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The Lc Ms Quantitation Of Vardenafil Levitrar In Postmortem Biological Specimens
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Book Synopsis The LC/MS Quantitation of Vardenafil (Levitra) in Postmortem Biological Specimens by :
Download or read book The LC/MS Quantitation of Vardenafil (Levitra) in Postmortem Biological Specimens written by and published by . This book was released on 2006 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. As new medications are introduced to the market and are subsequently used by aviation accident victims, CAMI's forensic toxicology laboratory is tasked with developing analytical methods for the determination of these compounds. This report presents a rapid and reliable method for the identification and quantitation of vardenafil (Levitra) in biological specimens. This procedure utilizes sildenafil-d8, which structurally is closely related to vardenafil, as an internal standard for more accurate and reliable quantitation. The method incorporates solid phase extraction and LC/MS/MS and MS/MS/MS utilizing an atmospheric pressure chemical ionization ion trap mass spectrometer in the positive chemical ionization mode. Solid-phase extraction proved to be exceptionally efficient providing recoveries that ranged from 94-97%. The limit of detection for vardenafil was determined to be 0.19 ng/mL. The linear dynamic range for this compound was 0.39 - 200 ng/mL. This method was successfully applied to postmortem fluid and tissue specimens obtained from an aviation accident victim. This novel analytical procedure proved to be simple, accurate, and robust for the identification and quantitation of vardenafil in postmortem specimens.
Book Synopsis The LC/MS Quantitation of Vardenafil (Levitra®) in Postmortem Biological Specimens by : Robert D. Johnson
Download or read book The LC/MS Quantitation of Vardenafil (Levitra®) in Postmortem Biological Specimens written by Robert D. Johnson and published by . This book was released on 2006 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. As new medications are introduced to the market and are subsequently used by aviation accident victims, CAMI's forensic toxicology laboratory is tasked with developing analytical methods for the determination of these compounds. This report presents a rapid and reliable method for the identification and quantitation of vardenafil (Levitra) in biological specimens. This procedure utilizes sildenafil-d8, which structurally is closely related to vardenafil, as an internal standard for more accurate and reliable quantitation. The method incorporates solid phase extraction and LC/MS/MS and MS/MS/MS utilizing an atmospheric pressure chemical ionization ion trap mass spectrometer in the positive chemical ionization mode. Solid-phase extraction proved to be exceptionally efficient providing recoveries that ranged from 94-97%. The limit of detection for vardenafil was determined to be 0.19 ng/mL. The linear dynamic range for this compound was 0.39 - 200 ng/mL. This method was successfully applied to postmortem fluid and tissue specimens obtained from an aviation accident victim. This novel analytical procedure proved to be simple, accurate, and robust for the identification and quantitation of vardenafil in postmortem specimens.
Book Synopsis The LC/MS Quantitation of Vardenafil (Levitra®) in Postmortem Biological Specimens by : Robert David Johnson
Download or read book The LC/MS Quantitation of Vardenafil (Levitra®) in Postmortem Biological Specimens written by Robert David Johnson and published by . This book was released on 2006 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. As new medications are introduced to the market and are subsequently used by aviation accident victims, CAMI's forensic toxicology laboratory is tasked with developing analytical methods for the determination of these compounds. This report presents a rapid and reliable method for the identification and quantitation of vardenafil (Levitra®) in biological specimens. This procedure utilizes sildenafil-d8, which structurally is closely related to vardenafil, as an internal standard for more accurate and reliable quantitation. The method incorporates solid phase extraction and LC/MS/MS and MS/MS/MS utilizing an atmospheric pressure chemical ionization ion trap mass spectrometer in the positive chemical ionization mode. Solid-phase extraction proved to be exceptionally efficient providing recoveries that ranged from 94-97%. The limit of detection for vardenafil was determined to be 0.19 ng/mL. The linear dynamic range for this compound was 0.39-200 ng/mL. This method was successfully applied to postmortem fluid and tissue specimens obtained from an aviation accident victim. This novel analytical procedure proved to be simple, accurate, and robust for the identification and quantitation of vardenafil in postmortem specimens.
Book Synopsis Effects of Psychoactive Chemicals on Commercial Driver Health and Performance: Stimulants, Hypnotics, Nutritional, and Other Supplements by : Gerald P Krueger
Download or read book Effects of Psychoactive Chemicals on Commercial Driver Health and Performance: Stimulants, Hypnotics, Nutritional, and Other Supplements written by Gerald P Krueger and published by Transportation Research Board. This book was released on 2011 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: TRB’s Commercial Truck and Bus Safety Synthesis Program (CTBSSP) Synthesis 19: Effects of Psychoactive Chemicals on Commercial Driver Health and Performance: Stimulants, Hypnotics, Nutritional, and Other Supplements identifies available information and research gaps relating to the use of chemical substances by commercial drivers and is intended to provide up-to-date information to inform decision makers about the near-, mid-, and long-range planning needs for research and educational outreach programs.
