The Oncogene Handbook

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The Oncogene Handbook

Author : E. Premkumar Reddy
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 612 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Oncogene Handbook by : E. Premkumar Reddy

Download or read book The Oncogene Handbook written by E. Premkumar Reddy and published by Elsevier Publishing Company. This book was released on 1988 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of Molecular Oncology has emerged in the last decade as an amalgamation of four of the foremost disciplines in cancer research: retrovirology, chemical carcinogenesis, cytogenetics, and cell growth regulation. The subject matter for this book forms the unifying factor for these four areas. Although the field of Molecular Oncology is still comparatively young, the technical vocabulary can be bewildering to the uninitiated. This book is clear in its divisions, grouping oncogenes by biochemical activity or cellular localization; the large group of tyrosine kinases are compared by relevant features. The Oncogene Handbook allows ready access and supplies excellent cross-referencing. An outstanding reference work, giving basic information on each oncogene in a concise and uniform format. The fundamental importance of the subject area and its medical implications, both reflected in The Oncogene Handbook, provide students, scientists in other fields, and clinicians with a very useful manual.

A SHORT HAND BOOK ON ONCOGENES ONCOGENES-AT A GLANCE

Author : Dr. Noopur Kulkarni
Publisher : Sankalp Publication
ISBN 13 : 9361665642
Total Pages : 167 pages
Book Rating : 4.3/5 (616 download)

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Book Synopsis A SHORT HAND BOOK ON ONCOGENES ONCOGENES-AT A GLANCE by : Dr. Noopur Kulkarni

Download or read book A SHORT HAND BOOK ON ONCOGENES ONCOGENES-AT A GLANCE written by Dr. Noopur Kulkarni and published by Sankalp Publication. This book was released on with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Targeted Therapies for Solid Tumors

Author : Antonio Russo
Publisher : Humana
ISBN 13 : 9781493943777
Total Pages : 0 pages
Book Rating : 4.9/5 (437 download)

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Book Synopsis Targeted Therapies for Solid Tumors by : Antonio Russo

Download or read book Targeted Therapies for Solid Tumors written by Antonio Russo and published by Humana. This book was released on 2016-10-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Molecular Chaperones in Health and Disease

Author : Matthias Gaestel
Publisher : Springer Science & Business Media
ISBN 13 : 9783540258759
Total Pages : 464 pages
Book Rating : 4.2/5 (587 download)

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Book Synopsis Molecular Chaperones in Health and Disease by : Matthias Gaestel

Download or read book Molecular Chaperones in Health and Disease written by Matthias Gaestel and published by Springer Science & Business Media. This book was released on 2005-09-27 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.

Handbook of Growth Factors

Author : Enrique Pimentel
Publisher : CRC Press
ISBN 13 : 9780849325052
Total Pages : 386 pages
Book Rating : 4.3/5 (25 download)

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Book Synopsis Handbook of Growth Factors by : Enrique Pimentel

Download or read book Handbook of Growth Factors written by Enrique Pimentel and published by CRC Press. This book was released on 1994-06-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume I of this book provides a comprehensive discussion of the factors involved in regulation of the cell cycle, the general biological properties of growth factors, and the receptor and postreceptor mechanisms of action of these signaling agents. It evaluates the possible role of growth factors in the regulation of proto-oncogene and tumor suppressor gene expression, and the development of neoplastic processes is discussed in detail.

Oncogenes

Author : Geoffrey M. Cooper
Publisher : Jones & Bartlett Learning
ISBN 13 : 9780867209372
Total Pages : 404 pages
Book Rating : 4.2/5 (93 download)

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Book Synopsis Oncogenes by : Geoffrey M. Cooper

Download or read book Oncogenes written by Geoffrey M. Cooper and published by Jones & Bartlett Learning. This book was released on 1995 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this authoritative text details major advances and developments in the field, such as the identification of many new tumor suppressor genes and the striking progress in understanding signal transduction pathways leading to cell proliferation. Oncogenes, Second Edition, addresses the needs of advanced undergraduates, graduate students, medical students, physicians, and scientists by examining the current state of oncogene study and where future research may lead.

