The More Complex Renin Angiotensin System

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Textbook of Nephro-Endocrinology

Author : Ajay K. Singh
Publisher : Academic Press
ISBN 13 : 0080920462
Total Pages : 534 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Textbook of Nephro-Endocrinology by : Ajay K. Singh

Download or read book Textbook of Nephro-Endocrinology written by Ajay K. Singh and published by Academic Press. This book was released on 2009-01-12 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. - Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems - Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work - Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field

Hypertension in Postmenopausal Women

Author : Michel E. Safar
Publisher : Springer Science & Business Media
ISBN 13 : 3642790771
Total Pages : 125 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Hypertension in Postmenopausal Women by : Michel E. Safar

Download or read book Hypertension in Postmenopausal Women written by Michel E. Safar and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: On the occasion of the symposium on Hypertension in Postmenopausal Women (Monte Carlo, January 19-22, 1994), international scientists and clinicians discussed the various aspects of high blood pressure in older women. This volume presents an overview of this important aspect of both cardiology and gynecology. Special emphasis is given to the different approaches to antihypertension treatment.

Neural Control of Renal Function

Author : Ulla Kopp
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615042318
Total Pages : 99 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Neural Control of Renal Function by : Ulla Kopp

Download or read book Neural Control of Renal Function written by Ulla Kopp and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. Increases in efferent renal sympathetic nerve activity reduce renal blood flow and urinary sodium excretion by activation of α1-adrenoceptors and increase renin secretion rate by activation of β1-adrenoceptors. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic tissue of a magnitude that may occur during increased urine flow rate. Activation of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension. Table of Contents: Part I: Efferent Renal Sympathetic Nerves / Introduction / Neuroanatomy / Neural Control of Renal Hemodynamics / Neural Control of Renal Tubular Function / Neural Control of Renin Secretion Rate / Part II: Afferent Renal Sensory Nerves / Introduction / Neuroanatomy / Renorenal Reflexes / Mechanisms Involved in the Activation of Afferent Renal Sensory Nerves / Part III: Pathophysiological States / Efferent Renal Sympathetic Nerves / Afferent Renal Sensory Nerves / Conclusions / References

The Protective Arm of the Renin Angiotensin System (RAS)

Author : Thomas Unger
Publisher : Academic Press
ISBN 13 : 0128014857
Total Pages : 312 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Protective Arm of the Renin Angiotensin System (RAS) by : Thomas Unger

Download or read book The Protective Arm of the Renin Angiotensin System (RAS) written by Thomas Unger and published by Academic Press. This book was released on 2015-04-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. - Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor - Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. - Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases - Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.

Aldosterone-Mineralocorticoid Receptor

Author : Brian Harvey
Publisher : BoD – Books on Demand
ISBN 13 : 1839621982
Total Pages : 302 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Aldosterone-Mineralocorticoid Receptor by : Brian Harvey

Download or read book Aldosterone-Mineralocorticoid Receptor written by Brian Harvey and published by BoD – Books on Demand. This book was released on 2019-09-25 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.

Renin-Angiotensin Aldosterone System

Author : Samy I. McFarlane
Publisher : BoD – Books on Demand
ISBN 13 : 1839682868
Total Pages : 170 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Renin-Angiotensin Aldosterone System by : Samy I. McFarlane

Download or read book Renin-Angiotensin Aldosterone System written by Samy I. McFarlane and published by BoD – Books on Demand. This book was released on 2021-11-24 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Renin-Angiotensin Aldosterone System (RAAS) plays an important role not only in salt and water homeostasis but also in the cardiovascular system, the kidney, and the brain. While several volumes address different aspects of the RAAS function, this book provides cutting-edge information on the pathogenesis of various disorders related to RAAS overactivation. It also presents unique aspects of RAAS functioning that have not been sufficiently described in the literature. Topics covered include assessment of hypoaldosteronism in infancy, RASS and cognitive decline, and the role of RAAS in the pathogenesis of COVID-19. Written by experts in the field in an easy-to-follow and illustrated format, this volume will benefit students and practitioners, as well as clinical and basic science investigators alike.

