The Local Cardiac Renin-Angiotensin Aldosterone System

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Publisher : Springer Science & Business Media
ISBN 13 : 1441905286
Total Pages : 187 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis The Local Cardiac Renin-Angiotensin Aldosterone System by : Edward D. Frohlich

Download or read book The Local Cardiac Renin-Angiotensin Aldosterone System written by Edward D. Frohlich and published by Springer Science & Business Media. This book was released on 2009-09-18 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system. Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest. Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION. Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.

Renin Angiotensin System and Cardiovascular Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 1607611864
Total Pages : 249 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis Renin Angiotensin System and Cardiovascular Disease by : Walmor C. DeMello

Download or read book Renin Angiotensin System and Cardiovascular Disease written by Walmor C. DeMello and published by Springer Science & Business Media. This book was released on 2009-09-01 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers the latest research into the role of the renin angiotensin system on cardiac and vascular functions and in cardiovascular diseases. It covers vital aspects such as intracellular signaling and regulation of cell volume in the failing heart.

Aldosterone-Mineralocorticoid Receptor

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Publisher : BoD – Books on Demand
ISBN 13 : 1839621982
Total Pages : 302 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Aldosterone-Mineralocorticoid Receptor by : Brian Harvey

Download or read book Aldosterone-Mineralocorticoid Receptor written by Brian Harvey and published by BoD – Books on Demand. This book was released on 2019-09-25 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.

Renin Angiotensin System and the Heart

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Publisher : John Wiley & Sons
ISBN 13 : 0470862947
Total Pages : 256 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Renin Angiotensin System and the Heart by : Walmor C. De Mello

Download or read book Renin Angiotensin System and the Heart written by Walmor C. De Mello and published by John Wiley & Sons. This book was released on 2005-10-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters that are activated by biomechanical stress. This book reviews the latest information on the way in which both the plasma and cardiac renin angiotensin systems affect heart function. It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signalling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angiotensin system are expressed. Other topics covered include wound healing as well as the trophic effects of aldosterone. Contains the most recent findings on the renin angiotensin system and the heart Written by an international team of distinguished scientists Covers both the cellular and molecular basis of the renin angiotensin system and the clinical relevance of this research

The Cardiac Renin-angiotensin System

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Author :
Publisher : Wiley-Blackwell
ISBN 13 : 9780879935719
Total Pages : 366 pages
Book Rating : 4.9/5 (357 download)

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Book Synopsis The Cardiac Renin-angiotensin System by : Klaus Lindpaintner

Download or read book The Cardiac Renin-angiotensin System written by Klaus Lindpaintner and published by Wiley-Blackwell. This book was released on 1994-01-01 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The potential significance of the cardiac renin–angiotensin system is indicated by the beneficial effects of angiotensin–converting enzyme inhibitors in the treatment of congestive heart failure and regional myocardial ischemia. It has become clear that the cardiac renin–angiotensin system may contribute to post–myocardial infarction ventricular remodeling. This book details the cardiac renin–angiotensin system and its importance as the key to new therapeutic strategies. It will be an important addition to the library of any physician who is involved with the treatment of hypertension or congestive heart failure

The Renin Angiotensin System in Cardiovascular Disease

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Publisher : Springer Nature
ISBN 13 : 3031149521
Total Pages : 453 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis The Renin Angiotensin System in Cardiovascular Disease by : Naranjan S. Dhalla

Download or read book The Renin Angiotensin System in Cardiovascular Disease written by Naranjan S. Dhalla and published by Springer Nature. This book was released on 2023-01-01 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.

