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The Molecular Immunology Of Neurological Diseases
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Book Synopsis The Molecular Immunology of Neurological Diseases by : Sunil Kumar
Download or read book The Molecular Immunology of Neurological Diseases written by Sunil Kumar and published by Academic Press. This book was released on 2021-02-16 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular Immunology of Neurological Diseases provides a comprehensive review of current updates in molecular immunogenetics of different neurological diseases. Readers will learn about the role of immune cells and their modulation strategies to help in the development of therapeutic approaches for both acute and chronic neurodegenerative disorders. There is no other book available on the topic. It has long been thought that the brain is an immune-privilege organ with very limited immune response. However recent studies have made clear that both systemic 'brain' and peripheral 'blood' immune cell responses play key roles in determining brain pathology in neurodegenerative disorders. This book summarizes the role of immune cell activation in the central nervous system microenvironment in acute and chronic neurodegenerative disorders. In addition, it discusses the key role of immune cells and their modulation strategies for the development of current therapeutic approaches. Discusses the molecular immunogenetics of different neurological diseases Covers strategies for the development of therapeutic approaches Encompasses both acute and chronic neurogenerative disorders Describes the molecular pathogenesis of viral genes in various diseases Features chapters on migraine, muscular dystrophy and cancer
Book Synopsis Molecular Neurology by : Stephen Waxman
Download or read book Molecular Neurology written by Stephen Waxman and published by Elsevier. This book was released on 2010-07-26 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. Describes the newest molecular aspects of neurological disorders Provides an introduction to neurological disorders for basic scientists Updates clinicians and clinical researchers on the most recent developments
Book Synopsis Neuro-Immuno-Gastroenterology by : Cris S. Constantinescu
Download or read book Neuro-Immuno-Gastroenterology written by Cris S. Constantinescu and published by Springer. This book was released on 2016-05-24 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.
Book Synopsis Inflammatory Disorders of the Nervous System by : Alireza Minagar
Download or read book Inflammatory Disorders of the Nervous System written by Alireza Minagar and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.
Book Synopsis Contemporary Topics in Molecular Immunology by : R. A. Reisfeld
Download or read book Contemporary Topics in Molecular Immunology written by R. A. Reisfeld and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: New information is developing so rapidly in the entire field of immunology that one is unable to remain abreast of all advancing fronts. In many cases, consider able information has accumulated as the result of the efforts of many investigators, but the conclusions from the various laboratories have not been summarized recently in a comprehensible manner. One such situation has to do with work on IgD. An up-to-date report on this immunoglobulin was included in Volume 10f this series, but since that time there has been considerable progress in the deter mination of its structure and function. In the present volume Leslie and Martin have reviewed the accomplishments of recent years and the problems remaining to be solved. New information regarding the concentration of IgD in body fluids in normal and disease states is presented. Studies of the ontogeny of surface IgD in animals are described, and the fmdings imply that it may be important in the primary immune response. The role of IgD on lymphocyte surfaces is thoroughly discussed especially in terms of stimulating or suppressive combinations of signals delivered to the lymphocyte by agents which bind or alter the surface rt:ceptors. The authors conclude by proposing a model for plasma-cell differentiation which accounts fo~ the existence of triple Ig-bearing cells, many IgM-IgD-bearing cells, and the low percentage of cells bearing a single isotype. Sometimes the serum of an individual contains abnormally large amounts of two distinct, homogeneous populations of immunoglobulins.
Book Synopsis Autoantibodies in Neurological Diseases by : Angela Vincent
Download or read book Autoantibodies in Neurological Diseases written by Angela Vincent and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers the immunological and clinical aspects of immune-mediated diseases of the central and peripheral nervous system, excluding multiple sclerosis. It includes paraneoplastic neurological disorders, and discusses the immune mechanisms in the growing number of recognised paraneoplastic conditions. It not only provides an overview of the field but also discusses the possible role of immunity in other neurological disorders such as epilepsy. Chapters are written by scientists and clinicians directly involved in each specific area, who have summarized the current understanding of neuroimmunology, with emphasis on the underlying abormalities of the immune responses, the different clinical expression of the diseases and the important use of immunotherapies in treatment. Figures and tables are included in each chapter.