The Renin-Angiotensin-Aldosterone System

Author : Sean E. Thatcher
Publisher : Humana Press
ISBN 13 : 9781493970285
Total Pages : 201 pages
Book Rating : 4.9/5 (72 download)

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Book Synopsis The Renin-Angiotensin-Aldosterone System by : Sean E. Thatcher

Download or read book The Renin-Angiotensin-Aldosterone System written by Sean E. Thatcher and published by Humana Press. This book was released on 2017-05-13 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses protocols that aid in measuring different components in the renin-angiotensin-aldosterone system (RAAS). The book also looks at the methods used to assess angiotensin peptides and discerning the influence of RAAS components on different mammalian diseases. The chapters cover topics such as the use of fluorescent substrate to measure ACE2 activity in the mouse abdominal aorta, blood pressure monitoring using the radio telemetry method, and the analysis of angiotensin metabolism in the kidney using mass spectrometry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and comprehensive, The Renin-Angiotensin-Aldosterone Systems: Methods and Protocols is a valuable resource that provides scientists and researchers with the best approaches to examine RAAS.

The Local Cardiac Renin-Angiotensin Aldosterone System

Author : Edward D. Frohlich
Publisher : Springer Science & Business Media
ISBN 13 : 1441905286
Total Pages : 187 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis The Local Cardiac Renin-Angiotensin Aldosterone System by : Edward D. Frohlich

Download or read book The Local Cardiac Renin-Angiotensin Aldosterone System written by Edward D. Frohlich and published by Springer Science & Business Media. This book was released on 2009-09-18 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system. Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest. Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION. Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.

Renal Vascular Disease

Author : Lilach O. Lerman
Publisher : Springer Science & Business Media
ISBN 13 : 1447128109
Total Pages : 360 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Renal Vascular Disease by : Lilach O. Lerman

Download or read book Renal Vascular Disease written by Lilach O. Lerman and published by Springer Science & Business Media. This book was released on 2014-03-28 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few references have been published on the renal vascular system and its effect on the cardiovascular system as a whole. Clearly the kidney exerts a huge influence on the circulation and hypertension in particular, but there is a growing concentration on its function across many diseases. This book details the diagnosis, treatment and management of all renal vascular disease.

Cellular and Molecular Biology of the Renin-Angiotensin System

Author : Mohan K. Raizada
Publisher : CRC Press
ISBN 13 : 1351087398
Total Pages : 455 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Cellular and Molecular Biology of the Renin-Angiotensin System by : Mohan K. Raizada

Download or read book Cellular and Molecular Biology of the Renin-Angiotensin System written by Mohan K. Raizada and published by CRC Press. This book was released on 2018-01-18 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Biology of the Renin-Angiotensin System provides the first review and update of the state-of-the-art cellular and molecular aspects of the renin-angiotensin system. The book presents detailed analyses from world experts on each component of this system, including future directions. Topics range from angiotensin II receptor subtypes to processing of renin to the use of transgenic animal models for studying the role of this system in hypertension. Cellular and Molecular Biology of the Renin-Angiotensin System is essential reading for physiologists of the renin-angiotensin system, endocrinologists, cardiovascular specialists, renal physiologists, and neurobiologists.

Heart Failure: A Companion to Braunwald's Heart Disease E-Book

Author : G. Michael Felker
Publisher : Elsevier Health Sciences
ISBN 13 : 0323609880
Total Pages : 937 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Heart Failure: A Companion to Braunwald's Heart Disease E-Book by : G. Michael Felker

Download or read book Heart Failure: A Companion to Braunwald's Heart Disease E-Book written by G. Michael Felker and published by Elsevier Health Sciences. This book was released on 2019-02-06 with total page 937 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald's Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. - Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. - Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. - Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). - Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. - Covers the pathophysiological basis for the development and progression of heart failure. - Serves as a definitive resource to prepare for the ABIM's Heart Failure board exam. - 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).

