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Author : Olivia Rachel-Rose Matthai
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.:/5 (94 download)
Download or read book The Isolation and Characterisation of Human Brain Proteins written by Olivia Rachel-Rose Matthai and published by . This book was released on 1983 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Olivia Rachel-Rose Matthai
Publisher :
ISBN 13 :
Total Pages : 210 pages
Book Rating : 4.:/5 (926 download)
Download or read book The Isolation Nd Characterisation of Human Brain Proteins written by Olivia Rachel-Rose Matthai and published by . This book was released on 1983 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gudrun Staub Bennett
Publisher :
ISBN 13 :
Total Pages : 100 pages
Book Rating : 4.:/5 (381 download)
Download or read book The Isolation and Characterization of Soluble Brain Proteins written by Gudrun Staub Bennett and published by . This book was released on 1968 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Linda Shoer Johnson
Publisher :
ISBN 13 :
Total Pages : 99 pages
Book Rating : 4.:/5 (774 download)
Download or read book Isolation and Partial Characterization of a Fibrous Protein from Mammalian Brain written by Linda Shoer Johnson and published by . This book was released on 1972 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kenneth S. Kosik
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (31 download)
Download or read book Characterization of Postmortem Human Brain Proteins by Two-dimensional Gel Electrophoresis written by Kenneth S. Kosik and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Wesley Longshore
Publisher :
ISBN 13 :
Total Pages : 202 pages
Book Rating : 4.:/5 (341 download)
Download or read book Isolation and Characterization of Human Brain Genes with CCA Trinucleotide Repeats written by John Wesley Longshore and published by . This book was released on 1995 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Eric Bertrand
Publisher : Springer Science & Business Media
ISBN 13 : 1402059434
Total Pages : 397 pages
Book Rating : 4.4/5 (2 download)
Download or read book Subcellular Proteomics written by Eric Bertrand and published by Springer Science & Business Media. This book was released on 2007-08-29 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jesus Avila
Publisher : Frontiers E-books
ISBN 13 : 288919261X
Total Pages : 114 pages
Book Rating : 4.8/5 (891 download)
Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Author :
Publisher : Elsevier
ISBN 13 : 0080538495
Total Pages : 273 pages
Book Rating : 4.0/5 (85 download)
Download or read book Pathobiology of Alzheimer's Disease written by and published by Elsevier. This book was released on 1995-10-17 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field.With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease.Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research. * * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective* A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease.* Up-to-date research data* Clear illustrations complement the text
Author : Shohreh Amini
Publisher : Humana
ISBN 13 : 9781071614396
Total Pages : 205 pages
Book Rating : 4.6/5 (143 download)
Download or read book Neuronal Cell Culture written by Shohreh Amini and published by Humana. This book was released on 2022-06-09 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume details the latest aspects of neural cells covering the practical and theoretical considerations of each techniques involved. Chapters guide readers through a general overview of the neuronal culturing principles, cell line models for neural cells, the isolation and propagation of primary cultures, stem cells, transfection and transduction of neural cultures, and other more advanced techniques. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and easy to use, Neuronal Cell Culture: Methods and Protocols, Second Edition aims to be of interest to scientists at all levels studying cell culture models for neuroscientific studies.
Author : Hafiz Ahmed
Publisher : CRC Press
ISBN 13 : 0203507436
Total Pages : 408 pages
Book Rating : 4.2/5 (35 download)
Download or read book Principles and Reactions of Protein Extraction, Purification, and Characterization written by Hafiz Ahmed and published by CRC Press. This book was released on 2017-07-27 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Reactions of Protein Extraction, Purification, and Characterization provides the mechanisms and experimental procedures for classic to cutting-edge techniques used in protein extraction, purification, and characterization. The author presents the principles and reactions behind each procedure and uses tables to compare the different
Author : Gene I. Sher
Publisher : Springer Science & Business Media
ISBN 13 : 1461444632
Total Pages : 836 pages
Book Rating : 4.4/5 (614 download)
Download or read book Handbook of Neuroevolution Through Erlang written by Gene I. Sher and published by Springer Science & Business Media. This book was released on 2012-11-06 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Neuroevolution Through Erlang presents both the theory behind, and the methodology of, developing a neuroevolutionary-based computational intelligence system using Erlang. With a foreword written by Joe Armstrong, this handbook offers an extensive tutorial for creating a state of the art Topology and Weight Evolving Artificial Neural Network (TWEANN) platform. In a step-by-step format, the reader is guided from a single simulated neuron to a complete system. By following these steps, the reader will be able to use novel technology to build a TWEANN system, which can be applied to Artificial Life simulation, and Forex trading. Because of Erlang’s architecture, it perfectly matches that of evolutionary and neurocomptational systems. As a programming language, it is a concurrent, message passing paradigm which allows the developers to make full use of the multi-core & multi-cpu systems. Handbook of Neuroevolution Through Erlang explains how to leverage Erlang’s features in the field of machine learning, and the system’s real world applications, ranging from algorithmic financial trading to artificial life and robotics.
Author :
Publisher :
ISBN 13 :
Total Pages : 1828 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ronald Trent
Publisher : Humana
ISBN 13 : 9781493947003
Total Pages : 0 pages
Book Rating : 4.9/5 (47 download)
Download or read book Clinical Bioinformatics written by Ronald Trent and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Clinical Bioinformatics, Second Edition, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Recent developments in omics, such as increasingly sophisticated analytic platforms allowing changes in diagnostic strategies from the traditional focus on single or small number of analytes to what might be possible when large numbers or all analytes are measured, are now impacting patient care. Covering such topics as gene discovery, gene function (microarrays), DNA sequencing, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly explores this cutting-edge subject. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Clinical Bioinformatics, Second Edition serves as an ideal guide for scientists and health professionals working in genetics and genomics.
Author : Hugh S. Markus
Publisher : Oxford Medical Publications
ISBN 13 : 0198515863
Total Pages : 362 pages
Book Rating : 4.1/5 (985 download)
Download or read book Stroke Genetics written by Hugh S. Markus and published by Oxford Medical Publications. This book was released on 2003 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.
Author : Roger Harrison
Publisher : Routledge
ISBN 13 : 1351421018
Total Pages : 398 pages
Book Rating : 4.3/5 (514 download)
Download or read book Protein Purification Process Engineering written by Roger Harrison and published by Routledge. This book was released on 2019-07-16 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers coverage of the development of protein purification processes for large-scale commercial operations, and addresses process development, scale-up, applications and mathematical descriptions. Technologies currently used at the commercial scale are covered in depth.