Book Synopsis Oral Pharmacotherapy for Male Sexual Dysfunction by : Gregory A. Broderick
Download or read book Oral Pharmacotherapy for Male Sexual Dysfunction written by Gregory A. Broderick and published by Springer Science & Business Media. This book was released on 2005-02 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Oral Drug Therapy of Male Sexual Dysfunction: A Guide to Clinical Management extensively reviews the physiology and pharmacology of male sexual dysfunction. In addition, it outlines current pharmacologic strategies in the management of erectile dysfunction as well as rapid ejaculation, and previews the next generation of phosphodiesterase inhibitors that are now pending final FDA review. Other areas of interest include the special risk factors that lead to ED and often impede or complicate its treatment, and the distinguishing of facts versus marketing of nutrition supplements in the management of ED.
Book Synopsis Essentials of Spinal Cord Injury by : Michael G. Fehlings
Download or read book Essentials of Spinal Cord Injury written by Michael G. Fehlings and published by Thieme. This book was released on 2012-10-29 with total page 995 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to putting spinal cord injury research into practice Essentials of Spinal Cord Injury is written for the spinal cord injury (SCI) team and reflects the multidisciplinary nature of treating patients with SCI. It integrates emerging medical and surgical approaches to SCI with neuroanatomy, neurophysiology, neuroimaging, neuroplasticity, and cellular transplantation. This comprehensive yet concise reference will enable neurosurgeons, orthopedic surgeons, neurologists, and allied health professionals caring for SCI patients to translate research results into patient care. It is also an excellent resource for those preparing for the board exam in SCI medicine. Key Features: Material is cross-referenced to highlight relationships between the different areas of SCI Chapters are concise, focused, and include key points, pearls, and pitfalls An Overview of the Literature table is provided in most chapters, giving readers a meaningful distillation of each publication referenced Each editor is a world-renowned expert in one of these core disciplines involved in the management of SCI patients: neurosurgery, orthopedic surgery, spinal cord science, and rehabilitative medicine This is a must-have guide that all neurosurgeons, orthopedic surgeons, neurologists, and allied health professionals involved in the care of spinal cord injury patients should have on their bookshelf.
Book Synopsis Posttraumatic Stress Disorder and Related Diseases in Combat Veterans by : Elspeth Cameron Ritchie
Download or read book Posttraumatic Stress Disorder and Related Diseases in Combat Veterans written by Elspeth Cameron Ritchie and published by Springer. This book was released on 2015-10-27 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book takes a case-based approach to addressing the challenges psychiatrists and other clinicians face when working with American combat veterans after their return from a war zone. Written by experts, the book concentrates on a wide variety of concerns associated with posttraumatic stress disorder (PTSD), including different treatments of PTSD. The text also looks at PTSD comorbidities, such as depression and traumatic brain injury (TBI) and other conditions masquerading as PTSD. Finally, the authors touch on other subjects concerning returning veterans, including pain, disability, facing the end of a career, sleep problems , suicidal thoughts, violence, , and mefloquine “toxidrome”. Each case study includes a case presentation, diagnosis and assessment, treatment and management, outcome and case resolution, and clinical pearls and pitfalls. Post-Traumatic Stress Disorder and Related Diseases in Combat Veterans is a valuable resource for civilian and military mental health practitioners, and primary care physicians on how to treat patients returning from active war zones.
Download or read book Interventions for Addiction written by and published by Academic Press. This book was released on 2013-05-20 with total page 1001 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interventions for Addiction examines a wide range of responses to addictive behaviors, including psychosocial treatments, pharmacological treatments, provision of health care to addicted individuals, prevention, and public policy issues. Its focus is on the practical application of information covered in the two previous volumes of the series, Comprehensive Addictive Behaviors and Disorders. Readers will find information on treatments beyond commonly used methods, including Internet-based and faith-based therapies, and criminal justice interventions. The volume features extensive coverage of pharmacotherapies for each of the major drugs of abuse—including disulfiram, buprenorphine, naltrexone, and others—as well as for behavioral addictions. In considering public policy, the book examines legislative efforts, price controls, and limits on advertising, as well as World Health Organization (WHO) efforts. Interventions for Addiction is one of three volumes comprising the 2,500-page series, Comprehensive Addictive Behaviors and Disorders. This series provides the most complete collection of current knowledge on addictive behaviors and disorders to date. In short, it is the definitive reference work on addictions. Includes descriptions of both psychosocial and pharmacological treatments. Addresses health services research on attempts to increase the use of evidence-based treatments in routine clinical practice. Covers attempts to slow the progress of addictions through prevention programs and changes in public policy.