Nutrition in the Prevention and Treatment of Abdominal Obesity

Author : Ronald Ross Watson
Publisher : Elsevier
ISBN 13 : 0124079342
Total Pages : 559 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Nutrition in the Prevention and Treatment of Abdominal Obesity by : Ronald Ross Watson

Download or read book Nutrition in the Prevention and Treatment of Abdominal Obesity written by Ronald Ross Watson and published by Elsevier. This book was released on 2014-02-26 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition in the Prevention and Treatment of Abdominal Obesity focuses on the important roles that exercise, dietary changes, and foods play in promoting as well as reducing visceral fat. Nutritionists, dieticians, and healthcare providers seeking to address the abdominal obesity epidemic will use this comprehensive resource as a tool in their long-term goal of preventing chronic diseases, especially heart, vascular, and diabetic diseases. Experts from a broad range of disciplines are involved in dealing with the consequences of excessive abdominal fat: cardiology, diabetes research, studies of lipids, endocrinology and metabolism, nutrition, obesity, and exercise physiology. They have contributed chapters that define a range of dietary approaches to reducing risk and associated chronic diseases. They begin by defining visceral obesity and its major outcomes; they also discuss the importance and the challenges of dietary approaches to reduce abdominal obesity, as compared to clinical approaches, with major costs and risks. - Offers detailed, well-documented reviews outlining the various dietary approaches to visceral obesity with their benefits and failures - Includes chapters on types of foods, exercise, and supplements in reducing obesity and its chronic clinical companions, especially diabetes and cardiovascular disease - Helps nutritionists, dieticians, and healthcare providers approach patients in making decision about nutritional therapies and clinical treatments for abdominal obesity, from an evidence-based perspective

Encyclopedic Reference of Molecular Pharmacology

Author : Stefan Offermanns
Publisher :
ISBN 13 :
Total Pages : 1152 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Encyclopedic Reference of Molecular Pharmacology by : Stefan Offermanns

Download or read book Encyclopedic Reference of Molecular Pharmacology written by Stefan Offermanns and published by . This book was released on 2004 with total page 1152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents current information on the molecular mechanisms of drug action. Provides 159 essays describing groups of drugs and drug targets. Several essays deal with general principles of pharmacology, such as drug tolerance, drug addiction, or drug metabolism.

Biology for AP ® Courses

Author : Julianne Zedalis
Publisher :
ISBN 13 : 9781947172401
Total Pages : 1923 pages
Book Rating : 4.1/5 (724 download)

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Book Synopsis Biology for AP ® Courses by : Julianne Zedalis

Download or read book Biology for AP ® Courses written by Julianne Zedalis and published by . This book was released on 2017-10-16 with total page 1923 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.

Thirst and Sodium Appetite

Author : Sebastian Peter Grossman
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Thirst and Sodium Appetite by : Sebastian Peter Grossman

Download or read book Thirst and Sodium Appetite written by Sebastian Peter Grossman and published by . This book was released on 1990 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thirst and Sodium Appetite ...

Normal and Abnormal Development of the Kidney

Author : Edith Louise Potter
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Normal and Abnormal Development of the Kidney by : Edith Louise Potter

Download or read book Normal and Abnormal Development of the Kidney written by Edith Louise Potter and published by . This book was released on 1972 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Renin Angiotensin System in Cardiovascular Disease

Author : Naranjan S. Dhalla
Publisher : Springer Nature
ISBN 13 : 3031149521
Total Pages : 453 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis The Renin Angiotensin System in Cardiovascular Disease by : Naranjan S. Dhalla

Download or read book The Renin Angiotensin System in Cardiovascular Disease written by Naranjan S. Dhalla and published by Springer Nature. This book was released on 2023-01-01 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.