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The Molecular Biology Of Autoimmune Disease
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Book Synopsis The Molecular Biology of Autoimmune Disease by : Andrew G. Demaine
Download or read book The Molecular Biology of Autoimmune Disease written by Andrew G. Demaine and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune diseases are common and often associated with considerable morbidity or - in diseases such as IDDM, myasthenia gravis and multiple sclerosis - mortality. In this volume, experts of international stature in basic science and clinical medicine with a common interest in understanding the normal and aberrant immune response present their experiences. It was their intention to fur- ther the understanding of potential clinical application of scientific observations and to help to comprehend the huge amount of results in autoimmunity research.
Book Synopsis The Autoimmune Diseases by : Noel R. Rose
Download or read book The Autoimmune Diseases written by Noel R. Rose and published by . This book was released on 1998 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Autoimmune Diseases comprehensively describes the clinical expressions of all known autoimmune diseases, as well as the experimental bases of autoimmunity and failure of tolerance. The scientific chapters include mechanisms of natural tolerance, the genetic basis of autoimmunity, the significance of apoptosis, the influence of cytokines, environmental influences, and experimental models. The clinical chapters cover autoimmune endocrine deficiencies, insulin-dependent diabetes, rheumatic disorders, neurological diseases, and diseases of the blood, skin, eye, kidney, and liver.
Book Synopsis The Molecular Pathology of Autoimmune Diseases by : Argyrios N Theofilopoulos
Download or read book The Molecular Pathology of Autoimmune Diseases written by Argyrios N Theofilopoulos and published by CRC Press. This book was released on 2002-12-06 with total page 1518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Remarkable advances have been made in the pathogenesis of autoimmunity, such as with bone marrow transplantation, which is becoming a powerful strategy in treating certain life-threatening diseases. The Molecular Pathology of Autoimmune Diseases is a concise and centralized resource for information on the topic, with a special focus on the molecular and genetic basis of these disorders. Dozens of international experts devote themselves to illuminating the reader in this volume, with discussions on the basic aspects of autoimmune processes to systemic and organ-specific diseases. This volume is an invaluable reference to students and professionals in immunology and related fields.
Author :David Ahmad Nemazee Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805574541 Total Pages :281 pages Book Rating :4.8/5 (55 download)
Book Synopsis B Cell Biology in Autoimmunity by : David Ahmad Nemazee
Download or read book B Cell Biology in Autoimmunity written by David Ahmad Nemazee and published by Karger Medical and Scientific Publishers. This book was released on 2003 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: B cells play a central role not only in adaptive immunity, but also in autoimmunity. To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases. These up-to-date chapters present the latest information on B cell signal transduction, apoptosis, genetics and molecular biology. Also featured are chapters with special reference to particular autoimmune diseases in which B cells have been shown to play a critical role, such as type 1 diabetes, chronic graft-versus-host disease and lupus erythematosus. Further topics covered include the role of the complement system, rheumatoid factors, and anti-DNA autoantibodies as well as important related areas such as natural autoantibodies, B cell immune tolerance, Toll receptor signaling, and the immunobiology of BAFF/BLyS. Both basic researchers and clinician scientists who wish to understand the role of B lymphocytes in immune tolerance and autoimmunity will benefit from this timely publication.
Book Synopsis The Quantal Theory of Immunity by : Kendall A. Smith
Download or read book The Quantal Theory of Immunity written by Kendall A. Smith and published by World Scientific. This book was released on 2010 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to ?count? the number of foreign antigenic molecular ?hits?, and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction. This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented. This molecular understanding of the immune system is especially important for the design of successful vaccines, and also explains why vaccines fail.
Book Synopsis B Cell Receptor Signaling by : Tomohiro Kurosaki
Download or read book B Cell Receptor Signaling written by Tomohiro Kurosaki and published by Springer. This book was released on 2015-12-26 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Book Synopsis Molecular and Cell Biology of Autoantibodies and Autoimmunity. Abstracts by : Ekkehard K.F. Bautz
Download or read book Molecular and Cell Biology of Autoantibodies and Autoimmunity. Abstracts written by Ekkehard K.F. Bautz and published by Springer. This book was released on 1989 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 1st International Workshop in the Molecular and Cell Biology of Autoan tibodies and Autoimmunity is convened at a time when recombinant DNA tech niques have yielded the first set of data providing initial glimpses of epitopes recognized by autoantibodies. It's aim is to bring together cell and molecular biologists with clinical scien tists to discuss the broad spectrum of questions concerning the relationship be tween clinical symptoms and the specificity of autoantibodies. The response to the call for abstracts was overwhelming: Nearly one hundred abstracts were received from many laboratories throughout the world. The topics covered by them are representative of the current research efforts going on to study cause and effect of autoimmune diseases. One of the aims of this workshop is to bring the rapid advances in the elucidation of the molecular structure of auto antigens to the attention of immunologists, cell biologists and clinical scien tists and also to make molecular biologists bei6ple aware of the difficulties lying ahead in trying to understand the cellular and molecular basis of rheumatic dis eases. The organisers wish to thank NIH, BMFT and the Japanese Educational Foundation for financial support, the Heidelberg Academy for the Humanities and Sciences for hosting the workshop, Springer Verlag for their generous cooperation in including late abstracts in this volume, and, last not least, Ms. Simone KRAMBS for untiring secretarial help.
