The Nuclear Receptor Superfamily

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The Nuclear Receptor Superfamily

Author : Iain J. McEwan, PhD
Publisher : Humana Press
ISBN 13 : 9781607610878
Total Pages : 240 pages
Book Rating : 4.6/5 (18 download)

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Book Synopsis The Nuclear Receptor Superfamily by : Iain J. McEwan, PhD

Download or read book The Nuclear Receptor Superfamily written by Iain J. McEwan, PhD and published by Humana Press. This book was released on 2009-03-13 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acting principally to control patterns of gene expression, nuclear receptors play vital roles during embryonic development and in the regulation of metabolic and reproductive functions in adult life, which proves this superfamily of ligand-activated transcription factors to be a crucial part of biological life. In The Nuclear Receptor Superfamily: Methods and Protocols, expert researchers describe a range of molecular, structural and cell biological techniques currently used to investigate the structure-function of nuclear receptors, together with experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters in this volume contain brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as notes from the experts to highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, The Nuclear Receptor Superfamily: Methods and Protocols provides beneficial and time-saving guidance for all those undertaking research in this ever-growing field of study.

Nuclear Receptors

Author : Didier Picard
Publisher : OUP Oxford
ISBN 13 : 019156592X
Total Pages : 306 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Nuclear Receptors by : Didier Picard

Download or read book Nuclear Receptors written by Didier Picard and published by OUP Oxford. This book was released on 1999-07-08 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone and characterize new receptors. Chapter 3 shows how to identify the ligands of novel receptors and chapter 4 explains the kinetic analysis of receptor interactions. In chapter 5, the reader is guided through the functional characterization of coactivators using microinjection. The next section covers receptor phosphorylation, ligand regulated transcription, and hormone resistance syndromes. Chapter 9 describes the in vitro assembly of Hsp90 complexes and chapter 10 explains yeast as a model system for looking at receptor function. The final chapter shows how heterologous proteins can be regulated by fusion to the hormone binding domain of a receptor. Nuclear Receptors: A Practical Approach is a comprehensive guide to studying members of the superfamily and will be invaluable to all researchers old and new.

The Nuclear Receptor Superfamily

Author : Iain J. McEwan, PhD
Publisher : Humana Press
ISBN 13 : 9781603275743
Total Pages : 0 pages
Book Rating : 4.2/5 (757 download)

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Book Synopsis The Nuclear Receptor Superfamily by : Iain J. McEwan, PhD

Download or read book The Nuclear Receptor Superfamily written by Iain J. McEwan, PhD and published by Humana Press. This book was released on 2008-12-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acting principally to control patterns of gene expression, nuclear receptors play vital roles during embryonic development and in the regulation of metabolic and reproductive functions in adult life, which proves this superfamily of ligand-activated transcription factors to be a crucial part of biological life. In The Nuclear Receptor Superfamily: Methods and Protocols, expert researchers describe a range of molecular, structural and cell biological techniques currently used to investigate the structure-function of nuclear receptors, together with experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters in this volume contain brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as notes from the experts to highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, The Nuclear Receptor Superfamily: Methods and Protocols provides beneficial and time-saving guidance for all those undertaking research in this ever-growing field of study.

Nuclear Receptors: From Structure to the Clinic

Author : Iain J. McEwan
Publisher : Springer
ISBN 13 : 3319187295
Total Pages : 236 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Nuclear Receptors: From Structure to the Clinic by : Iain J. McEwan

Download or read book Nuclear Receptors: From Structure to the Clinic written by Iain J. McEwan and published by Springer. This book was released on 2015-08-20 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.

