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The Gtpase Superfamily
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Book Synopsis The GTPase Superfamily by : Joan Marsh
Download or read book The GTPase Superfamily written by Joan Marsh and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a multidisciplinary approach, it features contributions and discussions of the latest research from leading scientists working on all aspects of GTPase activity. Covers all known members of the important superfamily of enzymes--the GTPases. Considers numerous key cellular functions and how they are regulated by GTPases. Also describes various regulatory proteins that modulate GTPase activity.
Book Synopsis Ras Superfamily Small G Proteins: Biology and Mechanisms 2 by : Alfred Wittinghofer
Download or read book Ras Superfamily Small G Proteins: Biology and Mechanisms 2 written by Alfred Wittinghofer and published by Springer. This book was released on 2014-09-26 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second of two volumes discusses subfamily proteins which function in molecular and vesicular transport mechanisms inside the cell. In this volume the focus lies on the Rab, Ran and Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 this book provides an comprehensive state-of-the-art work on small G-proteins (GTPases). It is written for Graduates and Professors in Biochemistry and Cell Biology interested in the mechanism and function of small G-proteins but are extremely valuable for those who want to move into the field.
Download or read book GTPase Protocols written by Ed Manser and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last 10 years researchers have firmly established key roles for R- related GTPases in almost every aspect of cell biology. In the 1980s the pro- oncogene Ras itself was the focus of interest, though in the 1990s this shifted to the increasing variety of Ras-related proteins. In this new decade much yet needs to be done to establish the role for all the small GTPases now uncovered by the human genome project. In particular, these GTPases need to be und- stood in the appropriate biochemical and cellular contexts. In the process of trying to uncover the role of these versatile proteins, a variety of novel te- niques and methodologies has been developed. These now enable investi- tors to move easily within a diversity of fields ranging from structural studies to real-time in vivo analysis of a GTPase. In recognition of the need for access to key background methodologies, GTPase Protocols: The Ras Superfamily is devoted to techniques that are pr- ently widely used and that will continue to be the standard for researchers worldwide. Each chapter is aimed at supplying detailed methodologies to allow reproduction in any laboratory, while also providing the general pr- ciples on which the methods are based. Some of the techniques grouped in the first section apply broadly to small GTPases, whereas others in Part II are more applicable within each GTPase subfamily.
Book Synopsis Dynamin Superfamily GTPases by : Rajesh Ramachandran
Download or read book Dynamin Superfamily GTPases written by Rajesh Ramachandran and published by Humana. This book was released on 2020-06-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides methods and protocols on dynamin superfamily GTPases. Chapters are divided into three parts; detailing expression, purification, initial biochemical steps, undescribed analytical techniques, and biophysical and cellular characterization of DSPs in membrane remodeling, fission and fusion. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Dynamin Superfamily GTPases: Methods and Protocols to ensure successful results in the further study of this vital field.
Book Synopsis The ras Superfamily of GTPases (1993) by : Juan Carlos Lacal
Download or read book The ras Superfamily of GTPases (1993) written by Juan Carlos Lacal and published by CRC Press. This book was released on 2017-11-22 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.
Book Synopsis The ras Superfamily of GTPases by : Juan Carlos Lacal
Download or read book The ras Superfamily of GTPases written by Juan Carlos Lacal and published by CRC Press. This book was released on 1993-06-11 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.
Book Synopsis Encyclopedic Reference of Cancer by : Manfred Schwab
Download or read book Encyclopedic Reference of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2001-10-15 with total page 1017 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid and focused information about topics of cancer research for the clinical and basic scientist, students and informed laymen. It will be readily accessible, both electronically and in print, such that it will be of value to both the scientific community and the public.
Book Synopsis Ras Superfamily Small G Proteins: Biology and Mechanisms 1 by : Alfred Wittinghofer
Download or read book Ras Superfamily Small G Proteins: Biology and Mechanisms 1 written by Alfred Wittinghofer and published by Springer. This book was released on 2014-09-22 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
Book Synopsis ARF Family GTPases by : Richard A. Kahn
Download or read book ARF Family GTPases written by Richard A. Kahn and published by Springer Science & Business Media. This book was released on 2004-02-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.
Book Synopsis Ras Signaling by : Lorenza Trabalzini
Download or read book Ras Signaling written by Lorenza Trabalzini and published by Humana. This book was released on 2014-01-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring experimental approaches that shed light on the complexity of Ras GTPase biological functions, Ras Signaling: Methods and Protocols contains general overviews and detailed applications of both well-established and recently developed research techniques, including biochemical, biophysical, molecular biology, genetic and behavioral approaches, advanced high resolution fluorescence and electron microscopy imaging and “omics” technologies. Through this, the detailed volume provides information on expression, post-translational modifications, subcellular localization and dynamics, regulatory mechanisms of upstream and downstream signaling pathways and ultimately, biological activities and functions of Ras GTPases in different model systems, including high and low eukaryotic organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include brief introductions, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Wide-ranging and authoritative, Ras Signaling: Methods and Protocols serves as an aid for investigators of different backgrounds and interests related to the multiple physiological and pathological functions of the large superfamily of Ras GTPases.