Book Synopsis Intolerant Bodies by : Warwick Anderson
Download or read book Intolerant Bodies written by Warwick Anderson and published by JHU Press. This book was released on 2014-11-15 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: A history of autoimmunity that validates the experience of patients while challenging assumptions about the distinction between the normal and the pathological. Winner of the NSW Premier's History Award of the Arts NSW Autoimmune diseases, which affect 5 to 10 percent of the population, are as unpredictable in their course as they are paradoxical in their cause. They produce persistent suffering as they follow a drawn-out, often lifelong, pattern of remission and recurrence. Multiple sclerosis, lupus, rheumatoid arthritis, and type 1 diabetes—the diseases considered in this book—are but a handful of the conditions that can develop when the immune system goes awry. Intolerant Bodies is a unique collaboration between Ian Mackay, one of the prominent founders of clinical immunology, and Warwick Anderson, a leading historian of twentieth-century biomedical science. The authors narrate the changing scientific understanding of the cause of autoimmunity and explore the significance of having a disease in which one’s body turns on itself. The book unfolds as a biography of a relatively new concept of pathogenesis, one that was accepted only in the 1950s. In their description of the onset, symptoms, and course of autoimmune diseases, Anderson and Mackay quote from the writings of Charles Dickens, Edgar Allan Poe, Joseph Heller, Flannery O’Connor, and other famous people who commented on or grappled with autoimmune disease. The authors also assess the work of the dedicated researchers and physicians who have struggled to understand the mysteries of autoimmunity. Connecting laboratory research, clinical medicine, social theory, and lived experience, Intolerant Bodies reveals how doctors and patients have come to terms, often reluctantly, with this novel and puzzling mechanism of disease causation.
Book Synopsis The Autoimmune Diseases II by : M. Eric Gershwin
Download or read book The Autoimmune Diseases II written by M. Eric Gershwin and published by Elsevier. This book was released on 2012-12-02 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with autoimmune disease in humans (as opposed to autoimmunity itself). It discusses the biological basis of disease at the molecular, genetic, cellular, and epidemiologic levels. It also describes the clinical problems of diagnosis, prognosis, and treatment. The intended audience includes physicians of all specialties in practice, physicians in training such as house staff and fellows, and medical students. It will also be valuable for basic scientists and graduate students interested in the solution of important clinical problems. The book concentrates on topics that have grown or changed dramatically since publication of The Autoimmune Diseases.
Book Synopsis Autoantibodies and Autoimmunity by : Kenneth Michael Pollard
Download or read book Autoantibodies and Autoimmunity written by Kenneth Michael Pollard and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled an all-star team of authors to report on the latest research, technologies, and applications. Following an introductory chapter, the book goes on to cover such topics as cellular mechanisms of autoantibody production, clinical and diagnostic usefulness in human disease, and animal models used to study the elicitation of autoantibodies. The whole is rounded off with a look at future perspectives. With its comprehensive coverage, this volume will appeal not only to immunologists and clinicians but also to cell and molecular biologists.
Book Synopsis The Molecular Biology of Immunosuppression by : Angus W. Thomson
Download or read book The Molecular Biology of Immunosuppression written by Angus W. Thomson and published by John Wiley & Sons. This book was released on 1992 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :International Workshop on the Molecular and Cell Biology of Autoantibodies and Autoimmunity. 2, 1991, San Diego, Calif.. Publisher : ISBN 13 : Total Pages :123 pages Book Rating :4.:/5 (256 download)
Book Synopsis Molecular and Cell Biology of Autoantibodies and Autoimmunity by : International Workshop on the Molecular and Cell Biology of Autoantibodies and Autoimmunity. 2, 1991, San Diego, Calif..
