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The Mechanism Of Actin Polymerization By Fh1fh2 Formins And Profilin
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Book Synopsis Actin-based Motility by : Marie-France Carlier
Download or read book Actin-based Motility written by Marie-France Carlier and published by Springer Science & Business Media. This book was released on 2010-09-23 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of actin by Straub in the 1950’s and the pioneering work of Oosawa on actin self-assembly in helical laments in the 1960’s, many books and conference proceedings have been published. As one of the most essential p- teins in life, essential for movement in organisms rangingfrom bacteria to higher eukaryotes, it is no surprise that actin has fascinated generations of scientists from many different elds. Actin can be considered as a “living treasure” of biology; the kinetics and thermodynamics of self-assembly, the dissipative nature of actin po- merization, the molecular interactions of monomeric and polymerized actin with regulators, the mechanical properties of actin gels, and more recently the force p- ducing motile and morphogenetic processes organized by the actin nanomachine in response to signaling, are all milestones in actin research. Discoveries that directly derive from and provide deeper insight into the fundamental properties of actin are constantly being made, making actin an ever appealing research molecule. At the same time, the explosion in new technologies and techniques in biological sciences has served to attract researchers from an expanding number of disciplines, to study actin. This book presents the latest developments of these new multiscale approaches of force and movement powered by self-assembly processes, with the hope to opening our perspectives on the many areas of actin-based motility research.
Book Synopsis Microtubule Dynamics by : Anne Straube
Download or read book Microtubule Dynamics written by Anne Straube and published by Humana Press. This book was released on 2017-04-30 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules are at the heart of cellular self-organization, and their dynamic nature allows them to explore the intracellular space and mediate the transport of cargoes from the nucleus to the outer edges of the cell and back. In Microtubule Dynamics: Methods and Protocols, experts in the field provide an up-to-date collection of methods and approaches that are used to investigate microtubule dynamics in vitro and in cells. Beginning with the question of how to analyze microtubule dynamics, the volume continues with detailed descriptions of how to isolate tubulin from different sources and with different posttranslational modifications, methods used to study microtubule dynamics and microtubule interactions in vitro, techniques to investigate the ultrastructure of microtubules and associated proteins, assays to study microtubule nucleation, turnover, and force production in cells, as well as approaches to isolate novel microtubule-associated proteins and their interacting proteins. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Definitive and practical, Microtubule Dynamics: Methods and Protocols provides the key protocols needed by novices and experts on how to perform a broad range of well-established and newly-emerging techniques in this vital field.
Download or read book The Plant Cytoskeleton written by Bo Liu and published by Springer Science & Business Media. This book was released on 2010-11-23 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant cells house highly dynamic cytoskeletal networks of microtubules and actin microfilaments. They constantly undergo remodeling to fulfill their roles in supporting cell division, enlargement, and differentiation. Following early studies on structural aspects of the networks, recent breakthroughs have connected them with more and more intracellular events essential for plant growth and development. Advanced technologies in cell biology (live-cell imaging in particular), molecular genetics, genomics, and proteomics have revolutionized this field of study. Stories summarized in this book may inspire enthusiastic scientists to pursue new directions toward understanding functions of the plant cytoskeleton. The Plant Cytoskeleton is divided into three sections: 1) Molecular Basis of the Plant Cytoskeleton; 2) Cytoskeletal Reorganization in Plant Cell Division; and 3) The Cytoskeleton in Plant Growth and Development. This book is aimed at serving as a resource for anyone who wishes to learn about the plant cytoskeleton beyond ordinary textbooks.
Book Synopsis Cytoskeleton by : Jose C. Jimenez-Lopez
Download or read book Cytoskeleton written by Jose C. Jimenez-Lopez and published by BoD – Books on Demand. This book was released on 2017-05-17 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.
Book Synopsis Actin Polymerization in Apicomplexan by : Avinash Kale
Download or read book Actin Polymerization in Apicomplexan written by Avinash Kale and published by Springer. This book was released on 2020-11-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.
Book Synopsis Platelets in Thrombotic and Non-Thrombotic Disorders by : Paolo Gresele
Download or read book Platelets in Thrombotic and Non-Thrombotic Disorders written by Paolo Gresele and published by Springer. This book was released on 2017-03-08 with total page 1402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.
Book Synopsis The Actin Cytoskeleton by : Brigitte M. Jockusch
Download or read book The Actin Cytoskeleton written by Brigitte M. Jockusch and published by Springer. This book was released on 2017-01-03 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.