Download or read book GTPases in Biology I written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: The GTPase switch appears to be almost as old as life itself, and nature has adapted it to a variety of purposes. This two-volume work surveys the major classes of GTPases, including their role in ensuring accuracy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer. 80 chapters contain much previously unpublished data and, at the rate the extended family of GTPases is growing, it is unlikely that it will again sit for a group portrait such as this. Thus, this could well become the standard reference work.
Book Synopsis GTPase Protocols by : Edward J. Manser
Download or read book GTPase Protocols written by Edward J. Manser and published by . This book was released on 2002 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small GTPase binding proteins (GTPases) are an ancient group of proteins that play key roles in almost every aspect of cell biology, from cell proliferation to nuclear transport. In GTPase Protocols: The Ras Superfamily, Edward J. Manser and Thomas Leung have collected the key techniques currently in use to probe the function of these ubiquitous proteins both in vitro and in vivo. Presented in a format that ensures ready reproducibility by accomplished experimentalists who have refined the various methods in their laboratories, each technique includes step-by-step instructions, tips on avoiding pitfalls and troubleshooting, and ancillary notes explaining how to adapt each procedure in the event of problems. The methods cover the spectrum of core techniques required for the five major GTPase subfamilies (Ras, Rho, Rab, Arf, and Ran) and permit a diversity of applications ranging from structural studies on a GTPase to real time in vivo analysis. Timely and highly practical, GTPase Protocols: The Ras Superfamily illuminates the powerful techniques used by investigators today to study this special family of proteins that plays such important roles in human health and disease.
Book Synopsis RAS Family GTPases by : Channing Der
Download or read book RAS Family GTPases written by Channing Der and published by Springer. This book was released on 2006-09-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.
Download or read book The Small GTPase Ran written by Mark Rush and published by Springer. This book was released on 2012-10-23 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: RAN: AN ATYPICAL GTPASE Mark G. Rush and Peter D'Eustachio New York University School o/Medicine. Department,o/Biochemistry New York NY 10016 ABSTRACT GTPases, proteins that bind and hydrolyze GTP (guanosine triphos phate) are critical regulators of many metabolic pathways. Although these proteins are enzymes that catalyze the hydrolysis of GTP to GDP + Pi, their primary function is not the hydrolysis of GTP per se, but rather the coupling of this hydrolysis to metabolic regulation. Such coupling is gen erally achieved through the interaction of the GTP-bound form of the GTPase with proteins known as ·effectors. Effectors are often enzymes whose activities are modulated by the GTPase. However, effectors can also be structural proteins involved in assembling intracellular macromo lecular complexes, such as actin filaments and microtubules, as well as proteins involved in the intracellular transport of proteins and RNAs. In deed, the subject of this anthology, the small GTPase Ran, may exert most or all of its regulatory functions by interacting with non-enzyme effectors. This property of Ran distinguishes it from other well studied GTPases, and has resulted in the elucidation of novel mechanisms of Ran action that are quite distinct from previously established paradigms of GTPase function. 1. INTRODUCTION The Ras-related nuclear protein Ran is a highly conserved (80% identity among yeasts and humans) member of the Ras superfamily of small GTP binding and hydrolyzing proteins.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Rab GTPases and Membrane Trafficking by : Guangpu Li
Download or read book Rab GTPases and Membrane Trafficking written by Guangpu Li and published by Bentham Science Publishers. This book was released on 2012-05-21 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Ypt/Rab GTPases form the largest branch of the Ras-related small GTPase superfamily and regulate intracellular membrane trafficking in all eukaryotes. Since their discovery over two decades ago, a wealth of information has accumulated about the roles that"
Download or read book GTPases written by Girdhar K. Pandey and published by Springer. This book was released on 2014-11-14 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: G proteins are the key regulators for a wide range of cellular processes in animals and plants. In comparison to animals and yeast, plants have a single Rho-GTPase subfamily called Rho-like GTPases (ROPs). The ROP family of monomeric GTPases has emerged as a versatile and key regulator in plant signal transduction processes. During the past few years’ studies on plant RHO-type (ROP) GTPase have generated new insights into their role in diverse processes ranging from cytoskeletal organization, polar growth, development to stress and hormonal responses. Studies have shown that plants have evolved specific regulators and effector molecules. ROP GTPases possess the ability to interact with these multiple regulator and effector molecules that ultimately determines their signaling specificity. Recently, genome wide studies in plants have shown that the Arabidopsis genome encodes 93, and rice has nearly 85 small GTPase homologs. And we have been able to identify four new homologs in the rice genome. Here, we focus on the complete phylogenetic, domain, structural and expression analysis during stress and various developmental processes of small GTPases in plants. The comparison of gene expression patterns of the individual members of the GTPase family may help to reveal potential plant specific signaling mechanisms and their relevance. Also, we are summarizing the role of currently known ROP GTPases and their interacting proteins with brief description, simultaneously, comparing their expression pattern based on microarray data. Overall, we will be discussing the functional genomic perspective of plant Rho like GTPases and their role in regulating several physiological processes such as stress, hormonal, pollen tube, root hair-growth and other developmental responses.