Download or read book Molecular and Cell Biology of Autoantibodies and Autoimmunity written by International Workshop on the Molecular and Cell Biology of Autoantibodies and Autoimmunity. 2, 1991, San Diego, Calif.. and published by . This book was released on 1991 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis B Cell Trophic Factors and B Cell Antagonism in Autoimmune Disease by : William Stohl
Download or read book B Cell Trophic Factors and B Cell Antagonism in Autoimmune Disease written by William Stohl and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The understanding of B cell biology has increased and expanded enormously in the last three decades. It is now known that B cells, in addition to just differentiating into antibody-secreting cells, serve many other vital functions. For example, their roles as antigen-presenting cells and cytokine-producing cells as well as effector cells and regulatory cells are well appreciated now. Indeed, the pathologic role of B cells in many autoimmune disorders may be largely autoantibody-independent. Today, the B cell is of considerable interest not only to immunologists but also to mainstream clinicians and scientists. The current volume covers the latest information on the functions of B cells in normal and disease states, and their therapeutic antagonism. Chapters cover cutting-edge topics from the basic to the clinical, including B cells in infection and autoimmunity, CD19-CD21 signal transduction complex, marginal zone B cell physiology and disease, B cell growth and differentiation, their role in rheumatoid arthritis, SLE treatment, the BAFF/APRIL system and B lymphocyte malignancies. This book is recommended reading for cellular and molecular immunologists as well as for rheumatologists, hematologists and clinical immunologists, and all those interested in human diseases in which B cells play an important contributory role.
Book Synopsis Systemic Autoimmunity by : P. E. Bigazzi
Download or read book Systemic Autoimmunity written by P. E. Bigazzi and published by CRC Press. This book was released on 1991-08-30 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surveys the biotechnologically influenced advances in the understanding of systemic autoimmune disorders, highlighting recent research using cell biology and biochemistry, the cloning of immune cells, recombinant DNA, and molecular genetics. Among the topics are the role of complement in inflammatio
Book Synopsis Immunogenetics of Autoimmune Disease by : Jorge R. Oksenberg
Download or read book Immunogenetics of Autoimmune Disease written by Jorge R. Oksenberg and published by Springer. This book was released on 2014-12-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches.
Book Synopsis Encyclopedia of Medical Immunology by : Ian R. Mackay
Download or read book Encyclopedia of Medical Immunology written by Ian R. Mackay and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a broad appeal to microbiologists, immunologists, and infectious disease specialists, this four volume encyclopedia covers all autoimmune, tropical, and infectious diseases. Emphasis will also be placed on genetics, physiology, metabolism, pathogenesis and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia will bring together an outstanding collection of contributions by top scientists in a variety of fields. Volumes 1-3: Diseases will be divided by the 11 main sections of the body, namely Integumentary, Skeletal, Respiratory, Digestive, Urinary, and Reproductive. For some of the autoimmune disease, more then one system will be involved but the delineation serves to broadly break down the diseases into systems. Volume 4 will cover the vaccines for said diseases and future prospects will be offered by leaders in industry and academia. Volume 4 will also be broken down into all the body systems, as in the other two volumes. For each vaccine, for each disease, and in each system the following will be included: • A list of the vaccines currently available along with a list of the companies that manufacture them • Molecular Immunology of the Vaccine • Type of Immunity involved in protection • Mode of Vaccination for each vaccine; repeated boosters and length of immunological memory • Commercial production of vaccines • Storage of vaccines • Standardization and Control of Vaccines • WHO programs and World-Wide Disease Eradication Programs based upon Vaccines.
Download or read book Autoimmunity written by Andras Perl and published by Humana Press. This book was released on 2012-08-30 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continued refinement of wide-spread access to transgenic technology has allowed for new animal models have been developed that exhibit features of autoimmune disease have been developed that exhibit features of autoimmune disease. The second edition of Autoimmunity: Methods and Protocols researchers in the field detail many of the most up-to-date methods which are now commonly used to study autoimmunity. The first half the book focuses on methods and protocols used to assess immunological and biochemical pathways of diseases pathogenesis in human subjects. While the second half investigates treatment of inflammatory arthritis, experimental allergic encephalomyelitis (EAE), IDDM, scleroderma, and uveitis in animal models and assessment of genetic, immunological, and biochemical parameters underlying spontaneous or exogenous antigen-induced diseases. Written in the highly successful Methods in Molecular Biology(tm) series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Through and intuitive, Autoimmunity: Methods and Protocols, Second Edition seeks to aid scientists in the autoimmunity field to extract new meaning of old models and developing new ones.