Download or read book Microtubules: in vivo written by and published by Academic Press. This book was released on 2010-09-24 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules: in vivo includes chapters by experts around the world on many aspects of microtubule imaging in living and fixed cells; assays to study microtubule function in a wide array of model organisms and cultured cells; high resolution approaches to study of the cytoskeleton. The authors share their years of experience, outlining potential pitfalls and critical factors to consider in experimental design, experimental implementation and data interpretation. - Includes chapters by experts around the world on many aspects of microtubule imaging in living and fixed cells; assays to study microtubule function in a wide array of model organisms and cultured cells; high resolution approaches to study of the cytoskeleton - The authors share their years of experience, outlining potential pitfalls and critical factors to consider in experimental design, experimental implementation and data interpretation
Book Synopsis Biophysics of the Failing Heart by : R. John Solaro
Download or read book Biophysics of the Failing Heart written by R. John Solaro and published by Springer Science & Business Media. This book was released on 2013-08-13 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Subjects in the monograph “Biophysics of the Failing Heart” include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies.
Book Synopsis Therapeutic, Probiotic, and Unconventional Foods by : Alexandru Mihai Grumezescu
Download or read book Therapeutic, Probiotic, and Unconventional Foods written by Alexandru Mihai Grumezescu and published by Academic Press. This book was released on 2018-04-18 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic, Probiotic and Unconventional Foods compiles the most recent, interesting and innovative research on unconventional and therapeutic foods, highlighting their role in improving health and life quality, their implications on safety, and their industrial and economic impact. The book focuses on probiotic foods, addressing the benefits and challenges associated with probiotic and prebiotic use. It then explores the most recently investigated and well-recognized nutraceutical and medicinal foods and the food products and ingredients that have both an impact on human health and a potential therapeutic effect. The third and final section explores unconventional foods and discusses intriguing and debated foods and food sources. While research has been conducted on the beneficial biological effects of probiotics and therapeutic food, the use of these foods remains controversial. To overcome the suspicion of the use of alternative, homeopathic and traditional products as therapy, this book reveals and discusses the most recent and scientifically sound and confirmed aspects of the research. - Compiles the most recent, interesting and innovative research on unconventional and therapeutic foods - Highlights the role of unconventional and therapeutic foods in improving health and life quality - Discusses the implications of unconventional and therapeutic foods on safety - Presents the industrial and economic impact of unconventional and therapeutic foods
Download or read book Dyneins written by Stephen M. King and published by Academic Press. This book was released on 2011-08-11 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. Broad-based up-to-date resource for the dynein class of molecular motors Chapters written by world experts in their topics Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features
Book Synopsis Molecular Evolution by : Roderick D.M. Page
Download or read book Molecular Evolution written by Roderick D.M. Page and published by John Wiley & Sons. This book was released on 2009-07-14 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility.
Book Synopsis Bacterial Protein Toxins by : K. Aktories
Download or read book Bacterial Protein Toxins written by K. Aktories and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
Book Synopsis Eukaryotic Membranes and Cytoskeleton by : Gáspár Jékely
Download or read book Eukaryotic Membranes and Cytoskeleton written by Gáspár Jékely and published by Springer. This book was released on 2007-09-14 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: The presence/absence of gene families with central roles in endomembrane and cytoskeleton dynamics in a variety of eukaryotic taxa and an understanding of eukaryote phylogeny allow the cellular machineries present in the last common ancestor of eukaryotes to be accurately reconstructed. Such a reconstruction is fundamental in order to understand eukaryotic diversification, since this is the ancestral cell from which all diversity arose. This book discusses the evolutionary origin and diversification of eukaryotic endomembranes and cytoskeleton from a cell biological and comparative genomic perspective.
Book Synopsis The Immunoglobulins by : Roald Nezlin
Download or read book The Immunoglobulins written by Roald Nezlin and published by Academic Press. This book was released on 1998-05-06 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in vitro even without immunization and to construct new variants of immunoglobulins and their fragments by fusing with various other active molecules. A survey of recent knowledge on immunoglobulin-binding molecules other than antigens and on flexibility of immunoglobulin molecules concludes the discussion of functional aspects of the problem. - Describes recent reviews on the structure and function of immunoglobulin molecules of various species - Summarizes in detail recent findings on the fine structure of the antigen-combining site - Presents comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cell receptors - Summarizes growing data on immunoglobulin binding sites responsible for the reaction of immunoglobulins with molecules other than antigens - Explores the rapid advance of recent biotechnological methods used for the construction of antibody molecules and their fragments with new properties - Presents extensive references and is lavishly illustrated
Book Synopsis Handbook of Cell Signaling by : Ralph A. Bradshaw
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field
Book Synopsis Current Protocols in Bioinformatics by : Andreas D. Baxevanis
Download or read book Current Protocols in Bioinformatics written by Andreas D. Baxevanis and published by Current Protocols. This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Protocols in Bioinformatics is the only publication that responds to the need for both a current and updateable source of bioinformatics methodology. This unique publication assures that you have access to a full range of bioinformatics protocols written by globally-recognized experts in the field, and that these proto-cols are updated and revised as new developments and innovations occur.
