The Molecular Basis Of Neuropathology

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Molecular Neurology

Author : Stephen Waxman
Publisher : Elsevier
ISBN 13 : 0080546188
Total Pages : 597 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Molecular Neurology by : Stephen Waxman

Download or read book Molecular Neurology written by Stephen Waxman and published by Elsevier. This book was released on 2010-07-26 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. - Describes the newest molecular aspects of neurological disorders - Provides an introduction to neurological disorders for basic scientists - Updates clinicians and clinical researchers on the most recent developments

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Author : Roger N. Rosenberg
Publisher : Elsevier
ISBN 13 : 0124105491
Total Pages : 1465 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease by : Roger N. Rosenberg

Download or read book Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease written by Roger N. Rosenberg and published by Elsevier. This book was released on 2014-10-28 with total page 1465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations

The Molecular Basis of Neuropathology

Author : Alan Nelson Davison
Publisher : Igaku-Shoin Medical Publishers
ISBN 13 :
Total Pages : 716 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis The Molecular Basis of Neuropathology by : Alan Nelson Davison

Download or read book The Molecular Basis of Neuropathology written by Alan Nelson Davison and published by Igaku-Shoin Medical Publishers. This book was released on 1981 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neurodegeneration

Author : Dennis Dickson
Publisher : John Wiley & Sons
ISBN 13 : 1405196939
Total Pages : 497 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Neurodegeneration by : Dennis Dickson

Download or read book Neurodegeneration written by Dennis Dickson and published by John Wiley & Sons. This book was released on 2011-11-07 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Essential Concepts in Molecular Pathology

Author : William B. Coleman
Publisher : Academic Press
ISBN 13 : 0128132582
Total Pages : 636 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Essential Concepts in Molecular Pathology by : William B. Coleman

Download or read book Essential Concepts in Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2019-11-23 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today's advances in pathology and medicine. - Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine - Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology - Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology

Molecular Pathology

Author : William B. Coleman
Publisher : Academic Press
ISBN 13 : 0128027878
Total Pages : 805 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Molecular Pathology by : William B. Coleman

Download or read book Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2017-11-09 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. - Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease - Explains the practice of "molecular medicine and the translational aspects of molecular pathology - Teaches from the perspective of "integrative systems biology - Enhanced digital version included with purchase

Neuropathology E-Book

Author : Richard A. Prayson
Publisher : Elsevier Health Sciences
ISBN 13 : 1455728284
Total Pages : 650 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Neuropathology E-Book by : Richard A. Prayson

Download or read book Neuropathology E-Book written by Richard A. Prayson and published by Elsevier Health Sciences. This book was released on 2012-02-23 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropathology, a title in the Foundations in Diagnostic Pathology series, provides all of the latest and most essential information on neoplastic and non-neoplastic conditions of the central and peripheral nervous systems in a high-yield, easy-to-use format. Renowned expert Richard A. Prayson, MD, along with a premier group of neuropathologists, provides unparalleled, expert guidance on the evaluation and diagnosis of a broad spectrum of neuropathic entities using morphologic, immunohistochemical, and molecular genetic techniques. The consistent, practical format with a wealth of illustrations, at-a-glance boxes, and tables make this title ideal for quick reference. Obtain expert, practical guidance on each pathologic entity, including clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnosis, and prognostic and therapeutic considerations. Reference key information quickly and easily with a consistent, user-friendly format and at-a-glance boxes and tables throughout the text. Recognize all the nuances of how pathological lesions present through over 800 full-color illustrations. Practice with confidence and overcome your toughest challenges with advice from the top minds in neuropathology. Make optimal use of the latest approaches for diagnosing fat and air emboli, vascular diseases, trauma, congenital malformations, perinatal diseases and phacomatoses, demyelinating and dysmyelinating disorders, neurodegenerative diseases, infections, metabolic and toxic disorders, glial and non-glial tumors, skeletal muscle and peripheral nerve disorders, and more. Prepare for the future of neuropathology with a new information dedicated to neurotransmitters as they relate to diseases such as Parkinson's and the development of new drugs for these disorders. Apply the latest molecular diagnostic techniques to recognize tumor entities added to the most recent WHO classification of tumors of the central nervous system. Access the fully searchable text online at www.expertconsult.com, along with a downloadable image bank, illustrations, boxes, tables, and more.