Steroid Dynamics

Author : Gregory Pincus
Publisher : Academic Press
ISBN 13 : 1483270858
Total Pages : 596 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Steroid Dynamics by : Gregory Pincus

Download or read book Steroid Dynamics written by Gregory Pincus and published by Academic Press. This book was released on 2013-10-22 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroid Dynamics compiles papers presented at the Symposium on the Dynamics of Steroid Hormones held in Tokyo, in May 1965. This compilation discusses the effect of LH and ACTH on production and excretion of testosterone in vivo, estrogen receptors in target tissues, and influence of morphine on corticoid production. The binding of steroids to follicular fluid proteins, conjugation and excretion of aldosterone, and active cholesterol pool for corticodogenesis in the rat adrenal are also elaborated. This book likewise covers the dynamics of steroid hormone distribution in the body, biosynthesis of steroids in testicular tissue in vitro, and isotopic dilution methods for the estimation of rates of secretion of the steroid hormones. This publication is a good reference for endocrinologists, biochemists, and medical practitioners interested in steroid dynamics.

The Nuclear Receptor Superfamily

Author : I. J. McEwan
Publisher :
ISBN 13 : 9781855781382
Total Pages : 0 pages
Book Rating : 4.7/5 (813 download)

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Book Synopsis The Nuclear Receptor Superfamily by : I. J. McEwan

Download or read book The Nuclear Receptor Superfamily written by I. J. McEwan and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nuclear Receptors and Genetic Disease

Author : Thomas P. Burris
Publisher : Academic Press
ISBN 13 : 0080917143
Total Pages : 437 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Nuclear Receptors and Genetic Disease by : Thomas P. Burris

Download or read book Nuclear Receptors and Genetic Disease written by Thomas P. Burris and published by Academic Press. This book was released on 2000-09-06 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Receptors and Genetic Disease provides the first compilation of the role of nuclear hormones in health and disease and incorporates the latest breakthroughs in the field. It provides comprehensive reviews of the major receptors prepared by the acknowledged experts in each area. Each chapter provides information on the history, physiology, structure, mechanism of action, genetics, pathophysiology, disease diagnosis, and disease treatment for a particular nuclear receptor. Each chapter also includes a table showing all the known mutations of the respective nuclear receptor with the corresponding clinical disorder. Receptors included in this book are: The Nuclear Receptor Superfamily Thyroid Hormone Receptors Estrogen and Progesterone Receptors The Androgen Receptor DAX-1 and Related Orphan Receptors The Vitamin D Receptor Retinoid Receptors Mineralocorticoid and Glucocorticoid Receptors Hepatocyte Nuclear Factor 4 a Peroxisome Proliferator Activated Receptors Coactivators and Corepressors

Innovative Medicine

Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Nuclear Receptor Coregulators

Author :
Publisher : Academic Press
ISBN 13 : 9780080522883
Total Pages : 304 pages
Book Rating : 4.5/5 (228 download)

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Book Synopsis Nuclear Receptor Coregulators by :

Download or read book Nuclear Receptor Coregulators written by and published by Academic Press. This book was released on 2004-08-11 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. *First published in 1943, Vitamins and Hormones is AP's longest running serial *Each volume contains cutting edge reviews by leading contributors

Nuclear Receptors

Author : Mostafa Z. Badr
Publisher : Springer Nature
ISBN 13 : 3030783154
Total Pages : 676 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Nuclear Receptors by : Mostafa Z. Badr

Download or read book Nuclear Receptors written by Mostafa Z. Badr and published by Springer Nature. This book was released on 2021-09-28 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.

Nuclear Receptors in Development and Disease

Author :
Publisher : Academic Press
ISBN 13 : 0128021969
Total Pages : 420 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Nuclear Receptors in Development and Disease by :

Download or read book Nuclear Receptors in Development and Disease written by and published by Academic Press. This book was released on 2017-05-17 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Receptors in Development and Disease, Volume 125, the latest volume in the Current Topics in Developmental Biology series, covers nuclear receptors in development and disease, and includes contributions from an international board of authors. The book's chapters provide a comprehensive set of reviews that cover such topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural development. Covers the area of nuclear receptors in development and disease Includes contributions from an International board of authors Provides a comprehensive set of reviews on topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural developments

