Author : Nobuhiko Saito
Publisher : World Scientific
ISBN 13 : 9810247109
Total Pages : 155 pages
Book Rating : 4.8/5 (12 download)
Book Synopsis The Physical Foundation of Protein Architecture by : Nobuhiko Saito
Download or read book The Physical Foundation of Protein Architecture written by Nobuhiko Saito and published by World Scientific. This book was released on 2001 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: A protein requires its own three-dimensional structure for its biological activity. If a chemical agent is added, the biological activity is lost, and the three dimensional structure is destroyed to become a random coil state. But when the chemical agent is removed, the biological activity is recovered, implying that the random coil state turns back into the original complex structure spontaneously. This is an astonishing event. The Physical Foundation of Protein Architecture is intended to solve this mystery from the physicochemical basis by elucidating the mechanism of various processes in protein folding. The main features of protein folding are shown to be described by the island model with long range hydrophobic interaction which is capable of finding the specific residue, and the lampshade criterion for disulfide bonding. Various proteins with known structure are refolded, with the purpose of uncovering the mechanism of protein folding. In addition, ab initio method for predicting protein structure from its amino acid sequence is proposed.