The Molecular and Genetic Basis of Neurologic and Psychiatric Disease

Author : Roger N. Rosenberg
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781769563
Total Pages : 930 pages
Book Rating : 4.7/5 (695 download)

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Book Synopsis The Molecular and Genetic Basis of Neurologic and Psychiatric Disease by : Roger N. Rosenberg

Download or read book The Molecular and Genetic Basis of Neurologic and Psychiatric Disease written by Roger N. Rosenberg and published by Lippincott Williams & Wilkins. This book was released on 2008 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely updated for its Fourth Edition, this book is the most comprehensive, current review of the molecular and genetic basis of neurologic and psychiatric diseases. More than 120 leading experts provide a fresh, new assessment of recent molecular, genetic, and genomic advances, offer new insights into disease pathogenesis, describe the newest available therapies, and explore promising areas of therapeutic development. This edition features an updated section on psychiatric disease and expanded, updated chapters on human genomics, gene therapy, and ethical issues. Six new chapters cover congenital myasthenic syndromes, hereditary spastic paraplegia, ion channel disorders, the phakomatoses, beta-galactosidase deficiency, and prion diseases. A Neurologic Gene Map describes the chromosome locus of all the genetic diseases and their gene product where known. The fully searchable online text will be available on a companion Website. (www.rosenbergneuroandpsychdisease.com)

Molecular Physiology and Metabolism of the Nervous System

Author : Gary A. Rosenberg
Publisher : OUP USA
ISBN 13 : 0195394275
Total Pages : 241 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Molecular Physiology and Metabolism of the Nervous System by : Gary A. Rosenberg

Download or read book Molecular Physiology and Metabolism of the Nervous System written by Gary A. Rosenberg and published by OUP USA. This book was released on 2012-04-30 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular basis for the physiology of the brain has advanced enormously in the past twenty years with an influx of new information gleaned through technological developments in neuroimaging and molecular discoveries. Molecular Physiology and Metabolism of the Nervous System, authored by Gary A. Rosenberg, an authority on the physiology of brain fluids and metabolism, combines the classic physiology that dates back to the beginning of the nineteenth century with the advances in molecular sciences, providing a strong framework for understanding the diseases that are commonly treated by neurologists. Molecular Physiology and Metabolism of the Nervous System focuses on the current neuropathology and implications of cerebrospinal fluid diseases and diseases of the blood-brain barrier: how the two affect stroke, infection, brain tumors, and increased intracranial pressure. The book discusses the effects of blood flow in stroke and dementia, the disruption of the blood-brain barrier in neuroinflammation, and the dysfunction due to brain edema and increased intracranial pressure. Molecular Physiology and Metabolism of the Nervous System is necessary reading for neurologists, neuroscientists, and residents in neurology, neurosurgery, and psychiatry, giving them a strong grounding in physiology and metabolism that will aid them in diagnosis and treatment.

The Neuropathology of Dementia

Author : Margaret M. Esiri
Publisher : Cambridge University Press
ISBN 13 : 9780521819152
Total Pages : 600 pages
Book Rating : 4.8/5 (191 download)

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Book Synopsis The Neuropathology of Dementia by : Margaret M. Esiri

Download or read book The Neuropathology of Dementia written by Margaret M. Esiri and published by Cambridge University Press. This book was released on 2004-07-22 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely rewritten and updated, this new edition is almost twice the size of its predecessor. Illustrated in colour throughout, and with contributions from the world's leading authorities, it is the definitive reference on the neuropathology of dementia. It gives practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes: Three entirely new chapters on neuroimaging, molecular diagnostics, and transgenic models. Two chapters on tauopathies under new authorship. A chapter under new authorship on synucleinopathies, which includes multiple system atrophy.

The Neuronal Ceroid Lipofuscinoses (Batten Disease)

Author : Sara Mole
Publisher : OUP Oxford
ISBN 13 : 019101558X
Total Pages : 772 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis The Neuronal Ceroid Lipofuscinoses (Batten Disease) by : Sara Mole

Download or read book The Neuronal Ceroid Lipofuscinoses (Batten Disease) written by Sara Mole and published by OUP Oxford. This book was released on 2011-03-10 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neuronal ceroid lipofuscinoses are an extremely rare group of inherited neurodegenerative diseases that primarily affect children. Core symptoms of these conditions typically include epilepsy, cognitive decline and visual failure. These diseases are so rare that professionals who come into contact with them need a consultative reference work that enables them to become expert, or identify who to contact for more details. Fully updated and revised, this second edition continues to be the definitive volume on this devastating group of disorders. Written by an international collection of authorities in the field, it provides invaluable advice on their diagnosis, patient care, and new treatments that are available. This new edition of the definitive reference text on the neuronal ceroid lipofuscinoses will prove useful for clinicians, family physicians, research scientists, diagnostic laboratories, families affected by the disease as well as by workers in industry planning translational research.