Download or read book Molecular Immunology written by and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neuroimmune Pharmacology by : Tsuneya Ikezu
Download or read book Neuroimmune Pharmacology written by Tsuneya Ikezu and published by Springer. This book was released on 2016-12-22 with total page 1045 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.
Book Synopsis Contemporary Topics in Molecular Immunology by : F. P. Inman
Download or read book Contemporary Topics in Molecular Immunology written by F. P. Inman and published by Springer. This book was released on 2013-01-23 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Included in this volume is a broad range of topics. Immunology is such a diverse field that many of the subspecialties overlap, and one finds it convenient and necessary to integrate information from several of them. We try to focus on the molecular aspects of immunology as much as is reasonable, but some con tributions consist of ablend of molecular and cellular immunology and even immunopathology. This is as it should be, since information at the molecular level often provides an explanation of phenomena observed at other levels. Myelin basic protein holds the interest of immunologists because it is impli cated in the induction of the autoimmune disease called experimental allergie encephalomyelitis (EAE). Although much biochemical and immunological information about this protein has been uncovered, it is not understood how such an inaccessible self-antigen can serve as the focal point in the central ner vous system for myelin basic protein-specific EAE-inducing T cells. Day dis cusses the problem by first reviewing the sequences of the proteins from several species and the antigenicity of the proteins and peptides derived from them. The reader is then led into a thorough discussion of the immunological relation ships that do and do not influence development of the encephalitis. From this discussion, the author promulgates the bystander model as the best overall mechanism to explain why different fragments of the highly conserved protein are needed by various species to give rise to the same type of localized central nervous system disease.
Book Synopsis Contemporary Topics in Molecular Immunology by : R. Reisfeld
Download or read book Contemporary Topics in Molecular Immunology written by R. Reisfeld and published by . This book was released on 2014-01-15 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Contemporary Topics in Molecular Immunology by :
Download or read book Contemporary Topics in Molecular Immunology written by and published by . This book was released on 1973 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Molecular Basis of Programmed Cell Death and Neuroinflammation in Neurodegenerative Diseases by : Ramkumar Mathur
Download or read book The Molecular Basis of Programmed Cell Death and Neuroinflammation in Neurodegenerative Diseases written by Ramkumar Mathur and published by Frontiers Media SA. This book was released on 2024-01-25 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Age-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuroinflammation as well as neuronal degeneration. Apoptosis, necrosis, and autophagy are all types of programmed cell death that are morphologically distinct from one another. Over the last decade, extensive research has been conducted on necroptosis, resulting in a better understanding of its molecular underpinnings and role in neurodegenerative diseases. A later study investigates the processes of apoptosis and necroptosis, as well as their roles in the activation of inflammatory immune responses. Although there is a distinct mode of cell death with distinct morphological characteristics, its identification and implications in neurological diseases are still unknown. Interestingly, emerging evidence has established a direct link between epigenetic and posttranslational modifications and neurodegenerative disease. Using epigenetic and proteomic methods, researchers uncovered genes and proteins that may play a function in the area of neuroinflammation, a role that has hitherto been overlooked. New pharmacological targets and therapeutic options for neurodegenerative diseases are being investigated in order to gain a better understanding of the disease's origins and progression by using neuronal death and neuroinflammation models that are associated with epigenetic changes.
Book Synopsis Humoral Immunity in Neurological Diseases by : D. Karcher
Download or read book Humoral Immunity in Neurological Diseases written by D. Karcher and published by Springer. This book was released on 1979 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular and Molecular Immunology by : Andrew H. Lichtman
Download or read book Cellular and Molecular Immunology written by Andrew H. Lichtman and published by . This book was released on 1991 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Medical Information Systems by : Ralph Grams
Download or read book Medical Information Systems written by Ralph Grams and published by Humana Press. This book was released on 2012-12-01 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.
Book Synopsis Molecular Pathology by : William B. Coleman
Download or read book Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2017-11-09 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase
Book Synopsis Introduction to Molecular Immunology by : Alfred Nisonoff
Download or read book Introduction to Molecular Immunology written by Alfred Nisonoff and published by Sinauer Associates, Incorporated. This book was released on 1982 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