GTPases in Biology I

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642782671
Total Pages : 708 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis GTPases in Biology I by :

Download or read book GTPases in Biology I written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: The GTPase switch appears to be almost as old as life itself, and nature has adapted it to a variety of purposes. This two-volume work surveys the major classes of GTPases, including their role in ensuring accuracy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer. 80 chapters contain much previously unpublished data and, at the rate the extended family of GTPases is growing, it is unlikely that it will again sit for a group portrait such as this. Thus, this could well become the standard reference work.

Radiation and the Gastrointestinal Tract

Author : Andre Dubois
Publisher : CRC Press
ISBN 13 : 9780849376672
Total Pages : 306 pages
Book Rating : 4.3/5 (766 download)

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Book Synopsis Radiation and the Gastrointestinal Tract by : Andre Dubois

Download or read book Radiation and the Gastrointestinal Tract written by Andre Dubois and published by CRC Press. This book was released on 1994-11-22 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book evolved from a two-day 1993 International Symposium on Radiation and the Gastrointestinal Tract held at the Uniformed Services University of the Health Sciences, Bethesda, Maryland. This area of investigation is particularly important because of growing medical needs and the documented occurrence of accidents involving overexposure of healthy subjects/patients. Some questions have been answered through cellular and animal research-results that lead to hypotheses that have been tested through clinical protocols. In an attempt to answer the unresolved questions, basic scientists and clinicians describe the data obtained to date, present in a critical manner the consensus that has been reached, and discuss what still remains to be investigated. The book is divided into five parts: Overview and Clinical Perspective, Emesis, Motility, Diarrhea, and Behavioral Correlates of Gastrointestinal Dysfunction. Each part consists of separate discussions on the pathophysiology, the methodology, and, when applicable, the clinical relevance of the observations. The book provides helpful information to both basic scientists involved in radiobiological research and to clinicians caring for patients exposed to radiation. It also serves as an introduction to the subject for young clinical investigators interested in the field and for scientists searching for correlates between their observations and disorders of the gastrointestinal tract.

Mouse Models of Cancer

Author : Cory Abate-Shen
Publisher :
ISBN 13 : 9781621820031
Total Pages : 0 pages
Book Rating : 4.8/5 (2 download)

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Book Synopsis Mouse Models of Cancer by : Cory Abate-Shen

Download or read book Mouse Models of Cancer written by Cory Abate-Shen and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The laboratory mouse is an important model for addressing questions in cancer biology. In recent years, the questions have become more refined, and mouse models are increasingly being used to develop and test cancer therapeutics. Thus, the need for more sophisticated and clinically relevant mouse models has grown, as has the need for innovative tools to analyze and validate them. This laboratory manual provides cutting-edge methods for generating and characterizing mouse models that accurately recapitulate many features of human cancer. The contributors describe strategies for producing genetic models, including transgenic germline models, gene knockouts and knockins, and conditional and inducible systems, as well as models derived using transposon-based insertional mutagenesis, RNA interference, viral-mediated gene delivery, and chemical carcinogens. Tissue recombination, organ reconstitution, and transplantation methods to develop chimeric, allograft, and xenograft models are covered. Approaches to characterize tumor development, progression, and metastasis in these models using state-of-the-art imaging, histopathological, surgical, and other techniques are also included. Other chapters cover the use of mouse models to test and optimize drugs in pre-, co-, and post-clinical trials. An appendix specifically addresses the use of mouse cancer models in translational studies and the integration of mouse and human clinical investigations. This manual is therefore an indispensable laboratory resource for all researchers, from the graduate level upwards, who study cancer and its treatment.

