The Organic Compounds Of Lead

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The Organic Chemistry of Drug Design and Drug Action

Author : Richard B. Silverman
Publisher : Elsevier
ISBN 13 : 0080513379
Total Pages : 650 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman

Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Elsevier. This book was released on 2012-12-02 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

Lead Optimization for Medicinal Chemists

Author : Florencio Zaragoza Dörwald
Publisher : John Wiley & Sons
ISBN 13 : 3527645659
Total Pages : 627 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Lead Optimization for Medicinal Chemists by : Florencio Zaragoza Dörwald

Download or read book Lead Optimization for Medicinal Chemists written by Florencio Zaragoza Dörwald and published by John Wiley & Sons. This book was released on 2013-02-04 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and synonyms to facilitate the location of any drug or functional group in the book. This compact working guide provides a wealth of information on the ways small structural modifications affect the pharmacokinetic properties of organic compounds, and offers plentiful, fact-based inspiration for the development of new drugs. This book is mainly aimed at medicinal chemists, but may also be of interest to graduate students in chemical or pharmaceutical sciences, preparing themselves for a job in the pharmaceutical industry, and to healthcare professionals in need of pharmacokinetic data.

Environmental Toxicants

Author : Morton Lippmann
Publisher : John Wiley & Sons
ISBN 13 : 0470442883
Total Pages : 1189 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Environmental Toxicants by : Morton Lippmann

Download or read book Environmental Toxicants written by Morton Lippmann and published by John Wiley & Sons. This book was released on 2009-03-26 with total page 1189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the most current information and research available for performing risk assessments on exposed individuals and populations, giving guidance to public health authorities, primary care physicians, and industrial managers Reviews current knowledge on human exposure to selected chemical agents and physical factors in the ambient environment Updates and revises the previous edition, in light of current scientific literature and its significance to public health concerns Includes new chapters on: airline cabin exposures, arsenic, endocrine disruptors, and nanoparticles

Contaminated Water Supplies at Camp Lejeune

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309136997
Total Pages : 338 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Contaminated Water Supplies at Camp Lejeune by : National Research Council

Download or read book Contaminated Water Supplies at Camp Lejeune written by National Research Council and published by National Academies Press. This book was released on 2009-09-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in North Carolina were found to be contaminated with the industrial solvents trichloroethylene (TCE) and perchloroethylene (PCE). The water systems were supplied by the Tarawa Terrace and Hadnot Point watertreatment plants, which served enlisted-family housing, barracks for unmarried service personnel, base administrative offices, schools, and recreational areas. The Hadnot Point water system also served the base hospital and an industrial area and supplied water to housing on the Holcomb Boulevard water system (full-time until 1972 and periodically thereafter). This book examines what is known about the contamination of the water supplies at Camp Lejeune and whether the contamination can be linked to any adverse health outcomes in former residents and workers at the base.

Veterinary Toxicology for Australia and New Zealand

Author : Rosalind Dalefield
Publisher : Elsevier
ISBN 13 : 0127999124
Total Pages : 630 pages
Book Rating : 4.1/5 (279 download)

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Book Synopsis Veterinary Toxicology for Australia and New Zealand by : Rosalind Dalefield

Download or read book Veterinary Toxicology for Australia and New Zealand written by Rosalind Dalefield and published by Elsevier. This book was released on 2017-06-23 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Veterinary Toxicology for Australia and New Zealand is a reference suited to the unique challenges of veterinary practice in Australia and New Zealand. Both streamlined and thorough in its coverage of poisons and treatments for those locations, this focused approach allows readers to quickly find relevant information that is presented in a concise and logical manner that is useful to clinicians. The authors draw upon a wealth of knowledge of the particularities of toxicology in Australia and New Zealand to present readers with the up-to-date information required to efficiently and effectively diagnose and treat their patients. - Highlights toxins of specific concern in Australia and New Zealand - Structures information in a logical way so that it can be located quickly - Offers up-to-date information on current and emerging risks

Biological Effects of Organolead Compounds

Author : Philippe Grandjean
Publisher : CRC Press
ISBN 13 : 9780367245191
Total Pages : 278 pages
Book Rating : 4.2/5 (451 download)

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Book Synopsis Biological Effects of Organolead Compounds by : Philippe Grandjean

Download or read book Biological Effects of Organolead Compounds written by Philippe Grandjean and published by CRC Press. This book was released on 2022-01-26 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1984: This book is a compilation of research on Organolead Compounds.

Toxicological Profile for Lead

Author :
Publisher :
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Lead by :

Download or read book Toxicological Profile for Lead written by and published by . This book was released on 2007 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nomenclature of Organic Chemistry

Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 0854041826
Total Pages : 1614 pages
Book Rating : 4.8/5 (54 download)

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Book Synopsis Nomenclature of Organic Chemistry by :

Download or read book Nomenclature of Organic Chemistry written by and published by Royal Society of Chemistry. This book was released on 2014 with total page 1614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailing the latest rules and international practice, this new volume can be considered a guide to the essential organic chemical nomenclature, commonly described as the "Blue Book."