Book Synopsis Stockley's Drug Interactions by : Karen Baxter
Download or read book Stockley's Drug Interactions written by Karen Baxter and published by . This book was released on 2010 with total page 1792 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stockley's Drug Interactions, now fully revised and revalidated, remains the world's most comprehensive and authoritative reference book on drug interactions and provides the busy healthcare professional with quick and easy access to clinically relevant, evaluated and evidence-based information on drug interactions. Contains detailed yet concise monographs: covers interactions between therapeutic drugs, proprietary medicines, herbal medicines, foods, drinks, pesticides and drugs of abuse; based on published sources and fully referenced; provides comprehensive details of the clinical evidence for the interactions under discussion, an assessment of their clinical importance and gives clear guidance on how to manage the interaction in practice; contains over 3,400 monographs; New drugs launched in the last two years added - including drugs such as fesoterodine, several monoclonal antibodies, new antidiabetics (e.g. sitagliptin) new antineoplastics (e.g. dasatinib) and new immunosuppressants (e.g. temsirolimus); updated information on seasonal flu vaccines and antivirals, including all available information on possible interactions with concurrent medication; increased commentary on the involvement of newer mechanisms in drug interactions, such as drug transporter proteins, and other genetic factors that affect the ability of individuals to metabolise medicines.
Book Synopsis Psychiatry Board Review by : Rebecca A. Schmidt
Download or read book Psychiatry Board Review written by Rebecca A. Schmidt and published by McGraw-Hill/Appleton & Lange. This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed as a results-oriented study guide that delivers everything needed to improve knowledge, confidence and recall. Over 3000 rapid-fire questions cover all topics on the psychiatry boards.
Book Synopsis Psychopharmacology by : Jerrold S. Meyer
Download or read book Psychopharmacology written by Jerrold S. Meyer and published by Sinauer Associates is. This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encompassing recent advances in molecular pharmacology and brain imaging, this text covers historical accounts of drug use, through clinical and preclinical behavioural studies, to the latest research on drug effects in transgenic mouse models.
Book Synopsis Stockley's Drug Interactions by : Karen Baxter
Download or read book Stockley's Drug Interactions written by Karen Baxter and published by . This book was released on 2008 with total page 1464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stockley's Drug Interactions, edited by Karen Baxter, remains the world's most comprehensive and authoritative reference book on drug interactions. It provides the busy healthcare professional with quick and easy access to clinically relevant, evaluated and evidence-based information on drug interactions.
Book Synopsis Fundamentals of Acids, Bases, Buffers and Their Application to Biochemical Systems by : Ralph Scorpio
Download or read book Fundamentals of Acids, Bases, Buffers and Their Application to Biochemical Systems written by Ralph Scorpio and published by Kendall Hunt Publishing Company. This book was released on 2000-08-01 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Emergency Medical Services by : Jane H. Brice
Download or read book Emergency Medical Services written by Jane H. Brice and published by John Wiley & Sons. This book was released on 2021-08-12 with total page 1184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two-volume Emergency Medical Services: Clinical Practice and Systems Oversight delivers a thorough foundation upon which to succeed as an EMS medical director and prepare for the NAEMSP National EMS Medical Directors Course and Practicum. Focusing on EMS in the 'real world', the book offers specific management tools that will be useful in the reader's own local EMS system and provides contextual understanding of how EMS functions within the broader emergency care system at a state, local, and national level. The two volumes offer the core knowledge trainees will need to successfully complete their training and begin their career as EMS physicians, regardless of the EMS systems in use in their areas. A companion website rounds out the book's offerings with audio and video clips of EMS best practice in action. Readers will also benefit from the inclusion of: A thorough introduction to the history of EMS An exploration of EMS airway management, including procedures and challenges, as well as how to manage ventilation, oxygenation, and breathing in patients, including cases of respiratory distress Practical discussions of medical problems, including the challenges posed by the undifferentiated patient, altered mental status, cardiac arrest and dysrhythmias, seizures, stroke, and allergic reactions An examination of EMS systems, structure, and leadership
Book Synopsis Postmortem Toxicology of Abused Drugs by : Steven B. Karch, MD, FFFLM
Download or read book Postmortem Toxicology of Abused Drugs written by Steven B. Karch, MD, FFFLM and published by CRC Press. This book was released on 2007-10-09 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Postmortem Toxicology of Abused Drugs considers the role of toxicology in the investigation of homicide, suicide, accident, natural death, and overdose. It gives practical insights and case reviews on co
Book Synopsis Standard Practice in Sexual Medicine by : Hartmut Porst
Download or read book Standard Practice in Sexual Medicine written by Hartmut Porst and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new international standard reference work for sexual medicine Written under the auspices of the International Society for Sexual Medicine, (www.issm.info), the leading professional society in sexual medicine and founder of the most influential journal in the field, The Journal of Sexual Medicine, published by Blackwell Publishing Comprehensive coverage of the full range of diagnostic and treatment options in all aspects of male and female sexual dysfunctions Provides information on recent progress in pharmacologic approaches, including the highly successful drug treatments for ED Useful for any part of the patient-clinician consultation, from gathering symptoms to diagnosis to treatment to reports on potential and developing treatments
Book Synopsis Cyclic Nucleotide Signaling by : XiaoDong Cheng
Download or read book Cyclic Nucleotide Signaling written by XiaoDong Cheng and published by CRC Press. This book was released on 2021-03-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.
