulously reported, The Gene Machine is both a scientific road map and a meditation on our power to shape the future. It is a book that gets to the very core of what it means to be human.

CRISPR Crops

Author : Aftab Ahmad
Publisher : Springer Nature
ISBN 13 : 9811571422
Total Pages : 311 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis CRISPR Crops by : Aftab Ahmad

Download or read book CRISPR Crops written by Aftab Ahmad and published by Springer Nature. This book was released on 2021-01-08 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the latest applications of the cutting-edge gene editing tool CRISPR/Cas in the area of crop improvement. It begins with an introduction to the technique and its application in crop plants. Next, it gives an updated overview of available delivery methods, design tools and resources in CRISPR/Cas. The book subsequently reviews the applications of CRISPR/Cas in connection with e.g. insect stress, disease stress, abiotic stress, nutritional and yield improvement in crop plants, etc. It also discusses the various regulatory, ethical and social aspects of the technique that must be kept in mind when designing experiments. In closing, the book summarizes the status quo and outlines future prospects for the tool in crop improvement and food security. Given its scope, the book will especially benefit students and researchers in food science, biotechnology, agriculture and the plant sciences.

Ethical Issues in Biomedical Publication

Author : Anne Hudson Jones
Publisher : JHU Press
ISBN 13 : 9780801863158
Total Pages : 404 pages
Book Rating : 4.8/5 (631 download)

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Book Synopsis Ethical Issues in Biomedical Publication by : Anne Hudson Jones

Download or read book Ethical Issues in Biomedical Publication written by Anne Hudson Jones and published by JHU Press. This book was released on 2000-05-08 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation "Highly recommended for those intending to undertake clinical trials or similar research, as well as for those presently engaged in this field, as a refresher course in medical ethics."--JAMA"A very thorough discussion of the various legal and administrative solutions ... The book is well-written, has case material and examples enough to make reading vicariously pleasurable."--Bulletin of Medical Ethics.

Gene Drives at Tipping Points

Author : Arnim von Gleich
Publisher : Springer Nature
ISBN 13 : 3030389340
Total Pages : 264 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Gene Drives at Tipping Points by : Arnim von Gleich

Download or read book Gene Drives at Tipping Points written by Arnim von Gleich and published by Springer Nature. This book was released on 2020-01-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book reports on a pilot project aiming at collecting information on the socio-ecological risks that could arise in the event of an uncontrolled spread of genetically engineered organisms into the environment. The researchers will, for instance, be taking a closer look at genetically engineered oilseed rape, genetically engineered olive flies as well as plants and animals with so-called gene drives. The book mainly adresses researchers.

Editing Humanity

Author : Kevin Davies
Publisher : Simon and Schuster
ISBN 13 : 1643133942
Total Pages : 402 pages
Book Rating : 4.6/5 (431 download)

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Book Synopsis Editing Humanity by : Kevin Davies

Download or read book Editing Humanity written by Kevin Davies and published by Simon and Schuster. This book was released on 2020-10-06 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the world's leading experts on genetics unravels one of the most important breakthroughs in modern science and medicine. IIf our genes are, to a great extent, our destiny, then what would happen if mankind could engineer and alter the very essence of our DNA coding? Millions might be spared the devastating effects of hereditary disease or the challenges of disability, whether it was the pain of sickle-cell anemia to the ravages of Huntington’s disease. But this power to “play God” also raises major ethical questions and poses threats for potential misuse. For decades, these questions have lived exclusively in the realm of science fiction, but as Kevin Davies powerfully reveals in his new book, this is all about to change. Engrossing and page-turning, Editing Humanity takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces readers to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale. Though the birth of the “CRISPR babies” in China made international news, there is much more to the story of CRISPR than headlines seemingly ripped from science fiction. In Editing Humanity, Davies sheds light on the implications that this new technology can have on our everyday lives and in the lives of generations to come.

Drawing Blood

Author : Keith Wailoo
Publisher : JHU Press
ISBN 13 : 0801870291
Total Pages : 305 pages
Book Rating : 4.8/5 (18 download)

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Book Synopsis Drawing Blood by : Keith Wailoo

Download or read book Drawing Blood written by Keith Wailoo and published by JHU Press. This book was released on 2002-10-15 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: How physicians in this century wielded medical technology to define disease, carve out medical specialties, and shape political agendas. Winner of the American Public Health Association Arthur Viseltear Prize In Drawing Blood, medical historian Keith Wailoo uses the story of blood diseases to explain how physicians in this century wielded medical technology to define disease, carve out medical specialties, and shape political agendas. As Wailoo's account makes clear, the seemingly straightforward process of identifying disease is invariably influenced by personal, professional, and social factors—and as a result produces not only clarity and precision but also bias and outright error. Drawing Blood reveals the ways in which physicians and patients as well as the diseases themselves are simultaneously shaping and being shaped by technology, medical professionalization, and society at large. This thought-provoking cultural history of disease, medicine, and technology offers an important perspective for current discussions of HIV and AIDS, genetic blood testing, prostate-specific antigen, and other important issues in an age of technological medicine. "Makes clear that the high stakes involved in medical technology are not just financial, but moral and far reaching. They have been harnessed to describe clinical phenomena and to reflect social and cultural realities that influence not only medical treatment but self-identity, power, and authority."—Susan E. Lederer, H-Net Humanities & Social Sciences On Line "Wailoo's masterful study of hematology and its disease discourse is a model of interdisciplinarity, combining cultural analysis, social history, and the history of medical ideas and technology to produce a complex narrative of disease definition, diagnosis, and treatment . . . He reminds us that medical technology is a neutral artifact of history. It can be, and has been, used to clarify and to cloud the understanding of disease, and it has the potential both to constrain and to emancipate its subjects."—Regina Morantz-Sanchez, Journal of Interdisciplinary History