Non-ionizing Radiation

Author :
Publisher :
ISBN 13 : 9789283212805
Total Pages : 0 pages
Book Rating : 4.2/5 (128 download)

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Book Synopsis Non-ionizing Radiation by :

Download or read book Non-ionizing Radiation written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

An Introduction to the Study of the Compounds of Carbon; Or, Organic Chemistry

Author : Ira Remsen
Publisher :
ISBN 13 :
Total Pages : 392 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis An Introduction to the Study of the Compounds of Carbon; Or, Organic Chemistry by : Ira Remsen

Download or read book An Introduction to the Study of the Compounds of Carbon; Or, Organic Chemistry written by Ira Remsen and published by . This book was released on 1885 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Aquatic Organic Matter Fluorescence

Author : Paula G. Coble
Publisher : Cambridge University Press
ISBN 13 : 0521764610
Total Pages : 407 pages
Book Rating : 4.5/5 (217 download)

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Book Synopsis Aquatic Organic Matter Fluorescence by : Paula G. Coble

Download or read book Aquatic Organic Matter Fluorescence written by Paula G. Coble and published by Cambridge University Press. This book was released on 2014-07-14 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: A core text on principles, laboratory/field methodologies, and data interpretation for fluorescence applications in aquatic science, for advanced students and researchers.

Pb Organolead Compounds

Author : Friedo Huber
Publisher : Springer Science & Business Media
ISBN 13 : 3662102919
Total Pages : 284 pages
Book Rating : 4.6/5 (621 download)

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Book Synopsis Pb Organolead Compounds by : Friedo Huber

Download or read book Pb Organolead Compounds written by Friedo Huber and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery in 1922 of the exceptional effectiveness of tetraethyllead in suppressing knock in the combustion of gasoline in engines and its introduction as a gasoline additive in 1923 stimulated an enormous number of studies on procedures for its synthesis and industrial production, on its behavior and uses, and also on the toxicology of this compound and on its environmental impact resulting from large scale lead distribution. The results of these investigations are collected in more than 3000 papers and patents. The quantity of information on this prominent compound fills the second volume of the series on organo lead compounds. Complete literature coverage was strived for but not all of the voluminous patent data have been considered. Certain publications on production of tetraethyllead or on use as a gasoline additive that are not reported in Chemical Abstracts (C.A.) may not have been found; similarly, publications that could not be clearly identified as relevant to the subject might be missing. Publications concerning the fate of inorganic lead compounds that are products of the combustion of leaded gasoline as weil as the vast amount of related papers on analytical and toxicological studies and on health and environmental aspects have been deliberately omitted. The literature is covered through 1988; C.A. has been evaluated through volume 110 of 1989.

Tables of Spectral Data for Structure Determination of Organic Compounds

Author : Ernö Pretsch
Publisher : Springer Science & Business Media
ISBN 13 : 3662224550
Total Pages : 325 pages
Book Rating : 4.6/5 (622 download)

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Book Synopsis Tables of Spectral Data for Structure Determination of Organic Compounds by : Ernö Pretsch

Download or read book Tables of Spectral Data for Structure Determination of Organic Compounds written by Ernö Pretsch and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although numerical data are, in principle, universal, the compilations presented in this book are extensively annotated and interleaved with text. This translation of the second German edition has been prepared to facilitate the use of this work, with all its valuable detail, by the large community of English-speaking scientists. Translation has also provided an opportunity to correct and revise the text, and to update the nomenclature. Fortunately, spectroscopic data and their relationship with structure do not change much with time so one can predict that this book will, for a long period of time, continue to be very useful to organic chemists involved in the identification of organic compounds or the elucidation of their structure. Klaus Biemann Cambridge, MA, April 1983 Preface to the First German Edition Making use of the information provided by various spectroscopic tech niques has become a matter of routine for the analytically oriented organic chemist. Those who have graduated recently received extensive training in these techniques as part of the curriculum while their older colleagues learned to use these methods by necessity. One can, therefore, assume that chemists are well versed in the proper choice of the methods suitable for the solution of a particular problem and to translate the experimental data into structural information.

Bioactive Compounds from Natural Sources, Second Edition

Author : Corrado Tringali
Publisher : CRC Press
ISBN 13 : 1439822298
Total Pages : 650 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Bioactive Compounds from Natural Sources, Second Edition by : Corrado Tringali

Download or read book Bioactive Compounds from Natural Sources, Second Edition written by Corrado Tringali and published by CRC Press. This book was released on 2011-09-27 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics. Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including: Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants, The tremendous potentiality of metabolic engineering of natural products biosynthesis The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.

Drug-like Properties: Concepts, Structure Design and Methods

Author : Li Di
Publisher : Elsevier
ISBN 13 : 0080557619
Total Pages : 549 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Drug-like Properties: Concepts, Structure Design and Methods by : Li Di

Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Public Health Consequences of E-Cigarettes

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 030946837X
Total Pages : 775 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Public Health Consequences of E-Cigarettes by : National Academies of Sciences, Engineering, and Medicine

Download or read book Public Health Consequences of E-Cigarettes written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-05-18 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes. Public Health Consequences of E-Cigarettes reviews and critically assesses the state of the emerging evidence about e-cigarettes and health. This report makes recommendations for the improvement of this research and highlights gaps that are a priority for future research.

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.