The Molecular Biology of Neurological Disease

Author : Roger N. Rosenberg
Publisher : Butterworth-Heinemann
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Molecular Biology of Neurological Disease by : Roger N. Rosenberg

Download or read book The Molecular Biology of Neurological Disease written by Roger N. Rosenberg and published by Butterworth-Heinemann. This book was released on 1988 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques us ...

The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy

Author : Udo Rüb
Publisher : Springer
ISBN 13 : 331919285X
Total Pages : 154 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy by : Udo Rüb

Download or read book The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy written by Udo Rüb and published by Springer. This book was released on 2015-09-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.

Neuropathology of Drug Addictions and Substance Misuse Volume 1

Author : Victor R Preedy
Publisher : Academic Press
ISBN 13 : 0128003766
Total Pages : 1134 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Neuropathology of Drug Addictions and Substance Misuse Volume 1 by : Victor R Preedy

Download or read book Neuropathology of Drug Addictions and Substance Misuse Volume 1 written by Victor R Preedy and published by Academic Press. This book was released on 2016-03-07 with total page 1134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropathology of Drug Addictions and Substance Misuse, Volume One: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids, Opioids and Emerging Addictions provides the latest research in an area that shows that the neuropathological features of one addiction are often applicable to those of others. The book also details how a further understanding of these commonalties can provide a platform for the study of specific addictions in greater depth, all in an effort to create new modes of understanding, causation, prevention, and treatment. The three volumes in this series address new research and challenges, offering comprehensive coverage on the adverse consequences of the most common drugs of abuse, with each volume serving to update the reader's knowledge on the broader field of addiction, while also deepening our understanding of specific addictive substances. Volume One addresses tobacco, alcohol, cannabinoids, and opioids, with each section providing data on the general, molecular/cellular, and structural/functional neurological aspects of a given substance, along with a focus on the adverse consequences of addictions. - Provides a modern approach on the pathology of substances of abuse, offering an evidence based ethos for understanding the neurology of addictions - Fills an existing gap in the literature by proving a one-stop-shopping synopsis of everything to do with the neuropathology of drugs of addiction and substance misuse - Includes a list of abbreviations, abstracts, applications to other addictions and substance misuse, mini-dictionary of terms, summary points, 6+ figures and tables, and full references in each chapter - Offers coverage of preclinical, clinical, and population studies, from the cell to whole organs, and the genome to whole body

Neuropathology of Neurodegenerative Diseases

Author : Gabor G. Kovacs
Publisher : Cambridge University Press
ISBN 13 : 1316337650
Total Pages : 320 pages
Book Rating : 4.3/5 (163 download)

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Book Synopsis Neuropathology of Neurodegenerative Diseases by : Gabor G. Kovacs

Download or read book Neuropathology of Neurodegenerative Diseases written by Gabor G. Kovacs and published by Cambridge University Press. This book was released on 2017-12-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.

Alcohol and the Nervous System

Author : Edith V. Sullivan
Publisher : Elsevier
ISBN 13 : 0444626220
Total Pages : 703 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Alcohol and the Nervous System by : Edith V. Sullivan

Download or read book Alcohol and the Nervous System written by Edith V. Sullivan and published by Elsevier. This book was released on 2014-10-08 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol is the most widely used drug in the world, yet alcoholism remains a serious addiction affecting nearly 20 million Americans. Our current understanding of alcohol's effect on brain structure and related functional damage is being revolutionized by genetic research, basic neuroscience, brain imaging science, and systematic study of cognitive, sensory, and motor abilities. Volume 125 of the Handbook of Clinical Neurology is a comprehensive, in-depth treatise of studies on alcohol and the brain covering the basic understanding of alcohol's effect on the central nervous system, the diagnosis and treatment of alcoholism, and prospect for recovery. The chapters within will be of interest to clinical neurologists, neuropsychologists, and researchers in all facets and levels of the neuroscience of alcohol and alcoholism. - The first focused reference specifically on alcohol and the brain - Details our current understanding of how alcohol impacts the central nervous system - Covers clinical and social impact of alcohol abuse disorders and the biomedical consequences of alcohol abuse - Includes section on neuroimaging of neurochemical markers and brain function

Etiology of Parkinson's Disease

Author : Jonas H. Ellenberg
Publisher : CRC Press
ISBN 13 : 9780824788230
Total Pages : 600 pages
Book Rating : 4.7/5 (882 download)

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Book Synopsis Etiology of Parkinson's Disease by : Jonas H. Ellenberg

Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.