Renin-Angiotensin Aldosterone System

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Publisher : BoD – Books on Demand
ISBN 13 : 1839682868
Total Pages : 170 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Renin-Angiotensin Aldosterone System by : Samy I. McFarlane

Download or read book Renin-Angiotensin Aldosterone System written by Samy I. McFarlane and published by BoD – Books on Demand. This book was released on 2021-11-24 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Renin-Angiotensin Aldosterone System (RAAS) plays an important role not only in salt and water homeostasis but also in the cardiovascular system, the kidney, and the brain. While several volumes address different aspects of the RAAS function, this book provides cutting-edge information on the pathogenesis of various disorders related to RAAS overactivation. It also presents unique aspects of RAAS functioning that have not been sufficiently described in the literature. Topics covered include assessment of hypoaldosteronism in infancy, RASS and cognitive decline, and the role of RAAS in the pathogenesis of COVID-19. Written by experts in the field in an easy-to-follow and illustrated format, this volume will benefit students and practitioners, as well as clinical and basic science investigators alike.

A Time for Metabolism and Hormones

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Publisher : Springer
ISBN 13 : 3319270699
Total Pages : 132 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis A Time for Metabolism and Hormones by : Paolo Sassone-Corsi

Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Textbook of Nephro-Endocrinology

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Publisher : Academic Press
ISBN 13 : 0080920462
Total Pages : 534 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Textbook of Nephro-Endocrinology by : Ajay K. Singh

Download or read book Textbook of Nephro-Endocrinology written by Ajay K. Singh and published by Academic Press. This book was released on 2009-01-12 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field

Thyroid and Heart Failure

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Publisher : Springer Science & Business Media
ISBN 13 : 8847011434
Total Pages : 264 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Thyroid and Heart Failure by : Giorgio Iervasi

Download or read book Thyroid and Heart Failure written by Giorgio Iervasi and published by Springer Science & Business Media. This book was released on 2009-08-29 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. Although there is no doubt regarding the close link between cardiovascular pathophysiology and thyroid homeostasis, our understanding of this association is far from being exhaustive. Thyroid hormone regulates the expression of cardiac-specific functional contractile and structural proteins and plays a pivotal role in modulating both diastolic and systolic function as well as peripheral vascular resistance. The close relationship between thyroid and heart dysfunction is strongly supported by recent evidence demonstrating that an altered thyroid profile is a negative prognostic predictor in patients with heart failure. The treatment of chronic heart failure, especially in advanced stages of the disease, continues to be an open and challenging field. The potential of novel thyroid hormone therapies that address the molecular biology of thyroid dysfunction and heart failure thus represents an attractive area of multidisciplinary scientific interest. This book is a readable, integrated, and highly up to date presentation of the clinical, pathophysiological, and basic science aspects of thyroid–heart failure interactions. It addresses a complex subject in an approach that targets a large audience of readers.

The Protective Arm of the Renin Angiotensin System (RAS)

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Publisher : Academic Press
ISBN 13 : 0128014857
Total Pages : 316 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Protective Arm of the Renin Angiotensin System (RAS) by : Thomas Unger

Download or read book The Protective Arm of the Renin Angiotensin System (RAS) written by Thomas Unger and published by Academic Press. This book was released on 2015-04-18 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.

Angiotensin and the Heart

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Author :
Publisher : Steinkopff
ISBN 13 : 9783798509368
Total Pages : 0 pages
Book Rating : 4.5/5 (93 download)

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Book Synopsis Angiotensin and the Heart by : Gerd Heusch