Molecular Diagnostics of Cancer

Author : Christoph Wagener
Publisher : Springer Science & Business Media
ISBN 13 : 3642775217
Total Pages : 214 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Molecular Diagnostics of Cancer by : Christoph Wagener

Download or read book Molecular Diagnostics of Cancer written by Christoph Wagener and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Present and potential future applications of new diagnostic strategies basedon the direct or indirect detection of cancer genes are delineated in this volume. Among the methodological aspects covered are enzymatic target amplification by the polymerase chain reaction and related techniques, DNA fingerprinting, transfer of putative cancer genes in appropriate receipient cells, and recent developments inthe application of monoclonal antibodies in immunohistochemistry and immunoscintigraphy. The diagnostic and functional implications of mutations in cancer genes such as ras and p53 are described. The characterization of cancer genes and their products is correlated with growth control anddissemination of tumour cells by in vitro or clinical evidence. The contributions in the present volume uptdate the information available on established or newly described cancer genes, and may help manage the transition from basic research to clinical practice.

Fields' Virology

Author : David Mahan Knipe
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781760607
Total Pages : 3116 pages
Book Rating : 4.7/5 (66 download)

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Book Synopsis Fields' Virology by : David Mahan Knipe

Download or read book Fields' Virology written by David Mahan Knipe and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 3116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM has same title as book.

Annual Report

Author : National Cancer Institute (U.S.). Division of Cancer Etiology
Publisher :
ISBN 13 :
Total Pages : 636 pages
Book Rating : 4.M/5 ( download)

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Book Synopsis Annual Report by : National Cancer Institute (U.S.). Division of Cancer Etiology

Download or read book Annual Report written by National Cancer Institute (U.S.). Division of Cancer Etiology and published by . This book was released on 1987 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Search for New Anticancer Drugs

Author : Michael Waring
Publisher : Springer Science & Business Media
ISBN 13 : 9780792389590
Total Pages : 300 pages
Book Rating : 4.3/5 (895 download)

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Book Synopsis The Search for New Anticancer Drugs by : Michael Waring

Download or read book The Search for New Anticancer Drugs written by Michael Waring and published by Springer Science & Business Media. This book was released on 1992-11-30 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the anti-cancer drugs in use today were discovered by happy accident rather than design, yet the rational design of better anti-cancer drugs remains a cherished goal, and one of the most important challenges facing medical science. This book represents a compilation of views and progress reports which illustrate the diversity of approaches to the problem. Recent research has confirmed the belief that critical genetic changes are at work in cancer cells. The genome, then (DNA in biochemical terms), surely represents a critical target for specific chemotherapy of cancer, and several chapters address the issue of attacking DNA, gene targetting, and the like. Others deal with principles of rational design, exploitation of novel modalities and targets, or the nuts and bolts of antitumour drug testing. While no attempt has been made to provide a comprehensive coverage of this wide-ranging and vitally important subject, the present volume in the series will provide much food for thought.

Handbook of Personalized Medicine

Author : Ioannis S. Vizirianakis
Publisher : CRC Press
ISBN 13 : 9814411191
Total Pages : 1562 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Handbook of Personalized Medicine by : Ioannis S. Vizirianakis

Download or read book Handbook of Personalized Medicine written by Ioannis S. Vizirianakis and published by CRC Press. This book was released on 2014-02-12 with total page 1562 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.

Peptide Growth Factors and Their Receptors II

Author : Michael B. Sporn
Publisher : Springer Science & Business Media
ISBN 13 : 3642747817
Total Pages : 740 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Peptide Growth Factors and Their Receptors II by : Michael B. Sporn

Download or read book Peptide Growth Factors and Their Receptors II written by Michael B. Sporn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entired field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost im anyone person to stay informed on this subject by reading the possible for At the same time it is becoming increasingly apparent that primary literature. these substances are of universal importance in biology and medicine and that the original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony-stimulating factors," was quite artifactual; they are in fact the basis of a common language for intercellular communication. As a set they affect es sentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research.

The ras Superfamily of GTPases (1993)

Author : Juan Carlos Lacal
Publisher : CRC Press
ISBN 13 : 1351356844
Total Pages : 598 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis The ras Superfamily of GTPases (1993) by : Juan Carlos Lacal

Download or read book The ras Superfamily of GTPases (1993) written by Juan Carlos Lacal and published by CRC Press. This book was released on 2017-11-22 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.