The Nuclear Receptor FactsBook

Author : Vincent Laudet
Publisher : Gulf Professional Publishing
ISBN 13 : 9780124377356
Total Pages : 486 pages
Book Rating : 4.3/5 (773 download)

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Book Synopsis The Nuclear Receptor FactsBook by : Vincent Laudet

Download or read book The Nuclear Receptor FactsBook written by Vincent Laudet and published by Gulf Professional Publishing. This book was released on 2002 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: The FactsBook Series has established itself as the best source of easily accessible and accurate facts about protein groups. They use an easy-to-follow format and are researched and compiled by experts in the field. This Factsbook is devoted to nuclear receptors. The first section presents an introduction and describes the mode of action of the receptors in general. The second section of the book contains detailed entries covering each type of receptor. Entries provide information on: Nomenclature and structure, Isolation, DNA binding properties, Ligands, Expression, Target genes, Knockouts, Disease association, Gene structure, promoter and isoforms, Chromosomal location, Amino acid sequences, Key references

Gene Regulation, Epigenetics and Hormone Signaling

Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
ISBN 13 : 3527322817
Total Pages : 678 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Gene Regulation, Epigenetics and Hormone Signaling by : Subhrangsu S. Mandal

Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

Computational Approaches to Nuclear Receptors

Author : Pietro Cozzini
Publisher : Royal Society of Chemistry
ISBN 13 : 1849735352
Total Pages : 300 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Computational Approaches to Nuclear Receptors by : Pietro Cozzini

Download or read book Computational Approaches to Nuclear Receptors written by Pietro Cozzini and published by Royal Society of Chemistry. This book was released on 2012-11-30 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear receptors (NR) are ligand-induced activated transcription factors that are involved in numerous biological processes. Since the 1990's when the first structures were determined by means of X ray diffraction, the number of NR structures has increased considerably. Moreover several 'omics' projects (genomics, pharmcogenomics and proteomics) have opened up great opportunities for the discovery of new targets, the characterization of abnormal protein patterns, the selection of "tailored" drugs and the evaluation of drug efficacy even with a lack of structural data. Furthermore, structure-based drug design, computational methods for in silico screening and nanobiotechnology- based tools are simplifying this time-consuming and money-intensive research of lead compounds and, possibly, new drugs. Biological interactions such as those that occur between a protein and ligand are concerted events where flexible molecules interact. Thus understanding flexibility of large molecules or biological complexes is of primary importance to help define the right model to approximate the reality for drug discovery, virtual screening, food safety analysis, etc. NRs are known as flexible targets, with many structural similarities, in particular for their Ligand Binding Domain: these similarities could be assumed to share behavioural qualities that belong to this class of compounds. Thus to supply a possible, complete and exhaustive answer to questions about the behaviour of NRs, their interactions with new potential drugs, endocrine disruptors such as animal and human food toxins, food additives or industry residuals, it is mandatory to approach the problem from a different point of view: a molecular modelling approach, steered synthesis, and in vitro and in vivo tests, etc. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors.

Biased Signaling in Physiology, Pharmacology and Therapeutics

Author : Brian J Arey
Publisher : Elsevier
ISBN 13 : 0124115071
Total Pages : 316 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Biased Signaling in Physiology, Pharmacology and Therapeutics by : Brian J Arey

Download or read book Biased Signaling in Physiology, Pharmacology and Therapeutics written by Brian J Arey and published by Elsevier. This book was released on 2014-06-05 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Hormone Signaling

Author : Vincent Goffin
Publisher : Springer Science & Business Media
ISBN 13 : 9780792376606
Total Pages : 340 pages
Book Rating : 4.3/5 (766 download)

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Book Synopsis Hormone Signaling by : Vincent Goffin

Download or read book Hormone Signaling written by Vincent Goffin and published by Springer Science & Business Media. This book was released on 2002-03-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.