Download or read book Angiotensin and the Heart written by Gerd Heusch and published by Steinkopff. This book was released on 1993-05-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade, ACE inhibitors have become a cornerstone of cardiovascular drug therapy. Beneficial effects in patients with hypertension, heart failure, and post myocardial infarction have been established in large clinical trials. In parallel, ex­ perimental research has shifted the interest from the immediate homeostatic function of the circulating renin-angiotensin-system to the multiple paracrine functions of local tissue renin-angiotensin-systems, including hypertrophy, hyperplasia, athe- oenesis, and vasomotion. . It was the aim or a symposium held in Hamburg, October 22-24, 1992, to bring together an international panel of experimental and clinical scientists and to discuss the most recent findings on the role of angiotensin and associated mediators in car­ diovascular adaptation and disease, with a particular emphasis on the treatment of such disease by ACE inhibitors. The meeting and this publication were generously supported by Astra Chemicals. H. Grobecker G. Heusch B. E. Strauer Contents Foreword. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V Introduction Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart Dzau, V. J. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Myocardial Perfusion Angiotensin, ACE-inhibitors and endothelial control of vasomotor tone Luscher, T. F. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Local and neurohumoral control of coronary blood flow Krajcar, M. , G. Heusch. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 ACE-inhibitors in coronary artery disease? Vogt, M. , W. Matz, B. E. Strauer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Myocardial Hypertrophy Molecular mechanisms of cardiac gene expression Nadal-Ginard, B. , V. Mahdavi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 Myocardial perfusion dependent and independent mechanisms of regional myocardial dysfunction in hypertrophy Vatner, S. F. , L. Hittinger . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Renin-Angiotensin System

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Publisher : BoD – Books on Demand
ISBN 13 : 9535133519
Total Pages : 270 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Renin-Angiotensin System by : Anna Tolekova

Download or read book Renin-Angiotensin System written by Anna Tolekova and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the contractile activity of smooth muscle segments isolated from various organs of healthy animals and animals with experimentally induced diabetes, she obtained original data about angiotensin II-induced force and time parameters. For the first time, she established the effect of ghrelin on angiotensin II-provoked contraction of the urinary bladder. Original data on the role of both types of angiotensin receptors for the contractile activity of the various segments of the gastrointestinal tract and bladder were obtained. By applying specific software for force and time parameter analysis, the contribution of different types of angiotensin receptors on muscle contractility has been shown. The new methodology was used to analyze the data obtained during the registration of smooth muscle relaxation activity, which allows the determination of not only the magnitude of the mechanical response but also the parameters related to the time and speed of the contractions. Plasma renin activity models have been developed using mathematical approaches to predict the effect of different drug doses on the behavior of the system.

Textbook of Vascular Medicine

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Publisher : Springer
ISBN 13 : 3030164810
Total Pages : 503 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Textbook of Vascular Medicine by : Rhian M. Touyz

Download or read book Textbook of Vascular Medicine written by Rhian M. Touyz and published by Springer. This book was released on 2019-08-02 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.

Mayo Clinic Cardiology

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Publisher : Oxford University Press
ISBN 13 : 0199915717
Total Pages : 1112 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Mayo Clinic Cardiology by : Mayo Clinic

Download or read book Mayo Clinic Cardiology written by Mayo Clinic and published by Oxford University Press. This book was released on 2012-12-06 with total page 1112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized to present a comprehensive overview of the field of cardiology in an accessible, reader-friendly format that can be covered in about 12 months, this new edition contains roughly 50% new material, the cardiac pharmacology section has been completely reworked, cardiovascular trials have been included, and the entire book has been updated to reflect current practice guidelines and recent developments. The book is peppered throughout with numerous tables and clinical pearls that aid the student, as well as the teacher, to remain focused.

Hypertension and the Heart

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Publisher : Springer
ISBN 13 : 9781461374589
Total Pages : 288 pages
Book Rating : 4.3/5 (745 download)

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Book Synopsis Hypertension and the Heart by : Alberto Zanchetti

Download or read book Hypertension and the Heart written by Alberto Zanchetti and published by Springer. This book was released on 2012-10-21 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the International Conference held as Part of the Menarinei Series on Cardiovascular Diseases in Berlin, Germany, February 27-28, 1998

Fundamentals of Anaesthesia

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Publisher : Cambridge University Press
ISBN 13 : 9781841101224
Total Pages : 990 pages
Book Rating : 4.1/5 (12 download)

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Book Synopsis Fundamentals of Anaesthesia by : Colin Pinnock

Download or read book Fundamentals of Anaesthesia written by Colin Pinnock and published by Cambridge University Press. This book was released on 2002-01-12 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate.